TWAS hub - TNRC6A

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Heart Atrial Appendage	0.1560	0.063	0.0069	0.000	NA	0.005	NA	0.003	0.33	NA	0.18	NA	0.24
2	NTR	Blood	0.0265	0.010	0.0012	-0.001	0.003	0.000	0.003	0.000	0.87	0.028	0.53	0.025	0.50

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Systolic blood pressure, automated reading	5.3	15.3	30.1	0.7	-5.5
Mood swings	5.2	9.4	9.7	-3.0	-3.1
Illnesses of father: Heart disease	4.8	6.7	10.3	-1.7	3.2
Current tobacco smoking	4.7	7.7	8.5	-2.9	-2.6
Fed-up feelings	4.5	8.2	14.4	-3.8	-1.4
Tense / ‘highly strung’	4.3	7.1	8.9	-3.0	-2.3
Smoking status: Current	4.1	6.5	6.6	-2.5	-2.6
Smoking Status	4.0	9.6	13.0	-2.5	-3.6
Diabetes (father)	3.8	4.7	9.4	3.1	-0.2
Maternal smoking around birth	3.8	5.5	10.1	-0.9	-3.2
Illnesses of siblings	3.8	5.3	10.1	-0.7	3.2
Mouth/teeth dental problems: Loose teeth	3.8	4.5	8.2	-0.9	-2.9
Ever smoked	3.7	6.5	8.4	-2.2	-2.9
Financial situation satisfaction	3.6	4.5	7.7	-2.8	1.2
Depressed Affect (Nagel 2018)	3.5	7.3	7.5	-2.7	-2.7
Number of incorrect matches in round	3.5	5.8	11.5	-3.4	-0.4
Medication for cholesterol	3.5	5.3	10.4	0.5	3.2
Ever unenthusiastic/disinterested for a whole week	3.4	4.2	8.1	-2.9	0.5
Time employed in main current job	3.3	3.8	4.1	-1.9	2.0
Diastolic blood pressure, automated reading	3.3	10.2	16.4	2.0	-4.0
Neuroticism score	3.2	6.7	11.4	-3.4	-1.4
Medication: Amlodipine	3.2	4.5	8.4	0.8	-2.9
High blood pressure (siblings)	3.2	4.6	8.8	0.7	-3.0
Pack years adult smoking proportion	3.1	4.7	4.9	-2.2	-2.1
Guilty feelings	3.1	4.7	9.2	-3.0	-0.4
Pack years of smoking	3.0	4.4	4.5	-2.1	-2.1
Average weekly fortified wine intake	2.9	3.3	3.5	1.9	1.8
Taking other prescription medications	2.8	4.3	4.7	-2.2	-2.0
Fluid intelligence score	2.8	5.8	8.8	1.7	3.0
Medication: Ventolin 100micrograms inhaler	2.7	3.5	4.9	-2.2	-1.5
Health satisfaction	2.7	3.5	6.0	-2.4	-1.0
Crohns Disease (2017)	2.6	5.7	11.0	-3.3	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	2.6	3.5	4.7	-2.2	-1.5
Falls in the last year	2.6	3.6	4.9	1.5	-2.2
Average weekly champagne plus white wine intake	2.6	3.6	5.1	2.3	1.5
Verbal and Numeric Reasoning (VNR)	2.5	6.0	7.2	2.2	2.7
Vascular/heart problems diagnosed by doctor	2.5	6.9	13.8	0.2	3.7
Schizophrenia (2018)	2.4	5.0	6.5	-2.5	-1.9
Wheeze or whistling in the chest in last year	2.4	4.3	5.2	-2.3	-1.8
Medication: Allopurinol	2.4	3.2	5.5	-2.3	-1.0
Heart attack/myocardial infarction (self-reported)	2.4	3.1	3.6	1.9	-1.6
Type 2 Diabetes (T2D) (2012)	2.3	2.7	4.3	-2.1	-1.0
Migraine (self-reported)	2.3	2.8	4.0	-1.2	2.0
