Hub : Genes

IMPA2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Subcutaneous 0.2280 0.0530 6.3e-07 0.120 NA 0.122 NA 0.108 5.1e-10 NA 3.4e-10 NA 3.6e-09
2 GTEx Adrenal Gland 0.4595 0.0897 3.3e-05 0.168 NA 0.078 NA 0.079 1.2e-06 NA 9.3e-04 NA 9.1e-04
3 GTEx Esophagus Mucosa 0.1000 0.0410 2.3e-03 0.056 NA 0.028 NA 0.052 1.3e-04 NA 5.4e-03 NA 2.2e-04
4 GTEx Ovary 0.4760 0.1280 4.1e-03 0.011 NA 0.225 NA 0.016 1.7e-01 NA 3.1e-06 NA 1.3e-01
5 GTEx Skin Not Sun Exposed Suprapubic 0.1290 0.0550 8.7e-03 0.008 NA 0.062 NA 0.018 1.1e-01 NA 2.7e-04 NA 3.2e-02
6 GTEx Skin Sun Exposed Lower leg 0.2230 0.0500 9.6e-09 0.157 NA 0.153 NA 0.166 5.9e-13 NA 1.1e-12 NA 1.1e-13
7 METSIM Adipose 0.1455 0.0338 3.2e-10 0.057 0.085 0.088 0.092 0.087 6.6e-09 9.7e-13 4.5e-13 1.2e-13 5.0e-13
8 NTR Blood 0.0248 0.0106 3.2e-03 0.004 0.005 0.010 0.006 0.007 1.2e-02 5.5e-03 1.8e-04 3.1e-03 1.7e-03
9 YFS Blood 0.1423 0.0245 0.0e+00 0.078 0.102 0.134 0.134 0.139 3.7e-24 1.1e-31 1.9e-41 1.7e-41 4.2e-43
10 TCGA Breast Invasive Carcinoma 0.0417 0.0192 6.9e-05 0.006 0.020 0.014 NA 0.006 1.6e-02 3.7e-05 5.7e-04 NA 1.4e-02
11 TCGA Kidney Renal Clear Cell Carcinoma 0.0777 0.0343 1.2e-05 0.025 0.045 0.046 NA 0.028 7.9e-04 7.1e-06 5.9e-06 NA 3.4e-04
12 TCGA Ovarian Serous Cystadenocarcinoma 0.0660 0.0400 8.0e-03 0.000 0.022 0.013 NA -0.003 3.3e-01 1.2e-02 4.2e-02 NA 6.4e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bipolar Disorder (2018) 1.4 2.2 4.6 -2.1 -1.7 -0.2 -1.9 -1.5 -0.5 -1.8 1.2 1.1 -0.6 2.2 -1.5
Bipolar Disorder or Schizophrenia 0.3 0.7 2.4 0.2 0.1 -0.7 -1.2 0.9 0.8 -0.2 -0.1 -1.5 0.9 1.3 0.7
Depressed Affect (Nagel 2018) 1.2 2.4 6.4 2.4 2.5 0.2 2.1 0.6 -0.3 1.7 -0.6 -0.2 0.6 -2.3 1.9
Depression (Nagel 2018) 0.6 0.9 4.2 1.7 0.3 -1.1 0.9 0.3 0.2 2.0 -0.5 -0.3 1.3 -0.4 -0.0
Intelligence (Savage-Jansen 2018) 0.3 1.0 4.0 -0.1 0.5 0.1 2.0 -0.0 -0.1 1.5 -0.0 0.1 -2.0 -0.8 0.6
Neuroticism (Nagel 2018) 0.6 1.3 4.1 1.7 1.7 0.4 0.3 1.0 0.3 1.7 -0.6 -0.3 1.0 -2.0 0.5
Schizophrenia (2018) 1.3 2.6 8.3 1.9 1.4 -0.7 -0.1 2.3 1.4 1.1 -1.3 -2.9 1.7 -0.1 2.0
Schizophrenia vs Biploar Disorder 1.9 2.6 7.2 2.0 1.6 -0.4 2.2 0.5 0.9 2.7 -1.4 -1.3 1.4 -0.8 2.0
Worry (Nagel 2018) 0.7 1.5 3.2 1.3 1.2 1.7 -0.9 0.8 1.2 1.4 -1.2 -0.5 0.9 -1.8 -1.0
Alzheimer’s Disease (in mother) 0.6 0.8 3.5 1.0 0.5 0.6 -0.4 1.2 0.0 0.6 -1.9 -0.9 1.1 -0.4 0.1
Alzheimer’s Disease (in father) 0.3 0.3 1.6 0.6 -0.3 0.3 -0.6 0.5 1.2 -0.0 -0.2 -0.6 -0.5 0.6 -0.6
Alzheimer’s Disease (including proxy) 0.3 0.4 1.4 0.4 -0.1 0.8 -0.7 0.7 0.5 -0.2 -1.2 -0.6 -0.2 0.2 -0.7
Crohns Disease (2017) 0.4 0.8 3.1 0.9 0.6 -1.6 -0.3 -0.2 -1.8 -0.5 -0.4 -0.1 0.9 -0.6 1.1
Irritable Bowel Disease (IBD) 0.1 0.3 1.1 0.1 0.5 0.1 -0.8 0.1 -0.7 -0.1 -1.0 -0.1 -0.1 -0.8 0.1
Ulcerative Colitis (UC) 0.4 0.8 2.5 -0.6 -0.0 1.6 -1.1 -0.6 0.4 0.2 -1.5 0.0 -0.8 -0.6 -1.1
Major Depression (MDD) 1.7 2.1 6.3 1.3 2.1 -0.3 0.3 1.0 0.5 1.0 -1.5 -2.5 1.0 -2.5 1.0
Reaction Time 0.3 0.5 1.6 -0.6 -0.9 -1.3 -0.0 -0.8 -1.1 -0.3 -0.4 0.9 0.1 0.6 0.2
Verbal and Numeric Reasoning (VNR) 1.0 2.5 6.6 1.4 2.1 -0.6 2.6 0.1 -1.4 2.1 0.9 0.3 -1.5 -2.3 1.0
Breast Cancer 0.4 0.9 3.5 0.6 0.6 -0.4 0.9 1.1 0.9 -0.1 -1.8 -0.7 0.1 -0.5 1.9
Ovarian Cancer 1.8 2.4 5.1 1.2 1.7 0.6 0.3 1.6 1.5 1.9 -2.3 -2.0 1.5 -1.2 1.8
Prostate Cancer 0.3 0.4 0.9 0.5 0.9 -0.2 -0.9 -0.0 -0.4 0.6 0.8 0.7 -0.5 -0.8 -0.8
Age at First Birth 0.6 0.9 3.2 0.0 0.2 1.7 0.1 -0.1 0.0 -0.4 0.8 1.0 -1.1 -1.8 -1.3
Bipolar Disorder (2011) 2.5 2.4 5.5 -2.3 -1.5 0.0 -1.9 -0.2 0.0 -2.3 1.6 0.9 -1.8 2.2 -0.9
Body Mass Index (BMI) (2010) 1.1 1.5 3.7 1.9 1.0 -0.5 1.9 0.9 0.5 1.2 -0.7 -1.3 1.1 -1.7 -0.2
Coronary Artery Disease (CAD) 0.4 0.5 2.8 -0.1 0.0 -0.1 -0.1 -1.7 -1.7 0.3 -0.0 0.8 -0.2 0.2 0.0
Crohns Disease (2012) 0.2 0.3 0.7 0.4 0.8 -0.3 -0.8 -0.3 -0.5 0.1 0.6 0.5 0.1 -0.8 -0.2
Mean Putamen Volume 0.3 0.3 0.9 -0.5 -0.8 0.3 0.0 0.9 0.5 -0.4 0.5 -0.6 0.0 -0.6 -0.8
Fasting Glucose 0.4 0.5 1.9 -0.0 0.4 -0.5 -0.5 -0.2 -0.9 0.1 -1.4 -1.4 0.7 0.7 -0.3
HbA1C 0.6 0.7 3.0 -0.7 0.2 -1.2 0.3 -1.7 -0.1 -0.1 1.1 0.6 -0.1 1.1 -0.7
HDL Cholesterol 2.9 4.8 12.2 0.8 2.3 -1.3 2.1 2.5 1.2 1.6 -2.1 -3.3 2.5 -1.1 3.5
LDL Cholesterol 0.6 1.0 2.5 -0.5 -1.6 0.3 -0.8 -0.7 0.1 -1.0 1.3 1.4 -0.4 0.8 -1.5
Lupus 0.7 1.1 4.6 -0.0 0.8 -0.5 2.2 -0.2 -1.2 0.7 -0.5 0.0 1.5 0.7 1.7
