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chr18:11,283,857-13,822,256

Best TWAS P=3.05e-23 · Best GWAS P=3.07e-23 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	CEP192	0.13	0.13	lasso	6	0.14	1.1e-16	9.6	9.4	3.3e-21	0.97	0.05	0.95	FALSE
2	GTEx	Adipose Subcutaneous	CEP192	0.38	0.44	enet	24	0.48	1.3e-44	9.5	9.6	1.1e-21	0.97	0.09	0.91	FALSE
3	GTEx	Adipose Subcutaneous	IMPA2	0.23	0.12	enet	26	0.12	3.4e-10	-4.9	-7.3	3.7e-13	-0.01	0.13	0.87	TRUE
4	GTEx	Adipose Visceral Omentum	CEP192	0.38	0.35	lasso	4	0.43	3.0e-24	9.6	9.0	2.4e-19	0.95	0.05	0.95	FALSE
5	GTEx	Adrenal Gland	CEP192	0.44	0.56	lasso	2	0.56	9.6e-24	9.5	9.4	7.2e-21	0.96	0.08	0.92	FALSE
6	GTEx	Adrenal Gland	IMPA2	0.46	0.17	lasso	13	0.08	9.1e-04	-5.2	-5.5	4.3e-08	0.02	0.07	0.81	FALSE
7	GTEx	Artery Aorta	CEP192	0.43	0.50	lasso	11	0.55	2.5e-35	9.5	9.5	1.8e-21	0.97	0.04	0.96	FALSE
8	GTEx	Artery Coronary	CEP192	0.32	0.35	lasso	5	0.33	8.2e-12	9.6	9.4	4.1e-21	0.97	0.02	0.98	FALSE
9	GTEx	Artery Tibial	CEP192	0.40	0.50	enet	29	0.54	7.3e-50	9.5	9.6	7.7e-22	0.97	0.08	0.92	FALSE
10	GTEx	Brain Caudate basal ganglia	CEP192	0.48	0.36	enet	19	0.36	4.2e-11	9.6	9.1	7.0e-20	0.96	0.04	0.96	FALSE
11	GTEx	Brain Cerebellar Hemisphere	CEP192	0.44	0.20	enet	22	0.26	2.2e-07	9.0	8.6	6.0e-18	0.93	0.02	0.97	FALSE
12	GTEx	Brain Cerebellum	CEP192	0.52	0.44	enet	31	0.52	5.6e-18	9.6	8.9	3.9e-19	0.92	0.03	0.97	FALSE
13	GTEx	Brain Cortex	CEP192	0.40	0.26	lasso	6	0.26	9.9e-08	9.6	9.1	1.2e-19	0.93	0.03	0.97	FALSE
14	GTEx	Brain Frontal Cortex BA9	SEH1L	0.29	-0.01	lasso	4	0.00	3.0e-01	8.4	7.1	1.1e-12	0.75	0.04	0.24	FALSE
15	GTEx	Brain Frontal Cortex BA9	CEP192	0.27	0.19	lasso	11	0.18	1.3e-05	9.0	9.1	1.4e-19	0.93	0.02	0.96	FALSE
16	GTEx	Brain Hippocampus	CEP192	0.43	0.35	lasso	9	0.44	9.8e-12	9.6	8.6	6.1e-18	0.93	0.02	0.98	TRUE
17	GTEx	Brain Hypothalamus	SEH1L	0.26	0.21	lasso	2	0.13	6.6e-04	9.1	8.8	1.5e-18	0.92	0.04	0.82	FALSE
18	GTEx	Brain Hypothalamus	CEP192	0.35	0.33	enet	29	0.33	1.8e-08	9.7	8.7	4.7e-18	0.94	0.02	0.97	FALSE
19	GTEx	Brain Nucleus accumbens basal ganglia	CEP192	0.38	0.28	lasso	9	0.28	4.8e-08	9.6	8.5	2.2e-17	0.93	0.03	0.97	FALSE
20	GTEx	Brain Nucleus accumbens basal ganglia	PTPN2	0.32	0.02	lasso	10	0.05	2.2e-02	-4.4	-8.0	1.7e-15	-0.80	0.04	0.62	FALSE
