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chr15:63,099,535-68,245,488

Best TWAS P=7.98e-22 · Best GWAS P=4.16e-39 conditioned to 5.69e-21

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	AAGAB	0.06	0.05	enet	11	0.05	3.2e-07	-5.2	-6.3	2.4e-10	0.02	1.00	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	DENND4A	0.06	0.05	enet	18	0.05	7.1e-07	8.7	8.3	1.2e-16	0.06	0.03	0.97	FALSE
3	CommonMind	Brain Pre-frontal Cortex	SLC24A1	0.05	0.03	lasso	7	0.03	3.0e-04	8.6	6.9	3.9e-12	0.04	0.04	0.95	FALSE
4	CommonMind	Brain Pre-frontal Cortex	TIPIN	0.21	0.22	lasso	11	0.22	5.3e-26	-5.5	-5.6	2.2e-08	0.02	1.00	0.00	FALSE
5	GTEx	Adipose Subcutaneous	TIPIN	0.34	0.38	lasso	9	0.38	2.7e-32	-5.6	-5.7	9.8e-09	0.01	1.00	0.00	FALSE
6	GTEx	Adipose Subcutaneous	RPL9P25	0.15	0.04	lasso	7	0.06	6.0e-06	-4.1	-5.6	2.5e-08	-0.01	0.58	0.02	FALSE
7	GTEx	Adrenal Gland	TIPIN	0.55	0.57	enet	23	0.57	1.0e-24	-5.6	-5.5	4.6e-08	0.01	1.00	0.00	FALSE
8	GTEx	Artery Aorta	TIPIN	0.44	0.38	lasso	9	0.40	8.8e-24	-5.6	-5.8	6.7e-09	0.01	1.00	0.00	FALSE
9	GTEx	Artery Coronary	TIPIN	0.35	0.20	lasso	10	0.25	5.2e-09	-5.6	-5.3	8.6e-08	0.02	1.00	0.00	FALSE
10	GTEx	Artery Tibial	DENND4A	0.05	0.01	enet	8	0.02	8.3e-03	7.6	8.6	6.8e-18	0.04	0.03	0.91	TRUE
11	GTEx	Brain Caudate basal ganglia	TIPIN	0.44	0.34	enet	8	0.34	1.5e-10	-5.6	-5.6	1.8e-08	0.03	0.99	0.00	FALSE
12	GTEx	Brain Cerebellar Hemisphere	TIPIN	0.27	0.23	lasso	10	0.20	5.7e-06	-5.6	-5.6	2.6e-08	0.01	0.54	0.03	FALSE
13	GTEx	Brain Cerebellar Hemisphere	IGDCC4	0.19	0.12	lasso	7	0.10	1.2e-03	8.3	-7.7	1.1e-14	-0.05	0.04	0.90	FALSE
14	GTEx	Brain Cerebellum	TIPIN	0.32	0.15	lasso	7	0.14	8.3e-05	-5.6	-5.6	2.7e-08	0.01	0.76	0.01	FALSE
15	GTEx	Brain Cerebellum	IGDCC4	0.28	0.27	lasso	5	0.24	9.6e-08	6.9	-6.5	7.8e-11	-0.04	0.16	0.80	FALSE
16	GTEx	Brain Frontal Cortex BA9	TIPIN	0.28	0.28	lasso	7	0.26	1.4e-07	-5.6	-5.5	2.8e-08	0.01	0.86	0.01	FALSE
17	GTEx	Brain Hippocampus	TIPIN	0.36	0.18	enet	37	0.18	5.8e-05	-5.6	-6.3	3.7e-10	0.04	0.38	0.22	TRUE
18	GTEx	Brain Hypothalamus	TIPIN	0.41	0.34	lasso	9	0.35	3.8e-09	-5.6	-5.4	5.8e-08	0.01	0.96	0.00	TRUE
19	GTEx	Brain Nucleus accumbens basal ganglia	SPG21	0.24	0.21	lasso	5	0.18	1.2e-05	5.3	5.2	2.1e-07	0.01	0.17	0.08	FALSE
20	GTEx	Brain Nucleus accumbens basal ganglia	DENND4A	0.16	0.09	lasso	4	0.06	8.8e-03	7.6	7.7	1.8e-14	0.02	0.07	0.38	FALSE
21	GTEx	Brain Putamen basal ganglia	DIS3L	0.37	0.01	lasso	4	0.02	1.4e-01	-2.6	-5.5	4.2e-08	-0.29	0.04	0.38	FALSE
