Hub : Genes

IMPA2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.2280	0.0530	6.3e-07	0.120	NA	0.122	NA	0.108	5.1e-10	NA	3.4e-10	NA	3.6e-09
2	GTEx	Adrenal Gland	0.4595	0.0897	3.3e-05	0.168	NA	0.078	NA	0.079	1.2e-06	NA	9.3e-04	NA	9.1e-04
3	GTEx	Esophagus Mucosa	0.1000	0.0410	2.3e-03	0.056	NA	0.028	NA	0.052	1.3e-04	NA	5.4e-03	NA	2.2e-04
4	GTEx	Ovary	0.4760	0.1280	4.1e-03	0.011	NA	0.225	NA	0.016	1.7e-01	NA	3.1e-06	NA	1.3e-01
5	GTEx	Skin Not Sun Exposed Suprapubic	0.1290	0.0550	8.7e-03	0.008	NA	0.062	NA	0.018	1.1e-01	NA	2.7e-04	NA	3.2e-02
6	GTEx	Skin Sun Exposed Lower leg	0.2230	0.0500	9.6e-09	0.157	NA	0.153	NA	0.166	5.9e-13	NA	1.1e-12	NA	1.1e-13
7	METSIM	Adipose	0.1455	0.0338	3.2e-10	0.057	0.085	0.088	0.092	0.087	6.6e-09	9.7e-13	4.5e-13	1.2e-13	5.0e-13
8	NTR	Blood	0.0248	0.0106	3.2e-03	0.004	0.005	0.010	0.006	0.007	1.2e-02	5.5e-03	1.8e-04	3.1e-03	1.7e-03
9	YFS	Blood	0.1423	0.0245	0.0e+00	0.078	0.102	0.134	0.134	0.139	3.7e-24	1.1e-31	1.9e-41	1.7e-41	4.2e-43
10	TCGA	Breast Invasive Carcinoma	0.0417	0.0192	6.9e-05	0.006	0.020	0.014	NA	0.006	1.6e-02	3.7e-05	5.7e-04	NA	1.4e-02
11	TCGA	Kidney Renal Clear Cell Carcinoma	0.0777	0.0343	1.2e-05	0.025	0.045	0.046	NA	0.028	7.9e-04	7.1e-06	5.9e-06	NA	3.4e-04
12	TCGA	Ovarian Serous Cystadenocarcinoma	0.0660	0.0400	8.0e-03	0.000	0.022	0.013	NA	-0.003	3.3e-01	1.2e-02	4.2e-02	NA	6.4e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Bipolar Disorder (2018)	1.4	2.2	4.6	-2.1	-1.7	-0.2	-1.9	-1.5	-0.5	-1.8	1.2	1.1	-0.6	2.2	-1.5
Bipolar Disorder or Schizophrenia	0.3	0.7	2.4	0.2	0.1	-0.7	-1.2	0.9	0.8	-0.2	-0.1	-1.5	0.9	1.3	0.7
Depressed Affect (Nagel 2018)	1.2	2.4	6.4	2.4	2.5	0.2	2.1	0.6	-0.3	1.7	-0.6	-0.2	0.6	-2.3	1.9
Depression (Nagel 2018)	0.6	0.9	4.2	1.7	0.3	-1.1	0.9	0.3	0.2	2.0	-0.5	-0.3	1.3	-0.4	-0.0
Intelligence (Savage-Jansen 2018)	0.3	1.0	4.0	-0.1	0.5	0.1	2.0	-0.0	-0.1	1.5	-0.0	0.1	-2.0	-0.8	0.6
Neuroticism (Nagel 2018)	0.6	1.3	4.1	1.7	1.7	0.4	0.3	1.0	0.3	1.7	-0.6	-0.3	1.0	-2.0	0.5
Schizophrenia (2018)	1.3	2.6	8.3	1.9	1.4	-0.7	-0.1	2.3	1.4	1.1	-1.3	-2.9	1.7	-0.1	2.0
Schizophrenia vs Biploar Disorder	1.9	2.6	7.2	2.0	1.6	-0.4	2.2	0.5	0.9	2.7	-1.4	-1.3	1.4	-0.8	2.0
Worry (Nagel 2018)	0.7	1.5	3.2	1.3	1.2	1.7	-0.9	0.8	1.2	1.4	-1.2	-0.5	0.9	-1.8	-1.0
Alzheimer’s Disease (in mother)	0.6	0.8	3.5	1.0	0.5	0.6	-0.4	1.2	0.0	0.6	-1.9	-0.9	1.1	-0.4	0.1
Alzheimer’s Disease (in father)	0.3	0.3	1.6	0.6	-0.3	0.3	-0.6	0.5	1.2	-0.0	-0.2	-0.6	-0.5	0.6	-0.6
Alzheimer’s Disease (including proxy)	0.3	0.4	1.4	0.4	-0.1	0.8	-0.7	0.7	0.5	-0.2	-1.2	-0.6	-0.2	0.2	-0.7
Crohns Disease (2017)	0.4	0.8	3.1	0.9	0.6	-1.6	-0.3	-0.2	-1.8	-0.5	-0.4	-0.1	0.9	-0.6	1.1
Irritable Bowel Disease (IBD)	0.1	0.3	1.1	0.1	0.5	0.1	-0.8	0.1	-0.7	-0.1	-1.0	-0.1	-0.1	-0.8	0.1
Ulcerative Colitis (UC)	0.4	0.8	2.5	-0.6	-0.0	1.6	-1.1	-0.6	0.4	0.2	-1.5	0.0	-0.8	-0.6	-1.1
Major Depression (MDD)	1.7	2.1	6.3	1.3	2.1	-0.3	0.3	1.0	0.5	1.0	-1.5	-2.5	1.0	-2.5	1.0
Reaction Time	0.3	0.5	1.6	-0.6	-0.9	-1.3	-0.0	-0.8	-1.1	-0.3	-0.4	0.9	0.1	0.6	0.2
Verbal and Numeric Reasoning (VNR)	1.0	2.5	6.6	1.4	2.1	-0.6	2.6	0.1	-1.4	2.1	0.9	0.3	-1.5	-2.3	1.0
Breast Cancer	0.4	0.9	3.5	0.6	0.6	-0.4	0.9	1.1	0.9	-0.1	-1.8	-0.7	0.1	-0.5	1.9
Ovarian Cancer	1.8	2.4	5.1	1.2	1.7	0.6	0.3	1.6	1.5	1.9	-2.3	-2.0	1.5	-1.2	1.8
Prostate Cancer	0.3	0.4	0.9	0.5	0.9	-0.2	-0.9	-0.0	-0.4	0.6	0.8	0.7	-0.5	-0.8	-0.8
Age at First Birth	0.6	0.9	3.2	0.0	0.2	1.7	0.1	-0.1	0.0	-0.4	0.8	1.0	-1.1	-1.8	-1.3
Bipolar Disorder (2011)	2.5	2.4	5.5	-2.3	-1.5	0.0	-1.9	-0.2	0.0	-2.3	1.6	0.9	-1.8	2.2	-0.9
Body Mass Index (BMI) (2010)	1.1	1.5	3.7	1.9	1.0	-0.5	1.9	0.9	0.5	1.2	-0.7	-1.3	1.1	-1.7	-0.2
Coronary Artery Disease (CAD)	0.4	0.5	2.8	-0.1	0.0	-0.1	-0.1	-1.7	-1.7	0.3	-0.0	0.8	-0.2	0.2	0.0
Crohns Disease (2012)	0.2	0.3	0.7	0.4	0.8	-0.3	-0.8	-0.3	-0.5	0.1	0.6	0.5	0.1	-0.8	-0.2
Mean Putamen Volume	0.3	0.3	0.9	-0.5	-0.8	0.3	0.0	0.9	0.5	-0.4	0.5	-0.6	0.0	-0.6	-0.8
Fasting Glucose	0.4	0.5	1.9	-0.0	0.4	-0.5	-0.5	-0.2	-0.9	0.1	-1.4	-1.4	0.7	0.7	-0.3
HbA1C	0.6	0.7	3.0	-0.7	0.2	-1.2	0.3	-1.7	-0.1	-0.1	1.1	0.6	-0.1	1.1	-0.7
HDL Cholesterol	2.9	4.8	12.2	0.8	2.3	-1.3	2.1	2.5	1.2	1.6	-2.1	-3.3	2.5	-1.1	3.5
LDL Cholesterol	0.6	1.0	2.5	-0.5	-1.6	0.3	-0.8	-0.7	0.1	-1.0	1.3	1.4	-0.4	0.8	-1.5
Lupus	0.7	1.1	4.6	-0.0	0.8	-0.5	2.2	-0.2	-1.2	0.7	-0.5	0.0	1.5	0.7	1.7