Bipolar Disorder or Schizophrenia	2.2	5.4	6.9	-2.0	-2.6
Primary Biliary Cirrhosis	2.2	3.1	4.5	-1.3	2.1
Systolic Blood Pressure	2.2	11.1	22.2	0.2	-4.7
Ever had hysterectomy (womb removed)	2.2	2.5	3.3	1.3	-1.8
Sitting height	2.2	15.6	30.8	-5.5	0.6
Ever had stillbirth, spontaneous miscarriage or termination	2.2	2.3	3.4	-1.1	-1.9
Osteoarthritis (self-reported)	2.2	2.8	3.0	1.6	1.7
Schizophrenia (2014)	2.1	4.6	4.6	-2.1	-2.1
Frequency of depressed mood in last 2 weeks	2.1	2.9	5.8	-2.4	-0.1
High blood pressure (mother)	2.1	3.0	4.6	-2.1	1.2
Medication: Omeprazole	2.1	2.6	4.8	-2.2	-0.6
Medication: Blood pressure	2.1	3.9	7.5	0.6	-2.7
Depression (Nagel 2018)	2.0	3.0	3.7	-1.9	-1.5
Supplements: Zinc	2.0	2.2	3.4	1.0	-1.8
Heel bone mineral density (BMD) T-score, automated (left)	2.0	4.6	8.0	1.0	-2.8
Chronic bronchitis/emphysema (father)	2.0	2.3	4.6	2.1	0.2
Illness, injury, bereavement, stress in last 2 years	2.0	2.5	2.7	1.5	1.6
Illnesses of father: High blood pressure	2.0	2.5	3.1	1.4	-1.8
Neuroticism	1.9	4.6	5.4	-2.3	-2.0
Townsend deprivation index at recruitment	1.9	2.6	5.0	0.5	-2.2
Heart attack	1.9	2.4	2.7	1.6	-1.5
Pain all over the body in last month	1.9	2.1	3.9	-0.5	-2.0
Standing height	1.9	19.2	38.1	-6.2	-0.6
Breastfed as a baby	1.9	2.3	3.5	1.1	1.9
Medication: Bendroflumethiazide	1.9	2.9	5.7	0.4	-2.4
Unable to work because of sickness or disability	1.9	2.5	4.3	-0.8	-2.1
Respiratory disease	1.8	4.0	8.0	0.0	-2.8
Medication for hormone replacement therapy	1.8	2.0	4.0	-0.2	-2.0
Bilateral oophorectomy (both ovaries removed)	1.8	2.0	2.3	1.3	-1.5
Heel bone mineral density (BMD) T-score, automated (right)	1.8	4.0	8.0	0.1	-2.8
Lung cancer (father)	1.8	2.1	3.3	0.9	-1.8
Ever highly irritable/argumentative for 2 days	1.8	2.2	4.0	-2.0	-0.6
Past tobacco smoking	1.7	3.1	4.7	1.2	2.2
Worrier / anxious feelings	1.7	3.2	5.3	-2.3	-1.0
Asthma	1.7	3.4	6.6	-0.4	-2.6
Exposure to tobacco smoke outside home	1.7	2.2	2.6	-1.6	-1.4
Number of children fathered	1.7	1.9	3.3	-0.7	1.8
Overall health rating	1.7	3.7	5.3	-1.4	-2.3
Commuting to job workplace: Car/motor vehicle	1.7	2.0	3.9	0.3	-2.0
Long-standing illness, disability or infirmity	1.7	2.6	3.0	-1.5	-1.7
Eye problems/disorders: Cataract	1.7	2.0	3.2	0.8	-1.8
Asthma (self-reported)	1.7	3.3	6.6	-0.3	-2.6
Alcohol drinker status: Previous	1.7	2.0	3.2	-1.8	-0.9
Neuroticism (Nagel 2018)	1.6	3.9	5.0	-2.2	-1.6
Bipolar Disorder (2011)	1.6	1.5	1.6	-1.2	-1.3
Qualifications: CSEs or equivalent	1.6	2.1	3.5	-0.8	1.9
Father’s age at death	1.6	2.2	4.3	2.1	0.4
