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chr1:217,760,821-221,753,645

Best TWAS P=5.24e-64 · Best GWAS P=8.96e-102 conditioned to 2.14e-57

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	LOC643723	0.12	0.08	blup	517	0.08	1.1e-09	4.9	-5.5	3.7e-08	0.01	1.00	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	LYPLAL1	0.04	0.05	lasso	3	0.03	3.6e-04	5.5	-5.9	2.8e-09	0.09	0.61	0.02	FALSE
3	CommonMind	Brain Pre-frontal Cortex	RRP15	0.55	0.46	enet	22	0.52	9.0e-74	9.4	10.2	1.6e-24	-0.04	1.00	0.00	FALSE
4	GTEx	Adipose Subcutaneous	RRP15	0.24	0.14	lasso	2	0.12	3.2e-10	9.0	9.1	6.1e-20	-0.06	1.00	0.00	FALSE
5	GTEx	Adipose Subcutaneous	RP11-295M18.6	0.35	0.24	lasso	6	0.37	5.5e-32	-2.7	-5.2	2.4e-07	-0.09	1.00	0.00	FALSE
6	GTEx	Adipose Visceral Omentum	RRP15	0.32	0.18	lasso	8	0.22	1.2e-11	9.3	6.8	7.4e-12	-0.08	1.00	0.00	FALSE
7	GTEx	Adipose Visceral Omentum	RP11-295M18.6	0.32	0.20	enet	10	0.29	2.1e-15	-2.7	-6.5	6.8e-11	-0.06	1.00	0.00	TRUE
8	GTEx	Adrenal Gland	RRP15	0.41	0.16	enet	30	0.12	5.6e-05	9.0	8.5	2.6e-17	-0.04	0.85	0.01	FALSE
9	GTEx	Artery Aorta	RRP15	0.23	0.17	lasso	3	0.15	8.3e-09	9.0	8.7	2.5e-18	-0.08	1.00	0.00	FALSE
10	GTEx	Artery Tibial	RRP15	0.19	0.16	lasso	4	0.14	8.7e-11	9.4	9.4	5.8e-21	-0.06	1.00	0.00	FALSE
11	GTEx	Artery Tibial	HLA-AS1	0.12	0.03	enet	13	0.05	3.9e-05	5.9	-8.7	2.3e-18	-0.03	0.18	0.72	FALSE
12	GTEx	Brain Nucleus accumbens basal ganglia	RRP15	0.34	0.25	lasso	4	0.22	1.9e-06	9.4	9.9	6.0e-23	-0.04	0.47	0.04	FALSE
13	GTEx	Cells Transformed fibroblasts	RRP15	0.38	0.28	lasso	6	0.28	1.9e-21	9.4	9.3	1.8e-20	-0.07	1.00	0.00	FALSE
14	GTEx	Cells Transformed fibroblasts	HLX	0.06	0.00	enet	9	0.00	5.3e-01	-2.9	-9.1	6.6e-20	0.03	0.02	0.71	TRUE
15	GTEx	Cells Transformed fibroblasts	HLA-AS1	0.10	0.03	lasso	7	0.04	8.9e-04	5.9	-7.8	8.3e-15	-0.10	0.15	0.52	FALSE
16	GTEx	Cells Transformed fibroblasts	RP11-295M18.6	0.40	0.28	lasso	8	0.33	2.5e-25	-2.7	-5.7	1.2e-08	-0.08	1.00	0.00	FALSE
17	GTEx	Esophagus Mucosa	RRP15	0.38	0.29	lasso	6	0.31	3.3e-21	9.0	9.7	2.3e-22	-0.06	1.00	0.00	FALSE
18	GTEx	Esophagus Mucosa	RP11-295M18.6	0.29	0.12	lasso	9	0.18	4.9e-12	-2.7	-5.6	1.8e-08	-0.11	1.00	0.00	FALSE
19	GTEx	Esophagus Muscularis	RRP15	0.22	0.23	enet	8	0.22	8.9e-14	9.4	9.1	7.3e-20	-0.02	1.00	0.00	FALSE
20	GTEx	Lung	RRP15	0.11	0.13	enet	21	0.13	2.6e-10	9.4	9.7	4.6e-22	-0.03	1.00	0.00	FALSE
21	GTEx	Lung	TGFB2	0.11	0.03	lasso	8	0.01	4.0e-02	-4.3	-7.9	3.8e-15	-0.44	0.03	0.89	TRUE
22	GTEx	Muscle Skeletal	RRP15	0.17	0.15	lasso	2	0.14	3.9e-14	9.4	9.6	1.4e-21	-0.05	1.00	0.00	FALSE
23	GTEx	Ovary	LYPLAL1	0.20	0.11	lasso	3	0.07	9.3e-03	5.6	-7.0	2.7e-12	0.04	0.10	0.09	FALSE
24	GTEx	Pituitary	RRP15	0.38	0.23	lasso	3	0.23	1.9e-06	9.3	10.1	6.7e-24	-0.03	0.34	0.06	FALSE
25	GTEx	Skin Sun Exposed Lower leg	RRP15	0.17	0.13	lasso	6	0.12	4.5e-10	9.0	8.9	8.0e-19	-0.07	1.00	0.00	FALSE
