Best TWAS P=1.33e-19 · Best GWAS P=2.24e-23 conditioned to 0.000756
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | DOCK9 | 0.09 | 0.02 | lasso | 3 | 0.03 | 1.2e-03 | 7.0 | -8.4 | 5.4e-17 | -0.60 | 0.09 | 0.75 | FALSE |
| 2 | GTEx | Brain Cerebellar Hemisphere | DOCK9-AS2 | 0.20 | 0.01 | lasso | 5 | -0.01 | 7.4e-01 | 4.6 | -5.4 | 5.9e-08 | -0.49 | 0.08 | 0.07 | FALSE |
| 3 | GTEx | Breast Mammary Tissue | DOCK9-AS2 | 0.14 | 0.08 | lasso | 9 | 0.08 | 7.7e-05 | 5.0 | -5.5 | 2.8e-08 | -0.56 | 0.89 | 0.08 | FALSE |
| 4 | GTEx | Breast Mammary Tissue (Female) | DOCK9-AS2 | 0.14 | 0.07 | lasso | 9 | 0.04 | 2.0e-02 | 5.3 | -6.2 | 6.9e-10 | -0.67 | 0.13 | 0.54 | FALSE |
| 5 | GTEx | Esophagus Mucosa | DOCK9 | 0.18 | 0.09 | lasso | 5 | 0.13 | 6.9e-09 | -3.3 | -5.6 | 1.8e-08 | -0.57 | 0.96 | 0.02 | FALSE |
| 6 | GTEx | Nerve Tibial | DOCK9 | 0.17 | 0.17 | lasso | 1 | 0.16 | 4.1e-11 | 9.1 | -9.1 | 1.3e-19 | -0.77 | 0.74 | 0.26 | TRUE |
| 7 | GTEx | Spleen | DOCK9 | 0.34 | 0.11 | enet | 35 | 0.12 | 5.3e-04 | 7.0 | 8.1 | 5.2e-16 | 0.61 | 0.14 | 0.61 | TRUE |
| 8 | The Cancer Genome Atlas | Breast Invasive Carcinoma | DOCK9 | 0.02 | 0.00 | blup | 213 | 0.01 | 1.7e-03 | -3.1 | -6.1 | 1.3e-09 | -0.42 | 0.08 | 0.15 | FALSE |