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chr18:19,692,435-21,863,589

Best TWAS P=2.51e-66 · Best GWAS P=3.94e-288 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	C18orf8	0.26	0.35	lasso	6	0.40	1.9e-52	-8.41	-7.7	1.2e-14	0.22	1.00	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	RBBP8	0.07	0.00	blup	352	0.02	5.9e-04	5.45	9.0	1.5e-19	-0.30	0.07	0.05	TRUE
3	CommonMind	Brain Pre-frontal Cortex	RIOK3	0.02	0.01	bslmm	348	0.00	1.8e-01	-12.64	-17.2	3.2e-66	0.44	0.14	0.06	TRUE
4	GTEx	Adipose Subcutaneous	TMEM241	0.07	0.00	enet	12	0.01	4.1e-02	-11.03	-11.5	2.2e-30	0.33	0.30	0.17	FALSE
5	GTEx	Adipose Subcutaneous	C18orf8	0.17	0.16	enet	13	0.16	2.6e-13	-8.56	-8.4	5.9e-17	0.23	1.00	0.00	FALSE
6	GTEx	Adipose Subcutaneous	NPC1	0.27	0.27	enet	12	0.30	2.4e-25	-8.37	-7.8	4.3e-15	0.26	1.00	0.00	FALSE
7	GTEx	Adipose Visceral Omentum	C18orf8	0.18	0.11	enet	10	0.04	4.5e-03	-9.03	-9.8	1.4e-22	0.32	0.85	0.01	FALSE
8	GTEx	Adipose Visceral Omentum	NPC1	0.20	0.19	lasso	3	0.17	2.9e-09	-8.37	-7.7	1.9e-14	0.25	1.00	0.00	FALSE
9	GTEx	Artery Tibial	C18orf8	0.18	0.12	lasso	3	0.10	1.5e-08	5.42	-5.2	1.7e-07	0.14	1.00	0.00	FALSE
10	GTEx	Brain Caudate basal ganglia	C18orf8	0.15	0.16	enet	11	0.11	5.9e-04	-8.52	-7.8	8.7e-15	0.23	0.44	0.03	FALSE
11	GTEx	Brain Cerebellar Hemisphere	RBBP8	0.22	0.16	enet	20	0.13	3.0e-04	-10.55	10.2	3.0e-24	-0.33	0.17	0.10	TRUE
12	GTEx	Brain Cerebellar Hemisphere	C18orf8	0.27	0.34	enet	19	0.34	1.3e-09	-8.41	-8.5	2.4e-17	0.24	0.96	0.00	FALSE
13	GTEx	Brain Cerebellum	RBBP8	0.35	0.23	lasso	4	0.19	2.4e-06	-8.56	8.8	1.4e-18	-0.24	0.45	0.09	FALSE
14	GTEx	Brain Cerebellum	C18orf8	0.23	0.18	enet	13	0.21	9.9e-07	-8.56	-8.9	7.8e-19	0.26	0.81	0.04	FALSE
15	GTEx	Brain Cerebellum	NPC1	0.20	0.10	enet	9	0.12	1.9e-04	-8.34	-6.4	1.2e-10	0.24	0.42	0.05	FALSE
16	GTEx	Brain Cortex	TMEM241	0.37	0.12	enet	19	0.22	1.3e-06	4.67	-9.3	8.4e-21	0.26	0.67	0.05	FALSE
17	GTEx	Brain Cortex	C18orf8	0.19	0.18	lasso	5	0.13	1.8e-04	-8.55	-8.5	1.9e-17	0.24	0.48	0.03	FALSE
18	GTEx	Brain Frontal Cortex BA9	C18orf8	0.42	0.30	enet	12	0.08	3.4e-03	-8.34	-7.9	3.4e-15	0.23	0.90	0.01	FALSE