Neuroticism (2016)	0.8	1.1	3.6	-0.5	-0.5	1.4	-1.3	0.9	1.9	0.2	-0.3	-0.6	-1.0	-0.6	-1.8
Primary Biliary Cirrhosis	0.1	0.1	0.5	-0.0	-0.1	0.5	-0.7	0.1	-0.5	-0.3	-0.2	-0.1	-0.3	-0.0	-0.2
Rheumatoid Arthritis	1.4	1.9	6.3	0.1	0.6	-1.6	0.9	-1.5	-2.5	0.8	-1.5	-0.1	2.2	0.1	1.8
Schizophrenia (2014)	1.1	2.5	7.5	1.9	0.9	0.1	-0.3	2.4	2.3	1.4	-1.8	-2.7	1.1	-0.1	0.8
Triglycerides	1.2	2.0	7.6	-0.6	-2.3	1.0	-0.5	-2.2	-1.0	-1.1	0.4	1.1	-0.2	1.2	-2.8
Type 2 Diabetes (T2D) (2012)	2.3	2.7	11.9	-1.4	-1.5	2.4	-2.1	-1.2	0.4	-1.8	-0.3	0.3	-0.8	-0.5	-3.4
Ulcerative Colitis	0.7	0.9	2.2	-1.4	-0.7	1.4	-1.5	-0.3	0.3	-0.2	-0.6	0.7	-1.0	-0.4	-1.5
Blood Eosinophil Count	0.1	0.6	2.7	1.6	0.5	0.3	-0.8	-0.5	0.6	0.4	-0.9	-0.7	0.2	-0.6	-0.9
Blood Platelet Count	0.1	1.4	4.7	-1.0	-1.2	0.0	-0.7	-1.2	-1.4	-2.2	1.2	1.2	-1.5	0.8	0.1
Blood Red Count	0.7	6.7	18.7	-4.3	-3.7	-1.3	-1.4	-1.3	-2.0	-3.7	1.7	2.1	-2.5	3.4	0.7
Blood White Count	0.4	2.7	7.8	-1.5	-2.8	-1.3	-1.9	-2.4	-1.4	-0.9	0.5	0.6	-0.5	2.2	-1.7
Heel T-Score	0.2	1.9	7.3	1.4	0.1	2.7	-0.8	-0.1	1.8	0.0	-0.9	0.2	0.0	-1.6	-2.6
BMI	0.6	3.6	9.6	3.1	2.2	-0.1	-0.1	1.3	1.1	2.3	-2.0	-2.0	1.7	-3.1	0.1
Height	0.8	15.5	52.9	-7.3	-5.5	-1.7	-1.8	-3.4	-1.5	-5.0	2.7	4.4	-3.3	4.4	-0.6
Waist Hip Ratio (WHR)	0.5	2.1	8.1	-2.8	-1.3	1.0	-0.4	-1.4	0.5	-2.1	-0.5	1.2	-2.2	0.8	0.7
Systolic Blood Pressure	0.8	4.2	14.0	-3.7	-2.2	-0.1	-1.7	-1.0	0.3	-3.0	1.5	1.9	-2.7	1.5	-1.6
Smoking Status	0.2	0.5	2.6	0.8	-0.0	0.5	0.3	-1.6	-0.5	0.4	-0.7	-0.3	-0.4	-1.1	-0.7
Allergy or Eczema	0.1	0.3	1.2	-0.8	0.7	-0.3	1.1	0.8	0.4	0.2	-0.5	-0.3	-0.3	-0.6	0.0
Cardiovascular Disease	0.5	1.8	6.3	-1.5	-1.7	0.2	-0.4	-2.5	-0.8	-1.1	0.5	1.9	-0.8	-0.2	-1.9
Hypothyroidism (self reported)	0.2	0.4	1.1	-0.9	-0.7	-0.8	-1.1	-0.4	-0.6	-0.6	-0.4	-0.4	0.1	0.9	-0.3
Respiratory disease	0.3	0.8	2.8	0.5	0.2	-1.5	0.8	-0.5	-0.8	-0.3	1.7	1.2	0.4	-0.2	0.8
Type 2 Diabetes (T2D) (2018)	0.3	0.5	1.4	0.7	0.4	-0.8	0.8	0.6	-0.2	-0.1	-1.2	-1.1	-0.1	-0.2	0.7
Lung FEV1/FVC ratio	0.2	1.1	3.1	0.2	0.8	1.7	-0.7	1.4	1.5	0.1	0.2	0.4	-0.6	-1.8	-0.8
Lung FVC	0.2	1.0	4.9	-0.2	-0.5	-2.2	0.1	-0.7	-1.3	-0.5	1.2	0.5	0.2	1.3	1.0
Neuroticism	0.5	1.1	4.1	1.5	1.4	0.8	0.3	-0.3	0.1	1.7	-0.4	0.1	1.0	-2.0	0.2
Chronotype (morning person)	0.8	2.0	5.6	-0.4	-1.4	-1.2	-0.6	-1.1	-2.4	-1.4	2.1	1.8	0.4	1.3	1.1
Hair Pigment	0.1	1.6	5.3	-0.9	-1.0	-1.2	0.1	-2.2	-2.3	-1.3	0.8	1.1	-1.0	1.2	-0.6
Tanning	0.0	0.3	1.4	-0.0	0.2	0.7	-0.6	-0.8	-0.1	0.3	-0.7	0.0	0.5	-1.2	-0.6
Hand grip strength (left)	0.8	2.2	4.1	-1.7	-1.4	-1.2	-0.3	-1.9	-1.9	-1.5	2.0	1.5	0.1	2.0	0.8
Number of treatments/medications taken	0.9	1.5	5.9	0.8	0.1	1.1	-0.1	1.7	2.4	0.3	-1.3	-1.3	0.4	-1.8	-0.9
Average weekly spirits intake	1.0	1.3	5.4	0.8	1.5	0.9	-0.1	0.9	2.3	-0.9	-0.8	-1.2	0.1	-1.5	-0.2
Sensitivity / hurt feelings	0.6	1.1	2.5	0.8	0.7	-1.6	0.2	-1.5	-1.3	0.3	1.3	1.1	1.2	0.3	0.7
Frequency of depressed mood in last 2 weeks	0.9	1.3	3.5	1.7	0.6	-0.1	0.8	1.9	1.0	1.6	-0.8	-1.4	1.0	-0.5	-0.2
Hearing difficulty/problems: Yes	0.8	1.2	6.6	-0.4	-0.7	0.2	-1.7	0.2	0.4	-0.4	-2.6	-1.6	1.1	0.4	-0.0
Relative age of first facial hair	0.5	1.0	3.2	0.7	0.6	-0.5	1.6	0.6	-0.5	0.7	-1.2	-1.6	0.8	-0.4	1.8
Other serious medical condition/disability diagnosed by doctor	0.7	1.0	2.6	0.8	0.4	0.8	1.3	1.2	1.6	1.4	-0.5	-0.9	-0.1	-1.2	0.2
Ever used hormone-replacement therapy (HRT)	1.6	2.1	11.1	1.4	1.2	0.6	0.6	3.3	1.4	0.7	-1.5	-1.3	-0.2	-1.6	0.6
Ever had hysterectomy (womb removed)	1.1	1.3	3.5	1.9	0.6	0.9	1.5	1.0	1.7	1.4	-0.9	-0.3	0.6	-0.8	-0.6
Systolic blood pressure, automated reading	1.0	2.8	6.2	-2.1	-2.4	1.3	-2.2	0.3	1.5	-1.7	0.1	0.6	-2.3	0.3	-2.5
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	1.8	-0.0	-0.6	0.4	-1.2	0.7	0.7	-0.2	-0.7	0.6	-0.6	-0.2	-1.4
Angina	1.2	1.5	9.8	0.4	-0.8	1.3	-0.5	-1.3	-0.7	0.3	1.0	1.1	0.4	-0.8	-3.1
Medication for hormone replacement therapy	0.2	0.2	0.7	-0.1	-0.1	0.4	-0.6	0.2	-0.7	-0.4	-0.9	-0.1	0.6	-0.2	0.1
Vitamin and mineral supplements	0.7	0.9	2.6	-0.9	-0.7	-1.1	-0.7	-1.6	-1.2	-0.2	0.8	1.3	-0.4	-0.5	-0.9
Supplements: Zinc	0.6	0.7	1.9	1.2	1.2	0.6	-0.7	0.4	0.7	0.6	-0.5	-1.4	-0.2	-0.9	0.5
Medication: Co-codamol	0.3	0.3	1.1	0.3	0.5	-0.1	0.7	0.6	1.0	0.4	0.1	-0.6	-0.1	0.8	-0.2
Medication: Metformin	0.4	0.5	1.7	0.0	-0.5	-0.6	-0.4	1.3	0.6	-0.7	-0.7	-0.8	-0.2	0.6	1.3
Diabetes (father)	1.0	1.3	3.8	1.7	1.8	-0.2	1.4	0.2	-0.4	1.2	0.9	0.2	0.9	-1.9	0.5