Forced vital capacity (FVC), Best measure	1.6	5.9	11.4	-3.4	-0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.6	1.9	2.7	1.1	1.6
Qualifications: NVQ or HND or HNC or equivalent	1.6	1.9	3.7	0.3	-1.9
Risk taking	1.6	2.4	4.6	0.4	2.1
Cholesterol lowering medication	1.6	2.4	3.9	0.9	-2.0
Age at First Birth	1.5	2.2	4.2	2.0	0.5
Heel T-Score	1.5	11.6	22.5	0.9	-4.7
Hand grip strength (left)	1.5	4.0	5.6	-1.6	-2.4
Mouth/teeth dental problems: Dentures	1.5	2.6	4.5	-0.8	-2.1
Hearing aid user	1.5	1.7	3.4	0.3	-1.9
Medication: Omeprazole (e.g. Zanprol)	1.5	1.9	3.7	-1.9	-0.1
Intelligence (Savage-Jansen 2018)	1.4	4.3	5.4	1.8	2.3
Neuroticism (2016)	1.4	2.1	2.7	-1.6	-1.2
Height	1.4	27.6	54.5	-7.4	-0.9
Serious illness, injury or assault to yourself	1.4	1.6	3.0	-1.7	0.5
High blood pressure	1.4	4.0	8.0	-0.0	-2.8
Supplements: Glucosamine	1.4	1.9	3.6	0.5	1.9
Exposure to tobacco smoke at home	1.4	1.6	2.4	-0.9	-1.6
Gout (self-reported)	1.4	1.9	3.2	-1.8	-0.8
Heart disease (mother)	1.4	1.7	2.6	1.6	-0.9
Comparative height size at age 10	1.4	8.0	15.7	-4.0	-0.5
Leg fat percentage (left)	1.4	5.2	8.5	1.4	-2.9
Irritable Bowel Disease (IBD)	1.3	3.1	5.7	-2.4	-0.6
Major Depression (MDD)	1.3	1.5	3.0	0.4	-1.7
Ovarian Cancer	1.3	1.8	2.9	-1.7	-0.8
Chronotype (morning person)	1.3	3.0	4.2	1.4	2.1
Happiness	1.3	1.6	3.2	-1.8	0.1
Depression (self-reported)	1.3	1.6	2.7	-1.6	-0.7
Worry too long after embarrassment	1.3	2.2	3.3	-1.0	1.8
Medication for pain relief, constipation, heartburn	1.3	2.2	3.0	1.7	1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.3	1.5	1.8	1.1	1.4
Miserableness	1.3	2.2	2.5	-1.6	-1.4
Irritability	1.3	2.2	4.0	-0.6	-2.0
Bipolar Disorder (2018)	1.2	1.9	3.8	-0.1	-1.9
Crohns Disease (2012)	1.2	1.9	3.7	-1.9	0.0
Blood White Count	1.2	9.2	18.1	0.5	-4.3
Number of treatments/medications taken	1.2	2.1	3.2	-1.0	-1.8
Hand grip strength (right)	1.2	3.2	5.8	-0.7	-2.4
Leg fat percentage (right)	1.2	4.3	8.1	0.7	-2.8
Comparative body size at age 10	1.2	3.2	6.2	2.5	-0.5
Loneliness, isolation	1.2	1.6	3.1	0.4	-1.8
Medication: Paracetamol	1.2	1.9	2.2	-1.2	-1.5
Number of operations (self-reported)	1.2	1.8	3.5	-1.9	-0.2
Worry (Nagel 2018)	1.1	2.3	2.9	-1.7	-1.3
Other serious medical condition/disability diagnosed by doctor	1.1	1.4	2.4	-1.6	0.6
Medication: Co-codamol	1.1	1.3	1.5	1.0	-1.2
Forced vital capacity (FVC)	1.1	4.3	7.9	-2.8	-0.8
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.3	1.3	-1.2	-1.1
Illnesses of mother	1.1	1.3	1.4	1.2	1.1
Medication: Paracetamol	1.1	1.9	2.9	-1.7	-0.9
Birth weight	1.1	2.4	3.2	1.3	1.8