19	GTEx	Brain Nucleus accumbens basal ganglia	TMEM241	0.17	0.02	lasso	6	-0.01	5.6e-01	-8.56	-7.6	3.1e-14	0.24	0.10	0.06	FALSE
20	GTEx	Breast Mammary Tissue	NPC1	0.27	0.13	enet	27	0.19	5.0e-10	-8.37	-7.2	4.5e-13	0.23	1.00	0.00	FALSE
21	GTEx	Breast Mammary Tissue (Female)	NPC1	0.43	0.24	lasso	3	0.27	1.1e-08	-8.10	-8.6	5.4e-18	0.27	0.98	0.00	FALSE
22	GTEx	Colon Transverse	NPC1	0.21	0.03	enet	23	0.05	3.0e-03	-0.55	7.4	1.4e-13	-0.15	0.11	0.38	TRUE
23	GTEx	Esophagus Mucosa	TMEM241	0.14	0.04	enet	28	0.05	2.6e-04	7.04	5.9	3.0e-09	-0.14	0.18	0.04	FALSE
24	GTEx	Esophagus Mucosa	NPC1	0.09	0.04	lasso	3	0.05	1.5e-04	-8.37	-10.2	2.1e-24	0.31	0.57	0.02	FALSE
25	GTEx	Esophagus Muscularis	C18orf8	0.14	0.13	lasso	3	0.10	8.0e-07	5.31	-6.4	1.2e-10	0.18	0.96	0.00	FALSE
26	GTEx	Esophagus Muscularis	NPC1	0.11	0.07	enet	4	0.09	7.3e-06	-9.03	-9.2	3.5e-20	0.26	0.76	0.01	FALSE
27	GTEx	Heart Left Ventricle	NPC1	0.19	0.15	enet	12	0.17	1.6e-09	-8.34	-8.2	2.0e-16	0.26	1.00	0.00	FALSE
28	GTEx	Lung	NPC1	0.11	0.06	enet	11	0.04	2.3e-04	-8.42	-6.8	9.0e-12	0.22	0.99	0.00	FALSE
29	GTEx	Nerve Tibial	TMEM241	0.16	0.04	enet	10	0.07	1.8e-05	-12.55	-17.2	2.5e-66	0.49	0.69	0.04	FALSE
30	GTEx	Nerve Tibial	NPC1	0.19	0.12	lasso	6	0.16	1.1e-11	5.31	-7.0	3.7e-12	0.22	1.00	0.00	FALSE
31	GTEx	Pancreas	NPC1	0.33	0.14	lasso	7	0.12	1.1e-05	-8.34	-7.3	1.9e-13	0.24	0.81	0.01	FALSE
32	GTEx	Skin Not Sun Exposed Suprapubic	C18orf8	0.21	0.27	enet	6	0.23	6.9e-13	-8.30	-8.5	2.0e-17	0.25	1.00	0.00	FALSE
33	GTEx	Skin Not Sun Exposed Suprapubic	NPC1	0.15	0.08	lasso	4	0.12	2.3e-07	-8.41	-8.0	1.6e-15	0.24	0.99	0.00	FALSE
34	GTEx	Skin Sun Exposed Lower leg	C18orf8	0.35	0.33	enet	23	0.36	1.7e-30	-8.52	-8.2	3.5e-16	0.25	1.00	0.00	FALSE
35	GTEx	Skin Sun Exposed Lower leg	NPC1	0.23	0.18	lasso	3	0.27	1.8e-22	-8.37	-7.3	2.2e-13	0.23	1.00	0.00	FALSE
36	GTEx	Testis	RBBP8	0.20	0.12	lasso	3	0.08	2.2e-04	-8.56	-8.6	8.4e-18	0.24	0.76	0.01	FALSE
37	GTEx	Testis	C18orf8	0.12	0.07	lasso	6	0.08	1.9e-04	-8.41	-15.6	6.0e-55	0.44	0.12	0.62	FALSE
38	GTEx	Vagina	NPC1	0.27	0.09	lasso	7	0.14	4.9e-04	-11.06	-12.7	5.4e-37	0.37	0.22	0.13	FALSE
