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chr1:225,576,058-231,834,901

Best TWAS P=1.78e-76 · Best GWAS P=8.33e-80 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	JMJD4	0.10	0.05	bslmm	381	0.04	6.8e-06	-18.82	-14.2	1.4e-45	0.85	0.01	0.99	TRUE
2	CommonMind	Brain Pre-frontal Cortex	LOC100130093	0.09	0.07	enet	30	0.10	5.6e-12	12.18	9.2	3.7e-20	-0.20	1.00	0.00	FALSE
3	CommonMind	Brain Pre-frontal Cortex	SNAP47	0.23	0.19	lasso	7	0.19	5.7e-23	-14.45	14.4	7.7e-47	-0.62	1.00	0.00	FALSE
4	GTEx	Adipose Subcutaneous	SNAP47	0.06	0.06	lasso	3	0.05	4.5e-05	-12.58	13.7	1.4e-42	-0.51	0.36	0.22	FALSE
5	GTEx	Adipose Subcutaneous	RP11-396C23.2	0.09	0.00	enet	14	0.00	7.9e-01	-4.23	-5.3	1.1e-07	-0.01	0.02	0.89	FALSE
6	GTEx	Adipose Subcutaneous	RP5-1139B12.2	0.08	0.02	enet	17	0.03	2.2e-03	5.67	5.9	4.0e-09	-0.07	0.21	0.05	FALSE
7	GTEx	Adipose Visceral Omentum	ADCK3	0.11	0.00	enet	36	0.03	1.7e-02	6.04	-5.9	4.0e-09	0.14	0.23	0.03	TRUE
8	GTEx	Artery Coronary	ARV1	0.19	0.15	lasso	4	0.07	1.7e-03	-5.93	5.9	3.7e-09	0.01	0.08	0.77	TRUE
9	GTEx	Artery Tibial	RP5-1139B12.2	0.09	0.05	lasso	5	0.05	4.5e-05	5.91	5.4	8.5e-08	-0.10	0.92	0.00	FALSE
10	GTEx	Brain Cortex	SNAP47	0.21	0.05	lasso	9	0.04	2.2e-02	-13.91	18.5	1.8e-76	-0.88	0.04	0.67	TRUE
11	GTEx	Brain Frontal Cortex BA9	OBSCN	0.27	0.00	lasso	5	0.00	2.9e-01	3.84	5.6	2.3e-08	-0.02	0.06	0.07	TRUE
12	GTEx	Brain Nucleus accumbens basal ganglia	SNAP47	0.38	0.05	lasso	6	0.07	4.9e-03	2.20	6.1	1.4e-09	-0.15	0.16	0.22	TRUE
13	GTEx	Breast Mammary Tissue (Male)	CDC42BPA	0.03	0.01	enet	1	0.00	3.0e-01	10.79	-10.8	3.9e-27	0.18	0.05	0.06	TRUE
14	GTEx	Cells EBV-transformed lymphocytes	JMJD4	0.13	0.06	lasso	4	0.03	2.9e-02	-16.92	-14.6	3.7e-48	0.51	0.05	0.45	FALSE
15	GTEx	Cells Transformed fibroblasts	SNAP47	0.17	0.12	enet	18	0.12	1.9e-09	-13.91	9.3	1.7e-20	-0.41	0.98	0.01	FALSE
16	GTEx	Colon Transverse	TTC13	0.11	0.08	enet	11	0.11	8.3e-06	-5.68	5.4	7.4e-08	-0.01	0.18	0.79	FALSE
17	GTEx	Colon Transverse	ARV1	0.34	0.25	enet	25	0.28	6.1e-14	-5.91	5.6	1.8e-08	-0.02	0.13	0.87	FALSE
18	GTEx	Esophagus Mucosa	IBA57	0.08	0.02	enet	12	0.07	1.8e-05	5.58	-5.2	1.9e-07	0.00	0.27	0.04	FALSE
19	GTEx	Esophagus Mucosa	ACBD3	0.14	0.07	lasso	3	0.08	8.3e-06	-4.23	5.1	2.8e-07	-0.04	0.22	0.69	FALSE
20	GTEx	Esophagus Muscularis	ADCK3	0.07	0.02	lasso	5	0.01	4.1e-02	4.54	-6.2	4.2e-10	0.18	0.27	0.05	TRUE
