Best TWAS P=1.59e-31 · Best GWAS P=9.28e-30 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | CNIH4 | 0.24 | 0.16 | enet | 38 | 0.20 | 3.5e-16 | -11.3 | 11.3 | 1.0e-29 | -0.93 | 0.02 | 0.98 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | CNIH4 | 0.23 | 0.19 | enet | 34 | 0.22 | 1.7e-11 | -11.3 | 9.0 | 3.0e-19 | -0.90 | 0.02 | 0.98 | TRUE |
| 3 | GTEx | Adrenal Gland | CNIH4 | 0.21 | 0.05 | lasso | 6 | 0.13 | 2.5e-05 | -11.3 | 11.4 | 3.4e-30 | -0.93 | 0.02 | 0.97 | FALSE |
| 4 | GTEx | Artery Aorta | CNIH4 | 0.15 | 0.10 | lasso | 3 | 0.12 | 5.2e-07 | 3.5 | 8.4 | 5.9e-17 | -0.66 | 0.05 | 0.84 | FALSE |
| 5 | GTEx | Artery Tibial | CNIH4 | 0.15 | 0.14 | lasso | 4 | 0.16 | 1.1e-12 | -11.2 | 11.3 | 1.8e-29 | -1.00 | 0.03 | 0.97 | FALSE |
| 6 | GTEx | Brain Nucleus accumbens basal ganglia | DISP1 | 0.35 | 0.05 | lasso | 6 | 0.03 | 5.7e-02 | -6.2 | 6.4 | 2.0e-10 | -0.01 | 0.02 | 0.89 | TRUE |
| 7 | GTEx | Breast Mammary Tissue | CNIH4 | 0.25 | 0.19 | lasso | 5 | 0.22 | 1.6e-11 | -11.3 | 11.4 | 4.5e-30 | -0.99 | 0.02 | 0.98 | FALSE |
| 8 | GTEx | Breast Mammary Tissue (Male) | CNIH4 | 0.26 | 0.16 | lasso | 4 | 0.11 | 2.0e-03 | -11.3 | 11.3 | 1.9e-29 | -1.00 | 0.02 | 0.90 | FALSE |
| 9 | GTEx | Breast Mammary Tissue (Female) | CNIH4 | 0.12 | 0.16 | lasso | 4 | 0.14 | 7.8e-05 | -11.3 | 11.3 | 1.7e-29 | -1.00 | 0.02 | 0.94 | FALSE |
| 10 | GTEx | Cells Transformed fibroblasts | CNIH4 | 0.14 | 0.07 | enet | 9 | 0.10 | 3.3e-08 | -11.3 | 8.8 | 9.4e-19 | -0.87 | 0.02 | 0.98 | FALSE |
| 11 | GTEx | Colon Transverse | CNIH4 | 0.28 | 0.20 | enet | 37 | 0.23 | 1.9e-11 | -11.2 | 10.8 | 3.2e-27 | -0.87 | 0.02 | 0.98 | FALSE |
| 12 | GTEx | Esophagus Gastroesophageal Junction | CNIH4 | 0.21 | 0.13 | lasso | 5 | 0.11 | 9.8e-05 | -11.3 | 11.4 | 2.8e-30 | -0.99 | 0.02 | 0.98 | FALSE |
| 13 | GTEx | Esophagus Mucosa | CNIH4 | 0.20 | 0.19 | lasso | 5 | 0.18 | 2.0e-12 | -11.3 | 11.2 | 2.9e-29 | -0.95 | 0.02 | 0.98 | FALSE |
| 14 | GTEx | Esophagus Muscularis | CNIH4 | 0.23 | 0.22 | lasso | 4 | 0.24 | 8.0e-15 | -11.3 | 11.4 | 5.2e-30 | -0.99 | 0.02 | 0.98 | FALSE |
| 15 | GTEx | Heart Atrial Appendage | CNIH4 | 0.20 | 0.11 | lasso | 6 | 0.07 | 3.3e-04 | -11.3 | 11.3 | 1.3e-29 | -1.00 | 0.02 | 0.97 | FALSE |
| 16 | GTEx | Heart Left Ventricle | CNIH4 | 0.11 | 0.09 | enet | 12 | 0.09 | 2.0e-05 | -11.2 | 11.3 | 1.8e-29 | -0.99 | 0.02 | 0.96 | FALSE |
| 17 | GTEx | Lung | CNIH4 | 0.25 | 0.20 | lasso | 15 | 0.25 | 1.9e-19 | -11.3 | 10.8 | 2.9e-27 | -0.95 | 0.02 | 0.98 | FALSE |
| 18 | GTEx | Muscle Skeletal | CNIH4 | 0.13 | 0.16 | lasso | 7 | 0.16 | 4.5e-15 | -11.3 | 11.3 | 1.8e-29 | -0.99 | 0.03 | 0.97 | FALSE |
| 19 | GTEx | Nerve Tibial | CNIH4 | 0.26 | 0.20 | lasso | 10 | 0.22 | 6.2e-16 | -11.3 | 11.1 | 1.1e-28 | -0.96 | 0.02 | 0.98 | FALSE |
| 20 | GTEx | Pancreas | CNIH4 | 0.21 | 0.07 | enet | 23 | 0.08 | 4.0e-04 | -11.3 | 8.4 | 3.1e-17 | -0.89 | 0.02 | 0.98 | FALSE |
| 21 | GTEx | Skin Not Sun Exposed Suprapubic | CNIH4 | 0.22 | 0.22 | lasso | 4 | 0.21 | 7.4e-12 | -11.3 | 11.3 | 1.2e-29 | -0.99 | 0.02 | 0.98 | FALSE |
| 22 | GTEx | Skin Sun Exposed Lower leg | CNIH4 | 0.28 | 0.26 | lasso | 8 | 0.26 | 8.6e-22 | -11.2 | 11.7 | 1.6e-31 | -0.98 | 0.03 | 0.97 | TRUE |