Diabetes (mother)	0.5	0.6	2.5	0.7	0.8	0.8	1.3	-0.3	-0.3	0.1	-1.6	-0.3	0.0	-1.0	0.7
Severe depression (siblings)	0.6	0.7	2.7	0.9	0.7	-1.7	0.1	-1.2	-0.8	0.5	1.3	0.2	0.3	-0.6	0.4
Pack years adult smoking proportion	1.3	2.0	3.6	-0.0	0.2	1.9	-1.8	0.7	1.8	-1.4	1.4	0.9	-1.6	-1.6	-1.8
Impedance of leg (right)	0.2	1.0	4.9	-0.1	0.5	-1.2	0.6	-0.4	-1.4	-0.8	0.7	-0.4	0.1	1.5	2.2
Leg fat-free mass (left)	0.1	0.8	2.4	-1.0	-1.5	-0.8	-1.4	-0.8	0.2	-0.3	0.1	0.9	-0.0	0.2	-1.3
Trunk fat percentage	0.5	2.0	4.5	1.9	0.3	-0.6	-1.3	1.5	0.9	1.3	-1.7	-2.1	1.7	-1.7	-0.7
Hand grip strength (right)	1.0	2.6	6.0	-1.8	-1.1	-1.8	-0.4	-2.2	-2.4	-1.5	2.2	1.6	-0.3	1.6	1.0
Townsend deprivation index at recruitment	0.3	0.5	3.0	0.4	0.5	0.4	0.2	-1.7	0.1	0.6	-0.3	1.0	0.1	-0.3	-0.8
Current tobacco smoking	0.5	0.8	4.4	0.1	-1.0	-0.4	0.9	-2.1	-1.2	-0.4	0.2	0.3	-0.8	0.9	0.3
Average weekly fortified wine intake	0.4	0.5	1.6	-0.5	0.3	-1.1	1.1	0.6	-0.6	0.5	0.1	0.4	0.0	0.3	1.3
Maternal smoking around birth	0.6	0.8	3.5	0.4	-0.3	1.9	0.4	-0.2	0.8	0.3	-1.4	-0.6	0.5	-1.0	-1.2
Fed-up feelings	1.3	2.4	6.2	2.5	1.8	-0.5	0.8	0.9	-0.4	2.3	-1.2	-1.7	1.9	-1.2	1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	1.9	1.4	-0.4	0.2	-0.7	0.2	1.1	1.1	-0.6	-0.1	1.1	-0.0	-1.2
Relative age voice broke	0.3	0.5	2.0	-1.0	-0.3	0.6	0.7	-0.2	0.5	-0.9	-1.4	0.0	-0.6	0.3	0.4
Taking other prescription medications	0.3	0.5	1.4	1.2	0.1	-0.8	1.0	0.6	0.4	0.9	-0.4	0.2	0.7	-1.0	0.6
Age when periods started (menarche)	1.2	3.0	7.3	-2.7	-1.5	-0.7	-1.8	-2.5	-0.2	-1.8	1.4	2.0	-1.4	1.7	-1.5
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	2.7	-0.2	-0.2	1.6	0.2	0.7	1.4	0.8	-1.7	-0.5	-0.1	-1.0	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.6	1.3	4.2	2.1	1.0	0.9	1.0	0.9	1.0	1.4	-1.7	-1.2	0.4	-0.6	0.1
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	7.1	-1.1	-0.4	0.9	-0.1	1.4	0.1	-0.8	-2.7	-0.6	0.8	0.4	1.3
Qualifications: CSEs or equivalent	0.4	0.5	1.3	0.4	0.3	-0.9	-0.8	-0.2	-0.9	0.6	0.1	-0.5	0.9	0.9	1.1
Serious illness, injury or assault to yourself	2.0	2.4	6.3	1.6	0.9	-1.5	0.4	2.5	1.5	1.8	-1.5	-2.4	1.7	0.3	0.8
High blood pressure	0.7	2.0	5.8	-0.6	-1.6	1.4	-1.3	-0.8	1.2	-1.7	-0.6	0.9	-1.8	-1.4	-2.4
Hayfever, allergic rhinitis or eczema	0.4	0.9	4.6	0.5	1.3	-0.8	2.2	0.5	0.1	1.1	0.2	-0.4	0.6	-0.8	0.7
Multivitamins +/- minerals	1.1	1.4	4.7	0.9	1.4	0.1	1.6	0.4	-0.5	0.9	-1.1	-1.3	1.5	-0.2	2.2
Stomach or abdominal pain in last month	1.4	1.8	7.1	1.7	1.3	-1.3	1.2	0.3	-0.4	1.5	-0.3	-1.0	2.7	-1.0	1.4
Supplements: Glucosamine	0.8	1.1	3.4	0.6	0.5	0.7	0.8	1.8	0.9	1.0	-1.6	-1.6	0.0	-0.4	0.7
Diverticular disease/diverticulitis (self-reported)	1.0	1.2	2.9	1.7	1.3	0.6	0.6	1.2	0.4	1.3	0.6	-0.6	1.4	-1.6	0.5
Medication: Atenolol	0.5	0.6	2.4	0.5	-0.2	0.6	-0.9	0.6	0.4	-0.5	-0.8	-1.6	0.2	-1.1	-0.7
Medication: Levothyroxine sodium	0.8	1.4	7.2	0.3	0.8	-2.7	1.1	0.5	-0.6	0.3	-0.5	-1.1	1.3	0.5	1.9
Sitting height	0.1	1.0	3.5	-1.4	-0.8	-0.6	-0.1	-1.0	-0.5	-0.7	1.9	1.5	-0.6	1.2	0.3
Chronic bronchitis/emphysema (father)	1.4	1.7	5.2	0.9	0.3	-1.9	1.2	-1.1	-2.1	0.5	-0.9	-0.3	2.3	0.1	1.4
High blood pressure (mother)	0.3	0.4	1.9	-0.1	0.5	0.1	-0.7	1.4	0.6	0.5	0.8	-0.1	-0.3	-0.6	-0.5
Body mass index (BMI)	0.6	2.6	5.3	2.3	0.5	0.0	-1.1	1.6	1.6	1.7	-2.0	-1.9	1.6	-2.1	-1.3
Impedance of leg (left)	0.3	1.4	7.2	-0.1	0.7	-1.1	0.7	-0.6	-2.1	-0.6	0.5	-0.6	0.3	1.4	2.7
Leg predicted mass (left)	0.1	0.7	2.3	-1.0	-1.5	-0.7	-1.4	-0.8	0.2	-0.3	0.1	0.9	-0.0	0.1	-1.3
Trunk fat mass	0.3	1.2	2.2	1.2	-0.2	-0.7	-1.5	1.0	0.7	0.9	-1.2	-1.5	1.3	-1.4	-0.9
Waist circumference	0.2	0.9	2.9	0.2	-0.2	0.0	-1.3	0.7	1.4	0.4	-1.7	-1.0	0.5	-1.2	-1.0
Number of incorrect matches in round	0.8	1.3	3.5	-1.6	-1.3	0.0	-1.7	-1.9	-1.3	-1.5	-0.4	0.5	-0.2	0.7	-0.8
Past tobacco smoking	0.2	0.3	1.7	-0.3	-0.4	-0.8	0.1	-0.3	-0.4	-0.2	0.3	0.5	0.1	1.3	0.7
Alcohol usually taken with meals	0.4	0.7	1.9	0.3	1.2	-1.1	0.5	0.1	-1.1	1.2	0.1	-0.5	0.7	-0.4	1.4
Nervous feelings	0.5	1.0	2.3	1.3	1.4	0.8	-0.6	0.6	1.0	1.2	-0.2	0.2	1.5	-1.3	-0.1
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.6	5.0	2.2	1.5	0.0	-0.2	1.0	1.3	1.8	-0.9	-1.2	1.2	-1.4	-0.3
Hearing difficulty/problems with background noise	0.7	1.1	3.9	0.3	-0.3	0.9	-0.8	-0.9	-0.6	0.9	-2.0	-0.8	1.0	-1.1	-1.6
Hair/balding pattern: Pattern 2	0.8	1.0	2.8	1.1	0.6	0.4	0.9	0.9	0.7	1.0	-1.7	-1.3	1.4	0.8	-0.1