39	METSIM	Adipose	C18orf8	0.08	0.02	enet	23	0.04	1.0e-06	5.35	-11.4	2.5e-30	0.25	0.80	0.01	FALSE
40	METSIM	Adipose	NPC1	0.06	0.05	enet	18	0.05	6.4e-08	-8.58	-6.5	7.0e-11	0.23	1.00	0.00	TRUE
41	ROSMAP	Brain Pre-frontal Cortex	CABLES1	0.11	0.05	enet	30	0.07	4.1e-09	-9.54	8.1	4.3e-16	-0.26	0.98	0.01	FALSE
42	YFS	Blood	RIOK3	0.04	0.02	lasso	5	0.02	1.5e-07	3.13	-7.1	1.2e-12	0.14	1.00	0.00	TRUE
43	The Cancer Genome Atlas	Breast Invasive Carcinoma	NPC1	0.03	0.03	blup	69	0.04	2.9e-09	-8.34	-6.9	5.3e-12	0.25	1.00	0.00	FALSE
44	The Cancer Genome Atlas	Esophageal Carcinoma	NPC1	0.16	0.10	lasso	3	0.10	3.7e-04	5.62	-6.7	2.2e-11	0.19	0.10	0.23	FALSE
45	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	NPC1	0.03	0.04	lasso	2	0.05	4.2e-06	-8.91	-8.9	3.7e-19	0.28	0.46	0.48	FALSE
46	The Cancer Genome Atlas	Brain Lower Grade Glioma	C18orf45	0.04	0.02	lasso	3	0.03	2.7e-04	8.84	-11.6	6.7e-31	0.34	0.70	0.02	TRUE
47	The Cancer Genome Atlas	Brain Lower Grade Glioma	C18orf8	0.07	0.05	lasso	5	0.03	9.5e-05	5.42	-5.5	4.4e-08	0.16	0.92	0.01	FALSE
48	The Cancer Genome Atlas	Brain Lower Grade Glioma	CABLES1	0.06	0.02	enet	12	0.04	6.8e-05	7.01	-11.7	1.3e-31	0.27	0.07	0.04	FALSE
49	The Cancer Genome Atlas	Brain Lower Grade Glioma	NPC1	0.07	0.08	lasso	3	0.10	1.6e-11	5.42	-7.6	2.3e-14	0.21	1.00	0.00	FALSE
50	The Cancer Genome Atlas	Prostate Adenocarcinoma	CABLES1	0.10	0.00	enet	14	0.01	2.0e-02	5.52	-9.6	1.0e-21	0.16	0.01	0.03	TRUE
51	The Cancer Genome Atlas	Prostate Adenocarcinoma	NPC1	0.05	0.02	blup	65	0.03	9.9e-04	-8.91	-7.1	9.7e-13	0.26	0.06	0.41	TRUE
52	The Cancer Genome Atlas	Prostate Adenocarcinoma	RIOK3	0.04	0.00	enet	10	0.01	1.2e-02	6.31	-7.2	5.9e-13	0.18	0.01	0.23	FALSE
53	The Cancer Genome Atlas	Soft Tissue Sarcoma	C18orf45	0.08	0.06	blup	114	0.06	1.7e-04	-13.98	-7.3	2.9e-13	0.22	0.60	0.02	FALSE
54	The Cancer Genome Atlas	Stomach Adenocarcinoma	NPC1	0.06	0.01	enet	6	0.05	2.2e-04	-9.75	-9.1	1.5e-19	0.29	0.03	0.73	TRUE
55	The Cancer Genome Atlas	Thyroid Carcinoma	NPC1	0.04	0.03	blup	70	0.05	9.4e-06	-8.39	-5.2	1.7e-07	0.22	0.82	0.10	FALSE