Best TWAS P=1.87e-13 · Best GWAS P=3.42e-13 conditioned to 0.296
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | G2E3 | 0.06 | 0.04 | blup | 397 | 0.04 | 4.4e-06 | 5.9 | -5.2 | 1.9e-07 | -0.77 | 0.03 | 0.97 | FALSE |
2 | CommonMind | Brain Pre-frontal Cortex | SCFD1 | 0.16 | 0.18 | lasso | 3 | 0.18 | 2.6e-21 | 7.1 | 7.1 | 1.4e-12 | 0.91 | 0.02 | 0.98 | FALSE |
3 | GTEx | Adipose Subcutaneous | SCFD1 | 0.12 | 0.11 | lasso | 2 | 0.10 | 8.5e-09 | 7.3 | -7.3 | 3.3e-13 | -0.96 | 0.01 | 0.99 | FALSE |
4 | GTEx | Adipose Visceral Omentum | G2E3 | 0.17 | 0.08 | lasso | 4 | 0.08 | 6.2e-05 | 7.2 | -7.0 | 3.5e-12 | -0.89 | 0.02 | 0.97 | FALSE |
5 | GTEx | Artery Tibial | G2E3 | 0.09 | 0.00 | enet | 2 | 0.00 | 2.1e-01 | 5.9 | -6.4 | 1.6e-10 | -0.77 | 0.03 | 0.76 | FALSE |
6 | GTEx | Colon Transverse | SCFD1 | 0.14 | 0.13 | lasso | 3 | 0.13 | 8.1e-07 | 7.3 | -7.1 | 1.2e-12 | -0.95 | 0.02 | 0.98 | FALSE |
7 | GTEx | Esophagus Mucosa | SCFD1 | 0.09 | 0.12 | enet | 11 | 0.11 | 1.0e-07 | 7.3 | -7.4 | 1.9e-13 | -0.94 | 0.02 | 0.98 | TRUE |
8 | GTEx | Muscle Skeletal | SCFD1 | 0.06 | 0.04 | lasso | 3 | 0.02 | 2.1e-03 | 7.3 | -7.0 | 2.7e-12 | -0.94 | 0.02 | 0.92 | FALSE |
9 | GTEx | Nerve Tibial | G2E3 | 0.06 | 0.04 | lasso | 4 | 0.01 | 1.2e-01 | 7.3 | -7.2 | 4.8e-13 | -1.00 | 0.02 | 0.97 | FALSE |
10 | GTEx | Skin Not Sun Exposed Suprapubic | SCFD1 | 0.14 | 0.05 | enet | 26 | 0.08 | 2.3e-05 | 7.3 | -6.1 | 1.1e-09 | -0.74 | 0.03 | 0.96 | FALSE |
11 | GTEx | Thyroid | SCFD1 | 0.10 | 0.08 | enet | 11 | 0.07 | 2.7e-06 | 7.1 | -7.4 | 1.9e-13 | -0.91 | 0.01 | 0.99 | FALSE |
12 | GTEx | Whole Blood | SCFD1 | 0.09 | 0.07 | lasso | 6 | 0.07 | 2.1e-07 | 7.1 | -7.2 | 7.8e-13 | -0.91 | 0.02 | 0.98 | FALSE |
13 | METSIM | Adipose | SCFD1 | 0.06 | 0.05 | enet | 8 | 0.05 | 2.0e-08 | 6.7 | -7.0 | 2.0e-12 | -0.90 | 0.06 | 0.94 | FALSE |
14 | NTR | Blood | SCFD1 | 0.02 | 0.02 | lasso | 6 | 0.01 | 5.4e-05 | 7.1 | -7.0 | 2.1e-12 | -0.89 | 0.02 | 0.98 | FALSE |
15 | YFS | Blood | SCFD1 | 0.05 | 0.04 | enet | 27 | 0.05 | 3.4e-17 | 6.5 | -6.5 | 8.5e-11 | -0.88 | 0.06 | 0.94 | FALSE |
16 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | SCFD1 | 0.09 | 0.04 | blup | 83 | 0.07 | 2.3e-04 | 6.5 | -6.1 | 1.1e-09 | -0.81 | 0.02 | 0.76 | FALSE |
17 | The Cancer Genome Atlas | Colon Adenocarcinoma | SCFD1 | 0.04 | 0.02 | blup | 80 | 0.02 | 2.4e-02 | 6.1 | -6.4 | 1.4e-10 | -0.83 | 0.06 | 0.57 | FALSE |
18 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SCFD1 | 0.03 | 0.01 | blup | 83 | 0.00 | 9.0e-02 | 6.7 | -6.6 | 3.3e-11 | -0.83 | 0.02 | 0.87 | FALSE |
19 | The Cancer Genome Atlas | Brain Lower Grade Glioma | G2E3 | 0.03 | 0.00 | enet | 6 | 0.02 | 6.7e-04 | 7.1 | -6.2 | 5.2e-10 | -0.73 | 0.02 | 0.87 | FALSE |
20 | The Cancer Genome Atlas | Thyroid Carcinoma | SCFD1 | 0.05 | 0.06 | enet | 14 | 0.07 | 2.9e-07 | 7.1 | -7.1 | 9.6e-13 | -0.93 | 0.01 | 0.99 | FALSE |