Had menopause	1.6	1.9	6.5	0.8	0.5	1.0	-0.4	2.5	2.2	1.0	-1.4	-1.3	-1.1	-1.8	-0.9
Had other major operations	0.4	0.5	1.4	-0.7	-1.1	0.4	0.4	0.0	0.3	-0.0	0.9	1.2	-0.3	1.0	-0.3
Forced vital capacity (FVC)	0.6	2.2	4.5	-1.9	-0.8	-2.0	0.2	-1.7	-2.1	-0.8	1.4	1.0	0.3	1.8	1.8
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.0	4.2	1.9	1.3	1.2	2.1	1.8	1.4	1.7	-1.6	-1.2	0.9	-0.9	0.3
Ever unenthusiastic/disinterested for a whole week	0.4	0.4	1.7	0.7	-0.3	0.1	1.3	-1.0	0.2	0.6	0.1	0.0	1.2	0.4	0.2
Qualifications: None of the above	0.4	0.9	2.4	0.5	-1.1	1.5	-0.8	-0.3	1.0	-1.6	0.3	0.5	-0.8	-0.2	-1.4
Financial difficulties in last 2 years	0.9	1.2	4.0	0.2	-0.4	-1.3	-0.5	-0.8	-2.0	1.1	-1.4	-1.5	1.0	1.1	0.4
Mouth/teeth dental problems	0.4	0.6	2.6	-0.1	-0.0	0.6	-0.6	0.9	0.6	0.0	-1.6	-1.3	-0.7	-0.1	-0.5
Heart attack	0.6	0.8	1.9	0.8	-0.3	1.4	-0.5	0.3	1.0	0.1	-0.6	-1.3	0.5	-1.2	-1.3
Allergy	0.4	0.9	3.0	0.2	-0.9	1.5	-1.7	0.1	-0.3	-0.6	-1.0	-0.5	-1.1	0.3	-1.1
Pain all over the body in last month	1.2	1.3	4.3	-1.4	-1.1	-0.7	2.0	-0.6	-0.4	-0.4	-0.5	1.2	-0.3	2.1	0.8
Diabetes (self-reported)	0.4	0.5	3.2	0.7	-0.3	0.3	-0.2	0.9	0.5	-0.4	-1.8	-1.0	-0.6	-0.2	-0.3
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	6.0	-0.1	1.4	-2.4	0.5	0.1	-1.1	1.0	-0.4	-0.9	1.0	-0.3	1.3
Medication: Ramipril	0.6	0.8	4.7	0.6	-0.5	-0.4	0.3	-2.2	-0.3	0.1	1.2	-0.2	0.1	0.7	-1.3
Medication: Simvastatin	1.0	1.4	5.4	0.1	-0.4	1.5	-1.1	-0.6	0.4	-0.2	-1.8	-0.3	-0.1	-2.0	-2.3
Fluid intelligence score	0.7	1.4	4.2	1.5	1.0	0.3	2.0	-0.8	-0.8	1.6	0.9	0.8	-0.9	-1.5	-0.9
Illnesses of siblings	1.4	1.9	4.9	-2.2	-2.1	-0.8	0.3	-0.6	-0.4	-1.5	2.2	1.0	-0.8	2.0	0.4
Neuroticism score	0.6	1.3	3.5	1.9	1.7	1.3	0.0	1.1	1.1	1.3	-0.4	-0.3	1.0	-1.7	0.2
Weight	0.1	0.7	2.5	0.3	-0.7	-0.5	-1.6	0.6	0.9	0.3	-0.8	-0.5	0.6	-0.8	-1.2
Impedance of arm (right)	0.3	1.3	5.5	-0.2	0.8	-1.7	0.8	-0.4	-1.4	-0.1	0.5	-0.4	0.7	1.6	2.3
Arm fat percentage (right)	0.6	2.4	5.2	2.3	0.8	-0.7	-0.7	1.4	1.1	1.7	-2.3	-2.2	1.8	-1.7	-0.5
Trunk fat-free mass	0.5	2.6	7.2	-2.7	-2.5	-0.2	-1.3	-1.2	0.3	-1.9	1.0	2.1	-1.7	1.1	-1.3
Hip circumference	0.4	1.5	3.2	1.7	0.4	-0.8	-0.9	1.1	0.8	1.8	-1.1	-1.5	1.7	-1.2	-0.9
Time employed in main current job	0.3	0.3	0.7	-0.6	0.3	0.5	-0.8	0.8	0.8	-0.2	-0.5	-0.5	-0.4	-0.5	0.0
Alcohol intake versus 10 years previously	0.5	0.7	2.9	-0.9	-0.7	1.1	-0.3	0.7	0.4	-1.7	-0.3	0.7	-1.3	0.1	-0.7
Father’s age at death	0.8	1.1	3.4	-0.7	-0.9	-1.4	0.8	1.7	0.5	-0.5	0.7	-0.4	0.5	1.8	1.2
Worrier / anxious feelings	1.5	2.9	8.0	0.9	1.5	2.4	-1.6	1.9	2.5	1.5	-0.9	-0.8	-0.4	-2.8	-1.3
Frequency of tiredness / lethargy in last 2 weeks	3.6	5.9	15.8	4.0	2.3	0.4	1.7	2.4	1.5	3.7	-2.4	-2.8	2.7	-1.6	0.6
Falls in the last year	0.3	0.5	1.3	-0.4	-1.1	-0.4	1.1	0.6	-0.2	0.4	-0.3	0.4	0.9	0.3	0.9
Hair/balding pattern: Pattern 3	0.3	0.4	2.3	-0.6	-0.1	-1.5	-0.4	-0.4	-0.1	-0.4	-0.5	-0.4	0.8	-0.6	0.1
Number of live births	0.8	1.2	3.6	-0.1	-0.5	1.3	0.1	1.6	1.5	-0.2	0.6	0.5	-1.9	-1.1	-1.5
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	2.8	-1.5	0.0	-1.4	0.0	-0.9	-1.4	-0.5	1.1	0.6	0.3	1.1	1.7
Pulse rate	0.4	0.7	2.6	-0.2	-0.6	1.6	-1.3	0.3	-0.1	0.4	-1.4	-0.6	-0.4	0.2	-1.1
Happiness	0.7	0.8	3.9	0.8	0.9	-1.1	0.1	-2.0	-1.0	0.2	0.4	-0.1	0.2	-0.1	1.6
Noisy workplace	1.2	1.5	4.3	-1.1	0.0	2.1	-1.3	1.4	2.0	-0.8	-1.1	-0.7	-0.9	-1.2	-0.6
Qualifications: A levels/AS levels or equivalent	0.8	1.8	6.7	0.2	0.9	-1.5	1.9	-0.2	-1.8	1.1	1.4	0.6	0.8	1.1	2.6
Serious illness, injury or assault of a close relative in last 2 years	1.5	1.7	5.5	1.0	1.7	0.2	0.5	0.7	0.9	1.8	-1.9	-2.3	1.0	-1.3	0.1
Mouth/teeth dental problems: Dentures	0.8	1.3	5.0	-0.5	-0.9	-0.2	-1.2	0.1	1.3	-1.2	2.2	1.7	-0.5	-0.0	-1.4
Asthma	0.3	0.6	3.0	0.2	0.8	-1.7	1.1	0.1	0.3	-0.2	0.5	0.3	0.3	-0.0	1.2
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	2.1	-0.1	-0.6	-0.8	-0.6	-0.3	-0.3	1.1	-0.7	-0.4	1.5	0.3	-0.3
Medication: Cholesterol lowering	0.8	1.3	7.6	-0.0	-0.5	1.2	-1.9	-0.9	0.0	-0.4	-0.2	-0.0	-0.5	-1.2	-2.8
Depression (self-reported)	1.8	2.2	6.0	1.8	1.7	0.1	0.9	2.4	1.5	1.2	-1.3	-1.8	1.5	-0.5	1.3
Medication: Lansoprazole	1.4	1.5	6.2	-0.1	1.1	2.5	-0.4	1.1	2.5	0.5	-0.8	-0.2	0.3	-1.3	-0.8
Prospective memory result	0.3	0.3	1.2	-0.5	-1.1	0.8	-0.2	-0.4	-0.6	-0.9	-0.8	0.1	-0.0	0.1	-0.0
Lung cancer (father)	1.5	1.8	5.9	-0.0	-0.6	2.3	-1.1	1.8	2.4	-0.4	-0.1	0.3	-1.8	-0.8	-1.2