Neuroticism (2016) 0.8 1.1 3.6 -0.5 -0.5 1.4 -1.3 0.9 1.9 0.2 -0.3 -0.6 -1.0 -0.6 -1.8
Primary Biliary Cirrhosis 0.1 0.1 0.5 -0.0 -0.1 0.5 -0.7 0.1 -0.5 -0.3 -0.2 -0.1 -0.3 -0.0 -0.2
Rheumatoid Arthritis 1.4 1.9 6.3 0.1 0.6 -1.6 0.9 -1.5 -2.5 0.8 -1.5 -0.1 2.2 0.1 1.8
Schizophrenia (2014) 1.1 2.5 7.5 1.9 0.9 0.1 -0.3 2.4 2.3 1.4 -1.8 -2.7 1.1 -0.1 0.8
Triglycerides 1.2 2.0 7.6 -0.6 -2.3 1.0 -0.5 -2.2 -1.0 -1.1 0.4 1.1 -0.2 1.2 -2.8
Type 2 Diabetes (T2D) (2012) 2.3 2.7 11.9 -1.4 -1.5 2.4 -2.1 -1.2 0.4 -1.8 -0.3 0.3 -0.8 -0.5 -3.4
Ulcerative Colitis 0.7 0.9 2.2 -1.4 -0.7 1.4 -1.5 -0.3 0.3 -0.2 -0.6 0.7 -1.0 -0.4 -1.5
Blood Eosinophil Count 0.1 0.6 2.7 1.6 0.5 0.3 -0.8 -0.5 0.6 0.4 -0.9 -0.7 0.2 -0.6 -0.9
Blood Platelet Count 0.1 1.4 4.7 -1.0 -1.2 0.0 -0.7 -1.2 -1.4 -2.2 1.2 1.2 -1.5 0.8 0.1
Blood Red Count 0.7 6.7 18.7 -4.3 -3.7 -1.3 -1.4 -1.3 -2.0 -3.7 1.7 2.1 -2.5 3.4 0.7
Blood White Count 0.4 2.7 7.8 -1.5 -2.8 -1.3 -1.9 -2.4 -1.4 -0.9 0.5 0.6 -0.5 2.2 -1.7
Heel T-Score 0.2 1.9 7.3 1.4 0.1 2.7 -0.8 -0.1 1.8 0.0 -0.9 0.2 0.0 -1.6 -2.6
BMI 0.6 3.6 9.6 3.1 2.2 -0.1 -0.1 1.3 1.1 2.3 -2.0 -2.0 1.7 -3.1 0.1
Height 0.8 15.5 52.9 -7.3 -5.5 -1.7 -1.8 -3.4 -1.5 -5.0 2.7 4.4 -3.3 4.4 -0.6
Waist Hip Ratio (WHR) 0.5 2.1 8.1 -2.8 -1.3 1.0 -0.4 -1.4 0.5 -2.1 -0.5 1.2 -2.2 0.8 0.7
Systolic Blood Pressure 0.8 4.2 14.0 -3.7 -2.2 -0.1 -1.7 -1.0 0.3 -3.0 1.5 1.9 -2.7 1.5 -1.6
Smoking Status 0.2 0.5 2.6 0.8 -0.0 0.5 0.3 -1.6 -0.5 0.4 -0.7 -0.3 -0.4 -1.1 -0.7
Allergy or Eczema 0.1 0.3 1.2 -0.8 0.7 -0.3 1.1 0.8 0.4 0.2 -0.5 -0.3 -0.3 -0.6 0.0
Cardiovascular Disease 0.5 1.8 6.3 -1.5 -1.7 0.2 -0.4 -2.5 -0.8 -1.1 0.5 1.9 -0.8 -0.2 -1.9
Hypothyroidism (self reported) 0.2 0.4 1.1 -0.9 -0.7 -0.8 -1.1 -0.4 -0.6 -0.6 -0.4 -0.4 0.1 0.9 -0.3
Respiratory disease 0.3 0.8 2.8 0.5 0.2 -1.5 0.8 -0.5 -0.8 -0.3 1.7 1.2 0.4 -0.2 0.8
Type 2 Diabetes (T2D) (2018) 0.3 0.5 1.4 0.7 0.4 -0.8 0.8 0.6 -0.2 -0.1 -1.2 -1.1 -0.1 -0.2 0.7
Lung FEV1/FVC ratio 0.2 1.1 3.1 0.2 0.8 1.7 -0.7 1.4 1.5 0.1 0.2 0.4 -0.6 -1.8 -0.8
Lung FVC 0.2 1.0 4.9 -0.2 -0.5 -2.2 0.1 -0.7 -1.3 -0.5 1.2 0.5 0.2 1.3 1.0
Neuroticism 0.5 1.1 4.1 1.5 1.4 0.8 0.3 -0.3 0.1 1.7 -0.4 0.1 1.0 -2.0 0.2
Chronotype (morning person) 0.8 2.0 5.6 -0.4 -1.4 -1.2 -0.6 -1.1 -2.4 -1.4 2.1 1.8 0.4 1.3 1.1
Hair Pigment 0.1 1.6 5.3 -0.9 -1.0 -1.2 0.1 -2.2 -2.3 -1.3 0.8 1.1 -1.0 1.2 -0.6
Tanning 0.0 0.3 1.4 -0.0 0.2 0.7 -0.6 -0.8 -0.1 0.3 -0.7 0.0 0.5 -1.2 -0.6
Hand grip strength (left) 0.8 2.2 4.1 -1.7 -1.4 -1.2 -0.3 -1.9 -1.9 -1.5 2.0 1.5 0.1 2.0 0.8
Number of treatments/medications taken 0.9 1.5 5.9 0.8 0.1 1.1 -0.1 1.7 2.4 0.3 -1.3 -1.3 0.4 -1.8 -0.9
Average weekly spirits intake 1.0 1.3 5.4 0.8 1.5 0.9 -0.1 0.9 2.3 -0.9 -0.8 -1.2 0.1 -1.5 -0.2
Sensitivity / hurt feelings 0.6 1.1 2.5 0.8 0.7 -1.6 0.2 -1.5 -1.3 0.3 1.3 1.1 1.2 0.3 0.7
Frequency of depressed mood in last 2 weeks 0.9 1.3 3.5 1.7 0.6 -0.1 0.8 1.9 1.0 1.6 -0.8 -1.4 1.0 -0.5 -0.2
Hearing difficulty/problems: Yes 0.8 1.2 6.6 -0.4 -0.7 0.2 -1.7 0.2 0.4 -0.4 -2.6 -1.6 1.1 0.4 -0.0
Relative age of first facial hair 0.5 1.0 3.2 0.7 0.6 -0.5 1.6 0.6 -0.5 0.7 -1.2 -1.6 0.8 -0.4 1.8
Other serious medical condition/disability diagnosed by doctor 0.7 1.0 2.6 0.8 0.4 0.8 1.3 1.2 1.6 1.4 -0.5 -0.9 -0.1 -1.2 0.2
Ever used hormone-replacement therapy (HRT) 1.6 2.1 11.1 1.4 1.2 0.6 0.6 3.3 1.4 0.7 -1.5 -1.3 -0.2 -1.6 0.6
Ever had hysterectomy (womb removed) 1.1 1.3 3.5 1.9 0.6 0.9 1.5 1.0 1.7 1.4 -0.9 -0.3 0.6 -0.8 -0.6
Systolic blood pressure, automated reading 1.0 2.8 6.2 -2.1 -2.4 1.3 -2.2 0.3 1.5 -1.7 0.1 0.6 -2.3 0.3 -2.5
Eye problems/disorders: Diabetes related eye disease 0.5 0.5 1.8 -0.0 -0.6 0.4 -1.2 0.7 0.7 -0.2 -0.7 0.6 -0.6 -0.2 -1.4
Angina 1.2 1.5 9.8 0.4 -0.8 1.3 -0.5 -1.3 -0.7 0.3 1.0 1.1 0.4 -0.8 -3.1
Medication for hormone replacement therapy 0.2 0.2 0.7 -0.1 -0.1 0.4 -0.6 0.2 -0.7 -0.4 -0.9 -0.1 0.6 -0.2 0.1
Vitamin and mineral supplements 0.7 0.9 2.6 -0.9 -0.7 -1.1 -0.7 -1.6 -1.2 -0.2 0.8 1.3 -0.4 -0.5 -0.9
Supplements: Zinc 0.6 0.7 1.9 1.2 1.2 0.6 -0.7 0.4 0.7 0.6 -0.5 -1.4 -0.2 -0.9 0.5
Medication: Co-codamol 0.3 0.3 1.1 0.3 0.5 -0.1 0.7 0.6 1.0 0.4 0.1 -0.6 -0.1 0.8 -0.2
Medication: Metformin 0.4 0.5 1.7 0.0 -0.5 -0.6 -0.4 1.3 0.6 -0.7 -0.7 -0.8 -0.2 0.6 1.3
Diabetes (father) 1.0 1.3 3.8 1.7 1.8 -0.2 1.4 0.2 -0.4 1.2 0.9 0.2 0.9 -1.9 0.5