22	GTEx	Breast Mammary Tissue	TIPIN	0.35	0.30	enet	29	0.33	2.3e-17	-5.6	-6.4	1.6e-10	-0.01	1.00	0.00	FALSE
23	GTEx	Breast Mammary Tissue (Male)	TIPIN	0.44	0.10	lasso	24	0.16	1.4e-04	-5.6	-9.6	8.0e-22	-0.18	0.19	0.37	TRUE
24	GTEx	Cells Transformed fibroblasts	TIPIN	0.11	0.02	lasso	4	0.02	1.0e-02	-4.1	-5.7	1.5e-08	0.02	0.23	0.03	FALSE
25	GTEx	Cells Transformed fibroblasts	DENND4A	0.08	0.06	lasso	2	0.04	3.3e-04	8.3	-8.3	7.2e-17	-0.06	0.05	0.94	FALSE
26	GTEx	Colon Sigmoid	TIPIN	0.53	0.40	lasso	6	0.38	2.0e-14	-5.5	-5.7	9.5e-09	0.04	1.00	0.00	FALSE
27	GTEx	Colon Transverse	TIPIN	0.18	0.04	lasso	9	0.11	5.4e-06	-4.1	-5.6	1.7e-08	0.01	0.41	0.08	FALSE
28	GTEx	Esophagus Muscularis	TIPIN	0.41	0.31	lasso	13	0.37	8.6e-24	-5.6	-6.2	7.6e-10	0.01	1.00	0.00	FALSE
29	GTEx	Heart Left Ventricle	TIPIN	0.39	0.40	lasso	10	0.46	1.3e-26	-5.6	-6.2	6.0e-10	0.01	1.00	0.00	FALSE
30	GTEx	Lung	TIPIN	0.25	0.18	enet	24	0.18	1.8e-13	-5.6	-6.1	1.1e-09	-0.01	1.00	0.00	FALSE
31	GTEx	Muscle Skeletal	TIPIN	0.16	0.10	lasso	6	0.14	3.9e-13	-5.6	-6.0	2.2e-09	0.02	1.00	0.00	FALSE
32	GTEx	Muscle Skeletal	IGDCC4	0.03	0.01	lasso	2	0.02	9.2e-03	7.5	-6.3	2.2e-10	-0.03	0.10	0.68	FALSE
33	GTEx	Muscle Skeletal	SMAD3	0.13	0.10	enet	8	0.10	4.2e-10	6.8	6.1	1.1e-09	0.03	1.00	0.00	FALSE
34	GTEx	Muscle Skeletal	RP11-352G18.2	0.12	0.02	enet	7	0.11	3.6e-11	-3.3	5.8	6.0e-09	0.02	0.99	0.00	FALSE
35	GTEx	Nerve Tibial	TIPIN	0.48	0.52	lasso	5	0.53	1.6e-43	-5.6	-5.6	2.8e-08	0.02	1.00	0.00	FALSE
36	GTEx	Ovary	TIPIN	0.65	0.29	enet	45	0.37	5.5e-10	-5.6	-6.2	4.6e-10	0.00	0.86	0.01	FALSE
37	GTEx	Pancreas	TIPIN	0.45	0.41	enet	29	0.41	1.1e-18	-5.6	-5.8	5.2e-09	0.02	1.00	0.00	FALSE
38	GTEx	Pituitary	TIPIN	0.61	0.56	lasso	11	0.56	1.2e-16	-5.6	-5.6	2.3e-08	0.01	1.00	0.00	FALSE
39	GTEx	Prostate	TIPIN	0.36	0.26	lasso	10	0.23	1.8e-06	-5.6	-5.5	2.9e-08	0.01	0.68	0.02	FALSE
40	GTEx	Skin Not Sun Exposed Suprapubic	TIPIN	0.40	0.39	lasso	5	0.39	5.7e-23	-5.6	-5.5	3.1e-08	0.03	1.00	0.00	FALSE
41	GTEx	Skin Sun Exposed Lower leg	TIPIN	0.31	0.35	lasso	10	0.36	1.2e-30	-5.6	-5.8	5.9e-09	0.02	1.00	0.00	FALSE
42	GTEx	Skin Sun Exposed Lower leg	IGDCC4	0.05	0.00	enet	9	0.00	6.1e-01	3.5	-5.2	2.6e-07	-0.06	0.04	0.13	FALSE
43	GTEx	Stomach	TIPIN	0.43	0.22	lasso	15	0.22	8.2e-11	-5.6	-5.5	4.6e-08	0.03	1.00	0.00	FALSE
44	GTEx	Testis	TIPIN	0.37	0.35	enet	13	0.38	1.2e-17	-5.6	-5.5	3.8e-08	0.02	1.00	0.00	FALSE