Illnesses of mother	0.7	0.9	2.7	-0.6	-0.3	-0.4	1.7	-1.3	-1.3	-1.2	-0.4	-0.1	-0.2	1.0	1.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	3.9	-0.4	0.5	-1.5	0.6	-0.5	-1.3	0.1	0.7	-0.1	0.7	0.8	2.0
Pulse wave Arterial Stiffness index	0.7	0.8	3.1	-0.1	-0.7	0.1	-0.3	1.1	1.4	-0.8	0.3	-0.3	-1.8	-0.7	-1.1
Impedance of arm (left)	0.2	0.8	3.3	-0.1	0.8	-1.2	0.9	-0.1	-1.2	0.1	1.0	-0.3	0.7	0.8	1.8
Arm fat mass (right)	0.4	1.8	3.6	1.9	0.3	-0.8	-1.0	1.1	1.0	1.5	-1.8	-1.7	1.7	-1.5	-0.7
Trunk predicted mass	0.4	2.6	7.0	-2.6	-2.5	-0.4	-1.3	-1.2	0.1	-1.8	1.0	2.1	-1.6	1.1	-1.3
Standing height	0.6	5.9	18.6	-4.3	-2.9	-1.3	-1.1	-2.3	-1.5	-2.8	2.6	2.9	-1.8	2.7	0.2
Length of working week for main job	1.5	1.7	5.1	2.0	1.7	0.3	1.5	0.4	0.4	1.2	-1.4	-1.2	0.7	-2.3	0.7
Exposure to tobacco smoke at home	0.5	0.6	1.8	0.0	0.5	-0.4	-1.1	0.4	-0.4	0.1	-1.1	-1.3	0.7	-0.6	0.9
Breastfed as a baby	0.6	0.8	4.6	-0.6	0.5	1.4	-2.1	0.1	0.9	0.2	0.7	0.1	-0.8	-0.4	-0.4
Tense / ‘highly strung’	0.3	0.4	1.8	1.0	0.1	0.8	0.4	0.1	0.2	0.8	-0.5	0.0	1.3	-0.6	-0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	2.4	3.6	10.3	3.0	3.0	-1.4	0.4	0.6	0.4	3.2	-0.0	-1.9	2.8	-0.5	0.9
Hair/balding pattern: Pattern 4	0.3	0.7	3.0	-0.7	0.4	0.0	-0.2	-0.7	-0.7	-0.9	0.9	1.7	-1.3	0.5	0.7
Birth weight of first child	0.6	1.1	3.2	-1.0	-1.1	1.4	-0.0	0.6	1.4	0.1	0.7	1.8	-1.6	0.2	-0.8
Peak expiratory flow (PEF)	0.2	0.5	3.0	-1.7	0.8	0.3	-0.2	-0.0	0.7	-0.4	0.2	-0.9	-0.3	-0.4	0.5
Pulse wave reflection index	0.9	1.1	3.9	0.2	1.0	-2.0	0.3	0.5	1.2	-0.9	1.8	0.1	-0.5	-0.1	1.3
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.7	-0.8	0.0	-0.6	-0.1	-1.3	-0.4	-1.1	0.1	0.8	-1.0	-0.2	0.4
Loud music exposure frequency	0.5	0.5	1.4	0.5	0.9	-1.0	0.6	-1.2	-0.9	0.6	-0.6	-0.3	0.5	-0.6	0.5
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	3.5	-0.3	-1.0	-1.0	0.4	-0.5	-1.9	0.4	0.4	-0.3	0.2	1.1	0.1
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	1.7	0.9	1.2	0.6	0.7	-0.2	-0.8	0.6	-0.6	-0.5	0.3	-1.3	0.8
Blood clot in the leg (DVT)	0.5	0.7	1.6	-0.2	-0.1	0.9	0.0	0.8	1.0	1.3	1.2	0.8	0.5	-0.8	-1.0
Medication: Paracetamol	0.5	0.8	2.8	1.1	0.5	-0.9	0.5	0.7	0.2	1.7	-0.5	-1.2	1.2	0.2	1.0
Headache pain in last month	1.4	2.4	7.1	2.7	2.6	0.1	0.7	0.1	-0.5	2.3	0.0	-1.0	2.2	-1.3	1.3
Medication for cholesterol, blood pressure or diabetes	0.6	1.1	3.3	0.6	1.2	-0.9	1.7	0.2	-0.5	1.1	1.1	0.7	0.2	0.8	1.8
Glaucoma (self-reported)	1.0	1.2	4.1	-0.5	-1.1	2.0	-0.3	-0.9	0.6	-1.5	0.3	0.8	-1.5	-0.9	-1.4
Gout (self-reported)	0.3	0.5	2.2	0.5	0.1	-0.4	-1.5	-1.1	0.1	0.7	0.0	-0.1	0.1	0.2	-1.0
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	3.0	0.2	0.5	-1.7	-0.1	-0.2	-1.0	0.2	-0.3	-0.6	0.9	0.1	0.6
Medication: Amlodipine	1.3	1.8	8.3	-1.2	-2.3	-0.6	-0.8	-2.9	-0.9	-1.5	-0.2	0.5	-1.1	0.8	-0.9
Medication: Ventolin 100micrograms inhaler	0.7	0.9	4.3	0.2	0.2	-2.1	0.5	-0.9	-0.7	0.2	0.7	-0.2	0.7	1.4	1.2
Birth weight	3.9	8.4	16.6	-3.4	-3.6	0.5	-1.6	-2.9	-1.5	-3.3	3.8	4.1	-3.3	2.2	-2.2
Chronic bronchitis/emphysema (mother)	1.6	1.9	8.0	0.3	-0.3	-1.1	1.2	-2.8	-2.7	0.0	0.5	0.9	0.9	1.1	1.1
High blood pressure (siblings)	0.8	1.1	2.5	1.5	1.2	0.5	-0.8	0.4	-0.4	1.4	-1.6	-0.8	1.1	-1.4	-0.4
Forced vital capacity (FVC), Best measure	0.6	2.0	6.2	-1.1	-0.4	-2.5	0.7	-1.2	-2.0	-0.3	1.0	0.2	0.5	1.9	2.4
Body fat percentage	0.6	2.2	4.7	2.1	0.5	-0.6	-1.1	1.5	0.9	1.5	-1.9	-2.2	1.8	-1.7	-0.5
Leg fat percentage (right)	0.6	2.3	6.2	2.5	0.7	-0.6	-0.9	1.6	0.9	1.6	-2.0	-2.1	1.5	-1.6	-0.6
Arm fat-free mass (right)	0.2	0.8	2.7	-1.1	-1.6	-0.0	-1.2	-0.6	0.3	-0.8	0.3	1.0	-0.8	-0.3	-1.3
Exposure to tobacco smoke outside home	0.8	1.1	2.8	0.7	1.3	0.7	1.0	-0.8	-0.4	1.0	-1.4	-1.0	1.7	-1.3	0.8
Comparative body size at age 10	0.5	1.5	5.4	2.1	1.5	0.8	0.8	0.4	0.2	1.5	-0.7	-1.0	0.9	-2.3	0.0
Number of full brothers	0.4	0.6	2.9	-0.6	-0.4	0.1	0.3	-0.8	0.0	-0.2	-1.7	-0.6	-0.8	1.1	0.4
Worry too long after embarrassment	0.2	0.4	1.3	0.1	-0.3	0.6	-0.7	0.8	0.9	0.4	-0.5	-0.4	-0.0	-0.5	-1.1
Seen a psychiatrist for nerves, anxiety, tension or depression	3.1	4.0	9.4	3.1	2.6	-0.7	1.0	0.4	-0.9	3.0	-1.4	-2.4	2.7	-0.1	2.3
Wheeze or whistling in the chest in last year	0.2	0.4	2.9	0.0	0.4	-1.7	0.1	-0.8	-0.1	0.0	-0.5	-0.4	0.6	-0.2	-0.3
Number of children fathered	0.6	0.6	2.9	-0.4	0.2	-0.3	0.8	0.5	-0.2	-0.1	-1.3	-1.7	-0.6	-0.9	0.9
