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chr18:43,698,447-47,686,517

Best TWAS P=5.27e-111 · Best GWAS P=1.42e-103 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	KATNAL2	0.07	0.01	bslmm	589	0.02	1.2e-03	5.8	5.3	9.6e-08	-0.01	0.18	0.41	FALSE
2	GTEx	Adipose Subcutaneous	PIAS2	0.07	0.02	lasso	5	0.01	2.1e-02	7.1	5.8	5.6e-09	-0.02	0.25	0.21	FALSE
3	GTEx	Adrenal Gland	DYM	0.30	0.01	enet	15	0.01	1.2e-01	18.5	18.7	2.0e-78	0.81	0.02	0.83	FALSE
4	GTEx	Adrenal Gland	HDHD2	0.11	0.11	lasso	1	0.08	5.9e-04	-6.2	6.2	5.3e-10	-0.09	0.22	0.46	FALSE
5	GTEx	Adrenal Gland	RP11-49K24.8	0.11	0.06	lasso	3	0.04	1.2e-02	-6.2	6.0	1.9e-09	-0.09	0.13	0.38	FALSE
6	GTEx	Brain Cerebellum	RP11-49K24.5	0.26	0.18	lasso	7	0.20	1.8e-06	4.9	-5.5	4.7e-08	0.11	0.55	0.15	FALSE
7	GTEx	Esophagus Mucosa	DYM	0.12	0.01	enet	12	0.04	1.0e-03	21.5	16.8	2.0e-63	0.73	0.01	0.97	TRUE
8	GTEx	Muscle Skeletal	HDHD2	0.13	0.03	enet	14	0.08	1.3e-08	-7.1	8.3	1.2e-16	-0.11	0.21	0.79	TRUE
9	GTEx	Muscle Skeletal	RP11-49K24.8	0.10	0.03	enet	36	0.03	2.8e-04	-6.2	6.8	1.0e-11	-0.12	0.26	0.70	FALSE
10	METSIM	Adipose	CTIF	0.06	0.00	blup	710	0.01	3.4e-03	2.9	-12.6	2.2e-36	-0.18	0.18	0.04	FALSE
11	METSIM	Adipose	HDHD2	0.03	0.02	blup	533	0.03	5.1e-05	4.9	6.1	1.3e-09	-0.10	0.91	0.03	FALSE
12	NTR	Blood	PIAS2	0.02	0.01	enet	14	0.01	7.5e-04	2.6	5.2	2.4e-07	-0.03	0.22	0.05	FALSE
13	YFS	Blood	DYM	0.05	0.05	lasso	4	0.04	1.5e-13	-20.0	22.4	5.3e-111	0.76	1.00	0.00	TRUE
14	YFS	Blood	HDHD2	0.06	0.05	bslmm	525	0.07	1.6e-21	4.9	6.7	2.5e-11	-0.10	1.00	0.00	FALSE
15	The Cancer Genome Atlas	Colon Adenocarcinoma	C18orf32	0.05	0.05	lasso	5	0.04	3.5e-03	-8.5	8.5	2.4e-17	0.41	0.05	0.04	TRUE
16	The Cancer Genome Atlas	Colon Adenocarcinoma	HDHD2	0.20	0.09	enet	10	0.11	9.6e-07	4.9	6.4	1.7e-10	-0.09	0.54	0.19	FALSE
17	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C18orf32	0.03	0.03	lasso	5	0.03	3.3e-04	-7.3	8.4	3.8e-17	0.39	0.39	0.03	TRUE
18	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	HDHD2	0.08	0.03	blup	48	0.07	2.6e-08	4.8	5.3	1.4e-07	-0.09	0.55	0.38	FALSE
19	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C18orf32	0.04	0.03	blup	48	0.04	6.5e-05	7.8	15.2	4.0e-52	0.57	0.66	0.05	FALSE
20	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	HDHD2	0.08	0.00	blup	48	0.02	5.8e-02	-7.3	6.8	1.3e-11	-0.10	0.01	0.62	FALSE
21	The Cancer Genome Atlas	Lung Adenocarcinoma	HDHD2	0.09	0.03	blup	47	0.05	4.9e-07	2.3	5.8	6.4e-09	-0.08	0.09	0.72	FALSE
22	The Cancer Genome Atlas	Prostate Adenocarcinoma	C18orf32	0.06	0.03	blup	47	0.02	7.6e-03	-9.6	5.6	2.2e-08	0.19	0.31	0.03	TRUE
23	The Cancer Genome Atlas	Prostate Adenocarcinoma	DYM	0.07	0.03	lasso	4	0.03	3.2e-04	-11.9	12.0	5.0e-33	0.39	0.92	0.02	TRUE
24	The Cancer Genome Atlas	Rectum Adenocarcinoma	HDHD2	0.37	0.19	blup	47	0.20	2.3e-05	4.9	5.2	1.7e-07	-0.11	0.10	0.09	FALSE
25	The Cancer Genome Atlas	Stomach Adenocarcinoma	HDHD2	0.08	0.03	blup	45	0.03	1.5e-03	2.3	5.3	1.4e-07	-0.09	0.10	0.33	FALSE
26	The Cancer Genome Atlas	Thyroid Carcinoma	C18orf32	0.04	0.03	lasso	1	0.03	3.5e-04	-7.3	7.3	2.3e-13	0.35	0.34	0.03	FALSE