Best TWAS P=5.98e-13 · Best GWAS P=2.88e-12 conditioned to 0.46
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | STX3 | 0.13 | 0.06 | lasso | 2 | 0.06 | 1.2e-05 | -5.8 | 6.0 | 2.4e-09 | -0.79 | 0.21 | 0.76 | FALSE |
2 | GTEx | Artery Tibial | STX3 | 0.06 | 0.09 | lasso | 2 | 0.08 | 1.3e-06 | -5.8 | 5.8 | 7.8e-09 | -0.77 | 0.77 | 0.22 | FALSE |
3 | GTEx | Brain Hippocampus | AP000442.1 | 0.20 | 0.17 | lasso | 2 | 0.09 | 4.3e-03 | -5.7 | -5.9 | 4.4e-09 | 0.77 | 0.11 | 0.28 | FALSE |
4 | GTEx | Brain Nucleus accumbens basal ganglia | AP000442.1 | 0.21 | 0.00 | lasso | 2 | 0.02 | 9.8e-02 | -5.8 | -5.8 | 8.6e-09 | 0.77 | 0.08 | 0.75 | FALSE |
5 | GTEx | Muscle Skeletal | AP000442.1 | 0.07 | 0.05 | enet | 9 | 0.05 | 4.9e-06 | -6.9 | -6.2 | 4.3e-10 | 0.84 | 0.01 | 0.98 | FALSE |
6 | GTEx | Nerve Tibial | STX3 | 0.16 | 0.15 | enet | 12 | 0.15 | 4.6e-11 | -5.8 | 6.3 | 3.7e-10 | -0.84 | 0.45 | 0.55 | FALSE |
7 | GTEx | Pituitary | AP000442.1 | 0.24 | 0.28 | enet | 15 | 0.24 | 1.3e-06 | -6.8 | -6.5 | 1.0e-10 | 0.88 | 0.02 | 0.98 | FALSE |
8 | GTEx | Testis | STX3 | 0.14 | 0.03 | lasso | 6 | 0.06 | 9.7e-04 | -6.2 | 5.3 | 1.4e-07 | -0.66 | 0.46 | 0.30 | FALSE |
9 | NTR | Blood | TCN1 | 0.03 | 0.02 | blup | 373 | 0.02 | 6.2e-06 | -4.7 | -7.2 | 6.0e-13 | 0.42 | 0.96 | 0.01 | TRUE |
10 | ROSMAP | Brain Pre-frontal Cortex | STX3 | 0.07 | 0.08 | lasso | 9 | 0.08 | 1.6e-10 | -7.0 | 6.9 | 4.3e-12 | -0.92 | 0.02 | 0.98 | FALSE |
11 | YFS | Blood | STX3 | 0.08 | 0.10 | lasso | 6 | 0.09 | 3.4e-29 | -6.9 | 6.9 | 4.2e-12 | -0.92 | 0.01 | 0.99 | FALSE |
12 | The Cancer Genome Atlas | Colon Adenocarcinoma | MS4A4A | 0.06 | 0.04 | blup | 79 | 0.05 | 1.1e-03 | -5.2 | -5.5 | 3.9e-08 | 0.19 | 0.05 | 0.90 | FALSE |
13 | The Cancer Genome Atlas | Esophageal Carcinoma | PATL1 | 0.14 | 0.04 | blup | 32 | 0.06 | 4.3e-03 | -6.9 | 6.6 | 3.5e-11 | -0.90 | 0.00 | 0.87 | TRUE |
14 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | MS4A4A | 0.05 | 0.07 | lasso | 2 | 0.06 | 4.6e-07 | -5.1 | -5.1 | 3.0e-07 | 0.19 | 0.02 | 0.98 | FALSE |
15 | The Cancer Genome Atlas | Brain Lower Grade Glioma | MS4A4A | 0.05 | 0.05 | blup | 79 | 0.05 | 1.3e-06 | -4.8 | -5.2 | 2.2e-07 | 0.20 | 0.03 | 0.96 | FALSE |
16 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | MS4A4A | 0.03 | 0.02 | blup | 79 | 0.02 | 4.2e-03 | -4.8 | -5.5 | 3.1e-08 | 0.19 | 0.05 | 0.85 | FALSE |
17 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | MS4A4A | 0.06 | 0.08 | lasso | 5 | 0.06 | 8.2e-05 | -5.1 | -5.2 | 2.6e-07 | 0.18 | 0.02 | 0.97 | FALSE |
18 | The Cancer Genome Atlas | Prostate Adenocarcinoma | MS4A4A | 0.07 | 0.03 | blup | 79 | 0.04 | 2.8e-05 | -5.6 | -5.2 | 2.4e-07 | 0.17 | 0.00 | 0.99 | FALSE |