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chr11:56,370,106-58,284,951

Best TWAS P=3.43e-19 · Best GWAS P=7.2e-19 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	TIMM10	0.06	0.04	bslmm	381	0.03	1.6e-04	4.3	6.5	1.0e-10	0.43	0.90	0.03	FALSE
2	GTEx	Artery Coronary	TIMM10	0.44	0.36	enet	26	0.42	2.4e-15	4.3	6.0	1.9e-09	0.62	0.84	0.16	FALSE
3	GTEx	Artery Coronary	MED19	0.13	0.07	enet	21	0.07	2.7e-03	-7.3	-6.4	1.6e-10	-0.45	0.24	0.18	FALSE
4	GTEx	Artery Tibial	MED19	0.22	0.12	enet	37	0.16	6.6e-13	-7.0	-6.3	3.4e-10	-0.26	1.00	0.00	TRUE
5	GTEx	Brain Hippocampus	SERPING1	0.23	0.13	lasso	7	0.07	8.7e-03	4.3	-5.7	1.4e-08	-0.50	0.06	0.40	FALSE
6	GTEx	Cells Transformed fibroblasts	MED19	0.10	0.09	lasso	3	0.09	4.7e-07	-7.3	-8.7	4.9e-18	-0.52	0.97	0.02	FALSE
7	GTEx	Esophagus Muscularis	MED19	0.20	0.15	lasso	4	0.12	5.7e-08	-7.3	-7.7	1.8e-14	-0.48	0.99	0.00	FALSE
8	GTEx	Heart Atrial Appendage	TIMM10	0.38	0.32	enet	19	0.40	2.5e-19	3.6	5.4	6.9e-08	0.58	1.00	0.00	FALSE
9	GTEx	Heart Left Ventricle	SMTNL1	0.09	0.08	lasso	4	0.07	1.8e-04	-4.6	-5.5	3.7e-08	-0.46	0.43	0.32	TRUE
10	GTEx	Lung	TIMM10	0.18	0.15	enet	11	0.22	1.8e-16	4.0	5.7	1.3e-08	0.48	1.00	0.00	TRUE
11	GTEx	Lung	YPEL4	0.05	0.06	lasso	3	0.05	6.7e-05	7.3	-7.8	4.5e-15	-0.79	0.04	0.96	FALSE
12	GTEx	Muscle Skeletal	MED19	0.06	0.06	lasso	7	0.06	1.9e-06	-7.0	-6.8	7.5e-12	-0.36	0.95	0.00	FALSE
13	GTEx	Nerve Tibial	MED19	0.12	0.00	enet	25	0.02	2.1e-02	-7.4	-5.9	3.4e-09	-0.21	0.71	0.01	FALSE
14	GTEx	Nerve Tibial	CTNND1	0.06	0.02	lasso	11	0.04	1.0e-03	8.6	8.5	1.6e-17	0.74	0.04	0.95	FALSE
15	GTEx	Skin Not Sun Exposed Suprapubic	YPEL4	0.13	0.05	lasso	6	0.05	9.0e-04	4.7	-7.4	1.5e-13	-0.79	0.05	0.90	FALSE
16	GTEx	Skin Sun Exposed Lower leg	ZDHHC5	0.05	0.03	lasso	8	0.02	6.2e-03	-2.5	-5.3	8.6e-08	-0.74	0.05	0.94	FALSE
17	GTEx	Skin Sun Exposed Lower leg	YPEL4	0.09	0.07	lasso	10	0.07	3.2e-06	8.9	-8.6	1.2e-17	-0.98	0.01	0.99	FALSE
18	GTEx	Spleen	TNKS1BP1	0.27	-0.01	lasso	5	0.00	4.1e-01	5.3	-5.3	8.6e-08	0.03	0.05	0.05	TRUE
19	GTEx	Spleen	MED19	0.20	0.17	lasso	8	0.08	5.4e-03	-7.4	-7.3	2.6e-13	-0.43	0.28	0.06	FALSE
20	GTEx	Spleen	SMTNL1	0.54	0.42	enet	30	0.43	1.8e-12	-4.3	-5.3	9.4e-08	-0.32	1.00	0.00	FALSE
21	GTEx	Stomach	SMTNL1	0.13	0.11	lasso	3	0.13	6.9e-07	-3.9	-5.5	3.4e-08	-0.28	0.68	0.01	TRUE
22	GTEx	Testis	MED19	0.16	0.15	enet	12	0.15	3.0e-07	8.7	-8.9	3.4e-19	-0.90	0.01	0.99	TRUE
23	GTEx	Uterus	TIMM10	0.39	0.14	lasso	7	0.22	3.6e-05	3.9	5.2	1.7e-07	0.43	0.16	0.12	FALSE
24	GTEx	Uterus	MED19	0.33	0.11	lasso	17	0.08	8.8e-03	-7.0	-7.7	1.7e-14	-0.55	0.17	0.28	FALSE