Chronic bronchitis/emphysema (mother)	1.1	1.2	2.4	-0.1	-1.6
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.4	1.7	-1.1	-1.3
Angina (self-reported)	1.1	1.5	2.8	0.4	-1.7
Hypertension (Self-reported)	1.1	3.0	5.9	0.2	-2.4
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.2	2.2	-1.5	1.5
Supplements: Fish oil (including cod liver oil)	1.1	1.4	1.5	1.2	-1.2
HDL Cholesterol	1.0	1.7	3.4	-0.1	1.9
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.5	2.5	-1.6	-0.7
Medication: Simvastatin	1.0	1.5	3.0	1.7	0.0
Alcohol intake versus 10 years previously	1.0	1.6	3.0	0.3	-1.7
Pulse wave Arterial Stiffness index	1.0	1.2	2.1	-1.4	0.5
Loud music exposure frequency	1.0	1.1	1.7	1.3	-0.7
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	3.2	0.1	1.8
Age at first live birth	1.0	1.8	2.3	1.5	1.2
Alcohol intake frequency.	1.0	2.3	3.5	1.1	-1.9
Illnesses of father: None of the above (group 1)	1.0	1.2	1.6	-1.3	-0.9
Commuting to job workplace: Public transport	1.0	1.2	2.3	0.4	1.5
BMI	0.9	5.3	9.6	1.0	-3.1
Waist Hip Ratio (WHR)	0.9	4.2	7.3	-2.7	-1.1
Angina	0.9	1.2	2.2	0.3	-1.5
Age when periods started (menarche)	0.9	2.2	3.3	1.0	-1.8
Medication: Ramipril	0.9	1.2	2.4	-0.2	-1.5
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.5	1.6	-1.2	-1.3
Pulse wave reflection index	0.9	1.2	2.2	-0.3	-1.5
Pulse rate, automated reading	0.9	2.7	2.8	-1.6	-1.7
Age at last live birth	0.9	1.3	1.8	1.3	0.9
Breast cancer (self-reported)	0.9	1.1	1.5	-0.8	-1.2
Medication: Lisinopril	0.9	1.2	2.4	0.1	-1.6
Ever had prostate specific antigen (PSA) test	0.9	1.0	1.5	-0.8	1.2
Alzheimer’s Disease (in mother)	0.8	1.0	1.7	-1.3	0.4
Mean Putamen Volume	0.8	0.9	0.9	0.9	0.9
Lung FEV1/FVC ratio	0.8	3.9	4.6	2.1	1.8
Average weekly spirits intake	0.8	0.9	1.7	1.3	0.4
Ever used hormone-replacement therapy (HRT)	0.8	1.0	2.0	0.3	-1.4
Body mass index (BMI)	0.8	3.4	3.7	1.8	-1.9
Hearing difficulty/problems with background noise	0.8	1.2	2.0	-0.7	1.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.6	5.0	-2.2	0.4
Suffer from ‘nerves’	0.8	1.3	2.3	-1.5	-0.5
Family relationship satisfaction	0.8	1.0	1.4	-0.7	-1.2
Osteoporosis (self-reported)	0.8	1.0	1.5	0.6	-1.2
Medication: Gliclazide	0.8	0.9	1.4	-1.2	-0.6
Number of self-reported non-cancer illnesses	0.8	1.3	2.3	-0.6	-1.5
Average weekly beer plus cider intake	0.8	1.1	1.5	0.8	-1.2
Age started oral contraceptive pill	0.8	1.0	1.9	1.4	0.4
Supplements: Calcium	0.8	0.9	1.6	-1.3	0.5
Prostate Cancer	0.7	1.0	1.4	1.2	0.8
Diabetes (mother)	0.7	0.8	1.7	-0.1	-1.3
Diabetes (self-reported)	0.7	1.0	2.0	-0.2	-1.4
