Best TWAS P=2.74e-36 · Best GWAS P=1.94e-36 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | VPS13C | 0.08 | 0.04 | lasso | 2 | 0.02 | 1.3e-02 | -8.6 | 8.7 | 5.0e-18 | -0.68 | 0.21 | 0.57 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | VPS13C | 0.16 | 0.06 | enet | 15 | 0.05 | 9.2e-04 | 9.0 | 6.7 | 1.6e-11 | -0.63 | 0.44 | 0.31 | FALSE |
| 3 | GTEx | Nerve Tibial | VPS13C | 0.13 | 0.12 | lasso | 3 | 0.10 | 1.1e-07 | 8.8 | 5.5 | 4.7e-08 | -0.51 | 0.98 | 0.01 | FALSE |
| 4 | GTEx | Skin Sun Exposed Lower leg | VPS13C | 0.09 | 0.09 | lasso | 2 | 0.08 | 1.8e-07 | 9.2 | 9.4 | 4.0e-21 | -0.82 | 0.41 | 0.59 | FALSE |
| 5 | GTEx | Spleen | VPS13C | 0.27 | 0.19 | lasso | 7 | 0.12 | 6.6e-04 | 8.4 | 9.1 | 6.4e-20 | -0.79 | 0.36 | 0.37 | FALSE |
| 6 | GTEx | Whole Blood | VPS13C | 0.09 | 0.00 | enet | 35 | 0.00 | 1.9e-01 | -11.4 | 8.7 | 3.2e-18 | -0.58 | 0.11 | 0.67 | FALSE |
| 7 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | C2CD4A | 0.03 | 0.01 | blup | 59 | 0.02 | 7.2e-03 | -12.0 | -9.9 | 5.2e-23 | 0.82 | 0.02 | 0.69 | FALSE |
| 8 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | C2CD4A | 0.09 | 0.11 | lasso | 1 | 0.08 | 9.4e-04 | -12.6 | -12.6 | 2.7e-36 | 1.00 | 0.01 | 0.92 | TRUE |
| 9 | The Cancer Genome Atlas | Thyroid Carcinoma | VPS13C | 0.07 | 0.03 | enet | 15 | 0.03 | 5.3e-04 | -12.6 | 9.5 | 2.4e-21 | -0.74 | 0.01 | 0.94 | FALSE |