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.5	4.9	1.0	2.2	-1.2	0.4	0.6	-0.9	0.6	-2.0	-1.6	1.1	-0.5	0.9
Age at first live birth	1.0	1.8	6.1	-2.0	-0.9	-0.9	1.4	-1.5	-2.5	-0.8	0.1	1.2	0.1	1.3	1.3
Pulse wave peak to peak time	0.7	0.9	2.8	-0.4	0.2	-0.2	0.1	-1.5	-1.7	0.3	-0.0	0.6	1.5	1.1	1.0
Health satisfaction	0.8	1.0	2.2	1.2	0.9	1.5	-0.1	0.5	1.2	1.3	-0.1	-0.7	0.2	-1.5	-1.4
Shortness of breath walking on level ground	0.7	0.8	2.3	-0.2	-1.0	0.6	-0.7	-1.0	0.0	0.1	1.5	1.3	0.8	-0.6	-1.5
Qualifications: College or University degree	0.4	1.1	7.8	-0.6	0.1	-1.0	2.8	-0.5	-0.7	0.5	0.4	0.2	-0.5	1.0	1.4
Eye problems/disorders: None of the above	0.8	1.0	3.5	-0.9	-0.9	0.5	0.4	-0.6	-0.3	-1.3	1.9	1.5	-0.7	0.3	-1.1
Mouth/teeth dental problems: Loose teeth	1.6	1.9	5.1	-1.7	-1.7	-0.1	-2.3	-0.8	-0.2	-1.1	0.0	0.2	-2.0	2.2	-0.8
Emphysema/chronic bronchitis	0.3	0.4	0.9	-0.1	-0.5	0.0	-0.4	-0.9	0.1	-0.7	1.0	0.9	0.9	0.2	0.1
Medication for pain relief, constipation, heartburn	1.8	3.1	5.2	-1.9	-0.7	-2.1	1.0	-1.7	-1.7	-2.3	1.5	2.3	-1.8	2.0	1.5
Neck or shoulder pain in last month	0.3	0.4	1.3	0.6	-0.2	0.2	-0.0	0.2	0.7	0.5	-0.9	-1.1	1.2	-0.3	0.0
Medication: Blood pressure	0.3	0.6	2.3	-0.4	-1.1	0.4	-1.5	-0.8	-0.2	-1.3	0.2	0.1	-0.0	-0.4	-1.1
Angina (self-reported)	1.2	1.6	10.7	0.4	-0.7	1.6	-0.6	-1.1	-0.5	0.5	0.9	0.9	0.4	-1.0	-3.3
Migraine (self-reported)	0.9	1.1	4.2	0.6	0.0	-2.0	0.7	-1.2	-1.9	0.5	0.8	1.0	-0.3	0.4	1.1
Medication: Ibuprofen	0.4	0.5	1.6	-1.3	-1.1	-0.8	-1.2	-0.3	-0.3	0.0	-0.0	-0.2	0.5	0.7	-0.4
Medication: Allopurinol	0.6	0.8	3.2	0.2	-1.0	-0.1	-1.2	-1.8	-0.2	-0.0	0.6	1.1	0.1	0.8	-1.2
Medication: Omeprazole	0.5	0.6	2.5	1.0	0.6	0.7	0.0	0.1	1.4	0.6	0.5	0.6	0.1	-1.6	0.1
Medication: Seretide 50 evohaler	1.5	1.8	3.9	0.2	1.2	-1.1	1.2	1.0	1.3	1.2	-1.9	-1.3	2.0	-0.3	1.9
Mean time to correctly identify matches	0.2	0.4	0.8	-0.9	-0.8	-0.2	-0.7	0.7	0.3	-0.7	-0.5	0.6	-0.8	-0.4	-0.6
Heart disease (mother)	1.9	2.3	5.0	1.0	1.3	0.8	-1.8	1.9	2.2	1.4	-0.3	-1.5	0.0	-2.1	-2.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	5.5	0.3	0.8	1.5	-1.6	1.0	0.9	0.4	0.2	-0.9	-0.0	-1.4	-2.3
Whole body fat mass	0.3	1.4	2.8	1.3	-0.1	-0.5	-1.5	0.8	0.8	1.1	-1.4	-1.4	1.3	-1.7	-1.1
Leg fat mass (right)	0.4	1.6	3.5	1.5	-0.2	-0.4	-1.3	0.9	0.9	1.3	-1.9	-1.5	1.4	-1.4	-1.2
Arm predicted mass (right)	0.2	0.8	2.7	-1.1	-1.6	-0.1	-1.2	-0.5	0.4	-0.7	0.4	0.9	-0.7	-0.4	-1.3
Pulse rate, automated reading	0.6	1.8	5.1	-0.6	-2.0	2.1	-2.1	0.9	0.5	-0.8	-1.2	-0.4	-0.6	0.4	-2.3
Alcohol intake frequency.	0.8	1.9	4.7	1.1	1.0	0.7	1.2	2.1	1.7	1.5	-2.2	-0.8	1.3	-1.4	0.3
Comparative height size at age 10	0.5	2.8	5.4	-2.3	-1.3	0.2	-2.1	-1.9	-0.7	-1.3	2.1	1.9	-1.8	-0.0	-2.3
Number of full sisters	0.9	1.1	4.5	0.0	-1.2	0.2	0.9	-2.1	-1.1	-0.5	1.1	1.1	-0.3	1.4	-0.5
Suffer from ‘nerves’	0.7	1.0	3.5	0.5	1.4	0.1	-0.1	0.7	1.1	0.6	-1.9	-1.5	1.2	-0.1	0.9
Overall health rating	1.1	2.4	4.9	2.2	1.3	0.5	0.5	0.6	0.7	1.9	-2.2	-1.9	2.2	-1.9	-0.2
Chest pain or discomfort	1.7	2.4	8.0	2.2	0.5	-0.3	1.3	-0.9	0.1	2.8	-1.4	-1.2	2.7	-1.5	-0.2
Had major operations	1.0	1.2	3.6	0.8	0.5	-0.9	1.1	0.7	0.4	1.3	-1.9	-1.9	0.6	-0.1	1.1
Age at last live birth	1.0	1.4	4.9	-0.6	-0.5	-1.5	2.2	-0.4	-1.9	-0.2	-0.3	0.7	0.9	1.4	1.6
Family relationship satisfaction	0.7	0.8	4.2	-0.3	-0.9	0.4	-0.8	-2.0	-0.8	-0.4	0.6	0.5	-0.8	1.0	-0.7
Leg pain on walking	1.1	1.4	3.7	1.7	1.7	1.7	0.1	0.3	0.6	1.6	0.2	-0.4	0.7	-1.9	-0.6
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	2.3	0.4	0.2	-1.5	0.2	0.0	-0.5	0.4	0.4	-0.2	1.3	-0.9	0.1
Commuting to job workplace: Car/motor vehicle	0.7	0.8	3.2	0.0	-0.7	-1.8	-0.4	0.6	0.3	-0.2	-0.1	-1.7	1.3	1.0	-0.5
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	2.9	-0.2	-0.9	1.5	0.5	-1.7	-0.9	-0.8	0.3	1.3	-1.7	-0.2	-0.6
Medication: Aspirin	2.0	2.6	10.5	-0.3	-0.9	2.2	-1.3	1.0	1.7	-0.4	-1.7	-2.2	-0.8	-0.6	-3.2
Supplements: Vitamin C	0.6	0.7	1.9	1.4	0.9	0.7	0.8	0.8	0.7	0.8	-0.6	-1.0	0.5	-0.2	0.9
Knee pain experienced in last month	1.1	1.7	3.8	1.6	1.2	0.8	-1.7	1.3	2.0	1.0	0.0	-1.3	-0.4	-1.6	-1.5
Hypertension (Self-reported)	0.6	1.6	5.1	-0.2	-1.6	1.2	-1.0	-0.9	1.0	-1.6	-0.3	0.8	-1.5	-1.2	-2.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	2.9	0.2	0.4	0.6	-0.6	0.9	1.7	-0.0	-0.9	-1.2	-0.5	-0.7	-1.3
Illnesses of father: Heart disease	2.9	4.0	11.8	2.9	3.4	0.9	1.4	0.8	0.1	2.2	-2.1	-1.5	1.1	-3.2	1.2