21	GTEx	Muscle Skeletal	SNAP47	0.09	0.08	lasso	10	0.08	7.7e-08	-14.45	16.0	1.4e-57	-0.61	0.94	0.06	FALSE
22	GTEx	Muscle Skeletal	CDC42BPA	0.12	0.06	enet	28	0.11	8.2e-11	-5.07	-6.8	9.9e-12	0.31	1.00	0.00	FALSE
23	GTEx	Nerve Tibial	SNAP47	0.06	0.01	enet	16	0.03	6.5e-03	-17.57	13.7	5.9e-43	-0.64	0.05	0.86	TRUE
24	GTEx	Nerve Tibial	ACBD3	0.11	0.03	lasso	3	0.02	7.3e-03	-4.14	5.1	2.9e-07	-0.01	0.07	0.76	FALSE
25	GTEx	Skin Not Sun Exposed Suprapubic	CDC42BPA	0.13	0.00	enet	30	0.03	8.6e-03	-13.91	-13.0	6.8e-39	0.48	0.08	0.70	FALSE
26	GTEx	Skin Sun Exposed Lower leg	CDC42BPA	0.10	0.00	enet	32	0.02	1.3e-02	1.19	-8.4	6.0e-17	0.31	0.20	0.24	FALSE
27	GTEx	Testis	SNAP47	0.23	0.21	enet	15	0.21	7.5e-10	-13.97	12.2	4.9e-34	-0.47	0.98	0.01	FALSE
28	GTEx	Thyroid	C1orf35	0.10	0.00	lasso	6	0.01	4.1e-02	6.52	-11.0	6.4e-28	0.37	0.05	0.07	FALSE
29	METSIM	Adipose	RNF187	0.07	0.02	lasso	5	0.03	2.2e-05	3.95	6.3	2.6e-10	-0.26	0.13	0.77	FALSE
30	METSIM	Adipose	SNAP47	0.06	0.06	lasso	6	0.08	2.0e-11	-17.57	16.6	7.2e-62	-0.77	0.94	0.06	FALSE
31	METSIM	Adipose	TTC13	0.08	0.06	enet	27	0.06	4.9e-09	-5.91	5.8	7.7e-09	0.01	0.16	0.84	FALSE
32	NTR	Blood	C1orf69	0.02	0.01	bslmm	343	0.01	1.4e-05	-0.34	-6.3	3.5e-10	0.08	0.83	0.00	FALSE
33	ROSMAP	Brain Pre-frontal Cortex	OBSCN	0.32	0.18	lasso	19	0.27	3.5e-34	2.20	5.2	1.8e-07	-0.11	1.00	0.00	FALSE
34	YFS	Blood	JMJD4	0.11	0.12	lasso	4	0.12	3.7e-36	-17.57	-17.7	4.1e-70	0.82	1.00	0.00	FALSE
35	YFS	Blood	SNAP47	0.02	0.00	bslmm	403	0.01	6.4e-04	-12.27	12.6	2.4e-36	-0.48	0.09	0.32	FALSE
36	YFS	Blood	TTC13	0.02	0.00	bslmm	627	0.00	1.8e-02	-5.90	5.8	5.3e-09	0.04	0.19	0.74	FALSE
37	YFS	Blood	URB2	0.10	0.11	bslmm	414	0.12	2.7e-37	5.67	5.9	4.0e-09	0.03	0.01	0.99	FALSE
38	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	ACBD3	0.04	0.04	blup	42	0.02	4.6e-03	-4.34	5.8	6.7e-09	-0.02	0.03	0.33	TRUE
39	The Cancer Genome Atlas	Breast Invasive Carcinoma	LOC100130093	0.02	0.01	lasso	4	0.01	4.0e-03	12.71	9.4	4.2e-21	-0.29	0.10	0.02	FALSE
40	The Cancer Genome Atlas	Breast Invasive Carcinoma	TAF5L	0.09	0.02	lasso	2	0.02	2.2e-05	5.67	5.7	1.2e-08	0.02	0.00	1.00	FALSE
41	The Cancer Genome Atlas	Breast Invasive Carcinoma	URB2	0.05	0.01	blup	85	0.02	1.6e-04	6.02	6.5	8.9e-11	0.03	0.00	0.99	TRUE
42	The Cancer Genome Atlas	Colon Adenocarcinoma	SNAP47	0.05	0.05	lasso	3	0.06	2.4e-04	-13.91	18.0	4.7e-72	-0.83	0.01	0.90	FALSE
