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chr10:63,414,038-66,034,105

Best TWAS P=1.02e-37 · Best GWAS P=3.66e-26 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	ADO	0.04	0.01	blup	465	0.02	1.8e-03	10.2	7.5	8.0e-14	0.19	0.00	0.96	FALSE
2	CommonMind	Brain Pre-frontal Cortex	REEP3	0.05	0.05	lasso	3	0.04	5.9e-06	9.0	9.9	3.7e-23	-0.95	0.02	0.98	FALSE
3	GTEx	Adipose Subcutaneous	REEP3	0.10	0.03	lasso	3	0.03	7.2e-04	-9.8	9.8	1.0e-22	-0.64	0.36	0.37	TRUE
4	GTEx	Brain Cortex	NRBF2	0.30	0.26	enet	24	0.21	1.4e-06	-9.0	-10.1	5.3e-24	0.95	0.02	0.97	FALSE
5	GTEx	Brain Frontal Cortex BA9	NRBF2	0.25	0.17	lasso	6	0.16	6.1e-05	9.0	-9.9	3.9e-23	0.96	0.02	0.97	FALSE
6	GTEx	Cells Transformed fibroblasts	REEP3	0.18	0.08	enet	9	0.13	1.1e-09	2.1	5.3	1.0e-07	-0.03	0.98	0.00	FALSE
7	GTEx	Esophagus Mucosa	NRBF2	0.14	0.11	lasso	10	0.11	6.4e-08	8.8	-9.1	6.9e-20	0.89	0.92	0.07	FALSE
8	GTEx	Muscle Skeletal	ADO	0.15	0.16	lasso	8	0.16	1.1e-15	10.0	10.3	1.2e-24	0.05	0.01	0.99	FALSE
9	GTEx	Muscle Skeletal	RP11-436D10.3	0.08	0.04	enet	13	0.06	3.2e-06	-7.2	9.4	4.5e-21	0.03	0.01	0.99	TRUE
10	GTEx	Nerve Tibial	NRBF2	0.08	0.09	enet	11	0.06	5.0e-05	8.8	-7.3	1.9e-13	0.88	0.09	0.90	FALSE
11	GTEx	Stomach	NRBF2	0.09	0.04	lasso	6	0.03	1.6e-02	-7.2	-9.0	3.0e-19	0.78	0.05	0.60	TRUE
12	GTEx	Testis	NRBF2	0.14	0.08	lasso	12	0.09	6.7e-05	8.8	-9.6	7.6e-22	0.92	0.14	0.82	FALSE
13	GTEx	Testis	ADO	0.21	0.23	lasso	7	0.22	6.6e-10	10.0	-10.1	7.3e-24	-0.07	0.01	0.99	FALSE
14	GTEx	Thyroid	EGR2	0.08	0.01	enet	40	0.02	6.4e-03	4.8	5.2	2.1e-07	-0.01	0.54	0.10	FALSE
15	NTR	Blood	NRBF2	0.03	0.01	bslmm	386	0.01	3.4e-05	5.1	12.8	1.0e-37	-0.51	0.12	0.45	TRUE
16	ROSMAP	Brain Pre-frontal Cortex	NRBF2	0.34	0.46	lasso	5	0.46	3.1e-66	9.0	-9.7	3.0e-22	0.94	1.00	0.00	FALSE
17	ROSMAP	Brain Pre-frontal Cortex	REEP3	0.10	0.11	lasso	8	0.09	7.2e-12	-8.7	9.3	1.0e-20	-0.75	1.00	0.00	FALSE
18	ROSMAP	Brain Pre-frontal Cortex	ADO	0.06	0.04	lasso	2	0.06	3.1e-08	-7.2	6.2	4.9e-10	0.12	0.96	0.03	FALSE
19	The Cancer Genome Atlas	Breast Invasive Carcinoma	ADO	0.03	0.02	blup	53	0.03	1.8e-06	6.9	9.8	1.8e-22	0.09	0.02	0.98	FALSE
20	The Cancer Genome Atlas	Breast Invasive Carcinoma	NRBF2	0.05	0.06	lasso	2	0.06	5.5e-12	9.0	-8.9	8.0e-19	0.89	0.09	0.91	FALSE
21	The Cancer Genome Atlas	Glioblastoma Multiforme	JMJD1C	0.11	0.02	blup	87	0.05	1.4e-02	9.1	-6.5	6.1e-11	0.79	0.05	0.10	FALSE
22	The Cancer Genome Atlas	Glioblastoma Multiforme	NRBF2	0.17	0.09	enet	10	0.13	1.1e-04	9.0	-5.8	4.9e-09	0.75	0.09	0.28	FALSE