Illnesses of siblings: Diabetes	0.5	0.6	2.6	0.3	0.9	0.7	-1.6	-0.2	0.6	0.8	-0.5	0.5	-0.4	-0.8	-0.7
Smoking status: Previous	0.4	0.6	3.4	0.5	1.1	0.8	-0.7	0.5	0.4	0.2	-0.1	-0.5	0.0	-1.8	-1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	3.8	-0.3	-0.5	-0.7	0.2	-1.4	-1.3	-0.2	1.9	2.0	0.2	0.5	0.6
Whole body fat-free mass	0.3	1.7	4.9	-2.1	-2.2	-0.4	-1.3	-1.0	0.2	-1.3	0.6	1.6	-1.0	0.7	-1.3
Leg fat-free mass (right)	0.1	0.7	2.2	-1.2	-1.5	-0.5	-1.2	-1.0	-0.1	-0.3	0.1	1.0	-0.1	0.1	-1.2
Arm fat percentage (left)	0.7	2.8	6.7	2.6	0.9	-0.6	-0.6	1.6	1.0	2.1	-2.1	-2.2	2.0	-2.1	-0.6
Average weekly red wine intake	0.4	0.5	2.2	-0.4	0.4	-0.3	0.2	0.6	0.8	1.2	0.3	-1.5	0.3	-0.5	0.8
Handedness (chirality/laterality): Left-handed	0.2	0.3	0.8	0.7	0.9	-0.2	-0.8	0.5	0.4	0.8	-0.2	0.1	0.3	0.5	-0.1
Mood swings	1.2	2.3	5.7	2.4	2.2	0.6	1.5	0.9	0.2	1.4	-1.3	-1.1	2.0	-0.9	1.8
Loneliness, isolation	1.4	1.9	7.6	2.8	2.1	0.8	1.3	0.7	0.9	2.1	0.2	0.5	0.8	-1.5	0.4
Long-standing illness, disability or infirmity	1.7	2.6	5.5	2.3	1.7	1.3	1.0	1.8	2.0	1.6	-1.6	-1.5	1.2	-1.8	-0.1
Ever had bowel cancer screening	0.6	0.7	3.4	-0.2	-0.1	-0.2	-0.8	1.4	0.3	0.1	-0.0	-0.5	0.4	-1.8	-1.1
Diabetes diagnosed by doctor	0.6	0.9	3.7	1.1	0.3	0.4	0.3	1.9	1.2	-0.2	-1.6	-1.0	-0.4	-0.7	0.1
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.2	3.4	0.7	1.2	-1.1	1.5	-1.2	-1.6	1.0	-0.5	-0.6	0.4	0.3	1.9
Friendships satisfaction	0.5	0.6	2.5	1.1	0.5	0.2	0.5	-0.9	-0.3	1.6	0.3	0.0	1.2	-0.1	-0.7
Qualifications: nursing, teaching	0.3	0.5	3.0	-0.3	0.3	0.4	-0.6	0.9	0.3	0.1	1.7	0.2	-1.2	-0.3	-0.1
Commuting to job workplace: Walk	0.4	0.4	2.2	-0.5	-0.3	0.2	-0.2	0.1	-0.4	-0.4	1.5	1.0	-0.3	1.0	-0.1
Eye problems/disorders: Cataract	0.4	0.4	2.0	-0.3	-0.1	-1.4	-0.6	-0.0	-0.6	0.3	-0.6	-0.6	0.8	0.5	0.5
Mouth/teeth dental problems: Mouth ulcers	1.1	1.8	3.7	1.1	0.5	-1.3	1.9	-1.9	-1.8	0.2	1.3	1.1	1.8	0.8	1.1
Medication for cholesterol	0.3	0.5	1.7	-0.2	0.4	-0.2	0.9	-0.1	-1.3	0.4	1.3	0.4	-0.5	0.5	0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	2.3	0.7	0.4	0.4	0.9	1.2	1.1	0.8	-0.6	-0.4	1.5	-0.3	-0.2
Back pain experienced in last month	0.3	0.4	1.0	-0.7	-0.1	0.3	-0.4	-0.3	1.0	-0.7	0.7	0.7	-0.5	0.8	-1.0
Mineral and other dietary supplements	0.5	0.7	1.6	0.4	-0.0	-1.1	-0.0	-1.3	-1.1	0.2	1.0	1.2	1.2	-0.0	-0.2
Breast cancer (self-reported)	0.4	0.5	2.0	-1.4	-0.3	0.7	-0.7	-0.1	0.5	-0.9	-0.9	-0.1	-0.4	0.9	-0.0
Asthma (self-reported)	0.4	0.8	3.2	0.6	1.1	-1.8	1.3	0.2	0.1	0.1	0.4	0.0	0.7	-0.4	1.4
Osteoporosis (self-reported)	2.2	2.8	9.5	1.1	2.5	0.8	1.2	2.4	2.1	-0.3	0.9	0.7	-0.9	-3.1	1.3
Osteoarthritis (self-reported)	0.3	0.4	2.4	-0.1	-0.2	0.7	0.1	0.4	1.6	0.3	0.3	-0.3	-1.0	0.3	0.2
Medication: Aspirin	2.9	3.8	15.4	-0.9	-1.5	2.9	-1.8	1.1	2.3	-0.9	-1.4	-1.8	-1.4	-0.7	-3.9
Medication: Gliclazide	0.8	0.9	2.5	0.9	0.7	0.4	-1.6	1.0	0.6	1.2	-1.0	-1.4	0.4	-0.3	-0.9
Illnesses of father: None of the above (group 1)	3.0	3.7	6.6	-2.4	-2.5	0.3	-2.0	-0.0	1.3	-2.0	2.3	1.2	-2.6	2.5	-1.7
Smoking status: Current	0.6	0.9	4.2	-0.2	-1.5	0.1	0.9	-2.1	-0.9	-0.6	0.3	0.4	-1.0	1.0	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.4	2.0	0.5	-1.0	0.1	-0.4	0.8	-0.4	0.3	-0.2	-1.4	0.3	0.2	-0.7
Whole body water mass	0.3	1.5	4.4	-2.0	-2.1	-0.4	-1.4	-1.0	0.2	-1.2	0.5	1.4	-1.0	0.6	-1.3
Leg predicted mass (right)	0.1	0.7	2.3	-1.2	-1.5	-0.5	-1.1	-0.9	-0.1	-0.2	0.2	1.1	-0.0	0.2	-1.1
Arm fat mass (left)	0.5	1.9	3.8	2.0	0.5	-0.7	-1.0	1.2	1.0	1.6	-1.7	-1.7	1.7	-1.7	-0.7
Number of self-reported non-cancer illnesses	1.1	1.9	4.8	-1.1	-1.3	0.0	-1.2	-0.4	0.7	-1.6	2.2	2.0	-1.9	-0.8	-1.4
Average weekly champagne plus white wine intake	1.2	1.6	3.3	1.5	1.3	-0.5	1.3	0.3	-1.0	1.3	-1.2	-1.8	1.3	-1.5	1.3
Miserableness	0.9	1.5	5.4	1.6	2.0	1.7	0.7	1.2	0.3	0.8	-0.4	-0.4	0.2	-2.3	0.6
Guilty feelings	0.4	0.5	1.8	0.2	-0.0	1.3	-0.9	1.1	0.7	-0.5	-0.3	0.1	-0.3	-1.2	-0.0
Wears glasses or contact lenses	1.8	2.0	7.3	1.1	-0.0	1.7	0.4	1.9	1.1	1.4	-1.3	-1.3	0.1	-2.7	-1.6
Ever taken oral contraceptive pill	1.2	1.4	5.3	-0.7	-0.8	-2.3	1.1	-0.7	-1.8	0.1	1.2	1.2	-0.0	1.3	0.7
Hearing aid user	0.9	1.0	2.3	1.5	0.9	-0.6	1.0	1.0	-0.4	1.3	-1.3	-1.1	1.0	-0.4	0.8
Mother’s age at death	0.3	0.4	1.6	1.3	0.4	0.6	0.2	0.9	-0.1	1.1	0.0	0.0	-0.3	-0.6	0.4
Financial situation satisfaction	0.4	0.5	1.9	-0.8	-0.1	0.2	0.3	-1.3	-0.7	-0.2	0.7	1.4	-0.1	0.5	0.6
