Best TWAS P=5.2e-22 · Best GWAS P=1.35e-32 conditioned to 1.25e-23
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | USP10 | 0.15 | 0.05 | enet | 85 | 0.05 | 1.7e-06 | -4.66 | -6.6 | 4.7e-11 | -0.10 | 1.00 | 0.00 | TRUE |
| 2 | GTEx | Artery Tibial | USP10 | 0.18 | 0.00 | lasso | 8 | 0.00 | 3.7e-01 | -4.06 | 5.3 | 1.4e-07 | 0.06 | 0.13 | 0.03 | FALSE |
| 3 | GTEx | Colon Transverse | TLDC1 | 0.39 | 0.16 | enet | 31 | 0.21 | 1.8e-10 | -0.96 | -5.3 | 1.1e-07 | -0.10 | 0.72 | 0.02 | TRUE |
| 4 | GTEx | Testis | USP10 | 0.47 | 0.16 | lasso | 10 | 0.11 | 1.0e-05 | 9.70 | 9.6 | 5.2e-22 | 0.00 | 0.94 | 0.00 | TRUE |
| 5 | The Cancer Genome Atlas | Colon Adenocarcinoma | CRISPLD2 | 0.24 | 0.23 | lasso | 4 | 0.22 | 7.6e-13 | 5.83 | 5.8 | 8.1e-09 | 0.01 | 1.00 | 0.00 | FALSE |
| 6 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CRISPLD2 | 0.13 | 0.09 | enet | 10 | 0.08 | 1.2e-09 | 4.22 | 6.0 | 1.9e-09 | 0.13 | 1.00 | 0.00 | TRUE |
| 7 | The Cancer Genome Atlas | Brain Lower Grade Glioma | OSGIN1 | 0.04 | 0.01 | blup | 81 | 0.02 | 2.2e-03 | 6.61 | 5.2 | 2.0e-07 | 0.00 | 0.00 | 0.97 | FALSE |
| 8 | The Cancer Genome Atlas | Prostate Adenocarcinoma | OSGIN1 | 0.28 | 0.33 | enet | 13 | 0.34 | 3.0e-37 | 6.61 | 6.3 | 2.7e-10 | 0.01 | 0.00 | 1.00 | TRUE |
| 9 | The Cancer Genome Atlas | Stomach Adenocarcinoma | CRISPLD2 | 0.12 | 0.08 | lasso | 2 | 0.05 | 1.0e-04 | 5.87 | 5.7 | 1.3e-08 | 0.01 | 0.62 | 0.02 | FALSE |