Best TWAS P=1.55e-19 · Best GWAS P=2.23e-26 conditioned to 0.581
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Heart Atrial Appendage | TNRC6A | 0.16 | 0.00 | enet | 21 | 0.01 | 1.8e-01 | 8.44 | -7.4 | 1.6e-13 | 0.29 | 0.09 | 0.07 | FALSE |
| 2 | METSIM | Adipose | SLC5A11 | 0.23 | 0.28 | lasso | 10 | 0.28 | 1.6e-42 | -8.07 | -7.9 | 2.5e-15 | 0.63 | 1.00 | 0.00 | FALSE |
| 3 | ROSMAP | Brain Pre-frontal Cortex | SLC5A11 | 0.10 | 0.07 | bslmm | 396 | 0.08 | 5.7e-11 | -0.31 | 5.2 | 1.6e-07 | -0.13 | 1.00 | 0.00 | TRUE |
| 4 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | SLC5A11 | 0.17 | 0.21 | lasso | 4 | 0.21 | 1.7e-17 | -7.73 | -8.2 | 2.2e-16 | 0.65 | 1.00 | 0.00 | FALSE |
| 5 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SLC5A11 | 0.12 | 0.17 | enet | 9 | 0.18 | 1.1e-35 | -8.00 | -9.0 | 1.5e-19 | 0.64 | 1.00 | 0.00 | TRUE |
| 6 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | SLC5A11 | 0.27 | 0.24 | lasso | 6 | 0.24 | 4.5e-12 | -8.08 | -8.1 | 4.2e-16 | 0.61 | 1.00 | 0.00 | FALSE |
| 7 | The Cancer Genome Atlas | Colon Adenocarcinoma | SLC5A11 | 0.27 | 0.21 | lasso | 2 | 0.20 | 5.2e-12 | -8.08 | -8.1 | 6.5e-16 | 0.64 | 1.00 | 0.00 | FALSE |
| 8 | The Cancer Genome Atlas | Glioblastoma Multiforme | RBBP6 | 0.22 | 0.16 | blup | 55 | 0.17 | 7.8e-06 | -7.64 | -7.1 | 1.0e-12 | -0.04 | 0.00 | 0.99 | TRUE |
| 9 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | SLC5A11 | 0.13 | 0.15 | enet | 8 | 0.15 | 6.6e-17 | -8.01 | -8.3 | 6.7e-17 | 0.62 | 1.00 | 0.00 | FALSE |
| 10 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SLC5A11 | 0.07 | 0.07 | enet | 7 | 0.06 | 1.7e-07 | -8.01 | -8.2 | 2.1e-16 | 0.66 | 0.56 | 0.44 | FALSE |
| 11 | The Cancer Genome Atlas | Lung Adenocarcinoma | SLC5A11 | 0.14 | 0.20 | enet | 9 | 0.20 | 2.2e-23 | -8.02 | -7.9 | 3.5e-15 | 0.62 | 1.00 | 0.00 | FALSE |
| 12 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | SLC5A11 | 0.06 | 0.05 | lasso | 1 | 0.05 | 4.9e-06 | -8.02 | -8.0 | 1.0e-15 | 0.64 | 0.35 | 0.60 | FALSE |
| 13 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | SLC5A11 | 0.30 | 0.33 | lasso | 2 | 0.32 | 2.8e-14 | -8.01 | -8.3 | 8.8e-17 | 0.59 | 1.00 | 0.00 | FALSE |
| 14 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | SLC5A11 | 0.54 | 0.32 | lasso | 6 | 0.30 | 1.8e-12 | -7.73 | -8.7 | 3.9e-18 | 0.67 | 0.75 | 0.25 | FALSE |
| 15 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SLC5A11 | 0.26 | 0.28 | lasso | 6 | 0.31 | 1.0e-32 | -8.00 | -8.9 | 4.6e-19 | 0.63 | 1.00 | 0.00 | FALSE |
| 16 | The Cancer Genome Atlas | Soft Tissue Sarcoma | SLC5A11 | 0.17 | 0.21 | lasso | 3 | 0.18 | 4.9e-11 | -8.01 | -7.9 | 3.2e-15 | 0.62 | 1.00 | 0.00 | FALSE |
| 17 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | SLC5A11 | 0.20 | 0.05 | lasso | 4 | 0.04 | 2.8e-02 | -8.02 | -8.3 | 9.2e-17 | 0.69 | 0.02 | 0.49 | FALSE |
| 18 | The Cancer Genome Atlas | Stomach Adenocarcinoma | SLC5A11 | 0.12 | 0.08 | enet | 7 | 0.07 | 7.0e-06 | -8.00 | -6.2 | 4.6e-10 | 0.53 | 0.79 | 0.05 | TRUE |
| 19 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | SLC5A11 | 0.21 | 0.10 | lasso | 5 | 0.07 | 2.2e-03 | -8.00 | -7.6 | 3.4e-14 | 0.61 | 0.21 | 0.23 | FALSE |
| 20 | The Cancer Genome Atlas | Thyroid Carcinoma | SLC5A11 | 0.35 | 0.44 | lasso | 4 | 0.44 | 4.2e-47 | -8.00 | -8.4 | 4.5e-17 | 0.65 | 1.00 | 0.00 | FALSE |
| 21 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | SLC5A11 | 0.24 | 0.15 | lasso | 3 | 0.14 | 1.1e-04 | -8.02 | -8.0 | 1.2e-15 | 0.63 | 0.16 | 0.14 | FALSE |