Hub : Genes

A2LD1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	NTR	Blood	0.0304	0.0107	3.9e-04	0.003	0.005	0.001	0.005	0.003	2.2e-02	5.6e-03	9.5e-02	0.0075	2.4e-02
2	TCGA	Head and Neck Squamous Cell Carcinoma	0.0234	0.0146	7.1e-03	0.029	0.011	0.020	NA	0.021	2.9e-04	1.8e-02	2.0e-03	NA	1.9e-03
3	TCGA	Kidney Renal Clear Cell Carcinoma	0.0983	0.0315	2.0e-14	0.154	0.132	0.154	NA	0.149	5.0e-17	1.1e-14	6.1e-17	NA	1.9e-16
4	TCGA	Pancreatic Adenocarcinoma	0.1800	0.0740	3.6e-03	0.102	-0.005	0.013	NA	0.114	4.8e-05	5.7e-01	8.8e-02	NA	1.7e-05
5	TCGA	Stomach Adenocarcinoma	0.1500	0.0480	9.0e-06	0.130	0.001	0.103	NA	0.117	1.2e-09	2.5e-01	7.0e-08	NA	8.8e-09

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.7	1.1	4.6	-2.1	-0.6	-0.9	0.0	0.0
Bipolar Disorder or Schizophrenia	0.1	0.3	0.9	0.1	1.0	0.6	0.0	0.0
Depressed Affect (Nagel 2018)	0.0	0.0	0.1	-0.2	0.3	-0.3	0.0	0.0
Depression (Nagel 2018)	0.2	0.4	1.7	-1.3	0.1	-0.2	0.0	0.0
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.4	-0.6	-0.3	0.4	-0.3	-0.3
Neuroticism (Nagel 2018)	0.5	1.2	2.5	-0.8	-0.2	-0.8	1.6	1.6
Schizophrenia (2018)	0.9	1.8	3.9	2.0	1.7	1.5	0.0	0.0
Schizophrenia vs Biploar Disorder	1.1	1.5	3.6	0.6	1.9	1.9	0.0	0.0
Worry (Nagel 2018)	0.0	0.1	0.2	-0.4	-0.0	-0.4	0.0	0.0
Alzheimer’s Disease (in mother)	1.3	1.6	3.3	1.8	0.4	0.2	-1.5	-1.5
Alzheimer’s Disease (in father)	0.5	0.5	0.6	-0.5	-0.8	-0.7	-0.7	-0.7
Alzheimer’s Disease (including proxy)	0.9	1.2	2.6	0.6	-0.5	-0.6	-1.6	-1.6
Crohns Disease (2017)	0.2	0.4	1.2	-1.1	0.2	-0.4	0.5	0.5
Irritable Bowel Disease (IBD)	0.4	0.9	1.7	-1.3	-1.1	-1.2	-0.0	-0.0
Ulcerative Colitis (UC)	0.6	1.1	2.5	-0.9	-1.6	-1.3	0.3	0.3
Major Depression (MDD)	0.0	0.0	0.0	0.2	-0.0	0.0	0.0	0.0
Reaction Time	1.3	2.5	5.9	-0.8	0.1	0.4	-2.4	-2.4
Verbal and Numeric Reasoning (VNR)	0.2	0.6	2.0	-1.4	-0.8	-0.4	0.1	0.1
Breast Cancer	0.0	0.1	0.2	-0.5	0.3	0.1	-0.2	-0.2
Ovarian Cancer	0.3	0.4	1.0	0.7	-0.5	-1.0	-0.4	-0.4
Prostate Cancer	0.2	0.3	0.4	-0.2	-0.4	-0.6	0.6	0.6
Age at First Birth	2.0	2.9	8.4	2.9	1.0	1.8	-1.0	-1.0
Bipolar Disorder (2011)	0.1	0.1	0.2	0.5	0.4	0.4	0.0	0.0
Body Mass Index (BMI) (2010)	0.1	0.1	0.6	0.8	-0.1	0.2	0.1	0.1
Coronary Artery Disease (CAD)	0.9	1.0	2.9	-0.7	1.7	1.4	0.0	0.0
Crohns Disease (2012)	0.8	1.3	3.2	-1.3	1.8	1.4	0.0	0.0
Mean Putamen Volume	0.0	0.0	0.0	0.2	0.1	0.1	0.0	0.0
Fasting Glucose	0.5	0.6	2.8	-1.7	0.2	-0.0	-0.4	-0.4
HbA1C	0.5	0.5	2.5	1.6	-0.0	-0.3	0.0	0.0
HDL Cholesterol	0.0	0.1	0.3	-0.1	-0.5	-0.1	0.0	0.0
LDL Cholesterol	0.2	0.3	1.2	-0.4	1.1	0.6	0.0	0.0
Lupus	0.5	0.7	2.5	-1.6	-0.8	-0.8	0.0	0.0
Neuroticism (2016)	0.1	0.1	0.3	0.6	0.4	0.2	0.0	0.0
Primary Biliary Cirrhosis	0.4	0.5	1.1	0.7	-1.0	-1.0	0.0	0.0
Rheumatoid Arthritis	0.3	0.4	1.5	-1.2	-0.6	-0.4	-0.0	-0.0
Schizophrenia (2014)	0.7	1.5	3.0	1.3	1.7	1.7	0.0	0.0