Forced expiratory volume in 1-second (FEV1)	0.7	2.4	4.6	-2.2	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.0	1.1	-1.0	-1.0
Emphysema/chronic bronchitis	0.7	0.8	1.5	-0.5	-1.2
Mean time to correctly identify matches	0.7	1.3	2.5	0.3	1.6
Leg fat mass (right)	0.7	2.7	5.5	-0.1	-2.3
Handedness (chirality/laterality): Left-handed	0.7	0.9	1.6	1.3	0.3
Qualifications: nursing, teaching	0.7	1.1	2.1	0.0	1.5
Fractured/broken bones in last 5 years	0.7	0.8	1.0	-1.0	-0.8
Leg fat mass (left)	0.7	2.8	5.6	0.2	-2.4
Reaction Time	0.6	1.2	2.0	-0.6	1.4
Blood Eosinophil Count	0.6	4.9	7.6	-2.8	1.5
Type 2 Diabetes (T2D) (2018)	0.6	1.0	1.5	0.8	-1.2
Relative age voice broke	0.6	0.9	1.8	1.3	0.0
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.3	1.1	-0.4
Waist circumference	0.6	2.2	4.4	0.1	-2.1
Alcohol usually taken with meals	0.6	1.0	2.0	-0.1	1.4
Hair/balding pattern: Pattern 3	0.6	0.9	1.0	1.0	0.8
Qualifications: A levels/AS levels or equivalent	0.6	1.4	2.7	-0.1	1.6
Arm fat mass (right)	0.6	2.4	4.7	0.2	-2.2
Hair/balding pattern: Pattern 4	0.6	1.5	2.6	0.7	-1.6
Pulse wave peak to peak time	0.6	0.7	1.2	1.1	-0.3
Number of full sisters	0.6	0.8	1.4	-0.3	1.2
Smoking status: Previous	0.6	0.8	1.7	0.0	-1.3
Average weekly red wine intake	0.6	0.9	1.6	-0.4	1.3
Diabetes diagnosed by doctor	0.6	1.0	1.8	-0.4	-1.3
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	1.7	-1.3	0.6
Ever depressed for a whole week	0.6	0.7	1.1	-0.6	1.1
Commuting to job workplace: Cycle	0.6	0.8	0.9	0.8	0.9
Myopia	0.6	0.9	1.5	-0.5	-1.2
Triglycerides	0.5	0.8	1.2	-1.1	-0.7
Blood Red Count	0.5	4.8	5.7	2.0	-2.4
Multivitamins +/- minerals	0.5	0.6	1.2	-1.1	-0.2
Medication: Atenolol	0.5	0.6	1.2	0.3	-1.1
Weight	0.5	2.6	4.2	-1.0	-2.0
Arm fat percentage (right)	0.5	2.0	3.2	0.9	-1.8
Trunk fat-free mass	0.5	2.9	4.8	-2.2	-1.0
Number of live births	0.5	0.6	1.0	-0.5	-1.0
Noisy workplace	0.5	0.7	1.3	-0.2	-1.1
Medication: Lansoprazole	0.5	0.5	1.0	0.2	-1.0
Impedance of arm (left)	0.5	2.5	3.8	-1.9	1.1
Trunk predicted mass	0.5	3.0	4.8	-2.2	-1.1
Medication: Seretide 50 evohaler	0.5	0.6	1.2	-0.1	-1.1
Whole body fat mass	0.5	2.2	4.2	-0.5	-2.0
Had major operations	0.5	0.6	1.0	-1.0	0.3
Knee pain experienced in last month	0.5	0.8	1.5	-0.2	-1.2
Tinnitus: Yes, now most or all of the time	0.5	0.5	0.7	-0.6	0.8
Deep venous thrombosis (DVT) (self-reported)	0.5	0.7	0.8	0.9	0.7
Cardiovascular Disease	0.4	1.2	2.3	0.3	-1.5
Sensitivity / hurt feelings	0.4	0.7	1.1	-0.6	-1.0
Tinnitus: Yes, but not now, but have in the past	0.4	0.5	0.7	-0.8	-0.5
Leg predicted mass (left)	0.4	1.9	3.6	-1.9	-0.3