Diabetes (mother) 0.5 0.6 2.5 0.7 0.8 0.8 1.3 -0.3 -0.3 0.1 -1.6 -0.3 0.0 -1.0 0.7
Severe depression (siblings) 0.6 0.7 2.7 0.9 0.7 -1.7 0.1 -1.2 -0.8 0.5 1.3 0.2 0.3 -0.6 0.4
Pack years adult smoking proportion 1.3 2.0 3.6 -0.0 0.2 1.9 -1.8 0.7 1.8 -1.4 1.4 0.9 -1.6 -1.6 -1.8
Impedance of leg (right) 0.2 1.0 4.9 -0.1 0.5 -1.2 0.6 -0.4 -1.4 -0.8 0.7 -0.4 0.1 1.5 2.2
Leg fat-free mass (left) 0.1 0.8 2.4 -1.0 -1.5 -0.8 -1.4 -0.8 0.2 -0.3 0.1 0.9 -0.0 0.2 -1.3
Trunk fat percentage 0.5 2.0 4.5 1.9 0.3 -0.6 -1.3 1.5 0.9 1.3 -1.7 -2.1 1.7 -1.7 -0.7
Hand grip strength (right) 1.0 2.6 6.0 -1.8 -1.1 -1.8 -0.4 -2.2 -2.4 -1.5 2.2 1.6 -0.3 1.6 1.0
Townsend deprivation index at recruitment 0.3 0.5 3.0 0.4 0.5 0.4 0.2 -1.7 0.1 0.6 -0.3 1.0 0.1 -0.3 -0.8
Current tobacco smoking 0.5 0.8 4.4 0.1 -1.0 -0.4 0.9 -2.1 -1.2 -0.4 0.2 0.3 -0.8 0.9 0.3
Average weekly fortified wine intake 0.4 0.5 1.6 -0.5 0.3 -1.1 1.1 0.6 -0.6 0.5 0.1 0.4 0.0 0.3 1.3
Maternal smoking around birth 0.6 0.8 3.5 0.4 -0.3 1.9 0.4 -0.2 0.8 0.3 -1.4 -0.6 0.5 -1.0 -1.2
Fed-up feelings 1.3 2.4 6.2 2.5 1.8 -0.5 0.8 0.9 -0.4 2.3 -1.2 -1.7 1.9 -1.2 1.6
Frequency of unenthusiasm / disinterest in last 2 weeks 0.5 0.7 1.9 1.4 -0.4 0.2 -0.7 0.2 1.1 1.1 -0.6 -0.1 1.1 -0.0 -1.2
Relative age voice broke 0.3 0.5 2.0 -1.0 -0.3 0.6 0.7 -0.2 0.5 -0.9 -1.4 0.0 -0.6 0.3 0.4
Taking other prescription medications 0.3 0.5 1.4 1.2 0.1 -0.8 1.0 0.6 0.4 0.9 -0.4 0.2 0.7 -1.0 0.6
Age when periods started (menarche) 1.2 3.0 7.3 -2.7 -1.5 -0.7 -1.8 -2.5 -0.2 -1.8 1.4 2.0 -1.4 1.7 -1.5
Bilateral oophorectomy (both ovaries removed) 0.7 0.8 2.7 -0.2 -0.2 1.6 0.2 0.7 1.4 0.8 -1.7 -0.5 -0.1 -1.0 -0.2
Heel bone mineral density (BMD) T-score, automated (left) 0.6 1.3 4.2 2.1 1.0 0.9 1.0 0.9 1.0 1.4 -1.7 -1.2 0.4 -0.6 0.1
Tinnitus: Yes, but not now, but have in the past 1.1 1.2 7.1 -1.1 -0.4 0.9 -0.1 1.4 0.1 -0.8 -2.7 -0.6 0.8 0.4 1.3
Qualifications: CSEs or equivalent 0.4 0.5 1.3 0.4 0.3 -0.9 -0.8 -0.2 -0.9 0.6 0.1 -0.5 0.9 0.9 1.1
Serious illness, injury or assault to yourself 2.0 2.4 6.3 1.6 0.9 -1.5 0.4 2.5 1.5 1.8 -1.5 -2.4 1.7 0.3 0.8
High blood pressure 0.7 2.0 5.8 -0.6 -1.6 1.4 -1.3 -0.8 1.2 -1.7 -0.6 0.9 -1.8 -1.4 -2.4
Hayfever, allergic rhinitis or eczema 0.4 0.9 4.6 0.5 1.3 -0.8 2.2 0.5 0.1 1.1 0.2 -0.4 0.6 -0.8 0.7
Multivitamins +/- minerals 1.1 1.4 4.7 0.9 1.4 0.1 1.6 0.4 -0.5 0.9 -1.1 -1.3 1.5 -0.2 2.2
Stomach or abdominal pain in last month 1.4 1.8 7.1 1.7 1.3 -1.3 1.2 0.3 -0.4 1.5 -0.3 -1.0 2.7 -1.0 1.4
Supplements: Glucosamine 0.8 1.1 3.4 0.6 0.5 0.7 0.8 1.8 0.9 1.0 -1.6 -1.6 0.0 -0.4 0.7
Diverticular disease/diverticulitis (self-reported) 1.0 1.2 2.9 1.7 1.3 0.6 0.6 1.2 0.4 1.3 0.6 -0.6 1.4 -1.6 0.5
Medication: Atenolol 0.5 0.6 2.4 0.5 -0.2 0.6 -0.9 0.6 0.4 -0.5 -0.8 -1.6 0.2 -1.1 -0.7
Medication: Levothyroxine sodium 0.8 1.4 7.2 0.3 0.8 -2.7 1.1 0.5 -0.6 0.3 -0.5 -1.1 1.3 0.5 1.9
Sitting height 0.1 1.0 3.5 -1.4 -0.8 -0.6 -0.1 -1.0 -0.5 -0.7 1.9 1.5 -0.6 1.2 0.3
Chronic bronchitis/emphysema (father) 1.4 1.7 5.2 0.9 0.3 -1.9 1.2 -1.1 -2.1 0.5 -0.9 -0.3 2.3 0.1 1.4
High blood pressure (mother) 0.3 0.4 1.9 -0.1 0.5 0.1 -0.7 1.4 0.6 0.5 0.8 -0.1 -0.3 -0.6 -0.5
Body mass index (BMI) 0.6 2.6 5.3 2.3 0.5 0.0 -1.1 1.6 1.6 1.7 -2.0 -1.9 1.6 -2.1 -1.3
Impedance of leg (left) 0.3 1.4 7.2 -0.1 0.7 -1.1 0.7 -0.6 -2.1 -0.6 0.5 -0.6 0.3 1.4 2.7
Leg predicted mass (left) 0.1 0.7 2.3 -1.0 -1.5 -0.7 -1.4 -0.8 0.2 -0.3 0.1 0.9 -0.0 0.1 -1.3
Trunk fat mass 0.3 1.2 2.2 1.2 -0.2 -0.7 -1.5 1.0 0.7 0.9 -1.2 -1.5 1.3 -1.4 -0.9
Waist circumference 0.2 0.9 2.9 0.2 -0.2 0.0 -1.3 0.7 1.4 0.4 -1.7 -1.0 0.5 -1.2 -1.0
Number of incorrect matches in round 0.8 1.3 3.5 -1.6 -1.3 0.0 -1.7 -1.9 -1.3 -1.5 -0.4 0.5 -0.2 0.7 -0.8
Past tobacco smoking 0.2 0.3 1.7 -0.3 -0.4 -0.8 0.1 -0.3 -0.4 -0.2 0.3 0.5 0.1 1.3 0.7
Alcohol usually taken with meals 0.4 0.7 1.9 0.3 1.2 -1.1 0.5 0.1 -1.1 1.2 0.1 -0.5 0.7 -0.4 1.4
Nervous feelings 0.5 1.0 2.3 1.3 1.4 0.8 -0.6 0.6 1.0 1.2 -0.2 0.2 1.5 -1.3 -0.1
Frequency of tenseness / restlessness in last 2 weeks 1.0 1.6 5.0 2.2 1.5 0.0 -0.2 1.0 1.3 1.8 -0.9 -1.2 1.2 -1.4 -0.3
Hearing difficulty/problems with background noise 0.7 1.1 3.9 0.3 -0.3 0.9 -0.8 -0.9 -0.6 0.9 -2.0 -0.8 1.0 -1.1 -1.6
Hair/balding pattern: Pattern 2 0.8 1.0 2.8 1.1 0.6 0.4 0.9 0.9 0.7 1.0 -1.7 -1.3 1.4 0.8 -0.1