Triglycerides	0.1	0.2	0.5	0.7	-0.1	-0.4	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.8	0.9	2.4	-1.6	-0.8	-1.2	0.0	0.0
Ulcerative Colitis	1.6	2.3	5.6	-1.5	-2.4	-1.9	0.0	0.0
Blood Eosinophil Count	0.2	1.8	5.8	2.4	-0.4	0.2	-1.2	-1.2
Blood Platelet Count	0.3	3.7	8.5	-2.0	-2.9	-2.4	0.4	0.4
Blood Red Count	0.1	0.7	3.3	-1.8	0.1	0.0	0.3	0.3
Blood White Count	0.6	4.3	5.8	-2.4	-1.5	-1.4	2.4	2.4
Heel T-Score	0.3	2.6	4.0	0.2	2.0	1.7	-1.8	-1.8
BMI	0.6	3.3	6.8	-0.9	-2.6	-2.1	-1.5	-1.5
Height	1.0	18.9	34.6	5.4	5.5	5.9	-0.5	-0.5
Waist Hip Ratio (WHR)	1.6	7.2	9.0	-2.7	-2.9	-3.0	2.4	2.4
Systolic Blood Pressure	0.1	0.5	1.0	-0.6	-0.2	-0.4	1.0	1.0
Smoking Status	4.5	10.7	16.9	-2.5	-3.5	-4.1	3.0	3.0
Allergy or Eczema	0.1	0.4	1.0	-0.4	0.7	1.0	0.4	0.4
Cardiovascular Disease	0.5	1.6	3.4	-0.3	-0.7	-0.7	1.8	1.8
Hypothyroidism (self reported)	0.9	2.0	5.4	-0.7	2.3	1.6	0.9	0.9
Respiratory disease	0.2	0.4	0.7	-0.8	-0.8	-0.6	-0.3	-0.3
Type 2 Diabetes (T2D) (2018)	0.2	0.3	0.5	0.7	0.2	0.6	-0.5	-0.5
Lung FEV1/FVC ratio	0.0	0.3	0.7	0.8	-0.5	-0.0	-0.4	-0.4
Lung FVC	0.3	1.5	3.2	-1.8	1.0	0.4	-1.2	-1.2
Neuroticism	0.9	2.1	4.7	-0.7	-0.5	-0.7	2.2	2.2
Chronotype (morning person)	0.3	0.6	1.0	0.9	0.7	1.0	-0.6	-0.6
Hair Pigment	0.1	3.4	5.3	-1.1	-2.1	-2.3	1.7	1.7
Tanning	0.0	0.2	0.7	-0.8	0.3	-0.1	-0.2	-0.2
Hand grip strength (left)	0.1	0.3	0.5	0.1	0.5	0.3	0.7	0.7
Number of treatments/medications taken	0.9	1.5	3.5	-0.8	0.2	0.2	1.9	1.9
Average weekly spirits intake	2.1	2.7	5.9	-1.2	-0.2	-0.2	2.4	2.4
Sensitivity / hurt feelings	0.5	0.8	1.2	-0.8	-0.6	-1.1	0.9	0.9
Frequency of depressed mood in last 2 weeks	0.7	1.0	2.3	-0.2	-0.1	-0.3	1.5	1.5
Hearing difficulty/problems: Yes	0.1	0.1	0.6	-0.8	-0.1	-0.1	0.3	0.3
Relative age of first facial hair	1.5	3.1	6.2	-0.9	-1.0	-1.3	-2.5	-2.5
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	1.5	0.0	0.8	0.6	1.2	1.2
Ever used hormone-replacement therapy (HRT)	0.6	0.8	1.6	-0.4	1.1	1.2	-0.7	-0.7
Ever had hysterectomy (womb removed)	0.2	0.3	1.3	1.1	0.1	0.0	-0.1	-0.1
Systolic blood pressure, automated reading	0.3	0.9	1.2	-1.1	-1.1	-1.0	0.7	0.7
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	1.0	-1.0	-0.2	0.0	0.2	0.2
Angina	0.4	0.5	0.8	-0.6	0.5	0.9	0.7	0.7
Medication for hormone replacement therapy	0.0	0.0	0.0	0.1	0.0	-0.2	-0.0	-0.0
Vitamin and mineral supplements	0.7	0.9	1.2	-0.9	-0.5	-1.1	-1.1	-1.1
Supplements: Zinc	2.1	2.3	5.7	-0.0	1.7	2.4	-1.2	-1.2
Medication: Co-codamol	1.3	1.5	3.3	-0.1	0.7	0.6	1.8	1.8
Medication: Metformin	0.8	1.1	2.3	-0.9	-0.5	-0.3	1.5	1.5
Diabetes (father)	2.1	2.6	4.3	-0.8	-2.1	-1.8	-1.5	-1.5
Diabetes (mother)	1.3	1.6	4.3	-2.1	-1.2	-1.3	0.6	0.6
Severe depression (siblings)	0.0	0.0	0.0	-0.2	-0.2	-0.0	-0.0	-0.0
Pack years adult smoking proportion	1.0	1.5	2.2	-0.7	-1.5	-1.2	-1.3	-1.3
Impedance of leg (right)	0.2	1.1	3.4	-1.9	-0.8	-1.0	0.4	0.4
Leg fat-free mass (left)	0.5	2.8	4.6	2.1	1.7	2.1	-1.0	-1.0