23	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	NRBF2	0.04	0.04	enet	5	0.03	1.3e-04	9.1	-9.9	4.6e-23	0.91	0.02	0.92	FALSE
24	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ADO	0.10	0.03	enet	6	0.06	4.6e-07	10.2	8.8	1.2e-18	0.04	0.00	1.00	FALSE
25	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	NRBF2	0.10	0.06	lasso	7	0.08	3.5e-09	-9.5	-10.6	4.4e-26	0.86	0.00	1.00	FALSE
26	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	NRBF2	0.08	0.01	blup	40	0.03	6.6e-03	-9.5	-5.3	1.0e-07	0.55	0.00	0.72	TRUE
27	The Cancer Genome Atlas	Brain Lower Grade Glioma	ADO	0.07	0.06	blup	53	0.05	2.5e-06	10.2	10.6	2.6e-26	0.07	0.00	1.00	FALSE
28	The Cancer Genome Atlas	Brain Lower Grade Glioma	ARID5B	0.05	0.05	lasso	2	0.04	3.7e-05	-5.7	5.9	3.5e-09	0.03	0.79	0.01	TRUE
29	The Cancer Genome Atlas	Brain Lower Grade Glioma	NRBF2	0.08	0.08	enet	6	0.08	4.3e-09	9.0	-9.1	1.4e-19	0.90	0.09	0.91	TRUE
30	The Cancer Genome Atlas	Brain Lower Grade Glioma	REEP3	0.04	0.04	blup	59	0.05	1.8e-06	-9.4	8.7	4.1e-18	-0.80	0.07	0.93	FALSE
31	The Cancer Genome Atlas	Lung Adenocarcinoma	NRBF2	0.09	0.06	enet	8	0.07	2.7e-08	9.1	-7.2	4.5e-13	0.82	0.08	0.91	TRUE
32	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	NRBF2	0.09	0.02	enet	6	0.04	1.4e-05	-3.2	-7.5	6.2e-14	0.74	0.01	0.99	FALSE
33	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	ADO	0.06	0.04	blup	55	0.01	1.4e-01	-7.2	7.3	3.8e-13	0.10	0.02	0.42	FALSE
34	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	LOC84989	0.10	0.05	blup	19	0.04	7.7e-03	-3.7	-6.6	5.3e-11	0.67	0.02	0.05	FALSE
35	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	NRBF2	0.18	0.13	enet	11	0.08	2.5e-04	9.1	-7.3	2.5e-13	0.82	0.07	0.78	TRUE
36	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	NRBF2	0.08	0.02	blup	40	0.04	8.6e-03	9.0	-7.4	1.8e-13	0.77	0.02	0.29	FALSE
37	The Cancer Genome Atlas	Prostate Adenocarcinoma	JMJD1C	0.04	0.01	blup	88	0.01	9.7e-03	9.0	-8.8	1.5e-18	0.80	0.03	0.74	FALSE
38	The Cancer Genome Atlas	Prostate Adenocarcinoma	NRBF2	0.08	0.09	lasso	6	0.08	9.7e-09	9.1	-9.6	7.3e-22	0.91	0.08	0.92	FALSE
39	The Cancer Genome Atlas	Skin Cutaneous Melanoma	EGR2	0.12	0.10	blup	56	0.10	1.4e-03	7.7	7.9	3.9e-15	0.03	0.03	0.11	FALSE
40	The Cancer Genome Atlas	Thyroid Carcinoma	ADO	0.12	0.10	lasso	5	0.09	5.2e-09	-7.2	8.4	3.9e-17	0.08	0.93	0.07	FALSE
41	The Cancer Genome Atlas	Thyroid Carcinoma	NRBF2	0.14	0.10	enet	16	0.09	8.1e-09	9.1	-8.7	4.1e-18	0.86	0.08	0.92	TRUE