Had menopause 1.6 1.9 6.5 0.8 0.5 1.0 -0.4 2.5 2.2 1.0 -1.4 -1.3 -1.1 -1.8 -0.9
Had other major operations 0.4 0.5 1.4 -0.7 -1.1 0.4 0.4 0.0 0.3 -0.0 0.9 1.2 -0.3 1.0 -0.3
Forced vital capacity (FVC) 0.6 2.2 4.5 -1.9 -0.8 -2.0 0.2 -1.7 -2.1 -0.8 1.4 1.0 0.3 1.8 1.8
Heel bone mineral density (BMD) T-score, automated (right) 0.9 2.0 4.2 1.9 1.3 1.2 2.1 1.8 1.4 1.7 -1.6 -1.2 0.9 -0.9 0.3
Ever unenthusiastic/disinterested for a whole week 0.4 0.4 1.7 0.7 -0.3 0.1 1.3 -1.0 0.2 0.6 0.1 0.0 1.2 0.4 0.2
Qualifications: None of the above 0.4 0.9 2.4 0.5 -1.1 1.5 -0.8 -0.3 1.0 -1.6 0.3 0.5 -0.8 -0.2 -1.4
Financial difficulties in last 2 years 0.9 1.2 4.0 0.2 -0.4 -1.3 -0.5 -0.8 -2.0 1.1 -1.4 -1.5 1.0 1.1 0.4
Mouth/teeth dental problems 0.4 0.6 2.6 -0.1 -0.0 0.6 -0.6 0.9 0.6 0.0 -1.6 -1.3 -0.7 -0.1 -0.5
Heart attack 0.6 0.8 1.9 0.8 -0.3 1.4 -0.5 0.3 1.0 0.1 -0.6 -1.3 0.5 -1.2 -1.3
Allergy 0.4 0.9 3.0 0.2 -0.9 1.5 -1.7 0.1 -0.3 -0.6 -1.0 -0.5 -1.1 0.3 -1.1
Pain all over the body in last month 1.2 1.3 4.3 -1.4 -1.1 -0.7 2.0 -0.6 -0.4 -0.4 -0.5 1.2 -0.3 2.1 0.8
Diabetes (self-reported) 0.4 0.5 3.2 0.7 -0.3 0.3 -0.2 0.9 0.5 -0.4 -1.8 -1.0 -0.6 -0.2 -0.3
Hayfever/allergic rhinitis (self-reported) 0.9 1.2 6.0 -0.1 1.4 -2.4 0.5 0.1 -1.1 1.0 -0.4 -0.9 1.0 -0.3 1.3
Medication: Ramipril 0.6 0.8 4.7 0.6 -0.5 -0.4 0.3 -2.2 -0.3 0.1 1.2 -0.2 0.1 0.7 -1.3
Medication: Simvastatin 1.0 1.4 5.4 0.1 -0.4 1.5 -1.1 -0.6 0.4 -0.2 -1.8 -0.3 -0.1 -2.0 -2.3
Fluid intelligence score 0.7 1.4 4.2 1.5 1.0 0.3 2.0 -0.8 -0.8 1.6 0.9 0.8 -0.9 -1.5 -0.9
Illnesses of siblings 1.4 1.9 4.9 -2.2 -2.1 -0.8 0.3 -0.6 -0.4 -1.5 2.2 1.0 -0.8 2.0 0.4
Neuroticism score 0.6 1.3 3.5 1.9 1.7 1.3 0.0 1.1 1.1 1.3 -0.4 -0.3 1.0 -1.7 0.2
Weight 0.1 0.7 2.5 0.3 -0.7 -0.5 -1.6 0.6 0.9 0.3 -0.8 -0.5 0.6 -0.8 -1.2
Impedance of arm (right) 0.3 1.3 5.5 -0.2 0.8 -1.7 0.8 -0.4 -1.4 -0.1 0.5 -0.4 0.7 1.6 2.3
Arm fat percentage (right) 0.6 2.4 5.2 2.3 0.8 -0.7 -0.7 1.4 1.1 1.7 -2.3 -2.2 1.8 -1.7 -0.5
Trunk fat-free mass 0.5 2.6 7.2 -2.7 -2.5 -0.2 -1.3 -1.2 0.3 -1.9 1.0 2.1 -1.7 1.1 -1.3
Hip circumference 0.4 1.5 3.2 1.7 0.4 -0.8 -0.9 1.1 0.8 1.8 -1.1 -1.5 1.7 -1.2 -0.9
Time employed in main current job 0.3 0.3 0.7 -0.6 0.3 0.5 -0.8 0.8 0.8 -0.2 -0.5 -0.5 -0.4 -0.5 0.0
Alcohol intake versus 10 years previously 0.5 0.7 2.9 -0.9 -0.7 1.1 -0.3 0.7 0.4 -1.7 -0.3 0.7 -1.3 0.1 -0.7
Father’s age at death 0.8 1.1 3.4 -0.7 -0.9 -1.4 0.8 1.7 0.5 -0.5 0.7 -0.4 0.5 1.8 1.2
Worrier / anxious feelings 1.5 2.9 8.0 0.9 1.5 2.4 -1.6 1.9 2.5 1.5 -0.9 -0.8 -0.4 -2.8 -1.3
Frequency of tiredness / lethargy in last 2 weeks 3.6 5.9 15.8 4.0 2.3 0.4 1.7 2.4 1.5 3.7 -2.4 -2.8 2.7 -1.6 0.6
Falls in the last year 0.3 0.5 1.3 -0.4 -1.1 -0.4 1.1 0.6 -0.2 0.4 -0.3 0.4 0.9 0.3 0.9
Hair/balding pattern: Pattern 3 0.3 0.4 2.3 -0.6 -0.1 -1.5 -0.4 -0.4 -0.1 -0.4 -0.5 -0.4 0.8 -0.6 0.1
Number of live births 0.8 1.2 3.6 -0.1 -0.5 1.3 0.1 1.6 1.5 -0.2 0.6 0.5 -1.9 -1.1 -1.5
Forced expiratory volume in 1-second (FEV1) 0.3 1.1 2.8 -1.5 0.0 -1.4 0.0 -0.9 -1.4 -0.5 1.1 0.6 0.3 1.1 1.7
Pulse rate 0.4 0.7 2.6 -0.2 -0.6 1.6 -1.3 0.3 -0.1 0.4 -1.4 -0.6 -0.4 0.2 -1.1
Happiness 0.7 0.8 3.9 0.8 0.9 -1.1 0.1 -2.0 -1.0 0.2 0.4 -0.1 0.2 -0.1 1.6
Noisy workplace 1.2 1.5 4.3 -1.1 0.0 2.1 -1.3 1.4 2.0 -0.8 -1.1 -0.7 -0.9 -1.2 -0.6
Qualifications: A levels/AS levels or equivalent 0.8 1.8 6.7 0.2 0.9 -1.5 1.9 -0.2 -1.8 1.1 1.4 0.6 0.8 1.1 2.6
Serious illness, injury or assault of a close relative in last 2 years 1.5 1.7 5.5 1.0 1.7 0.2 0.5 0.7 0.9 1.8 -1.9 -2.3 1.0 -1.3 0.1
Mouth/teeth dental problems: Dentures 0.8 1.3 5.0 -0.5 -0.9 -0.2 -1.2 0.1 1.3 -1.2 2.2 1.7 -0.5 -0.0 -1.4
Asthma 0.3 0.6 3.0 0.2 0.8 -1.7 1.1 0.1 0.3 -0.2 0.5 0.3 0.3 -0.0 1.2
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.5 2.1 -0.1 -0.6 -0.8 -0.6 -0.3 -0.3 1.1 -0.7 -0.4 1.5 0.3 -0.3
Medication: Cholesterol lowering 0.8 1.3 7.6 -0.0 -0.5 1.2 -1.9 -0.9 0.0 -0.4 -0.2 -0.0 -0.5 -1.2 -2.8
Depression (self-reported) 1.8 2.2 6.0 1.8 1.7 0.1 0.9 2.4 1.5 1.2 -1.3 -1.8 1.5 -0.5 1.3
Medication: Lansoprazole 1.4 1.5 6.2 -0.1 1.1 2.5 -0.4 1.1 2.5 0.5 -0.8 -0.2 0.3 -1.3 -0.8
Prospective memory result 0.3 0.3 1.2 -0.5 -1.1 0.8 -0.2 -0.4 -0.6 -0.9 -0.8 0.1 -0.0 0.1 -0.0
Lung cancer (father) 1.5 1.8 5.9 -0.0 -0.6 2.3 -1.1 1.8 2.4 -0.4 -0.1 0.3 -1.8 -0.8 -1.2