Trunk fat percentage	0.1	0.4	1.1	-0.8	-1.0	-0.7	-0.1	-0.1
Hand grip strength (right)	0.4	1.0	2.0	1.0	1.4	1.4	0.4	0.4
Townsend deprivation index at recruitment	2.8	3.9	7.9	-1.8	-0.2	-0.8	2.8	2.8
Current tobacco smoking	1.1	1.8	2.8	-1.4	-0.7	-1.1	1.7	1.7
Average weekly fortified wine intake	0.6	0.7	2.0	-0.0	1.1	1.4	-0.4	-0.4
Maternal smoking around birth	3.1	4.5	5.1	-2.1	-1.9	-2.1	2.3	2.3
Fed-up feelings	1.6	3.0	6.8	0.4	1.0	0.2	2.6	2.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	2.0	-1.4	0.3	0.1	0.5	0.5
Relative age voice broke	2.0	3.1	5.0	-0.3	-1.6	-1.6	-2.2	-2.2
Taking other prescription medications	1.1	1.7	3.4	-1.0	0.8	0.7	1.8	1.8
Age when periods started (menarche)	0.2	0.4	1.1	-1.1	0.4	0.8	-0.2	-0.2
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.1	0.1	0.3	0.3	-0.3	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	1.4	0.1	0.4	0.4	-1.2	-1.2
Tinnitus: Yes, but not now, but have in the past	1.0	1.0	2.6	-0.7	-1.6	-1.1	-0.6	-0.6
Qualifications: CSEs or equivalent	1.3	1.7	4.0	-0.8	-1.4	-2.0	0.9	0.9
Serious illness, injury or assault to yourself	0.2	0.3	1.1	1.0	0.0	0.2	0.2	0.2
High blood pressure	0.2	0.5	1.4	1.2	-0.2	-0.2	0.8	0.8
Hayfever, allergic rhinitis or eczema	0.0	0.1	0.3	-0.4	0.2	0.5	-0.1	-0.1
Multivitamins +/- minerals	0.4	0.5	0.8	0.7	-0.0	0.4	0.9	0.9
Stomach or abdominal pain in last month	3.3	4.1	7.0	-2.0	-2.6	-2.6	1.1	1.1
Supplements: Glucosamine	1.2	1.5	3.7	-0.7	1.6	1.9	-0.7	-0.7
Diverticular disease/diverticulitis (self-reported)	1.6	1.9	4.3	-0.1	-0.6	-0.7	2.1	2.1
Medication: Atenolol	0.5	0.6	1.0	0.9	0.4	0.2	1.0	1.0
Medication: Levothyroxine sodium	0.7	1.2	2.6	-0.5	1.6	1.0	1.0	1.0
Sitting height	0.2	1.7	3.0	0.7	1.7	1.7	-1.0	-1.0
Chronic bronchitis/emphysema (father)	2.5	2.9	10.5	-3.2	-0.3	-0.2	1.4	1.4
High blood pressure (mother)	1.1	1.6	2.8	0.1	1.0	1.1	-1.7	-1.7
Body mass index (BMI)	0.3	1.3	3.3	-1.1	-1.8	-1.4	0.2	0.2
Impedance of leg (left)	0.3	1.6	3.6	-1.9	-0.9	-1.3	1.0	1.0
Leg predicted mass (left)	0.6	3.1	5.3	2.3	1.8	2.1	-1.1	-1.1
Trunk fat mass	0.0	0.0	0.1	-0.0	-0.3	0.2	-0.2	-0.2
Waist circumference	0.3	1.2	3.1	-1.0	-1.8	-1.2	0.4	0.4
Number of incorrect matches in round	0.3	0.6	1.4	0.7	-1.0	-1.2	-0.2	-0.2
Past tobacco smoking	6.4	11.7	23.3	2.3	4.8	4.8	-1.9	-1.9
Alcohol usually taken with meals	5.0	8.1	14.6	3.1	3.4	3.8	-1.6	-1.6
Nervous feelings	0.2	0.4	0.7	-0.1	-0.4	-0.7	0.8	0.8
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	1.6	-1.1	0.5	-0.1	1.3	1.3
Hearing difficulty/problems with background noise	0.4	0.6	1.3	1.1	-0.9	-0.8	0.4	0.4
Hair/balding pattern: Pattern 2	6.1	7.7	19.6	-0.7	-4.4	-4.3	-0.1	-0.1
Had menopause	1.3	1.6	3.2	0.8	0.3	0.9	-1.8	-1.8
Had other major operations	0.3	0.3	0.7	0.2	0.7	0.9	0.4	0.4
Forced vital capacity (FVC)	0.6	2.3	5.7	0.3	2.4	2.0	-0.9	-0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	1.6	-0.1	0.4	0.5	-1.3	-1.3