21	GTEx	Brain Putamen basal ganglia	CEP192	0.50	0.39	lasso	5	0.36	2.4e-09	9.6	8.9	4.4e-19	0.95	0.03	0.97	FALSE
22	GTEx	Breast Mammary Tissue	CEP192	0.38	0.40	lasso	4	0.42	4.7e-23	9.5	9.5	1.7e-21	0.96	0.03	0.97	FALSE
23	GTEx	Breast Mammary Tissue (Male)	CEP192	0.58	0.26	lasso	11	0.30	1.3e-07	9.5	9.8	1.3e-22	0.95	0.02	0.98	FALSE
24	GTEx	Breast Mammary Tissue (Female)	CEP192	0.34	0.23	lasso	11	0.26	2.4e-08	9.5	9.3	2.1e-20	0.94	0.03	0.97	FALSE
25	GTEx	Cells EBV-transformed lymphocytes	SEH1L	0.18	0.13	lasso	4	0.08	1.3e-03	9.5	8.9	4.8e-19	0.93	0.04	0.74	TRUE
26	GTEx	Cells EBV-transformed lymphocytes	CEP76	0.17	-0.01	enet	30	0.02	7.7e-02	3.8	5.8	6.8e-09	0.23	0.08	0.11	TRUE
27	GTEx	Cells EBV-transformed lymphocytes	CEP192	0.52	0.34	lasso	5	0.36	1.6e-12	9.5	9.5	1.5e-21	0.90	0.03	0.97	FALSE
28	GTEx	Cells Transformed fibroblasts	SEH1L	0.10	0.03	enet	18	0.04	7.8e-04	9.0	7.0	2.7e-12	0.63	0.06	0.90	FALSE
29	GTEx	Cells Transformed fibroblasts	CEP192	0.32	0.32	enet	39	0.39	2.7e-31	9.6	9.4	3.7e-21	0.93	0.03	0.97	FALSE
30	GTEx	Colon Sigmoid	CEP192	0.33	0.32	enet	23	0.32	3.6e-12	9.5	8.7	4.4e-18	0.96	0.05	0.95	FALSE
31	GTEx	Colon Transverse	CEP192	0.45	0.54	lasso	8	0.57	1.2e-32	9.5	9.1	8.3e-20	0.96	0.06	0.94	FALSE
32	GTEx	Esophagus Gastroesophageal Junction	CEP192	0.38	0.39	lasso	4	0.39	4.7e-15	9.5	9.6	1.1e-21	0.97	0.05	0.95	FALSE
33	GTEx	Esophagus Mucosa	SEH1L	0.09	0.02	enet	25	0.03	2.4e-03	-5.8	5.9	3.4e-09	0.47	0.15	0.62	FALSE
34	GTEx	Esophagus Mucosa	CEP192	0.39	0.51	enet	29	0.52	7.4e-40	9.5	9.5	1.6e-21	0.97	0.04	0.96	FALSE
35	GTEx	Esophagus Muscularis	CEP192	0.39	0.46	lasso	9	0.52	2.1e-36	9.6	9.4	5.6e-21	0.97	0.07	0.93	FALSE
36	GTEx	Heart Atrial Appendage	CEP192	0.29	0.28	lasso	5	0.26	4.3e-12	9.5	9.0	2.8e-19	0.95	0.02	0.98	FALSE
37	GTEx	Heart Left Ventricle	CEP192	0.24	0.06	lasso	4	0.09	1.4e-05	9.5	9.2	3.0e-20	0.91	0.02	0.98	FALSE
38	GTEx	Liver	CEP192	0.41	0.29	lasso	6	0.41	1.6e-12	9.5	8.2	2.8e-16	0.92	0.02	0.98	FALSE
39	GTEx	Lung	SEH1L	0.13	0.09	lasso	9	0.09	2.9e-07	9.5	8.6	8.0e-18	0.92	0.06	0.94	TRUE
40	GTEx	Lung	CEP192	0.32	0.29	lasso	7	0.34	3.8e-27	9.5	9.3	1.9e-20	0.96	0.05	0.95	FALSE
41	GTEx	Muscle Skeletal	CEP192	0.10	0.07	lasso	3	0.07	3.1e-07	9.5	9.0	1.6e-19	0.95	0.02	0.98	FALSE
