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chr11:60,760,530-62,346,131

Best TWAS P=1.6e-23 · Best GWAS P=2.5e-22 conditioned to 0.00655

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	FADS1	0.14	0.16	lasso	2	0.16	7.2e-19	-9.0	9.0	2.7e-19	-0.91	0.64	0.36	FALSE
2	CommonMind	Brain Pre-frontal Cortex	FEN1	0.07	0.06	lasso	4	0.06	1.1e-07	-9.0	-9.0	2.0e-19	0.91	0.04	0.96	FALSE
3	GTEx	Artery Tibial	FADS2	0.08	0.02	lasso	4	0.02	6.9e-03	-8.2	-6.3	3.9e-10	0.68	0.08	0.84	FALSE
4	GTEx	Artery Tibial	TMEM258	0.08	0.05	lasso	5	0.02	1.1e-02	-8.9	-8.9	7.0e-19	0.89	0.05	0.94	FALSE
5	GTEx	Brain Cerebellum	FADS1	0.35	0.24	enet	16	0.30	2.1e-09	-9.7	9.5	2.7e-21	-0.92	0.01	0.99	FALSE
6	GTEx	Brain Cerebellum	FADS3	0.26	0.18	lasso	4	0.14	5.7e-05	-9.7	9.6	5.8e-22	-0.99	0.01	0.96	FALSE
7	GTEx	Brain Putamen basal ganglia	FADS1	0.29	0.21	enet	30	0.16	1.4e-04	-9.0	8.2	1.6e-16	-0.72	0.01	0.95	FALSE
8	GTEx	Breast Mammary Tissue (Female)	TMEM258	0.20	0.02	lasso	7	0.00	2.3e-01	-5.8	-7.5	6.2e-14	0.71	0.02	0.68	FALSE
9	GTEx	Cells Transformed fibroblasts	TMEM258	0.15	0.05	enet	15	0.07	1.1e-05	-8.2	-8.0	1.4e-15	0.75	0.04	0.95	FALSE
10	GTEx	Colon Transverse	FADS2	0.18	0.11	lasso	7	0.16	8.1e-08	-3.1	-6.1	8.3e-10	0.80	0.01	0.99	FALSE
11	GTEx	Esophagus Mucosa	FADS1	0.11	0.00	lasso	4	0.02	1.9e-02	-8.7	8.2	2.1e-16	-0.80	0.02	0.95	FALSE
12	GTEx	Muscle Skeletal	FADS2	0.08	0.04	lasso	2	0.03	5.9e-04	-9.3	-8.0	1.8e-15	0.78	0.20	0.78	FALSE
13	GTEx	Pancreas	FADS1	0.17	0.13	lasso	6	0.12	1.2e-05	-9.7	9.8	6.9e-23	-0.99	0.00	1.00	FALSE
14	NTR	Blood	C11orf10	0.06	0.08	bslmm	399	0.08	1.3e-24	-8.2	-8.6	8.2e-18	0.85	0.94	0.06	FALSE
15	ROSMAP	Brain Pre-frontal Cortex	TMEM258	0.14	0.16	lasso	4	0.15	4.7e-19	-8.2	-8.4	3.6e-17	0.84	0.94	0.06	FALSE
16	ROSMAP	Brain Pre-frontal Cortex	FADS1	0.08	0.08	enet	10	0.09	1.5e-11	-8.7	9.1	1.0e-19	-0.94	0.02	0.98	FALSE
17	YFS	Blood	FADS1	0.11	0.08	lasso	8	0.09	6.1e-29	-3.1	-6.3	3.1e-10	0.82	1.00	0.00	FALSE
18	The Cancer Genome Atlas	Breast Invasive Carcinoma	FADS1	0.04	0.00	blup	53	0.01	1.4e-03	-1.1	7.9	3.9e-15	-0.68	0.01	0.67	FALSE
19	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	FADS1	0.06	0.03	lasso	4	0.04	7.4e-03	-9.7	8.8	1.1e-18	-0.92	0.01	0.86	FALSE
20	The Cancer Genome Atlas	Colon Adenocarcinoma	FADS2	0.30	0.21	lasso	2	0.22	6.7e-13	-3.1	-5.2	1.9e-07	0.76	0.96	0.04	FALSE
21	The Cancer Genome Atlas	Glioblastoma Multiforme	TMEM216	0.29	-0.01	enet	20	0.01	1.4e-01	3.6	5.4	5.2e-08	0.04	0.00	0.00	TRUE
22	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PGA5	0.06	0.04	blup	5	0.03	1.1e-04	4.9	5.4	5.3e-08	-0.02	0.00	0.88	FALSE
23	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	FADS2	0.33	0.27	lasso	9	0.35	9.3e-21	-3.1	-5.5	2.9e-08	0.80	0.22	0.78	FALSE
24	The Cancer Genome Atlas	Brain Lower Grade Glioma	FADS1	0.05	0.05	blup	53	0.04	6.8e-05	-7.3	7.8	4.6e-15	-0.74	0.24	0.73	FALSE
25	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	FADS1	0.20	0.01	blup	51	0.07	3.2e-04	-9.0	10.0	1.6e-23	-0.85	0.02	0.94	TRUE
26	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	FADS2	0.02	0.01	blup	71	0.02	1.9e-03	-9.3	-8.2	3.3e-16	0.85	0.02	0.82	FALSE
27	The Cancer Genome Atlas	Prostate Adenocarcinoma	C11orf10	0.02	0.01	enet	11	0.01	1.6e-02	-8.2	-6.2	7.5e-10	0.61	0.04	0.29	FALSE
28	The Cancer Genome Atlas	Prostate Adenocarcinoma	FADS1	0.06	0.04	blup	53	0.03	2.0e-04	-9.7	9.5	1.7e-21	-0.85	0.00	0.98	FALSE
29	The Cancer Genome Atlas	Stomach Adenocarcinoma	FADS2	0.15	0.05	blup	71	0.11	2.5e-08	-3.1	-5.8	6.8e-09	0.72	0.06	0.94	FALSE
30	The Cancer Genome Atlas	Thyroid Carcinoma	C11orf10	0.02	0.02	blup	44	0.02	1.8e-03	-7.5	-9.0	1.8e-19	0.92	0.01	0.78	FALSE