Illnesses of mother 0.7 0.9 2.7 -0.6 -0.3 -0.4 1.7 -1.3 -1.3 -1.2 -0.4 -0.1 -0.2 1.0 1.3
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 0.9 3.9 -0.4 0.5 -1.5 0.6 -0.5 -1.3 0.1 0.7 -0.1 0.7 0.8 2.0
Pulse wave Arterial Stiffness index 0.7 0.8 3.1 -0.1 -0.7 0.1 -0.3 1.1 1.4 -0.8 0.3 -0.3 -1.8 -0.7 -1.1
Impedance of arm (left) 0.2 0.8 3.3 -0.1 0.8 -1.2 0.9 -0.1 -1.2 0.1 1.0 -0.3 0.7 0.8 1.8
Arm fat mass (right) 0.4 1.8 3.6 1.9 0.3 -0.8 -1.0 1.1 1.0 1.5 -1.8 -1.7 1.7 -1.5 -0.7
Trunk predicted mass 0.4 2.6 7.0 -2.6 -2.5 -0.4 -1.3 -1.2 0.1 -1.8 1.0 2.1 -1.6 1.1 -1.3
Standing height 0.6 5.9 18.6 -4.3 -2.9 -1.3 -1.1 -2.3 -1.5 -2.8 2.6 2.9 -1.8 2.7 0.2
Length of working week for main job 1.5 1.7 5.1 2.0 1.7 0.3 1.5 0.4 0.4 1.2 -1.4 -1.2 0.7 -2.3 0.7
Exposure to tobacco smoke at home 0.5 0.6 1.8 0.0 0.5 -0.4 -1.1 0.4 -0.4 0.1 -1.1 -1.3 0.7 -0.6 0.9
Breastfed as a baby 0.6 0.8 4.6 -0.6 0.5 1.4 -2.1 0.1 0.9 0.2 0.7 0.1 -0.8 -0.4 -0.4
Tense / ‘highly strung’ 0.3 0.4 1.8 1.0 0.1 0.8 0.4 0.1 0.2 0.8 -0.5 0.0 1.3 -0.6 -0.6
Seen doctor (GP) for nerves, anxiety, tension or depression 2.4 3.6 10.3 3.0 3.0 -1.4 0.4 0.6 0.4 3.2 -0.0 -1.9 2.8 -0.5 0.9
Hair/balding pattern: Pattern 4 0.3 0.7 3.0 -0.7 0.4 0.0 -0.2 -0.7 -0.7 -0.9 0.9 1.7 -1.3 0.5 0.7
Birth weight of first child 0.6 1.1 3.2 -1.0 -1.1 1.4 -0.0 0.6 1.4 0.1 0.7 1.8 -1.6 0.2 -0.8
Peak expiratory flow (PEF) 0.2 0.5 3.0 -1.7 0.8 0.3 -0.2 -0.0 0.7 -0.4 0.2 -0.9 -0.3 -0.4 0.5
Pulse wave reflection index 0.9 1.1 3.9 0.2 1.0 -2.0 0.3 0.5 1.2 -0.9 1.8 0.1 -0.5 -0.1 1.3
Ever highly irritable/argumentative for 2 days 0.4 0.5 1.7 -0.8 0.0 -0.6 -0.1 -1.3 -0.4 -1.1 0.1 0.8 -1.0 -0.2 0.4
Loud music exposure frequency 0.5 0.5 1.4 0.5 0.9 -1.0 0.6 -1.2 -0.9 0.6 -0.6 -0.3 0.5 -0.6 0.5
Qualifications: O levels/GCSEs or equivalent 0.4 0.6 3.5 -0.3 -1.0 -1.0 0.4 -0.5 -1.9 0.4 0.4 -0.3 0.2 1.1 0.1
Mouth/teeth dental problems: Bleeding gums 0.5 0.6 1.7 0.9 1.2 0.6 0.7 -0.2 -0.8 0.6 -0.6 -0.5 0.3 -1.3 0.8
Blood clot in the leg (DVT) 0.5 0.7 1.6 -0.2 -0.1 0.9 0.0 0.8 1.0 1.3 1.2 0.8 0.5 -0.8 -1.0
Medication: Paracetamol 0.5 0.8 2.8 1.1 0.5 -0.9 0.5 0.7 0.2 1.7 -0.5 -1.2 1.2 0.2 1.0
Headache pain in last month 1.4 2.4 7.1 2.7 2.6 0.1 0.7 0.1 -0.5 2.3 0.0 -1.0 2.2 -1.3 1.3
Medication for cholesterol, blood pressure or diabetes 0.6 1.1 3.3 0.6 1.2 -0.9 1.7 0.2 -0.5 1.1 1.1 0.7 0.2 0.8 1.8
Glaucoma (self-reported) 1.0 1.2 4.1 -0.5 -1.1 2.0 -0.3 -0.9 0.6 -1.5 0.3 0.8 -1.5 -0.9 -1.4
Gout (self-reported) 0.3 0.5 2.2 0.5 0.1 -0.4 -1.5 -1.1 0.1 0.7 0.0 -0.1 0.1 0.2 -1.0
Hypothyroidism/myxoedema (self-reported) 0.3 0.5 3.0 0.2 0.5 -1.7 -0.1 -0.2 -1.0 0.2 -0.3 -0.6 0.9 0.1 0.6
Medication: Amlodipine 1.3 1.8 8.3 -1.2 -2.3 -0.6 -0.8 -2.9 -0.9 -1.5 -0.2 0.5 -1.1 0.8 -0.9
Medication: Ventolin 100micrograms inhaler 0.7 0.9 4.3 0.2 0.2 -2.1 0.5 -0.9 -0.7 0.2 0.7 -0.2 0.7 1.4 1.2
Birth weight 3.9 8.4 16.6 -3.4 -3.6 0.5 -1.6 -2.9 -1.5 -3.3 3.8 4.1 -3.3 2.2 -2.2
Chronic bronchitis/emphysema (mother) 1.6 1.9 8.0 0.3 -0.3 -1.1 1.2 -2.8 -2.7 0.0 0.5 0.9 0.9 1.1 1.1
High blood pressure (siblings) 0.8 1.1 2.5 1.5 1.2 0.5 -0.8 0.4 -0.4 1.4 -1.6 -0.8 1.1 -1.4 -0.4
Forced vital capacity (FVC), Best measure 0.6 2.0 6.2 -1.1 -0.4 -2.5 0.7 -1.2 -2.0 -0.3 1.0 0.2 0.5 1.9 2.4
Body fat percentage 0.6 2.2 4.7 2.1 0.5 -0.6 -1.1 1.5 0.9 1.5 -1.9 -2.2 1.8 -1.7 -0.5
Leg fat percentage (right) 0.6 2.3 6.2 2.5 0.7 -0.6 -0.9 1.6 0.9 1.6 -2.0 -2.1 1.5 -1.6 -0.6
Arm fat-free mass (right) 0.2 0.8 2.7 -1.1 -1.6 -0.0 -1.2 -0.6 0.3 -0.8 0.3 1.0 -0.8 -0.3 -1.3
Exposure to tobacco smoke outside home 0.8 1.1 2.8 0.7 1.3 0.7 1.0 -0.8 -0.4 1.0 -1.4 -1.0 1.7 -1.3 0.8
Comparative body size at age 10 0.5 1.5 5.4 2.1 1.5 0.8 0.8 0.4 0.2 1.5 -0.7 -1.0 0.9 -2.3 0.0
Number of full brothers 0.4 0.6 2.9 -0.6 -0.4 0.1 0.3 -0.8 0.0 -0.2 -1.7 -0.6 -0.8 1.1 0.4
Worry too long after embarrassment 0.2 0.4 1.3 0.1 -0.3 0.6 -0.7 0.8 0.9 0.4 -0.5 -0.4 -0.0 -0.5 -1.1
Seen a psychiatrist for nerves, anxiety, tension or depression 3.1 4.0 9.4 3.1 2.6 -0.7 1.0 0.4 -0.9 3.0 -1.4 -2.4 2.7 -0.1 2.3
Wheeze or whistling in the chest in last year 0.2 0.4 2.9 0.0 0.4 -1.7 0.1 -0.8 -0.1 0.0 -0.5 -0.4 0.6 -0.2 -0.3
Number of children fathered 0.6 0.6 2.9 -0.4 0.2 -0.3 0.8 0.5 -0.2 -0.1 -1.3 -1.7 -0.6 -0.9 0.9