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.3	-0.9	-1.1	-1.0	0.0	0.0
Qualifications: None of the above	0.8	1.6	5.2	-2.3	-1.1	-1.0	0.6	0.6
Financial difficulties in last 2 years	0.8	1.1	3.3	-1.8	-0.9	-1.2	0.1	0.1
Mouth/teeth dental problems	0.5	0.7	1.3	1.1	1.1	1.0	0.1	0.1
Heart attack	0.8	1.1	2.4	0.7	0.1	0.1	1.5	1.5
Allergy	0.1	0.2	0.4	0.5	-0.3	-0.7	-0.3	-0.3
Pain all over the body in last month	1.1	1.2	3.0	-0.5	1.7	1.7	0.1	0.1
Diabetes (self-reported)	0.6	0.9	2.6	0.0	-1.6	-1.1	-0.5	-0.5
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	2.0	0.9	1.1	1.4	-1.2	-1.2
Medication: Ramipril	0.3	0.3	0.6	0.5	-0.4	-0.3	0.8	0.8
Medication: Simvastatin	0.4	0.6	0.9	0.7	-0.7	-0.6	0.9	0.9
Fluid intelligence score	0.1	0.3	0.7	-0.1	0.5	0.8	-0.5	-0.5
Illnesses of siblings	1.0	1.5	2.5	-0.0	-0.9	-1.6	1.4	1.4
Neuroticism score	0.6	1.3	2.7	-0.7	0.7	0.3	1.6	1.6
Weight	0.1	0.6	1.4	0.8	0.7	1.2	-0.4	-0.4
Impedance of arm (right)	0.1	0.5	1.6	0.5	1.3	0.8	-0.2	-0.2
Arm fat percentage (right)	0.4	1.5	3.0	-1.5	-1.7	-1.5	0.1	0.1
Trunk fat-free mass	0.7	3.8	7.5	2.3	2.2	2.7	-0.9	-0.9
Hip circumference	0.2	0.7	1.0	0.9	0.3	0.8	-1.0	-1.0
Time employed in main current job	1.0	1.1	3.7	-1.9	-0.7	-1.0	-0.4	-0.4
Alcohol intake versus 10 years previously	0.6	1.0	1.6	-0.8	-0.7	-0.7	-1.3	-1.3
Father’s age at death	0.9	1.2	4.8	2.2	0.8	0.5	-0.4	-0.4
Worrier / anxious feelings	0.6	1.1	1.9	-1.3	-1.2	-1.4	0.4	0.4
Frequency of tiredness / lethargy in last 2 weeks	1.3	2.1	3.4	-0.0	1.5	1.2	1.8	1.8
Falls in the last year	0.1	0.2	0.7	-0.8	-0.2	-0.2	0.1	0.1
Hair/balding pattern: Pattern 3	3.5	5.2	12.5	1.5	3.5	3.3	0.1	0.1
Number of live births	2.2	3.1	7.5	-2.7	-0.9	-1.2	1.7	1.7
Forced expiratory volume in 1-second (FEV1)	0.6	2.1	5.0	0.5	2.2	1.8	-1.0	-1.0
Pulse rate	1.5	2.6	9.7	-3.1	-1.1	-1.4	0.0	0.0
Happiness	0.2	0.3	0.6	0.4	0.1	0.2	0.8	0.8
Noisy workplace	0.5	0.6	1.5	-1.2	-0.2	-0.2	-0.9	-0.9
Qualifications: A levels/AS levels or equivalent	3.6	7.9	15.1	3.9	2.2	3.2	-2.2	-2.2
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	1.1	0.2	-0.1	0.3	-1.0	-1.0
Mouth/teeth dental problems: Dentures	1.1	1.9	4.3	-1.4	-2.1	-1.5	0.7	0.7
Asthma	0.1	0.1	0.3	-0.3	-0.0	0.0	0.6	0.6
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.4	1.2	0.5	0.8	-0.3	-0.3
Medication: Cholesterol lowering	0.6	0.9	1.4	1.2	-1.1	-0.8	0.8	0.8
Depression (self-reported)	0.3	0.4	1.4	-1.2	-0.2	-0.4	0.4	0.4
Medication: Lansoprazole	1.4	1.6	2.1	-1.0	-1.1	-1.4	1.4	1.4
Prospective memory result	2.4	3.0	4.7	1.0	1.7	2.2	-1.7	-1.7
Lung cancer (father)	0.4	0.5	1.2	0.2	0.2	0.2	1.1	1.1
Illnesses of mother	1.1	1.4	3.1	-0.0	-0.2	-0.8	1.8	1.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.4	2.3	0.1	1.5	1.1	-1.3	-1.3
Pulse wave Arterial Stiffness index	1.9	2.2	6.2	0.7	2.0	2.5	-0.1	-0.1
