Best TWAS P=5.22e-16 · Best GWAS P=4.28e-23 conditioned to NaN
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | WWOX | 0.33 | 0.08 | enet | 64 | 0.17 | 2.1e-20 | -2.9 | -6.2 | 4.2e-10 | 0.14 | 1.00 | 0.00 | FALSE |
2 | GTEx | Adipose Subcutaneous | WWOX | 0.29 | 0.17 | lasso | 7 | 0.21 | 4.0e-17 | 4.3 | -6.8 | 1.2e-11 | 0.31 | 1.00 | 0.00 | FALSE |
3 | GTEx | Artery Aorta | WWOX | 0.34 | 0.07 | lasso | 9 | 0.17 | 9.2e-10 | 4.6 | -7.0 | 3.1e-12 | 0.17 | 0.94 | 0.01 | FALSE |
4 | GTEx | Artery Coronary | WWOX | 0.66 | 0.09 | enet | 6 | 0.08 | 9.8e-04 | -8.6 | -7.9 | 2.7e-15 | 0.06 | 0.48 | 0.04 | TRUE |
5 | GTEx | Artery Tibial | WWOX | 0.22 | 0.07 | enet | 33 | 0.07 | 4.5e-06 | 4.4 | -6.4 | 1.5e-10 | 0.13 | 0.97 | 0.00 | TRUE |
6 | GTEx | Brain Putamen basal ganglia | WWOX | 0.57 | 0.04 | enet | 23 | 0.01 | 1.6e-01 | -8.3 | -8.1 | 5.2e-16 | 0.01 | 0.18 | 0.05 | TRUE |
7 | GTEx | Cells Transformed fibroblasts | WWOX | 0.26 | 0.00 | lasso | 5 | 0.00 | 5.4e-01 | 4.0 | -5.2 | 2.1e-07 | 0.30 | 0.26 | 0.03 | TRUE |
8 | GTEx | Esophagus Gastroesophageal Junction | WWOX | 0.58 | 0.00 | lasso | 19 | -0.01 | 6.1e-01 | 4.3 | -5.4 | 5.9e-08 | 0.27 | 0.16 | 0.30 | TRUE |
9 | GTEx | Esophagus Muscularis | WWOX | 0.33 | 0.09 | lasso | 5 | 0.06 | 1.0e-04 | -6.2 | -6.5 | 8.3e-11 | 0.19 | 0.59 | 0.11 | FALSE |
10 | GTEx | Liver | WWOX | 0.49 | 0.00 | enet | 16 | 0.02 | 8.2e-02 | 6.1 | -7.2 | 4.3e-13 | 0.26 | 0.19 | 0.12 | FALSE |
11 | GTEx | Lung | WWOX | 0.33 | 0.07 | lasso | 11 | 0.10 | 5.7e-08 | 4.5 | -7.8 | 7.0e-15 | 0.25 | 0.92 | 0.01 | TRUE |
12 | GTEx | Nerve Tibial | WWOX | 0.55 | 0.23 | lasso | 15 | 0.28 | 5.6e-20 | -6.2 | -8.0 | 1.6e-15 | 0.18 | 1.00 | 0.00 | TRUE |
13 | GTEx | Skin Sun Exposed Lower leg | WWOX | 0.31 | 0.15 | enet | 14 | 0.16 | 4.3e-13 | 4.3 | -6.5 | 1.1e-10 | 0.32 | 1.00 | 0.00 | TRUE |
14 | METSIM | Adipose | WWOX | 0.31 | 0.07 | enet | 69 | 0.17 | 4.8e-25 | -2.5 | -6.7 | 1.6e-11 | 0.10 | 1.00 | 0.00 | TRUE |
15 | The Cancer Genome Atlas | Brain Lower Grade Glioma | WWOX | 0.34 | 0.04 | lasso | 10 | 0.16 | 4.3e-18 | -6.2 | -5.3 | 1.1e-07 | 0.02 | 1.00 | 0.00 | TRUE |