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chr16:80,779,331-82,901,701

Best TWAS P=3.49e-31 · Best GWAS P=6.52e-29 conditioned to 0.276

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	MPHOSPH6	0.30	0.24	lasso	8	0.23	2.1e-27	10.83	-9.9	2.6e-23	-0.80	0.08	0.92	FALSE
2	GTEx	Adipose Subcutaneous	MPHOSPH6	0.15	0.08	enet	8	0.09	5.1e-08	11.03	9.5	2.6e-21	0.87	0.01	0.99	FALSE
3	GTEx	Adipose Visceral Omentum	MPHOSPH6	0.32	0.14	lasso	4	0.17	3.5e-09	10.71	11.1	1.3e-28	0.96	0.01	0.99	FALSE
4	GTEx	Adrenal Gland	MPHOSPH6	0.34	0.25	lasso	3	0.26	8.4e-10	11.08	10.9	1.4e-27	0.95	0.00	1.00	FALSE
5	GTEx	Adrenal Gland	CMIP	0.23	0.04	lasso	8	0.05	8.2e-03	-3.57	-5.5	3.4e-08	-0.04	0.19	0.05	TRUE
6	GTEx	Artery Aorta	MPHOSPH6	0.32	0.15	lasso	6	0.17	7.8e-10	11.03	10.9	8.8e-28	0.93	0.01	0.99	FALSE
7	GTEx	Artery Tibial	MPHOSPH6	0.36	0.24	enet	9	0.27	1.9e-21	11.03	11.3	2.1e-29	0.95	0.01	0.99	FALSE
8	GTEx	Brain Cerebellar Hemisphere	MPHOSPH6	0.49	0.30	enet	12	0.31	8.5e-09	11.08	10.7	6.1e-27	0.96	0.01	0.99	FALSE
9	GTEx	Brain Cerebellum	MPHOSPH6	0.40	0.36	enet	10	0.39	1.8e-12	8.04	10.0	1.8e-23	0.94	0.01	0.99	FALSE
10	GTEx	Cells EBV-transformed lymphocytes	MPHOSPH6	0.38	0.14	lasso	7	0.18	1.2e-06	7.54	8.7	2.8e-18	0.79	0.05	0.93	FALSE
11	GTEx	Cells Transformed fibroblasts	CMIP	0.20	0.05	lasso	6	0.07	1.0e-05	-6.21	-8.8	1.9e-18	-0.27	0.89	0.10	FALSE
12	GTEx	Colon Transverse	MPHOSPH6	0.21	0.16	lasso	3	0.17	1.4e-08	11.03	11.3	1.4e-29	0.97	0.01	0.99	FALSE
13	GTEx	Esophagus Gastroesophageal Junction	MPHOSPH6	0.43	0.19	enet	30	0.19	1.8e-07	10.96	9.0	1.7e-19	0.83	0.00	0.99	FALSE
14	GTEx	Esophagus Muscularis	MPHOSPH6	0.36	0.23	lasso	7	0.20	1.7e-12	11.03	11.2	4.9e-29	0.97	0.01	0.99	FALSE
15	GTEx	Heart Atrial Appendage	MPHOSPH6	0.33	0.19	enet	27	0.21	5.4e-10	11.03	10.7	1.2e-26	0.88	0.01	0.99	FALSE
16	GTEx	Heart Left Ventricle	MPHOSPH6	0.28	0.24	lasso	3	0.24	8.9e-13	11.03	11.1	8.3e-29	0.97	0.01	0.99	FALSE
17	GTEx	Lung	MPHOSPH6	0.16	0.10	lasso	4	0.11	8.3e-09	11.08	11.4	6.7e-30	0.98	0.00	1.00	FALSE
18	GTEx	Muscle Skeletal	MPHOSPH6	0.27	0.19	lasso	7	0.23	1.4e-22	11.08	11.1	2.1e-28	0.96	0.00	1.00	FALSE
19	GTEx	Nerve Tibial	MPHOSPH6	0.40	0.22	lasso	7	0.28	1.0e-19	11.03	10.9	7.9e-28	0.95	0.01	0.99	FALSE
20	GTEx	Pancreas	MPHOSPH6	0.25	0.14	enet	15	0.15	9.2e-07	11.03	11.6	3.5e-31	0.90	0.01	0.99	TRUE
21	GTEx	Skin Not Sun Exposed Suprapubic	MPHOSPH6	0.24	0.13	enet	7	0.14	6.5e-08	0.55	5.8	5.6e-09	0.57	0.14	0.84	FALSE
22	GTEx	Stomach	MPHOSPH6	0.41	0.10	lasso	7	0.09	3.5e-05	10.84	11.3	2.0e-29	0.93	0.01	0.99	FALSE
23	GTEx	Testis	MPHOSPH6	0.52	0.32	lasso	11	0.35	2.0e-16	11.03	10.9	1.5e-27	0.94	0.00	1.00	FALSE
24	GTEx	Thyroid	MPHOSPH6	0.31	0.21	lasso	4	0.26	4.7e-20	10.71	11.2	5.0e-29	0.96	0.01	0.99	FALSE
25	GTEx	Whole Blood	MPHOSPH6	0.21	0.08	lasso	2	0.15	2.3e-13	7.99	5.9	3.8e-09	0.46	0.76	0.24	FALSE
26	METSIM	Adipose	MPHOSPH6	0.12	0.07	bslmm	741	0.08	2.0e-11	10.96	10.5	7.3e-26	0.93	0.00	1.00	FALSE
27	NTR	Blood	MPHOSPH6	0.10	0.08	lasso	6	0.09	2.7e-26	7.93	9.0	2.2e-19	0.74	1.00	0.00	FALSE
28	YFS	Blood	MPHOSPH6	0.12	0.09	lasso	4	0.13	3.4e-39	7.54	7.2	4.5e-13	0.53	1.00	0.00	FALSE
29	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MPHOSPH6	0.14	0.15	lasso	6	0.15	7.0e-17	10.85	10.8	4.3e-27	0.89	0.04	0.96	FALSE
30	The Cancer Genome Atlas	Lung Adenocarcinoma	MPHOSPH6	0.04	0.01	blup	90	0.02	2.2e-03	7.76	8.1	4.0e-16	0.62	0.04	0.52	FALSE
31	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	MPHOSPH6	0.13	0.09	lasso	2	0.12	2.4e-05	7.76	9.8	1.6e-22	0.87	0.02	0.91	FALSE
32	The Cancer Genome Atlas	Prostate Adenocarcinoma	MPHOSPH6	0.07	0.03	lasso	4	0.06	8.0e-07	11.16	8.7	3.6e-18	0.79	0.01	0.98	FALSE
33	The Cancer Genome Atlas	Thyroid Carcinoma	MPHOSPH6	0.18	0.16	lasso	3	0.16	5.1e-15	11.08	11.3	1.4e-29	0.99	0.00	1.00	FALSE