Impedance of arm (left)	0.2	1.0	2.9	0.8	1.7	1.2	-0.1	-0.1
Arm fat mass (right)	0.1	0.5	1.2	-0.6	-1.1	-0.8	-0.1	-0.1
Trunk predicted mass	0.7	3.9	7.6	2.3	2.2	2.8	-0.9	-0.9
Standing height	1.5	15.0	29.9	4.1	5.1	5.5	-1.2	-1.2
Length of working week for main job	0.7	0.8	1.4	1.0	-0.5	-0.1	-1.2	-1.2
Exposure to tobacco smoke at home	0.3	0.4	1.3	-1.1	0.1	0.0	0.6	0.6
Breastfed as a baby	2.4	3.0	7.0	2.6	0.8	1.1	-1.8	-1.8
Tense / ‘highly strung’	1.1	1.9	4.4	0.8	2.1	1.5	1.0	1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	2.4	3.7	7.2	-2.7	-0.6	-1.1	2.2	2.2
Hair/balding pattern: Pattern 4	0.1	0.3	0.4	0.2	-0.7	-0.6	-0.7	-0.7
Birth weight of first child	0.3	0.6	1.0	0.1	0.7	0.6	-1.0	-1.0
Peak expiratory flow (PEF)	0.1	0.2	0.6	-0.4	0.8	0.4	-0.2	-0.2
Pulse wave reflection index	2.6	3.2	4.4	1.5	1.3	1.8	-2.1	-2.1
Ever highly irritable/argumentative for 2 days	2.1	2.5	5.9	-0.6	-0.3	-0.5	2.4	2.4
Loud music exposure frequency	0.2	0.2	0.3	-0.6	-0.3	-0.2	-0.5	-0.5
Qualifications: O levels/GCSEs or equivalent	2.9	4.6	8.5	2.4	2.6	2.9	-0.9	-0.9
Mouth/teeth dental problems: Bleeding gums	1.8	2.3	3.6	-1.2	-1.4	-1.0	-1.9	-1.9
Blood clot in the leg (DVT)	1.3	1.7	2.8	-1.1	-1.0	-0.8	1.7	1.7
Medication: Paracetamol	0.9	1.5	5.3	-2.3	0.1	0.1	1.1	1.1
Headache pain in last month	0.5	0.8	0.9	-0.9	0.9	1.0	-0.8	-0.8
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	1.1	-1.0	0.8	0.6	-0.5	-0.5
Glaucoma (self-reported)	0.4	0.4	0.7	0.8	0.3	0.5	-0.8	-0.8
Gout (self-reported)	0.9	1.2	2.2	0.0	-0.6	-1.5	1.3	1.3
Hypothyroidism/myxoedema (self-reported)	0.7	1.3	4.3	-0.6	2.1	1.3	0.3	0.3
Medication: Amlodipine	0.1	0.1	0.4	0.4	-0.7	-0.1	-0.1	-0.1
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.1	0.7	-1.0	-1.1	0.1	0.1
Birth weight	0.5	1.0	2.1	0.7	-0.5	-0.4	-1.4	-1.4
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.4	-0.6	-0.7	-0.3	0.3	0.3
High blood pressure (siblings)	1.6	2.4	4.4	0.4	1.7	2.1	-1.5	-1.5
Forced vital capacity (FVC), Best measure	0.6	2.1	3.1	-0.1	1.8	1.5	-1.6	-1.6
Body fat percentage	0.3	1.1	2.2	-1.3	-1.5	-1.2	0.5	0.5
Leg fat percentage (right)	0.6	2.2	2.9	-1.7	-1.7	-1.5	1.2	1.2
Arm fat-free mass (right)	0.3	1.4	2.8	1.5	1.1	1.7	-0.7	-0.7
Exposure to tobacco smoke outside home	0.6	0.8	1.3	-0.7	0.7	0.3	1.1	1.1
Comparative body size at age 10	1.1	3.1	5.7	1.7	2.2	2.4	-1.1	-1.1
Number of full brothers	1.5	1.9	7.3	-2.7	-1.2	-0.6	-0.1	-0.1
Worry too long after embarrassment	0.0	0.0	0.1	-0.3	-0.3	-0.1	0.0	0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	4.0	-2.0	-0.2	-0.1	0.5	0.5
Wheeze or whistling in the chest in last year	0.6	1.0	1.4	-1.2	-0.9	-0.7	1.1	1.1
Number of children fathered	0.1	0.1	0.2	-0.4	-0.2	-0.3	0.2	0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.0	1.2	1.0	0.8	1.0	-1.1	-1.1
Age at first live birth	2.7	4.8	18.8	4.3	0.4	1.0	-1.5	-1.5
Pulse wave peak to peak time	1.2	1.5	4.4	-0.4	-1.6	-2.1	0.1	0.1