25	GTEx	Uterus	SMTNL1	0.63	0.16	lasso	9	0.23	2.1e-05	-3.9	-5.7	1.4e-08	-0.23	0.21	0.06	TRUE
26	GTEx	Whole Blood	MED19	0.05	0.01	lasso	8	0.01	5.2e-02	-5.7	-7.4	9.8e-14	-0.34	0.28	0.04	FALSE
27	METSIM	Adipose	MED19	0.11	0.08	lasso	5	0.07	4.5e-11	-6.9	-6.0	1.5e-09	-0.36	1.00	0.00	FALSE
28	METSIM	Adipose	YPEL4	0.04	0.03	enet	11	0.04	3.5e-06	7.3	-7.7	1.2e-14	-0.68	0.15	0.85	FALSE
29	NTR	Blood	MED19	0.04	0.04	enet	18	0.04	2.4e-13	-7.3	-8.3	8.5e-17	-0.48	1.00	0.00	FALSE
30	NTR	Blood	SERPING1	0.01	0.00	blup	399	0.00	2.9e-02	7.8	-6.2	4.1e-10	-0.76	0.05	0.85	TRUE
31	YFS	Blood	MED19	0.47	0.18	enet	73	0.28	7.1e-93	-7.3	-6.8	7.5e-12	-0.23	1.00	0.00	FALSE
32	The Cancer Genome Atlas	Breast Invasive Carcinoma	TIMM10	0.42	0.23	enet	24	0.25	1.2e-51	4.3	5.7	1.4e-08	0.42	0.51	0.44	FALSE
33	The Cancer Genome Atlas	Breast Invasive Carcinoma	TMX2	0.01	0.01	enet	7	0.01	3.3e-03	8.6	-8.1	6.6e-16	-0.86	0.01	0.91	FALSE
34	The Cancer Genome Atlas	Breast Invasive Carcinoma	YPEL4	0.02	0.03	lasso	3	0.02	5.4e-06	8.7	-8.5	1.5e-17	-0.85	0.00	1.00	TRUE
35	The Cancer Genome Atlas	Breast Invasive Carcinoma	ZDHHC5	0.02	0.01	blup	34	0.01	1.5e-03	-7.4	-8.0	1.2e-15	-0.60	0.07	0.36	FALSE
36	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	SMTNL1	0.18	0.12	enet	15	0.16	3.2e-08	-4.0	-6.0	1.5e-09	-0.43	0.79	0.20	FALSE
37	The Cancer Genome Atlas	Colon Adenocarcinoma	SMTNL1	0.14	0.13	lasso	9	0.14	2.2e-08	-3.9	-5.5	3.0e-08	-0.37	0.21	0.79	FALSE
38	The Cancer Genome Atlas	Colon Adenocarcinoma	ZDHHC5	0.10	0.05	blup	34	0.04	1.8e-03	-7.4	-7.5	5.5e-14	-0.46	0.10	0.16	FALSE
39	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	YPEL4	0.04	0.05	blup	33	0.04	2.6e-05	7.3	-7.4	9.7e-14	-0.76	0.00	1.00	FALSE
40	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MED19	0.15	0.05	enet	11	0.08	1.4e-09	-7.3	-5.2	2.5e-07	-0.22	0.98	0.00	FALSE
41	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	TIMM10	0.54	0.33	blup	43	0.33	4.9e-16	4.3	5.5	3.3e-08	0.43	0.52	0.44	FALSE
42	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	TIMM10	0.40	0.32	blup	44	0.31	1.3e-21	4.3	6.1	8.1e-10	0.45	0.51	0.44	FALSE
43	The Cancer Genome Atlas	Prostate Adenocarcinoma	TMX2	0.03	0.02	blup	29	0.02	3.7e-03	8.5	-7.8	8.3e-15	-0.83	0.01	0.91	FALSE
44	The Cancer Genome Atlas	Prostate Adenocarcinoma	ZDHHC5	0.10	0.11	lasso	3	0.11	2.9e-11	-7.4	-7.3	2.0e-13	-0.45	1.00	0.00	FALSE
45	The Cancer Genome Atlas	Soft Tissue Sarcoma	MED19	0.09	0.08	lasso	1	0.08	1.2e-05	-7.4	-7.4	1.6e-13	-0.45	0.51	0.05	FALSE