45	GTEx	Thyroid	TIPIN	0.49	0.60	lasso	14	0.60	4.1e-57	-5.6	-5.7	1.5e-08	0.01	1.00	0.00	FALSE
46	GTEx	Uterus	TIPIN	0.44	0.35	lasso	14	0.31	3.5e-07	-5.6	-5.7	1.6e-08	0.01	0.58	0.02	FALSE
47	GTEx	Vagina	TIPIN	0.31	0.29	enet	26	0.25	1.7e-06	-5.6	-5.9	3.5e-09	0.03	0.71	0.02	FALSE
48	GTEx	Whole Blood	ANKDD1A	0.14	0.07	enet	33	0.06	4.6e-06	3.2	8.4	3.1e-17	0.07	0.96	0.02	TRUE
49	METSIM	Adipose	TIPIN	0.16	0.16	blup	524	0.16	1.7e-23	-5.6	-7.3	3.5e-13	-0.05	1.00	0.00	FALSE
50	NTR	Blood	USP3	0.02	0.02	enet	4	0.02	5.4e-07	8.2	8.3	1.3e-16	-0.02	0.00	1.00	TRUE
51	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	DPP8	0.07	0.00	enet	9	0.03	2.9e-03	-3.8	-5.5	4.1e-08	0.02	0.03	0.10	FALSE
52	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	IQCH	0.13	0.07	blup	112	0.10	5.2e-09	-4.5	6.2	5.0e-10	-0.03	0.08	0.92	FALSE
53	The Cancer Genome Atlas	Breast Invasive Carcinoma	DENND4A	0.01	0.01	blup	68	0.01	7.5e-03	7.2	-7.6	2.8e-14	-0.04	0.02	0.27	FALSE
54	The Cancer Genome Atlas	Breast Invasive Carcinoma	DPP8	0.08	0.02	lasso	4	0.05	6.1e-10	7.6	-7.4	1.3e-13	-0.01	0.15	0.85	FALSE
55	The Cancer Genome Atlas	Breast Invasive Carcinoma	IQCH	0.06	0.05	blup	112	0.06	5.2e-12	-6.0	5.6	2.2e-08	-0.03	0.02	0.98	FALSE
56	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	PTPLAD1	0.09	0.06	blup	46	0.06	5.2e-04	-4.8	-5.8	8.6e-09	0.00	0.06	0.45	FALSE
57	The Cancer Genome Atlas	Colon Adenocarcinoma	IQCH	0.08	0.02	blup	111	0.05	4.2e-04	-4.3	5.5	2.8e-08	-0.03	0.06	0.87	FALSE
58	The Cancer Genome Atlas	Glioblastoma Multiforme	DPP8	0.25	0.14	enet	6	0.12	1.8e-04	-3.8	-6.2	6.9e-10	0.00	0.03	0.16	FALSE
59	The Cancer Genome Atlas	Glioblastoma Multiforme	TIPIN	0.39	0.17	enet	15	0.22	1.9e-07	-5.6	-6.1	8.1e-10	-0.02	0.01	0.98	FALSE
60	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	DENND4A	0.04	0.01	blup	68	0.01	8.0e-03	-3.7	-6.7	2.8e-11	-0.05	0.04	0.10	FALSE
61	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PTPLAD1	0.05	0.01	enet	10	0.02	4.3e-03	-3.4	-6.6	3.0e-11	-0.03	0.04	0.18	FALSE
62	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	DPP8	0.03	0.01	blup	53	0.01	8.4e-03	6.9	-6.2	4.1e-10	0.01	0.03	0.55	FALSE
63	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	IQCH	0.12	0.10	enet	22	0.12	4.0e-13	-4.4	5.5	3.3e-08	-0.03	0.98	0.02	FALSE
64	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MAP2K1	0.13	0.12	blup	55	0.12	3.1e-13	-5.5	-5.7	1.0e-08	0.03	0.01	0.99	FALSE