43	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CABC1	0.04	0.01	blup	116	0.02	1.3e-03	2.95	-5.5	3.7e-08	0.07	0.17	0.02	TRUE
44	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	TTC13	0.07	0.01	blup	90	0.03	1.1e-02	-4.19	5.6	1.7e-08	0.02	0.02	0.59	FALSE
45	The Cancer Genome Atlas	Brain Lower Grade Glioma	JMJD4	0.07	0.01	enet	9	0.03	3.6e-04	-18.85	-10.0	1.0e-23	0.67	0.00	0.80	TRUE
46	The Cancer Genome Atlas	Brain Lower Grade Glioma	SNAP47	0.08	0.06	blup	54	0.08	1.2e-09	-13.91	13.4	9.3e-41	-0.58	0.98	0.02	FALSE
47	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	SNAP47	0.07	0.05	blup	54	0.05	2.9e-03	-13.91	15.6	6.0e-55	-0.66	0.02	0.37	FALSE
48	The Cancer Genome Atlas	Lung Adenocarcinoma	LOC100130093	0.03	0.02	enet	3	0.03	7.2e-05	12.41	7.3	3.7e-13	-0.24	0.14	0.04	FALSE
49	The Cancer Genome Atlas	Lung Adenocarcinoma	SNAP47	0.03	0.02	enet	4	0.02	1.5e-03	-13.97	14.2	5.8e-46	-0.54	0.41	0.15	FALSE
50	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ARV1	0.04	0.03	enet	9	0.03	9.8e-05	-3.71	5.6	2.1e-08	-0.01	0.10	0.21	FALSE
51	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	TAF5L	0.09	0.00	blup	68	0.01	3.5e-02	4.01	5.5	3.1e-08	0.05	0.00	0.50	FALSE
52	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	TTC13	0.04	0.04	blup	90	0.03	3.0e-03	-4.26	5.5	4.9e-08	0.03	0.07	0.45	FALSE
53	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	JMJD4	0.36	0.06	blup	42	0.13	5.6e-06	-1.02	-5.4	7.3e-08	0.41	0.05	0.32	FALSE
54	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	LOC100130093	0.16	0.10	blup	42	0.05	4.7e-03	13.14	14.5	9.1e-48	-0.58	0.22	0.25	FALSE
55	The Cancer Genome Atlas	Prostate Adenocarcinoma	ACBD3	0.03	0.02	blup	42	0.04	7.0e-05	-4.36	5.2	1.6e-07	-0.03	0.10	0.48	FALSE
56	The Cancer Genome Atlas	Prostate Adenocarcinoma	ARF1	0.06	0.02	blup	31	0.03	1.0e-03	-2.29	-7.2	5.4e-13	0.16	0.19	0.68	FALSE
57	The Cancer Genome Atlas	Prostate Adenocarcinoma	MRPL55	0.04	0.00	enet	7	0.02	8.2e-03	-6.24	-7.4	1.7e-13	0.10	0.01	0.80	TRUE
58	The Cancer Genome Atlas	Prostate Adenocarcinoma	ZNF678	0.03	0.01	blup	91	0.02	2.4e-03	-14.13	-17.2	1.2e-66	0.76	0.03	0.57	TRUE
59	The Cancer Genome Atlas	Soft Tissue Sarcoma	MRPL55	0.05	0.02	blup	22	0.04	2.8e-03	3.92	-5.5	4.9e-08	0.12	0.02	0.16	FALSE
60	The Cancer Genome Atlas	Soft Tissue Sarcoma	URB2	0.11	0.05	lasso	2	0.03	3.9e-03	6.02	6.1	1.4e-09	0.01	0.00	0.92	FALSE