Trunk fat mass	0.4	1.9	2.9	-1.0	-1.7
Qualifications: None of the above	0.4	0.8	1.0	-1.0	-0.8
Mouth/teeth dental problems	0.4	0.6	0.7	0.7	0.8
Pulse rate	0.4	0.6	0.9	-1.0	0.6
Blood clot in the leg (DVT)	0.4	0.6	0.8	0.9	0.6
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	0.8	-0.9	0.8
Body fat percentage	0.4	1.6	3.2	0.0	-1.8
Arm fat-free mass (right)	0.4	2.0	3.8	-2.0	-0.3
Shortness of breath walking on level ground	0.4	0.5	0.8	-0.9	-0.4
Arm predicted mass (right)	0.4	1.9	3.5	-1.9	-0.6
Leg pain on walking	0.4	0.5	0.7	0.8	-0.5
Whole body fat-free mass	0.4	2.2	3.9	-2.0	-0.7
Medication: Aspirin	0.4	0.6	1.1	1.1	-0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	1.4	-1.2	0.5
Whole body water mass	0.4	2.6	4.7	-2.2	-0.6
Arm fat mass (left)	0.4	1.8	3.6	0.3	-1.9
Mother’s age at death	0.4	0.5	0.8	0.9	-0.5
Pain type(s) experienced in last month: Hip pain	0.4	0.5	0.8	-0.9	0.4
Basal metabolic rate	0.4	2.4	3.4	-1.8	-1.2
Arm fat-free mass (left)	0.4	2.1	3.0	-1.7	-1.1
Pain experienced in last month	0.4	0.7	0.7	0.8	0.8
Basal cell carcinoma (self-reported)	0.4	0.5	0.9	-0.9	-0.1
Arm predicted mass (left)	0.4	2.0	2.7	-1.6	-1.1
Alzheimer’s Disease (including proxy)	0.3	0.4	0.7	-0.8	0.4
LDL Cholesterol	0.3	0.5	0.8	0.4	0.9
Lupus	0.3	0.5	0.7	0.6	-0.8
Ulcerative Colitis	0.3	0.4	0.7	-0.2	-0.8
Lung FVC	0.3	1.6	1.8	-1.1	-1.4
Hearing difficulty/problems: Yes	0.3	0.5	0.9	1.0	0.1
Relative age of first facial hair	0.3	0.6	1.0	0.4	-1.0
Eye problems/disorders: Diabetes related eye disease	0.3	0.4	0.8	0.0	0.9
Impedance of leg (right)	0.3	1.5	2.0	-1.4	-0.9
Leg fat-free mass (left)	0.3	1.8	3.4	-1.9	-0.3
Trunk fat percentage	0.3	1.2	2.4	-0.4	-1.5
Hayfever, allergic rhinitis or eczema	0.3	0.6	0.6	-0.8	0.7
Medication: Levothyroxine sodium	0.3	0.5	1.0	-0.2	-1.0
Financial difficulties in last 2 years	0.3	0.5	0.9	-0.1	-0.9
Allergy	0.3	0.7	1.1	1.0	0.6
Impedance of arm (right)	0.3	1.6	3.1	-1.8	0.3
Hip circumference	0.3	1.5	2.1	0.9	-1.5
Medication: Cholesterol lowering	0.3	0.5	1.0	1.0	-0.0
Prospective memory result	0.3	0.4	0.6	0.5	-0.7
Headache pain in last month	0.3	0.5	0.7	-0.4	0.9
Medication: Aspirin	0.3	0.4	0.4	0.7	-0.6
Illnesses of siblings: Diabetes	0.3	0.4	0.7	0.4	-0.8
Arm fat percentage (left)	0.3	1.3	1.9	0.8	-1.4
Impedance of whole body	0.3	1.4	2.7	-1.6	0.2
Schizophrenia vs Biploar Disorder	0.2	0.3	0.3	-0.6	0.5
Alzheimer’s Disease (in father)	0.2	0.2	0.3	-0.5	0.3
Ulcerative Colitis (UC)	0.2	0.3	0.5	-0.3	-0.7
Breast Cancer	0.2	0.5	0.6	-0.6	0.8
Coronary Artery Disease (CAD)	0.2	0.2	0.4	-0.2	0.6