65	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	TIPIN	0.15	0.18	lasso	8	0.18	2.7e-10	-5.6	-5.4	5.9e-08	0.02	0.01	0.99	FALSE
66	The Cancer Genome Atlas	Brain Lower Grade Glioma	TIPIN	0.21	0.23	enet	18	0.26	6.5e-29	-5.6	-5.3	1.1e-07	0.00	0.01	0.99	FALSE
67	The Cancer Genome Atlas	Lung Adenocarcinoma	DPP8	0.07	0.01	blup	53	0.03	1.7e-04	-3.6	-5.9	4.2e-09	0.02	0.22	0.22	FALSE
68	The Cancer Genome Atlas	Lung Adenocarcinoma	SMAD3	0.06	0.06	lasso	2	0.06	2.5e-07	7.0	6.6	5.5e-11	0.02	0.93	0.00	TRUE
69	The Cancer Genome Atlas	Lung Adenocarcinoma	TIPIN	0.03	0.03	lasso	4	0.03	1.9e-04	-5.6	-5.4	8.0e-08	0.01	0.01	0.91	FALSE
70	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	DENND4A	0.04	0.02	blup	67	0.02	1.3e-02	7.6	-8.5	1.7e-17	-0.05	0.02	0.63	FALSE
71	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	DPP8	0.07	0.03	blup	53	0.01	5.4e-02	-3.1	-6.3	2.3e-10	-0.05	0.01	0.22	FALSE
72	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	IQCH	0.35	0.04	blup	112	0.12	1.5e-05	-4.5	7.6	3.2e-14	-0.03	0.06	0.88	TRUE
73	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	TIPIN	0.40	0.39	lasso	9	0.39	9.9e-17	-5.6	-5.6	2.6e-08	0.01	0.01	0.99	FALSE
74	The Cancer Genome Atlas	Prostate Adenocarcinoma	DPP8	0.08	0.08	lasso	4	0.07	1.6e-07	7.6	-7.2	4.2e-13	-0.01	0.78	0.22	FALSE
75	The Cancer Genome Atlas	Prostate Adenocarcinoma	TIPIN	0.33	0.36	lasso	10	0.36	1.3e-38	-5.6	-5.8	6.7e-09	0.02	0.01	0.99	FALSE
76	The Cancer Genome Atlas	Rectum Adenocarcinoma	DENND4A	0.17	0.08	blup	68	0.07	1.0e-02	7.6	-7.2	6.1e-13	-0.05	0.04	0.54	FALSE
77	The Cancer Genome Atlas	Soft Tissue Sarcoma	DPP8	0.16	0.01	blup	53	0.03	9.7e-03	-3.4	-6.8	1.2e-11	0.02	0.01	0.31	FALSE
78	The Cancer Genome Atlas	Soft Tissue Sarcoma	TIPIN	0.05	0.00	blup	41	0.01	9.8e-02	-5.6	-5.5	3.8e-08	0.01	0.01	0.63	FALSE
79	The Cancer Genome Atlas	Stomach Adenocarcinoma	IQCH	0.08	0.03	blup	111	0.04	9.2e-04	-4.5	5.5	3.3e-08	-0.03	0.04	0.62	FALSE
80	The Cancer Genome Atlas	Stomach Adenocarcinoma	SPG21	0.04	0.04	lasso	4	0.04	3.6e-04	-4.7	5.2	2.6e-07	0.02	0.01	0.96	FALSE
81	The Cancer Genome Atlas	Testicular Germ Cell Tumors	DENND4A	0.09	0.05	lasso	4	0.03	3.3e-02	8.3	-8.2	2.5e-16	-0.06	0.03	0.46	FALSE
82	The Cancer Genome Atlas	Thyroid Carcinoma	DPP8	0.05	0.02	lasso	5	0.04	5.9e-05	7.6	-5.9	2.8e-09	-0.01	0.14	0.44	FALSE
83	The Cancer Genome Atlas	Thyroid Carcinoma	TIPIN	0.46	0.50	lasso	6	0.53	7.8e-60	-5.6	-5.8	6.1e-09	0.02	0.01	0.99	FALSE