Reason for reducing amount of alcohol drunk: Health precaution 1.3 1.5 4.9 1.0 2.2 -1.2 0.4 0.6 -0.9 0.6 -2.0 -1.6 1.1 -0.5 0.9
Age at first live birth 1.0 1.8 6.1 -2.0 -0.9 -0.9 1.4 -1.5 -2.5 -0.8 0.1 1.2 0.1 1.3 1.3
Pulse wave peak to peak time 0.7 0.9 2.8 -0.4 0.2 -0.2 0.1 -1.5 -1.7 0.3 -0.0 0.6 1.5 1.1 1.0
Health satisfaction 0.8 1.0 2.2 1.2 0.9 1.5 -0.1 0.5 1.2 1.3 -0.1 -0.7 0.2 -1.5 -1.4
Shortness of breath walking on level ground 0.7 0.8 2.3 -0.2 -1.0 0.6 -0.7 -1.0 0.0 0.1 1.5 1.3 0.8 -0.6 -1.5
Qualifications: College or University degree 0.4 1.1 7.8 -0.6 0.1 -1.0 2.8 -0.5 -0.7 0.5 0.4 0.2 -0.5 1.0 1.4
Eye problems/disorders: None of the above 0.8 1.0 3.5 -0.9 -0.9 0.5 0.4 -0.6 -0.3 -1.3 1.9 1.5 -0.7 0.3 -1.1
Mouth/teeth dental problems: Loose teeth 1.6 1.9 5.1 -1.7 -1.7 -0.1 -2.3 -0.8 -0.2 -1.1 0.0 0.2 -2.0 2.2 -0.8
Emphysema/chronic bronchitis 0.3 0.4 0.9 -0.1 -0.5 0.0 -0.4 -0.9 0.1 -0.7 1.0 0.9 0.9 0.2 0.1
Medication for pain relief, constipation, heartburn 1.8 3.1 5.2 -1.9 -0.7 -2.1 1.0 -1.7 -1.7 -2.3 1.5 2.3 -1.8 2.0 1.5
Neck or shoulder pain in last month 0.3 0.4 1.3 0.6 -0.2 0.2 -0.0 0.2 0.7 0.5 -0.9 -1.1 1.2 -0.3 0.0
Medication: Blood pressure 0.3 0.6 2.3 -0.4 -1.1 0.4 -1.5 -0.8 -0.2 -1.3 0.2 0.1 -0.0 -0.4 -1.1
Angina (self-reported) 1.2 1.6 10.7 0.4 -0.7 1.6 -0.6 -1.1 -0.5 0.5 0.9 0.9 0.4 -1.0 -3.3
Migraine (self-reported) 0.9 1.1 4.2 0.6 0.0 -2.0 0.7 -1.2 -1.9 0.5 0.8 1.0 -0.3 0.4 1.1
Medication: Ibuprofen 0.4 0.5 1.6 -1.3 -1.1 -0.8 -1.2 -0.3 -0.3 0.0 -0.0 -0.2 0.5 0.7 -0.4
Medication: Allopurinol 0.6 0.8 3.2 0.2 -1.0 -0.1 -1.2 -1.8 -0.2 -0.0 0.6 1.1 0.1 0.8 -1.2
Medication: Omeprazole 0.5 0.6 2.5 1.0 0.6 0.7 0.0 0.1 1.4 0.6 0.5 0.6 0.1 -1.6 0.1
Medication: Seretide 50 evohaler 1.5 1.8 3.9 0.2 1.2 -1.1 1.2 1.0 1.3 1.2 -1.9 -1.3 2.0 -0.3 1.9
Mean time to correctly identify matches 0.2 0.4 0.8 -0.9 -0.8 -0.2 -0.7 0.7 0.3 -0.7 -0.5 0.6 -0.8 -0.4 -0.6
Heart disease (mother) 1.9 2.3 5.0 1.0 1.3 0.8 -1.8 1.9 2.2 1.4 -0.3 -1.5 0.0 -2.1 -2.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.1 1.3 5.5 0.3 0.8 1.5 -1.6 1.0 0.9 0.4 0.2 -0.9 -0.0 -1.4 -2.3
Whole body fat mass 0.3 1.4 2.8 1.3 -0.1 -0.5 -1.5 0.8 0.8 1.1 -1.4 -1.4 1.3 -1.7 -1.1
Leg fat mass (right) 0.4 1.6 3.5 1.5 -0.2 -0.4 -1.3 0.9 0.9 1.3 -1.9 -1.5 1.4 -1.4 -1.2
Arm predicted mass (right) 0.2 0.8 2.7 -1.1 -1.6 -0.1 -1.2 -0.5 0.4 -0.7 0.4 0.9 -0.7 -0.4 -1.3
Pulse rate, automated reading 0.6 1.8 5.1 -0.6 -2.0 2.1 -2.1 0.9 0.5 -0.8 -1.2 -0.4 -0.6 0.4 -2.3
Alcohol intake frequency. 0.8 1.9 4.7 1.1 1.0 0.7 1.2 2.1 1.7 1.5 -2.2 -0.8 1.3 -1.4 0.3
Comparative height size at age 10 0.5 2.8 5.4 -2.3 -1.3 0.2 -2.1 -1.9 -0.7 -1.3 2.1 1.9 -1.8 -0.0 -2.3
Number of full sisters 0.9 1.1 4.5 0.0 -1.2 0.2 0.9 -2.1 -1.1 -0.5 1.1 1.1 -0.3 1.4 -0.5
Suffer from ‘nerves’ 0.7 1.0 3.5 0.5 1.4 0.1 -0.1 0.7 1.1 0.6 -1.9 -1.5 1.2 -0.1 0.9
Overall health rating 1.1 2.4 4.9 2.2 1.3 0.5 0.5 0.6 0.7 1.9 -2.2 -1.9 2.2 -1.9 -0.2
Chest pain or discomfort 1.7 2.4 8.0 2.2 0.5 -0.3 1.3 -0.9 0.1 2.8 -1.4 -1.2 2.7 -1.5 -0.2
Had major operations 1.0 1.2 3.6 0.8 0.5 -0.9 1.1 0.7 0.4 1.3 -1.9 -1.9 0.6 -0.1 1.1
Age at last live birth 1.0 1.4 4.9 -0.6 -0.5 -1.5 2.2 -0.4 -1.9 -0.2 -0.3 0.7 0.9 1.4 1.6
Family relationship satisfaction 0.7 0.8 4.2 -0.3 -0.9 0.4 -0.8 -2.0 -0.8 -0.4 0.6 0.5 -0.8 1.0 -0.7
Leg pain on walking 1.1 1.4 3.7 1.7 1.7 1.7 0.1 0.3 0.6 1.6 0.2 -0.4 0.7 -1.9 -0.6
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.5 2.3 0.4 0.2 -1.5 0.2 0.0 -0.5 0.4 0.4 -0.2 1.3 -0.9 0.1
Commuting to job workplace: Car/motor vehicle 0.7 0.8 3.2 0.0 -0.7 -1.8 -0.4 0.6 0.3 -0.2 -0.1 -1.7 1.3 1.0 -0.5
Illness, injury, bereavement, stress in last 2 years 0.9 1.1 2.9 -0.2 -0.9 1.5 0.5 -1.7 -0.9 -0.8 0.3 1.3 -1.7 -0.2 -0.6
Medication: Aspirin 2.0 2.6 10.5 -0.3 -0.9 2.2 -1.3 1.0 1.7 -0.4 -1.7 -2.2 -0.8 -0.6 -3.2
Supplements: Vitamin C 0.6 0.7 1.9 1.4 0.9 0.7 0.8 0.8 0.7 0.8 -0.6 -1.0 0.5 -0.2 0.9
Knee pain experienced in last month 1.1 1.7 3.8 1.6 1.2 0.8 -1.7 1.3 2.0 1.0 0.0 -1.3 -0.4 -1.6 -1.5
Hypertension (Self-reported) 0.6 1.6 5.1 -0.2 -1.6 1.2 -1.0 -0.9 1.0 -1.6 -0.3 0.8 -1.5 -1.2 -2.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.6 0.7 2.9 0.2 0.4 0.6 -0.6 0.9 1.7 -0.0 -0.9 -1.2 -0.5 -0.7 -1.3
Illnesses of father: Heart disease 2.9 4.0 11.8 2.9 3.4 0.9 1.4 0.8 0.1 2.2 -2.1 -1.5 1.1 -3.2 1.2
