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chr13:100,487,469-102,022,883

Best TWAS P=1.75e-12 · Best GWAS P=3.28e-13 conditioned to 1.68e-15

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	TMTC4	0.23	0.09	lasso	6	0.19	3.5e-15	-5.0	-5.6	1.9e-08	-0.05	0.83	0.17	FALSE
2	GTEx	Adipose Visceral Omentum	TMTC4	0.19	0.15	lasso	5	0.14	1.1e-07	-5.0	-5.4	5.2e-08	-0.04	0.92	0.07	FALSE
3	GTEx	Artery Coronary	TMTC4	0.22	0.12	enet	17	0.12	9.1e-05	-6.1	-6.5	9.8e-11	0.03	0.39	0.14	FALSE
4	GTEx	Artery Tibial	TMTC4	0.37	0.29	lasso	9	0.35	1.9e-28	-6.1	-6.2	4.8e-10	-0.06	0.65	0.35	FALSE
5	GTEx	Breast Mammary Tissue	TMTC4	0.16	0.02	enet	6	0.04	4.0e-03	-5.7	-5.6	2.2e-08	-0.04	0.55	0.10	FALSE
6	GTEx	Breast Mammary Tissue (Female)	TMTC4	0.26	0.09	lasso	6	0.09	9.5e-04	-5.0	-6.5	9.5e-11	0.04	0.11	0.06	FALSE
7	GTEx	Cells Transformed fibroblasts	TMTC4	0.21	0.23	lasso	4	0.23	6.5e-17	-4.9	-5.3	9.1e-08	-0.03	1.00	0.00	FALSE
8	GTEx	Colon Transverse	TMTC4	0.34	0.20	enet	21	0.26	1.4e-12	-4.9	-6.0	2.6e-09	-0.03	0.90	0.10	FALSE
9	GTEx	Esophagus Gastroesophageal Junction	TMTC4	0.29	0.26	lasso	5	0.26	5.5e-10	-5.0	-5.2	2.4e-07	-0.03	0.97	0.03	FALSE
10	GTEx	Esophagus Mucosa	TMTC4	0.20	0.11	enet	21	0.15	4.3e-10	-6.3	-7.0	1.8e-12	-0.09	0.59	0.41	TRUE
11	GTEx	Esophagus Muscularis	TMTC4	0.31	0.24	lasso	4	0.27	6.3e-17	-5.7	-6.3	2.2e-10	-0.05	0.89	0.11	FALSE
12	GTEx	Heart Atrial Appendage	TMTC4	0.23	0.12	enet	20	0.14	5.1e-07	-4.9	-7.0	3.3e-12	-0.01	0.86	0.12	FALSE
13	GTEx	Lung	TMTC4	0.28	0.27	enet	12	0.28	5.2e-22	-5.0	-5.5	3.0e-08	-0.04	1.00	0.00	FALSE
14	GTEx	Muscle Skeletal	TMTC4	0.11	0.04	lasso	4	0.06	3.5e-06	-5.7	-5.9	4.1e-09	-0.04	0.88	0.11	FALSE
15	GTEx	Nerve Tibial	TMTC4	0.39	0.10	enet	25	0.25	1.4e-17	-5.7	-5.7	1.4e-08	-0.06	0.96	0.04	FALSE
16	GTEx	Ovary	TMTC4	0.34	0.21	lasso	5	0.23	2.2e-06	-6.4	-6.3	3.6e-10	-0.04	0.47	0.32	FALSE
17	GTEx	Skin Not Sun Exposed Suprapubic	TMTC4	0.23	0.07	lasso	6	0.14	2.6e-08	-5.7	-6.4	1.4e-10	-0.05	0.89	0.08	FALSE
18	GTEx	Skin Sun Exposed Lower leg	TMTC4	0.19	0.12	enet	37	0.15	1.6e-12	-5.0	-6.5	5.8e-11	-0.01	0.98	0.02	FALSE
19	GTEx	Spleen	TMTC4	0.35	0.25	lasso	5	0.24	6.3e-07	-5.0	-5.2	2.3e-07	-0.02	0.80	0.04	FALSE
20	GTEx	Thyroid	TMTC4	0.30	0.21	lasso	13	0.27	1.3e-20	4.4	-5.2	2.2e-07	-0.06	1.00	0.00	FALSE
21	GTEx	Whole Blood	TMTC4	0.17	0.15	lasso	3	0.14	2.8e-13	-5.0	-5.2	1.6e-07	-0.01	1.00	0.00	FALSE
22	METSIM	Adipose	TMTC4	0.13	0.14	bslmm	576	0.15	6.3e-22	-5.0	-5.6	1.9e-08	0.00	1.00	0.00	FALSE
23	NTR	Blood	A2LD1	0.03	0.00	blup	461	0.01	5.6e-03	2.5	5.4	7.0e-08	0.02	0.14	0.05	FALSE
24	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	A2LD1	0.02	0.03	lasso	2	0.02	1.9e-03	5.5	5.5	3.4e-08	0.05	0.09	0.51	FALSE
25	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	TMTC4	0.06	0.04	blup	69	0.05	1.7e-06	-5.0	-5.3	1.2e-07	-0.04	0.06	0.94	FALSE
26	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	A2LD1	0.10	0.15	enet	9	0.15	6.1e-17	5.7	5.9	4.0e-09	0.04	0.11	0.89	FALSE
27	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	TMTC4	0.09	0.06	blup	68	0.10	3.4e-06	4.1	-6.2	4.7e-10	-0.06	0.02	0.97	FALSE
28	The Cancer Genome Atlas	Lung Adenocarcinoma	TMTC4	0.04	0.03	lasso	3	0.03	1.5e-04	-6.1	-6.1	1.1e-09	-0.05	0.01	0.97	FALSE
29	The Cancer Genome Atlas	Stomach Adenocarcinoma	TMTC4	0.07	0.00	blup	75	0.03	5.9e-03	-4.9	-6.8	1.1e-11	-0.07	0.02	0.67	FALSE
30	The Cancer Genome Atlas	Thyroid Carcinoma	TMTC4	0.10	0.08	enet	10	0.10	9.9e-10	-5.0	-5.7	1.6e-08	-0.04	0.08	0.92	FALSE