42	GTEx	Nerve Tibial	CEP192	0.44	0.52	lasso	12	0.55	3.1e-46	9.5	9.4	3.5e-21	0.97	0.04	0.96	FALSE
43	GTEx	Ovary	CEP192	0.43	0.42	enet	25	0.43	6.5e-12	9.5	9.8	1.6e-22	0.97	0.02	0.98	FALSE
44	GTEx	Pancreas	CEP192	0.44	0.37	lasso	8	0.44	3.1e-20	9.5	8.6	6.6e-18	0.94	0.06	0.94	FALSE
45	GTEx	Pituitary	CEP192	0.51	0.24	enet	29	0.39	1.0e-10	9.5	8.2	3.5e-16	0.86	0.04	0.96	FALSE
46	GTEx	Prostate	CEP192	0.57	0.59	enet	23	0.66	1.8e-21	9.5	9.1	9.4e-20	0.96	0.02	0.98	FALSE
47	GTEx	Skin Not Sun Exposed Suprapubic	CEP192	0.34	0.35	enet	20	0.40	1.6e-23	9.6	8.9	4.7e-19	0.96	0.03	0.97	FALSE
48	GTEx	Skin Sun Exposed Lower leg	CEP192	0.34	0.36	lasso	3	0.38	3.5e-33	9.5	9.5	1.9e-21	0.97	0.09	0.91	FALSE
49	GTEx	Spleen	CEP192	0.54	0.52	lasso	5	0.49	2.8e-14	9.5	9.6	1.1e-21	0.97	0.05	0.95	FALSE
50	GTEx	Stomach	CEP192	0.37	0.44	lasso	5	0.43	1.5e-22	9.5	9.4	3.8e-21	0.96	0.06	0.94	FALSE
51	GTEx	Thyroid	CEP192	0.37	0.48	lasso	7	0.52	3.2e-46	9.5	9.6	1.2e-21	0.97	0.06	0.94	FALSE
52	GTEx	Uterus	CEP192	0.52	0.43	lasso	6	0.41	1.7e-09	9.5	9.7	4.1e-22	0.96	0.02	0.98	FALSE
53	GTEx	Vagina	CEP192	0.51	0.31	lasso	4	0.37	2.3e-09	9.5	9.6	1.3e-21	0.94	0.02	0.98	TRUE
54	GTEx	Whole Blood	CEP192	0.17	0.16	enet	15	0.17	3.7e-15	9.5	9.3	1.7e-20	0.97	0.04	0.96	FALSE
55	METSIM	Adipose	CEP192	0.19	0.32	lasso	5	0.32	1.0e-48	9.5	9.4	5.8e-21	0.96	0.08	0.92	FALSE
56	METSIM	Adipose	CEP76	0.04	0.00	bslmm	395	0.01	1.8e-02	3.8	5.4	5.2e-08	0.31	0.24	0.03	FALSE
57	NTR	Blood	CEP192	0.02	0.01	lasso	7	0.02	1.1e-06	9.4	8.4	5.0e-17	0.82	0.05	0.95	FALSE
58	ROSMAP	Brain Pre-frontal Cortex	CEP192	0.30	0.42	enet	46	0.45	4.1e-64	9.9	8.6	1.0e-17	0.94	0.01	0.99	FALSE
59	YFS	Blood	SEH1L	0.04	0.02	blup	393	0.02	7.6e-08	-5.8	6.7	2.5e-11	0.59	0.93	0.07	FALSE
60	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	CEP192	0.07	0.09	lasso	2	0.09	9.4e-08	9.9	9.9	3.1e-23	1.00	0.01	0.99	TRUE
61	The Cancer Genome Atlas	Breast Invasive Carcinoma	CEP192	0.06	0.13	enet	9	0.13	3.4e-26	9.5	9.5	2.7e-21	0.97	0.02	0.98	FALSE
62	The Cancer Genome Atlas	Breast Invasive Carcinoma	SEH1L	0.02	0.01	lasso	3	0.02	2.5e-04	-5.9	7.1	1.1e-12	0.54	0.18	0.42	FALSE
63	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	CEP192	0.16	0.20	lasso	4	0.19	1.6e-09	9.4	9.4	3.6e-21	0.98	0.01	0.99	FALSE
