Best TWAS P=3.79e-12 · Best GWAS P=5.57e-22 conditioned to 6.21e-13
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | KIF16B | 0.13 | 0.02 | lasso | 5 | 0.01 | 4.9e-02 | -5.1 | -6.0 | 2.4e-09 | -0.02 | 0.06 | 0.91 | TRUE |
| 2 | GTEx | Skin Sun Exposed Lower leg | RRBP1 | 0.11 | 0.09 | lasso | 5 | 0.07 | 1.7e-06 | -6.1 | -6.2 | 6.6e-10 | -0.02 | 0.96 | 0.01 | TRUE |
| 3 | GTEx | Thyroid | KIF16B | 0.35 | 0.27 | lasso | 9 | 0.28 | 1.6e-21 | 4.7 | -5.3 | 1.3e-07 | 0.03 | 0.78 | 0.22 | FALSE |
| 4 | YFS | Blood | CSRP2BP | 0.03 | 0.00 | bslmm | 536 | 0.01 | 1.9e-03 | 2.4 | 6.3 | 3.4e-10 | -0.27 | 0.05 | 0.07 | TRUE |
| 5 | YFS | Blood | DSTN | 0.29 | 0.22 | enet | 50 | 0.27 | 8.0e-89 | 7.0 | 6.9 | 3.8e-12 | -0.27 | 1.00 | 0.00 | TRUE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | KIF16B | 0.12 | 0.08 | lasso | 5 | 0.11 | 1.6e-21 | 4.7 | -5.5 | 5.0e-08 | 0.02 | 0.36 | 0.64 | FALSE |
| 7 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | KIF16B | 0.10 | 0.09 | lasso | 2 | 0.07 | 2.1e-05 | -5.1 | -5.8 | 7.9e-09 | -0.03 | 0.17 | 0.59 | FALSE |