Illnesses of siblings: Diabetes 0.5 0.6 2.6 0.3 0.9 0.7 -1.6 -0.2 0.6 0.8 -0.5 0.5 -0.4 -0.8 -0.7
Smoking status: Previous 0.4 0.6 3.4 0.5 1.1 0.8 -0.7 0.5 0.4 0.2 -0.1 -0.5 0.0 -1.8 -1.0
Forced expiratory volume in 1-second (FEV1), predicted 0.5 1.1 3.8 -0.3 -0.5 -0.7 0.2 -1.4 -1.3 -0.2 1.9 2.0 0.2 0.5 0.6
Whole body fat-free mass 0.3 1.7 4.9 -2.1 -2.2 -0.4 -1.3 -1.0 0.2 -1.3 0.6 1.6 -1.0 0.7 -1.3
Leg fat-free mass (right) 0.1 0.7 2.2 -1.2 -1.5 -0.5 -1.2 -1.0 -0.1 -0.3 0.1 1.0 -0.1 0.1 -1.2
Arm fat percentage (left) 0.7 2.8 6.7 2.6 0.9 -0.6 -0.6 1.6 1.0 2.1 -2.1 -2.2 2.0 -2.1 -0.6
Average weekly red wine intake 0.4 0.5 2.2 -0.4 0.4 -0.3 0.2 0.6 0.8 1.2 0.3 -1.5 0.3 -0.5 0.8
Handedness (chirality/laterality): Left-handed 0.2 0.3 0.8 0.7 0.9 -0.2 -0.8 0.5 0.4 0.8 -0.2 0.1 0.3 0.5 -0.1
Mood swings 1.2 2.3 5.7 2.4 2.2 0.6 1.5 0.9 0.2 1.4 -1.3 -1.1 2.0 -0.9 1.8
Loneliness, isolation 1.4 1.9 7.6 2.8 2.1 0.8 1.3 0.7 0.9 2.1 0.2 0.5 0.8 -1.5 0.4
Long-standing illness, disability or infirmity 1.7 2.6 5.5 2.3 1.7 1.3 1.0 1.8 2.0 1.6 -1.6 -1.5 1.2 -1.8 -0.1
Ever had bowel cancer screening 0.6 0.7 3.4 -0.2 -0.1 -0.2 -0.8 1.4 0.3 0.1 -0.0 -0.5 0.4 -1.8 -1.1
Diabetes diagnosed by doctor 0.6 0.9 3.7 1.1 0.3 0.4 0.3 1.9 1.2 -0.2 -1.6 -1.0 -0.4 -0.7 0.1
Ever had stillbirth, spontaneous miscarriage or termination 1.1 1.2 3.4 0.7 1.2 -1.1 1.5 -1.2 -1.6 1.0 -0.5 -0.6 0.4 0.3 1.9
Friendships satisfaction 0.5 0.6 2.5 1.1 0.5 0.2 0.5 -0.9 -0.3 1.6 0.3 0.0 1.2 -0.1 -0.7
Qualifications: nursing, teaching 0.3 0.5 3.0 -0.3 0.3 0.4 -0.6 0.9 0.3 0.1 1.7 0.2 -1.2 -0.3 -0.1
Commuting to job workplace: Walk 0.4 0.4 2.2 -0.5 -0.3 0.2 -0.2 0.1 -0.4 -0.4 1.5 1.0 -0.3 1.0 -0.1
Eye problems/disorders: Cataract 0.4 0.4 2.0 -0.3 -0.1 -1.4 -0.6 -0.0 -0.6 0.3 -0.6 -0.6 0.8 0.5 0.5
Mouth/teeth dental problems: Mouth ulcers 1.1 1.8 3.7 1.1 0.5 -1.3 1.9 -1.9 -1.8 0.2 1.3 1.1 1.8 0.8 1.1
Medication for cholesterol 0.3 0.5 1.7 -0.2 0.4 -0.2 0.9 -0.1 -1.3 0.4 1.3 0.4 -0.5 0.5 0.9
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.6 0.7 2.3 0.7 0.4 0.4 0.9 1.2 1.1 0.8 -0.6 -0.4 1.5 -0.3 -0.2
Back pain experienced in last month 0.3 0.4 1.0 -0.7 -0.1 0.3 -0.4 -0.3 1.0 -0.7 0.7 0.7 -0.5 0.8 -1.0
Mineral and other dietary supplements 0.5 0.7 1.6 0.4 -0.0 -1.1 -0.0 -1.3 -1.1 0.2 1.0 1.2 1.2 -0.0 -0.2
Breast cancer (self-reported) 0.4 0.5 2.0 -1.4 -0.3 0.7 -0.7 -0.1 0.5 -0.9 -0.9 -0.1 -0.4 0.9 -0.0
Asthma (self-reported) 0.4 0.8 3.2 0.6 1.1 -1.8 1.3 0.2 0.1 0.1 0.4 0.0 0.7 -0.4 1.4
Osteoporosis (self-reported) 2.2 2.8 9.5 1.1 2.5 0.8 1.2 2.4 2.1 -0.3 0.9 0.7 -0.9 -3.1 1.3
Osteoarthritis (self-reported) 0.3 0.4 2.4 -0.1 -0.2 0.7 0.1 0.4 1.6 0.3 0.3 -0.3 -1.0 0.3 0.2
Medication: Aspirin 2.9 3.8 15.4 -0.9 -1.5 2.9 -1.8 1.1 2.3 -0.9 -1.4 -1.8 -1.4 -0.7 -3.9
Medication: Gliclazide 0.8 0.9 2.5 0.9 0.7 0.4 -1.6 1.0 0.6 1.2 -1.0 -1.4 0.4 -0.3 -0.9
Illnesses of father: None of the above (group 1) 3.0 3.7 6.6 -2.4 -2.5 0.3 -2.0 -0.0 1.3 -2.0 2.3 1.2 -2.6 2.5 -1.7
Smoking status: Current 0.6 0.9 4.2 -0.2 -1.5 0.1 0.9 -2.1 -0.9 -0.6 0.3 0.4 -1.0 1.0 -0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.4 2.0 0.5 -1.0 0.1 -0.4 0.8 -0.4 0.3 -0.2 -1.4 0.3 0.2 -0.7
Whole body water mass 0.3 1.5 4.4 -2.0 -2.1 -0.4 -1.4 -1.0 0.2 -1.2 0.5 1.4 -1.0 0.6 -1.3
Leg predicted mass (right) 0.1 0.7 2.3 -1.2 -1.5 -0.5 -1.1 -0.9 -0.1 -0.2 0.2 1.1 -0.0 0.2 -1.1
Arm fat mass (left) 0.5 1.9 3.8 2.0 0.5 -0.7 -1.0 1.2 1.0 1.6 -1.7 -1.7 1.7 -1.7 -0.7
Number of self-reported non-cancer illnesses 1.1 1.9 4.8 -1.1 -1.3 0.0 -1.2 -0.4 0.7 -1.6 2.2 2.0 -1.9 -0.8 -1.4
Average weekly champagne plus white wine intake 1.2 1.6 3.3 1.5 1.3 -0.5 1.3 0.3 -1.0 1.3 -1.2 -1.8 1.3 -1.5 1.3
Miserableness 0.9 1.5 5.4 1.6 2.0 1.7 0.7 1.2 0.3 0.8 -0.4 -0.4 0.2 -2.3 0.6
Guilty feelings 0.4 0.5 1.8 0.2 -0.0 1.3 -0.9 1.1 0.7 -0.5 -0.3 0.1 -0.3 -1.2 -0.0
Wears glasses or contact lenses 1.8 2.0 7.3 1.1 -0.0 1.7 0.4 1.9 1.1 1.4 -1.3 -1.3 0.1 -2.7 -1.6
Ever taken oral contraceptive pill 1.2 1.4 5.3 -0.7 -0.8 -2.3 1.1 -0.7 -1.8 0.1 1.2 1.2 -0.0 1.3 0.7
Hearing aid user 0.9 1.0 2.3 1.5 0.9 -0.6 1.0 1.0 -0.4 1.3 -1.3 -1.1 1.0 -0.4 0.8
Mother’s age at death 0.3 0.4 1.6 1.3 0.4 0.6 0.2 0.9 -0.1 1.1 0.0 0.0 -0.3 -0.6 0.4
Financial situation satisfaction 0.4 0.5 1.9 -0.8 -0.1 0.2 0.3 -1.3 -0.7 -0.2 0.7 1.4 -0.1 0.5 0.6