64	The Cancer Genome Atlas	Colon Adenocarcinoma	CEP192	0.06	0.05	blup	84	0.04	1.5e-03	9.0	9.6	7.0e-22	0.93	0.03	0.91	FALSE
65	The Cancer Genome Atlas	Glioblastoma Multiforme	CEP192	0.24	0.13	blup	84	0.13	7.9e-05	9.5	8.8	1.7e-18	0.88	0.02	0.97	FALSE
66	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CEP192	0.21	0.31	lasso	4	0.31	1.0e-35	9.5	9.4	5.7e-21	0.97	0.04	0.96	FALSE
67	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SEH1L	0.03	0.01	blup	60	0.01	4.0e-02	-6.0	8.0	1.2e-15	0.70	0.02	0.31	FALSE
68	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	CEP192	0.30	0.33	lasso	2	0.33	1.8e-19	9.5	9.3	1.0e-20	0.95	0.04	0.96	FALSE
69	The Cancer Genome Atlas	Brain Lower Grade Glioma	CEP192	0.27	0.38	blup	84	0.38	1.5e-45	9.5	8.8	1.0e-18	0.95	0.06	0.94	FALSE
70	The Cancer Genome Atlas	Brain Lower Grade Glioma	SEH1L	0.05	0.00	blup	60	0.01	1.0e-02	9.5	8.1	5.7e-16	0.74	0.01	0.60	FALSE
71	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	CEP192	0.11	0.16	lasso	3	0.16	7.6e-08	9.9	9.9	5.7e-23	0.99	0.01	0.99	FALSE
72	The Cancer Genome Atlas	Lung Adenocarcinoma	CEP192	0.09	0.14	blup	85	0.14	8.4e-16	9.6	8.9	4.9e-19	0.94	0.05	0.95	FALSE
73	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	CEP192	0.05	0.03	blup	84	0.03	4.4e-04	9.4	6.7	1.9e-11	0.83	0.01	0.97	FALSE
74	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	CEP192	0.09	0.07	blup	84	0.09	2.1e-06	9.1	8.9	4.9e-19	0.92	0.04	0.96	FALSE
75	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	CEP192	0.12	0.06	blup	84	0.08	2.0e-04	8.8	9.4	5.3e-21	0.95	0.02	0.97	FALSE
76	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	CEP192	0.49	0.07	enet	29	0.05	3.2e-03	9.6	8.4	5.5e-17	0.73	0.01	0.92	FALSE
77	The Cancer Genome Atlas	Prostate Adenocarcinoma	CEP192	0.33	0.49	lasso	5	0.49	1.0e-57	9.4	9.6	1.2e-21	0.98	0.01	0.99	FALSE
78	The Cancer Genome Atlas	Soft Tissue Sarcoma	CEP192	0.10	0.07	blup	84	0.08	1.2e-05	9.5	8.9	5.2e-19	0.96	0.03	0.97	FALSE
79	The Cancer Genome Atlas	Skin Cutaneous Melanoma	CEP192	0.16	0.15	enet	6	0.14	1.8e-04	9.1	7.9	2.5e-15	0.90	0.03	0.90	FALSE
80	The Cancer Genome Atlas	Stomach Adenocarcinoma	CEP192	0.07	0.04	blup	84	0.07	1.7e-05	8.8	9.2	3.8e-20	0.97	0.02	0.98	FALSE
81	The Cancer Genome Atlas	Thyroid Carcinoma	CEP192	0.36	0.53	enet	19	0.54	2.6e-61	9.5	9.4	7.0e-21	0.98	0.01	0.99	FALSE