| 23 | GTEx | Skin Sun Exposed Lower leg | WDR26 | 0.08 | 0.00 | lasso | 2 | 0.01 | 5.1e-02 | 2.4 | 8.7 | 3.0e-18 | -0.78 | 0.03 | 0.80 | FALSE |
| 24 | GTEx | Stomach | CNIH4 | 0.15 | 0.07 | lasso | 4 | 0.08 | 7.3e-05 | -11.3 | 9.7 | 5.0e-22 | -0.92 | 0.03 | 0.94 | FALSE |
| 25 | GTEx | Thyroid | CNIH4 | 0.20 | 0.23 | lasso | 3 | 0.25 | 8.4e-19 | -11.2 | 11.3 | 1.6e-29 | -0.99 | 0.03 | 0.97 | FALSE |
| 26 | GTEx | Whole Blood | CNIH4 | 0.07 | 0.04 | lasso | 2 | 0.05 | 2.0e-05 | -11.3 | 11.3 | 1.3e-29 | -0.98 | 0.02 | 0.98 | FALSE |
| 27 | METSIM | Adipose | CNIH4 | 0.16 | 0.20 | lasso | 2 | 0.20 | 2.4e-29 | -11.3 | 11.2 | 3.4e-29 | -0.98 | 0.02 | 0.98 | FALSE |
| 28 | NTR | Blood | CNIH4 | 0.02 | 0.02 | lasso | 5 | 0.02 | 1.7e-06 | -11.3 | 9.6 | 1.1e-21 | -0.92 | 0.02 | 0.98 | FALSE |
| 29 | YFS | Blood | CNIH4 | 0.12 | 0.13 | bslmm | 358 | 0.13 | 5.1e-40 | -11.3 | 9.9 | 3.2e-23 | -0.96 | 0.02 | 0.98 | FALSE |
| 30 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CNIH4 | 0.04 | 0.02 | blup | 33 | 0.03 | 1.1e-06 | -11.2 | 10.4 | 3.3e-25 | -0.85 | 0.02 | 0.98 | FALSE |
| 31 | The Cancer Genome Atlas | Esophageal Carcinoma | CNIH4 | 0.10 | 0.07 | lasso | 7 | 0.06 | 7.3e-03 | -11.3 | 11.3 | 1.5e-29 | -1.00 | 0.01 | 0.74 | FALSE |
| 32 | The Cancer Genome Atlas | Glioblastoma Multiforme | CNIH4 | 0.33 | 0.00 | blup | 33 | 0.05 | 1.1e-02 | 1.6 | 6.4 | 1.6e-10 | -0.50 | 0.01 | 0.21 | FALSE |
| 33 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | CNIH4 | 0.04 | 0.04 | blup | 33 | 0.04 | 2.3e-05 | -11.3 | 10.9 | 1.6e-27 | -0.91 | 0.01 | 0.97 | FALSE |
| 34 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CNIH4 | 0.07 | 0.06 | enet | 29 | 0.07 | 3.1e-08 | -11.3 | 10.0 | 1.2e-23 | -0.87 | 0.01 | 0.99 | FALSE |
| 35 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | DISP1 | 0.03 | 0.04 | lasso | 2 | 0.03 | 2.0e-04 | -6.0 | -6.0 | 2.5e-09 | -0.01 | 0.03 | 0.92 | FALSE |
| 36 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | CNIH4 | 0.15 | 0.08 | blup | 33 | 0.11 | 9.7e-06 | -11.3 | 8.6 | 7.1e-18 | -0.69 | 0.01 | 0.95 | FALSE |
| 37 | The Cancer Genome Atlas | Lung Adenocarcinoma | CNIH4 | 0.03 | 0.01 | blup | 33 | 0.01 | 6.1e-02 | -11.2 | 11.2 | 5.5e-29 | -0.97 | 0.02 | 0.96 | FALSE |
| 38 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | CNIH4 | 0.02 | 0.02 | lasso | 5 | 0.01 | 1.0e-02 | -11.3 | 11.3 | 1.0e-29 | -1.00 | 0.01 | 0.88 | FALSE |
| 39 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | CNIH4 | 0.19 | 0.22 | lasso | 15 | 0.20 | 7.3e-09 | -11.3 | 11.3 | 2.2e-29 | -0.98 | 0.01 | 0.99 | FALSE |
| 40 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CNIH4 | 0.08 | 0.14 | enet | 13 | 0.15 | 2.4e-15 | -11.3 | 11.3 | 1.1e-29 | -1.00 | 0.01 | 0.99 | FALSE |
| 41 | The Cancer Genome Atlas | Rectum Adenocarcinoma | CNIH4 | 0.25 | 0.00 | blup | 33 | 0.07 | 1.2e-02 | -11.3 | 7.3 | 2.2e-13 | -0.74 | 0.01 | 0.32 | FALSE |
| 42 | The Cancer Genome Atlas | Stomach Adenocarcinoma | CNIH4 | 0.07 | 0.05 | lasso | 10 | 0.04 | 7.1e-04 | -11.3 | 11.3 | 1.0e-29 | -0.99 | 0.01 | 0.98 | FALSE |
| 43 | The Cancer Genome Atlas | Thyroid Carcinoma | CNIH4 | 0.09 | 0.09 | enet | 10 | 0.09 | 3.7e-09 | -11.3 | 10.2 | 1.9e-24 | -0.90 | 0.01 | 0.99 | FALSE |