Health satisfaction	1.3	1.6	4.7	0.2	1.9	2.2	0.1	0.1
Shortness of breath walking on level ground	1.8	2.1	6.5	-2.5	0.0	0.5	1.4	1.4
Qualifications: College or University degree	2.7	8.5	16.8	4.1	3.1	3.6	-1.2	-1.2
Eye problems/disorders: None of the above	0.7	0.8	1.4	-0.9	-0.9	-1.2	-0.7	-0.7
Mouth/teeth dental problems: Loose teeth	0.9	1.1	1.9	-0.9	-0.8	-0.6	1.4	1.4
Emphysema/chronic bronchitis	0.8	0.9	1.5	0.7	0.7	1.2	-1.0	-1.0
Medication for pain relief, constipation, heartburn	0.4	0.7	2.5	1.6	0.4	0.2	-0.6	-0.6
Neck or shoulder pain in last month	0.7	1.0	1.5	-1.2	1.2	1.2	-0.7	-0.7
Medication: Blood pressure	0.1	0.1	0.6	0.8	-0.0	-0.1	0.2	0.2
Angina (self-reported)	0.5	0.7	1.0	-0.6	0.7	1.0	0.9	0.9
Migraine (self-reported)	0.4	0.5	1.4	-0.2	1.0	1.2	-0.2	-0.2
Medication: Ibuprofen	0.3	0.4	1.5	1.2	0.4	0.5	0.2	0.2
Medication: Allopurinol	0.5	0.6	1.7	-1.0	-0.7	-1.3	0.0	0.0
Medication: Omeprazole	0.9	1.1	3.6	-1.9	-0.0	0.5	-1.0	-1.0
Medication: Seretide 50 evohaler	1.0	1.1	1.8	1.0	1.4	1.2	0.9	0.9
Mean time to correctly identify matches	0.7	1.3	2.0	-1.0	0.6	1.0	-1.4	-1.4
Heart disease (mother)	0.7	0.8	1.8	0.3	-0.6	0.2	-1.3	-1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.6	1.9	6.5	-2.6	-0.3	-0.8	1.0	1.0
Whole body fat mass	0.1	0.2	0.8	-0.4	-0.9	-0.4	0.1	0.1
Leg fat mass (right)	0.1	0.5	0.9	-0.6	-1.0	-0.6	0.6	0.6
Arm predicted mass (right)	0.3	1.7	3.4	1.8	1.3	1.8	-0.6	-0.6
Pulse rate, automated reading	1.0	3.1	10.1	-3.2	-1.2	-1.3	1.1	1.1
Alcohol intake frequency.	0.8	1.8	3.9	-1.2	-1.8	-2.0	0.3	0.3
Comparative height size at age 10	0.7	4.0	9.3	1.2	2.6	3.0	-1.1	-1.1
Number of full sisters	0.9	1.1	2.8	-0.3	-1.7	-1.5	0.4	0.4
Suffer from ‘nerves’	0.6	0.9	2.1	-1.4	-0.2	-0.8	0.9	0.9
Overall health rating	0.1	0.2	0.3	-0.4	-0.5	-0.4	0.5	0.5
Chest pain or discomfort	0.4	0.5	1.2	-1.1	-0.6	-0.5	-0.7	-0.7
Had major operations	0.8	1.0	2.3	-0.3	1.3	1.5	0.7	0.7
Age at last live birth	0.6	0.9	3.1	1.8	-0.3	-0.0	-0.8	-0.8
Family relationship satisfaction	0.6	0.7	1.6	0.8	1.3	1.1	-0.3	-0.3
Leg pain on walking	0.6	0.7	2.8	-1.7	-0.2	-0.4	0.6	0.6
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	1.5	0.1	-0.4	-0.5	1.2	1.2
Commuting to job workplace: Car/motor vehicle	0.8	0.9	2.4	-1.6	-1.1	-0.9	0.1	0.1
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	2.1	0.3	-0.1	-0.4	1.5	1.5
Medication: Aspirin	0.2	0.2	0.9	0.9	-0.2	0.3	0.2	0.2
Supplements: Vitamin C	0.5	0.6	2.0	-0.0	0.9	1.4	-0.3	-0.3
Knee pain experienced in last month	0.9	1.4	3.0	-1.1	-1.7	-1.7	0.3	0.3
Hypertension (Self-reported)	0.2	0.6	2.2	1.5	-0.1	-0.0	0.5	0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.0	2.5	-1.6	-1.0	-0.8	-0.7	-0.7
Illnesses of father: Heart disease	0.4	0.6	2.4	1.6	-0.2	0.5	-0.2	-0.2
Illnesses of siblings: Diabetes	0.8	1.0	1.4	0.8	-1.2	-0.7	-1.1	-1.1