Fasting Glucose	0.2	0.2	0.4	-0.3	0.6
Rheumatoid Arthritis	0.2	0.2	0.3	0.5	-0.5
Vitamin and mineral supplements	0.2	0.2	0.4	0.7	0.1
Medication: Metformin	0.2	0.3	0.4	-0.5	-0.6
Impedance of leg (left)	0.2	0.8	1.2	-0.7	-1.1
Nervous feelings	0.2	0.5	0.9	-1.0	0.1
Had other major operations	0.2	0.2	0.4	-0.0	-0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.3	-0.4	0.5
Eye problems/disorders: None of the above	0.2	0.2	0.4	-0.0	-0.6
Medication: Blood pressure	0.2	0.4	0.7	0.3	-0.8
Chest pain or discomfort	0.2	0.3	0.5	-0.5	0.7
Supplements: Vitamin C	0.2	0.3	0.5	0.7	-0.3
Leg fat-free mass (right)	0.2	1.1	2.1	-1.4	-0.2
Ever had bowel cancer screening	0.2	0.2	0.3	-0.4	0.5
Friendships satisfaction	0.2	0.2	0.3	-0.6	0.3
Back pain experienced in last month	0.2	0.3	0.5	0.7	-0.2
Leg predicted mass (right)	0.2	1.2	2.4	-1.6	-0.2
Medication: Atorvastatin	0.2	0.2	0.3	0.2	-0.6
Alcohol drinker status: Never	0.2	0.2	0.3	0.4	-0.6
Heart disease (siblings)	0.2	0.2	0.4	-0.6	-0.3
Body Mass Index (BMI) (2010)	0.1	0.1	0.2	0.1	-0.5
HbA1C	0.1	0.1	0.1	-0.3	-0.3
Hypothyroidism (self reported)	0.1	0.2	0.2	-0.5	-0.3
Hair Pigment	0.1	1.5	1.9	1.4	1.0
Severe depression (siblings)	0.1	0.1	0.3	-0.1	0.5
Stomach or abdominal pain in last month	0.1	0.1	0.2	-0.5	0.2
Hair/balding pattern: Pattern 2	0.1	0.2	0.3	0.0	0.6
Hayfever/allergic rhinitis (self-reported)	0.1	0.2	0.4	-0.6	0.1
Length of working week for main job	0.1	0.1	0.2	-0.1	0.5
Birth weight of first child	0.1	0.1	0.2	0.4	-0.2
Peak expiratory flow (PEF)	0.1	0.3	0.6	-0.1	0.7
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.2	0.5	0.1
Glaucoma (self-reported)	0.1	0.1	0.1	-0.2	-0.4
Hypothyroidism/myxoedema (self-reported)	0.1	0.3	0.4	-0.3	-0.7
Number of full brothers	0.1	0.2	0.3	-0.0	-0.6
Qualifications: College or University degree	0.1	0.2	0.3	0.6	0.2
Neck or shoulder pain in last month	0.1	0.2	0.3	-0.5	-0.3
Medication: Ibuprofen	0.1	0.1	0.2	0.4	0.2
Commuting to job workplace: Walk	0.1	0.1	0.2	-0.2	0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.1	0.2	-0.3
Mineral and other dietary supplements	0.1	0.1	0.3	0.2	0.5
Wears glasses or contact lenses	0.1	0.1	0.2	-0.0	-0.5
Ever taken oral contraceptive pill	0.1	0.1	0.2	0.1	0.5
Eye problems/disorders: Glaucoma	0.1	0.2	0.2	-0.4	-0.4
High cholesterol (Self-reported)	0.1	0.3	0.4	0.3	0.7
Blood Platelet Count	0.0	0.2	0.4	-0.0	0.6
Allergy or Eczema	0.0	0.1	0.1	-0.2	0.3
Tanning	0.0	0.6	1.0	-1.0	-0.3
Had menopause	0.0	0.0	0.0	0.1	0.1
Medication: Ibuprofen (e.g. Nurofen)	0.0	0.0	0.1	0.2	-0.2

Hub : Genes

TNRC6A

Models

Trait associations