Tinnitus: Yes, now most or all of the time	1.2	1.4	3.9	-1.4	-1.5	0.3	-1.7	-0.0	1.3	-1.9	-0.3	-0.0	-0.3	2.0	-0.7
Commuting to job workplace: Public transport	0.4	0.4	2.0	-0.4	0.2	0.6	0.3	-0.5	-1.1	-0.5	-0.1	0.8	-0.1	-0.3	1.4
Eye problems/disorders: Glaucoma	0.7	0.8	2.9	-0.3	-0.5	1.7	-0.5	-0.5	0.9	-0.7	0.1	0.5	-1.3	-1.1	-1.2
Medication: Blood pressure	0.8	1.4	5.6	0.1	-1.4	0.9	-1.0	-0.6	2.3	-0.9	-0.3	0.6	-0.7	-0.7	-2.4
Pain type(s) experienced in last month: Hip pain	4.7	5.9	15.1	3.7	2.5	-1.8	0.9	2.3	1.2	3.9	-1.7	-3.3	2.8	-1.0	1.4
Supplements: Fish oil (including cod liver oil)	1.4	1.9	4.0	-1.9	-1.6	1.7	-1.1	0.2	1.0	-1.6	-1.2	-0.8	-2.0	0.2	-1.6
High cholesterol (Self-reported)	0.4	0.6	3.8	0.0	-0.1	0.3	-0.7	-0.7	0.4	-0.5	-0.5	0.5	-0.4	-1.3	-2.0
Medication: Bendroflumethiazide	0.9	1.4	7.3	0.2	-1.2	1.0	-0.6	1.2	2.7	-0.6	0.2	0.8	-1.4	-0.7	-1.3
Medication: Paracetamol	0.6	1.0	2.7	0.9	0.3	-1.0	0.7	0.9	0.1	1.6	-0.6	-1.5	1.6	0.3	0.9
Medication: Lisinopril	1.3	1.7	9.5	-1.0	-1.5	0.9	-3.1	-1.1	1.3	-1.3	0.3	0.5	0.0	-0.0	-1.5
Medication: Atorvastatin	2.3	2.8	7.7	-1.5	-2.1	0.4	-2.8	-1.0	0.3	-1.9	1.0	0.9	-2.6	0.9	-2.3
Illnesses of father: High blood pressure	1.1	1.4	7.0	1.1	0.4	-0.7	1.0	-0.1	-1.0	1.2	-1.3	-1.4	2.7	0.6	0.6
Alcohol drinker status: Never	0.5	0.6	1.8	-0.8	-0.6	0.6	1.2	0.5	0.4	-0.4	-0.0	1.3	-1.0	0.4	0.4
Ever smoked	0.2	0.3	1.4	-0.4	-0.8	0.1	0.3	-1.2	-0.7	-0.4	0.2	0.0	-0.3	0.1	-0.4
Basal metabolic rate	0.2	0.9	3.2	-1.4	-1.8	-0.6	-1.4	-0.7	0.3	-0.7	0.2	1.0	-0.5	0.3	-1.2
Leg fat percentage (left)	0.7	2.6	7.5	2.7	0.9	-0.5	-0.9	1.4	0.6	1.8	-2.1	-2.3	1.7	-1.9	-0.3
Arm fat-free mass (left)	0.2	1.1	3.8	-1.3	-1.9	-0.2	-1.5	-0.6	0.4	-1.1	-0.1	0.8	-0.8	0.2	-1.3
Number of operations (self-reported)	0.1	0.2	0.6	-0.1	-0.4	0.1	0.6	-0.4	-0.4	0.7	0.5	0.8	-0.3	-0.1	0.3
Average weekly beer plus cider intake	0.4	0.5	3.0	-0.6	-0.5	-0.1	0.1	-0.4	-0.2	-0.7	-1.0	0.2	-0.3	1.7	0.9
Irritability	0.9	1.5	4.0	1.4	1.2	-0.1	0.0	1.6	0.3	1.2	-1.0	-1.3	2.0	-1.1	1.6
Risk taking	1.6	2.3	6.8	1.6	1.1	-1.9	1.1	-0.4	-1.2	1.0	-1.5	-1.1	2.6	-0.6	2.5
Ever had prostate specific antigen (PSA) test	0.3	0.3	1.9	-0.3	-0.5	0.3	-0.0	1.4	0.6	0.0	-1.0	-0.4	-0.1	-0.1	0.4
Fractured/broken bones in last 5 years	0.3	0.4	1.1	-1.0	-0.2	-1.0	0.3	0.1	-0.1	-1.0	0.7	0.3	-0.6	0.7	0.5
Age started oral contraceptive pill	1.3	1.6	5.6	-1.5	-0.1	0.5	-0.7	2.4	2.1	-0.8	-0.0	-0.3	-2.3	-0.1	-0.4
Diastolic blood pressure, automated reading	0.3	1.0	3.3	-0.4	-1.2	1.5	-0.5	1.2	1.1	-0.1	0.2	-0.7	-1.3	-0.7	-1.8
Ever depressed for a whole week	1.6	2.0	7.1	2.2	1.1	-0.4	2.7	0.0	-0.5	2.2	0.1	-0.8	1.8	-0.9	0.8
Unable to work because of sickness or disability	0.7	0.8	4.2	1.3	0.6	0.5	0.6	-0.2	0.4	1.4	-2.0	-0.9	0.2	-0.6	-0.4
Commuting to job workplace: Cycle	2.3	2.7	8.2	-1.6	-1.3	-1.7	-0.2	-2.9	-1.7	-2.0	2.0	1.8	-0.2	1.8	0.3
Myopia	0.9	1.3	4.1	0.4	0.9	2.0	1.9	-0.3	0.0	0.7	0.7	1.3	0.5	-1.6	-1.4
Vascular/heart problems diagnosed by doctor	1.1	2.9	9.3	0.7	1.8	-2.2	1.6	0.6	-1.5	1.8	0.7	-0.7	1.9	2.0	3.1
Cholesterol lowering medication	0.9	1.3	3.9	-1.1	-1.5	0.5	-1.5	-0.6	1.1	-2.0	-0.5	0.4	-0.9	0.1	-1.8
Medication: Omeprazole (e.g. Zanprol)	0.8	1.0	3.1	0.8	0.3	1.2	-0.1	-0.1	1.6	0.3	0.9	1.4	0.7	-1.8	-0.2
Pain experienced in last month	0.5	0.9	2.5	-1.5	-1.2	0.1	-0.2	-0.9	-1.1	-1.6	-0.8	0.4	-0.9	0.6	-0.1
Supplements: Calcium	2.4	2.6	8.6	2.1	2.2	0.1	1.5	2.0	0.4	1.2	-1.0	-1.9	0.0	-1.0	2.9
Basal cell carcinoma (self-reported)	1.3	1.5	3.7	-1.2	-1.9	-0.7	-0.9	-0.8	-0.2	-1.6	1.5	0.9	-1.4	1.8	-0.7
Heart attack/myocardial infarction (self-reported)	0.7	0.9	2.0	1.0	-0.2	1.4	-0.6	0.6	1.3	0.2	-0.3	-1.3	0.7	-1.3	-1.3
Deep venous thrombosis (DVT) (self-reported)	0.6	0.7	2.2	0.1	-0.1	0.8	0.4	1.1	0.8	1.5	1.2	0.7	1.0	-0.7	-0.6
Heart disease (siblings)	0.4	0.5	2.2	0.1	-0.1	-1.0	-0.1	-1.5	-0.8	-0.3	-0.9	-0.2	0.7	0.2	-0.0
Alcohol drinker status: Previous	1.9	2.1	6.1	1.1	1.7	-0.9	1.1	1.0	0.2	0.8	-2.5	-2.3	1.7	-1.1	1.5
Pack years of smoking	1.9	2.7	5.0	-0.5	0.1	2.1	-1.9	1.0	2.2	-1.7	1.4	1.2	-2.1	-1.7	-2.2
Impedance of whole body	0.2	1.3	6.0	-0.0	0.7	-1.2	1.1	-0.4	-1.8	-0.3	0.9	-0.5	0.5	1.2	2.4
Leg fat mass (left)	0.4	1.6	3.2	1.6	0.0	-0.4	-1.3	0.8	0.7	1.4	-1.8	-1.6	1.5	-1.7	-1.0
Arm predicted mass (left)	0.2	0.8	3.0	-1.2	-1.7	-0.5	-1.3	-0.6	0.4	-0.9	0.1	0.8	-0.6	0.3	-0.9