Smoking status: Previous	5.5	8.2	18.8	-1.9	-4.3	-4.1	0.8	0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	1.3	0.8	-0.0	-0.2	-1.1	-1.1
Whole body fat-free mass	0.5	3.0	5.6	2.1	1.9	2.4	-0.9	-0.9
Leg fat-free mass (right)	0.5	2.8	4.9	2.2	1.8	2.1	-0.9	-0.9
Arm fat percentage (left)	0.3	1.0	2.1	-1.1	-1.4	-1.3	0.3	0.3
Average weekly red wine intake	2.9	4.3	8.2	2.2	2.8	2.9	-0.5	-0.5
Handedness (chirality/laterality): Left-handed	0.1	0.2	0.3	0.3	0.2	0.2	-0.6	-0.6
Mood swings	1.2	2.1	3.6	-1.4	-0.7	-1.1	1.9	1.9
Loneliness, isolation	0.3	0.5	0.9	0.9	0.9	0.7	-0.4	-0.4
Long-standing illness, disability or infirmity	0.1	0.1	0.4	-0.2	-0.6	-0.4	-0.2	-0.2
Ever had bowel cancer screening	1.2	1.4	3.2	-0.9	1.4	1.8	0.7	0.7
Diabetes diagnosed by doctor	0.3	0.4	1.4	-0.5	-1.2	-0.7	0.2	0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	1.9	1.4	0.1	-0.1	1.2	1.2
Friendships satisfaction	0.4	0.5	1.3	-0.0	-0.2	-0.2	-1.1	-1.1
Qualifications: nursing, teaching	1.4	2.2	3.4	1.0	1.3	1.3	-1.8	-1.8
Commuting to job workplace: Walk	2.6	2.8	9.2	3.0	1.0	1.4	0.9	0.9
Eye problems/disorders: Cataract	0.5	0.6	1.2	-0.4	0.2	0.6	1.1	1.1
Mouth/teeth dental problems: Mouth ulcers	1.6	2.5	5.9	1.5	2.4	2.1	-0.1	-0.1
Medication for cholesterol	0.3	0.4	1.5	-1.2	-0.1	-0.3	-0.5	-0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	0.7	0.5	0.5	0.9	-0.6	-0.6
Back pain experienced in last month	0.2	0.2	0.5	-0.1	-0.7	-0.2	0.6	0.6
Mineral and other dietary supplements	0.7	0.9	2.0	-0.8	-0.9	-1.4	0.7	0.7
Breast cancer (self-reported)	1.9	2.3	2.8	-0.7	-1.7	-1.6	1.7	1.7
Asthma (self-reported)	0.1	0.1	0.3	-0.2	-0.1	-0.1	0.5	0.5
Osteoporosis (self-reported)	0.6	0.8	1.8	0.7	1.3	1.2	0.4	0.4
Osteoarthritis (self-reported)	0.3	0.4	1.2	-1.1	-0.2	0.1	-0.7	-0.7
Medication: Aspirin	0.4	0.5	1.4	1.2	-0.5	0.1	0.6	0.6
Medication: Gliclazide	0.3	0.4	0.8	-0.9	-0.6	-0.6	-0.3	-0.3
Illnesses of father: None of the above (group 1)	0.6	0.7	1.1	-0.2	1.0	0.5	1.0	1.0
Smoking status: Current	1.0	1.6	3.0	-1.0	-0.5	-0.9	1.7	1.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.3	-0.2	0.4	0.3	-0.5	-0.5
Whole body water mass	0.5	3.0	5.5	2.1	1.8	2.3	-1.0	-1.0
Leg predicted mass (right)	0.5	2.8	4.8	2.2	1.8	2.1	-0.9	-0.9
Arm fat mass (left)	0.1	0.5	1.2	-0.7	-1.1	-0.8	0.2	0.2
Number of self-reported non-cancer illnesses	0.4	0.6	1.1	-1.0	0.0	0.2	1.0	1.0
Average weekly champagne plus white wine intake	0.3	0.4	0.8	0.4	0.6	0.9	-0.6	-0.6
Miserableness	0.6	1.1	1.9	-1.2	0.3	-0.4	1.4	1.4
Guilty feelings	2.6	3.9	9.5	0.2	3.1	2.9	0.8	0.8
Wears glasses or contact lenses	0.4	0.4	1.1	1.0	-0.1	0.7	-0.5	-0.5
Ever taken oral contraceptive pill	1.1	1.2	3.0	-1.7	-1.0	-1.4	-0.4	-0.4
Hearing aid user	0.3	0.3	0.7	0.4	0.7	0.9	0.4	0.4
Mother’s age at death	0.2	0.3	0.8	0.9	-0.6	-0.1	-0.2	-0.2
Financial situation satisfaction	0.6	0.8	1.9	-0.9	0.9	1.4	-0.4	-0.4