26	GTEx	Testis	RRP15	0.70	0.65	lasso	4	0.64	6.6e-36	9.4	9.3	1.4e-20	-0.06	1.00	0.00	FALSE
27	GTEx	Testis	ZC3H11B	0.33	0.28	lasso	3	0.27	1.5e-12	-11.4	-11.5	1.5e-30	0.04	0.00	1.00	TRUE
28	GTEx	Thyroid	RRP15	0.28	0.16	lasso	7	0.17	9.8e-13	9.0	10.0	1.6e-23	-0.03	1.00	0.00	FALSE
29	GTEx	Thyroid	TGFB2	0.14	0.07	lasso	2	0.06	2.8e-05	7.6	7.6	2.2e-14	0.24	0.82	0.01	TRUE
30	METSIM	Adipose	RRP15	0.28	0.24	bslmm	489	0.23	1.7e-34	9.0	10.5	7.7e-26	0.00	1.00	0.00	FALSE
31	YFS	Blood	LYPLAL1	0.02	0.01	bslmm	480	0.01	2.6e-05	-6.5	8.9	6.0e-19	-0.07	0.93	0.01	TRUE
32	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	LYPLAL1	0.04	0.00	blup	39	0.01	1.9e-02	4.9	7.7	1.3e-14	-0.07	0.02	0.72	FALSE
33	The Cancer Genome Atlas	Breast Invasive Carcinoma	RRP15	0.11	0.11	lasso	5	0.10	2.5e-20	9.4	9.3	1.1e-20	-0.05	0.86	0.14	FALSE
34	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	RRP15	0.13	0.13	lasso	1	0.10	1.4e-05	9.3	9.3	9.8e-21	-0.06	0.69	0.11	FALSE
35	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	LYPLAL1	0.06	0.03	enet	6	0.03	9.5e-05	5.4	5.3	9.2e-08	-0.03	0.68	0.21	FALSE
36	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	RRP15	0.07	0.07	lasso	2	0.06	2.0e-07	10.2	10.7	8.2e-27	-0.03	0.00	1.00	TRUE
37	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	RRP15	0.17	0.11	enet	9	0.12	7.4e-13	9.4	7.9	3.2e-15	-0.03	0.86	0.14	FALSE
38	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	RRP15	0.14	0.04	enet	11	0.06	4.0e-04	9.4	8.2	2.2e-16	-0.03	0.11	0.39	FALSE
39	The Cancer Genome Atlas	Brain Lower Grade Glioma	LYPLAL1	0.09	0.08	blup	39	0.08	1.8e-09	5.0	6.1	1.1e-09	-0.04	0.98	0.02	FALSE
40	The Cancer Genome Atlas	Brain Lower Grade Glioma	RRP15	0.10	0.10	lasso	1	0.10	4.7e-11	9.4	9.4	5.0e-21	-0.05	0.86	0.14	FALSE
41	The Cancer Genome Atlas	Lung Adenocarcinoma	RRP15	0.09	0.09	lasso	3	0.09	3.2e-10	9.4	9.1	6.4e-20	-0.06	0.85	0.15	FALSE
42	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	RRP15	0.10	0.09	lasso	3	0.08	9.8e-10	9.3	9.3	1.3e-20	-0.06	0.92	0.08	FALSE
43	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	RRP15	0.16	0.04	blup	61	0.05	3.8e-03	9.3	7.4	1.6e-13	-0.03	0.01	0.15	FALSE
44	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	RRP15	0.15	0.12	lasso	2	0.12	1.9e-05	9.0	9.2	2.6e-20	-0.06	0.16	0.15	FALSE
45	The Cancer Genome Atlas	Prostate Adenocarcinoma	RRP15	0.29	0.29	lasso	2	0.29	2.7e-30	9.4	9.4	4.0e-21	-0.06	0.85	0.15	FALSE
46	The Cancer Genome Atlas	Soft Tissue Sarcoma	TGFB2	0.05	0.03	blup	73	0.03	4.5e-03	18.9	-16.9	5.2e-64	-0.90	0.01	0.88	TRUE
47	The Cancer Genome Atlas	Stomach Adenocarcinoma	RRP15	0.11	0.09	lasso	3	0.07	8.2e-06	9.3	9.3	1.5e-20	-0.06	0.24	0.72	FALSE
48	The Cancer Genome Atlas	Thyroid Carcinoma	RRP15	0.22	0.25	lasso	3	0.24	1.7e-23	9.4	9.4	3.6e-21	-0.06	0.85	0.15	FALSE
49	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	TGFB2	0.24	0.11	enet	10	0.14	1.4e-04	16.5	-16.8	2.4e-63	-0.80	0.08	0.63	FALSE