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chr20:19,318,837-22,188,798

Best TWAS P=8.31e-29 · Best GWAS P=3.18e-32 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	C20orf26	0.20	0.17	lasso	6	0.18	4.9e-21	-5.4	5.3	1.3e-07	-0.06	1.00	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	INSM1	0.07	0.00	bslmm	522	0.02	2.2e-03	5.8	6.9	6.6e-12	-0.01	0.08	0.20	TRUE
3	CommonMind	Brain Pre-frontal Cortex	PLK1S1	0.08	0.01	lasso	3	0.04	1.1e-05	8.5	9.0	2.5e-19	0.81	0.02	0.98	FALSE
4	GTEx	Artery Tibial	PLK1S1	0.07	0.08	enet	10	0.08	4.0e-07	11.7	11.1	8.3e-29	0.98	0.02	0.98	TRUE
5	GTEx	Esophagus Mucosa	PLK1S1	0.11	0.11	lasso	5	0.09	7.8e-07	9.0	8.9	6.8e-19	0.84	0.16	0.84	FALSE
6	GTEx	Heart Atrial Appendage	PLK1S1	0.15	-0.01	lasso	4	0.00	6.1e-01	1.4	7.7	1.7e-14	0.57	0.05	0.40	FALSE
7	GTEx	Skin Not Sun Exposed Suprapubic	PLK1S1	0.21	0.09	lasso	6	0.12	5.3e-07	11.4	10.0	1.9e-23	0.93	0.07	0.93	FALSE
8	GTEx	Skin Sun Exposed Lower leg	PLK1S1	0.15	0.13	enet	10	0.15	3.9e-12	9.0	8.6	8.3e-18	0.83	0.96	0.04	FALSE
9	GTEx	Testis	PLK1S1	0.64	0.34	enet	33	0.39	1.0e-18	9.0	7.9	2.8e-15	0.77	0.48	0.52	FALSE
10	GTEx	Thyroid	RALGAPA2	0.17	0.05	lasso	6	0.10	3.3e-08	1.9	-5.5	3.8e-08	-0.12	0.67	0.01	TRUE
11	GTEx	Whole Blood	PLK1S1	0.08	0.04	enet	9	0.02	4.0e-03	9.0	9.9	5.7e-23	0.89	0.05	0.95	FALSE
12	ROSMAP	Brain Pre-frontal Cortex	NKX2-2	0.11	0.06	lasso	5	0.06	2.3e-08	5.8	-6.3	3.4e-10	-0.61	1.00	0.00	FALSE
13	YFS	Blood	CRNKL1	0.21	0.25	enet	18	0.27	2.3e-89	-5.0	-5.5	4.9e-08	0.04	1.00	0.00	FALSE
14	YFS	Blood	XRN2	0.34	0.61	lasso	10	0.61	3.5e-258	7.1	7.1	1.1e-12	0.48	1.00	0.00	FALSE
15	The Cancer Genome Atlas	Breast Invasive Carcinoma	PLK1S1	0.05	0.07	enet	9	0.07	5.5e-15	8.7	9.7	2.0e-22	0.89	0.17	0.83	FALSE
16	The Cancer Genome Atlas	Brain Lower Grade Glioma	NKX2-2	0.02	0.03	lasso	4	0.02	1.0e-03	5.8	-5.7	1.1e-08	-0.56	0.09	0.18	FALSE
17	The Cancer Genome Atlas	Lung Adenocarcinoma	PLK1S1	0.04	0.03	blup	64	0.04	4.0e-05	9.0	9.3	1.9e-20	0.88	0.16	0.84	FALSE
18	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	PLK1S1	0.09	0.02	blup	64	0.05	3.1e-03	8.5	7.6	2.2e-14	0.76	0.03	0.52	FALSE
19	The Cancer Genome Atlas	Prostate Adenocarcinoma	PLK1S1	0.19	0.12	enet	14	0.13	4.3e-13	9.0	8.3	1.0e-16	0.78	0.99	0.01	FALSE
20	The Cancer Genome Atlas	Thyroid Carcinoma	PLK1S1	0.06	0.04	lasso	3	0.04	1.5e-04	9.0	9.1	6.9e-20	0.86	0.19	0.49	FALSE