Tinnitus: Yes, now most or all of the time	0.7	0.8	1.9	1.4	1.1	0.6	-0.5	-0.5
Commuting to job workplace: Public transport	0.2	0.3	0.6	-0.2	0.4	-0.0	0.8	0.8
Eye problems/disorders: Glaucoma	0.4	0.5	2.3	1.5	0.2	0.3	0.0	0.0
Medication: Blood pressure	1.3	2.4	5.4	2.3	1.5	1.6	1.0	1.0
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.8	-0.6	-0.9	-0.5	-0.6	-0.6
Supplements: Fish oil (including cod liver oil)	1.1	1.4	2.2	1.5	1.3	1.4	-0.8	-0.8
High cholesterol (Self-reported)	0.6	1.0	2.1	0.9	-0.0	-0.0	1.4	1.4
Medication: Bendroflumethiazide	2.0	3.0	7.0	0.9	0.5	0.3	2.6	2.6
Medication: Paracetamol	1.3	2.0	3.2	-1.7	0.7	0.7	1.8	1.8
Medication: Lisinopril	0.1	0.1	0.2	0.5	-0.1	0.0	0.3	0.3
Medication: Atorvastatin	0.9	1.2	2.2	1.5	1.1	1.3	0.6	0.6
Illnesses of father: High blood pressure	2.7	3.3	8.2	2.9	1.2	1.3	-1.6	-1.6
Alcohol drinker status: Never	0.1	0.1	0.2	0.1	-0.5	-0.3	-0.1	-0.1
Ever smoked	7.8	13.7	28.8	-2.5	-5.3	-5.4	1.6	1.6
Basal metabolic rate	0.4	2.3	4.5	1.8	1.6	2.1	-0.7	-0.7
Leg fat percentage (left)	0.8	2.9	3.3	-1.6	-1.8	-1.6	1.7	1.7
Arm fat-free mass (left)	0.3	1.5	3.0	1.5	1.2	1.7	-0.7	-0.7
Number of operations (self-reported)	1.0	1.4	2.4	0.2	1.1	1.1	1.5	1.5
Average weekly beer plus cider intake	4.1	5.9	9.0	-2.3	-2.1	-3.0	2.3	2.3
Irritability	0.1	0.2	0.3	0.4	0.5	-0.0	0.6	0.6
Risk taking	0.8	1.2	3.2	1.8	-0.7	-0.9	-0.8	-0.8
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.2	0.3	0.7	0.4	1.1	1.1
Fractured/broken bones in last 5 years	0.8	1.1	1.4	0.8	-1.0	-1.0	-1.2	-1.2
Age started oral contraceptive pill	2.9	3.6	5.9	2.4	1.1	1.8	-1.9	-1.9
Diastolic blood pressure, automated reading	0.1	0.4	0.9	-0.6	-0.9	-0.9	-0.1	-0.1
Ever depressed for a whole week	0.6	0.7	1.5	-1.2	-1.1	-1.0	-0.0	-0.0
Unable to work because of sickness or disability	0.2	0.3	1.1	-0.2	-1.0	-0.5	0.3	0.3
Commuting to job workplace: Cycle	1.0	1.2	4.6	2.1	0.3	0.2	-0.7	-0.7
Myopia	5.5	7.9	17.5	2.0	4.0	4.2	-1.0	-1.0
Vascular/heart problems diagnosed by doctor	0.2	0.6	1.4	-1.2	0.5	0.4	-0.9	-0.9
Cholesterol lowering medication	0.3	0.4	0.9	-0.1	0.2	0.5	0.9	0.9
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	2.6	-1.6	0.2	0.8	-0.8	-0.8
Pain experienced in last month	0.2	0.3	1.2	1.1	0.0	-0.2	-0.3	-0.3
Supplements: Calcium	1.1	1.2	2.2	1.5	0.3	0.4	1.3	1.3
Basal cell carcinoma (self-reported)	0.1	0.2	0.3	-0.5	0.1	0.0	0.5	0.5
Heart attack/myocardial infarction (self-reported)	1.1	1.5	3.3	0.7	0.3	0.3	1.8	1.8
Deep venous thrombosis (DVT) (self-reported)	1.2	1.6	2.7	-1.0	-0.9	-0.7	1.7	1.7
Heart disease (siblings)	0.1	0.1	0.1	-0.4	-0.3	0.3	0.2	0.2
Alcohol drinker status: Previous	0.2	0.2	0.4	0.4	-0.2	-0.4	0.6	0.6
Pack years of smoking	0.7	1.0	1.5	-0.4	-1.2	-0.8	-1.2	-1.2
Impedance of whole body	0.0	0.1	0.4	-0.6	0.5	-0.0	0.2	0.2
Leg fat mass (left)	0.2	0.6	1.2	-0.4	-1.1	-0.7	0.8	0.8
Arm predicted mass (left)	0.3	1.5	3.2	1.3	1.2	1.8	-0.8	-0.8