Tinnitus: Yes, now most or all of the time 1.2 1.4 3.9 -1.4 -1.5 0.3 -1.7 -0.0 1.3 -1.9 -0.3 -0.0 -0.3 2.0 -0.7
Commuting to job workplace: Public transport 0.4 0.4 2.0 -0.4 0.2 0.6 0.3 -0.5 -1.1 -0.5 -0.1 0.8 -0.1 -0.3 1.4
Eye problems/disorders: Glaucoma 0.7 0.8 2.9 -0.3 -0.5 1.7 -0.5 -0.5 0.9 -0.7 0.1 0.5 -1.3 -1.1 -1.2
Medication: Blood pressure 0.8 1.4 5.6 0.1 -1.4 0.9 -1.0 -0.6 2.3 -0.9 -0.3 0.6 -0.7 -0.7 -2.4
Pain type(s) experienced in last month: Hip pain 4.7 5.9 15.1 3.7 2.5 -1.8 0.9 2.3 1.2 3.9 -1.7 -3.3 2.8 -1.0 1.4
Supplements: Fish oil (including cod liver oil) 1.4 1.9 4.0 -1.9 -1.6 1.7 -1.1 0.2 1.0 -1.6 -1.2 -0.8 -2.0 0.2 -1.6
High cholesterol (Self-reported) 0.4 0.6 3.8 0.0 -0.1 0.3 -0.7 -0.7 0.4 -0.5 -0.5 0.5 -0.4 -1.3 -2.0
Medication: Bendroflumethiazide 0.9 1.4 7.3 0.2 -1.2 1.0 -0.6 1.2 2.7 -0.6 0.2 0.8 -1.4 -0.7 -1.3
Medication: Paracetamol 0.6 1.0 2.7 0.9 0.3 -1.0 0.7 0.9 0.1 1.6 -0.6 -1.5 1.6 0.3 0.9
Medication: Lisinopril 1.3 1.7 9.5 -1.0 -1.5 0.9 -3.1 -1.1 1.3 -1.3 0.3 0.5 0.0 -0.0 -1.5
Medication: Atorvastatin 2.3 2.8 7.7 -1.5 -2.1 0.4 -2.8 -1.0 0.3 -1.9 1.0 0.9 -2.6 0.9 -2.3
Illnesses of father: High blood pressure 1.1 1.4 7.0 1.1 0.4 -0.7 1.0 -0.1 -1.0 1.2 -1.3 -1.4 2.7 0.6 0.6
Alcohol drinker status: Never 0.5 0.6 1.8 -0.8 -0.6 0.6 1.2 0.5 0.4 -0.4 -0.0 1.3 -1.0 0.4 0.4
Ever smoked 0.2 0.3 1.4 -0.4 -0.8 0.1 0.3 -1.2 -0.7 -0.4 0.2 0.0 -0.3 0.1 -0.4
Basal metabolic rate 0.2 0.9 3.2 -1.4 -1.8 -0.6 -1.4 -0.7 0.3 -0.7 0.2 1.0 -0.5 0.3 -1.2
Leg fat percentage (left) 0.7 2.6 7.5 2.7 0.9 -0.5 -0.9 1.4 0.6 1.8 -2.1 -2.3 1.7 -1.9 -0.3
Arm fat-free mass (left) 0.2 1.1 3.8 -1.3 -1.9 -0.2 -1.5 -0.6 0.4 -1.1 -0.1 0.8 -0.8 0.2 -1.3
Number of operations (self-reported) 0.1 0.2 0.6 -0.1 -0.4 0.1 0.6 -0.4 -0.4 0.7 0.5 0.8 -0.3 -0.1 0.3
Average weekly beer plus cider intake 0.4 0.5 3.0 -0.6 -0.5 -0.1 0.1 -0.4 -0.2 -0.7 -1.0 0.2 -0.3 1.7 0.9
Irritability 0.9 1.5 4.0 1.4 1.2 -0.1 0.0 1.6 0.3 1.2 -1.0 -1.3 2.0 -1.1 1.6
Risk taking 1.6 2.3 6.8 1.6 1.1 -1.9 1.1 -0.4 -1.2 1.0 -1.5 -1.1 2.6 -0.6 2.5
Ever had prostate specific antigen (PSA) test 0.3 0.3 1.9 -0.3 -0.5 0.3 -0.0 1.4 0.6 0.0 -1.0 -0.4 -0.1 -0.1 0.4
Fractured/broken bones in last 5 years 0.3 0.4 1.1 -1.0 -0.2 -1.0 0.3 0.1 -0.1 -1.0 0.7 0.3 -0.6 0.7 0.5
Age started oral contraceptive pill 1.3 1.6 5.6 -1.5 -0.1 0.5 -0.7 2.4 2.1 -0.8 -0.0 -0.3 -2.3 -0.1 -0.4
Diastolic blood pressure, automated reading 0.3 1.0 3.3 -0.4 -1.2 1.5 -0.5 1.2 1.1 -0.1 0.2 -0.7 -1.3 -0.7 -1.8
Ever depressed for a whole week 1.6 2.0 7.1 2.2 1.1 -0.4 2.7 0.0 -0.5 2.2 0.1 -0.8 1.8 -0.9 0.8
Unable to work because of sickness or disability 0.7 0.8 4.2 1.3 0.6 0.5 0.6 -0.2 0.4 1.4 -2.0 -0.9 0.2 -0.6 -0.4
Commuting to job workplace: Cycle 2.3 2.7 8.2 -1.6 -1.3 -1.7 -0.2 -2.9 -1.7 -2.0 2.0 1.8 -0.2 1.8 0.3
Myopia 0.9 1.3 4.1 0.4 0.9 2.0 1.9 -0.3 0.0 0.7 0.7 1.3 0.5 -1.6 -1.4
Vascular/heart problems diagnosed by doctor 1.1 2.9 9.3 0.7 1.8 -2.2 1.6 0.6 -1.5 1.8 0.7 -0.7 1.9 2.0 3.1
Cholesterol lowering medication 0.9 1.3 3.9 -1.1 -1.5 0.5 -1.5 -0.6 1.1 -2.0 -0.5 0.4 -0.9 0.1 -1.8
Medication: Omeprazole (e.g. Zanprol) 0.8 1.0 3.1 0.8 0.3 1.2 -0.1 -0.1 1.6 0.3 0.9 1.4 0.7 -1.8 -0.2
Pain experienced in last month 0.5 0.9 2.5 -1.5 -1.2 0.1 -0.2 -0.9 -1.1 -1.6 -0.8 0.4 -0.9 0.6 -0.1
Supplements: Calcium 2.4 2.6 8.6 2.1 2.2 0.1 1.5 2.0 0.4 1.2 -1.0 -1.9 0.0 -1.0 2.9
Basal cell carcinoma (self-reported) 1.3 1.5 3.7 -1.2 -1.9 -0.7 -0.9 -0.8 -0.2 -1.6 1.5 0.9 -1.4 1.8 -0.7
Heart attack/myocardial infarction (self-reported) 0.7 0.9 2.0 1.0 -0.2 1.4 -0.6 0.6 1.3 0.2 -0.3 -1.3 0.7 -1.3 -1.3
Deep venous thrombosis (DVT) (self-reported) 0.6 0.7 2.2 0.1 -0.1 0.8 0.4 1.1 0.8 1.5 1.2 0.7 1.0 -0.7 -0.6
Heart disease (siblings) 0.4 0.5 2.2 0.1 -0.1 -1.0 -0.1 -1.5 -0.8 -0.3 -0.9 -0.2 0.7 0.2 -0.0
Alcohol drinker status: Previous 1.9 2.1 6.1 1.1 1.7 -0.9 1.1 1.0 0.2 0.8 -2.5 -2.3 1.7 -1.1 1.5
Pack years of smoking 1.9 2.7 5.0 -0.5 0.1 2.1 -1.9 1.0 2.2 -1.7 1.4 1.2 -2.1 -1.7 -2.2
Impedance of whole body 0.2 1.3 6.0 -0.0 0.7 -1.2 1.1 -0.4 -1.8 -0.3 0.9 -0.5 0.5 1.2 2.4
Leg fat mass (left) 0.4 1.6 3.2 1.6 0.0 -0.4 -1.3 0.8 0.7 1.4 -1.8 -1.6 1.5 -1.7 -1.0
Arm predicted mass (left) 0.2 0.8 3.0 -1.2 -1.7 -0.5 -1.3 -0.6 0.4 -0.9 0.1 0.8 -0.6 0.3 -0.9