TWAS hub - DSTN

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Heart Left Ventricle	0.261	0.0805	0.00099	0.188	NA	0.129	NA	0.185	2.6e-10	NA	2.4e-07	NA	4.0e-10
2	YFS	Blood	0.286	0.0289	0.00000	0.224	0.257	0.271	0.266	0.270	9.5e-72	1.7e-83	8.0e-89	6.2e-87	1.9e-88

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Blood Eosinophil Count	4.4	33.5	67.0	-0.2	8.2
Hearing aid user	4.2	4.8	9.4	0.3	-3.1
Commuting to job workplace: Car/motor vehicle	3.8	4.3	8.4	-2.9	0.4
Illnesses of mother	3.5	4.4	7.9	2.8	0.9
Crohns Disease (2012)	3.2	5.2	10.2	0.4	-3.2
Mouth/teeth dental problems: Loose teeth	3.1	3.7	6.1	1.2	-2.5
Schizophrenia vs Biploar Disorder	3.0	3.9	7.9	0.0	2.8
Ever taken oral contraceptive pill	2.9	3.2	4.2	2.0	1.5
Primary Biliary Cirrhosis	2.8	3.9	5.4	1.6	-2.3
Medication: Lansoprazole	2.8	3.2	6.1	-0.5	2.5
Mouth/teeth dental problems: Mouth ulcers	2.7	4.3	5.9	1.7	-2.4
Mouth/teeth dental problems	2.5	3.9	6.1	-1.3	2.5
Loud music exposure frequency	2.5	2.7	4.7	-2.2	-0.8
Gout (self-reported)	2.4	3.3	4.8	1.4	2.2
Birth weight	2.4	5.1	9.9	3.1	-0.6
Systolic Blood Pressure	2.3	11.3	21.0	-4.6	-1.2
Pulse wave reflection index	2.3	2.8	4.9	-0.8	-2.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.3	2.7	3.5	-1.9	1.4
Breast cancer (self-reported)	2.3	2.7	3.3	-1.8	1.5
Depressed Affect (Nagel 2018)	2.2	4.6	8.7	2.9	0.8
Neck or shoulder pain in last month	2.2	3.1	5.7	2.4	0.7
Friendships satisfaction	2.2	2.7	4.9	2.2	0.7
Back pain experienced in last month	2.2	3.2	6.2	2.5	0.5
Wears glasses or contact lenses	2.2	2.5	3.4	1.3	-1.8
Lupus	2.1	3.2	6.3	-0.3	-2.5
Other serious medical condition/disability diagnosed by doctor	2.1	2.7	3.5	-1.4	1.9
Systolic blood pressure, automated reading	2.1	6.1	12.2	-3.5	-0.0
Chronic bronchitis/emphysema (father)	2.1	2.5	4.9	-0.1	2.2
Emphysema/chronic bronchitis	2.1	2.4	3.4	1.2	1.9
Medication: Allopurinol	2.1	2.8	5.0	0.8	2.2
Medication: Seretide 50 evohaler	2.1	2.5	4.3	-0.8	2.1
Loneliness, isolation	2.1	2.9	4.0	2.0	1.3
Alzheimer’s Disease (including proxy)	2.0	3.0	3.2	-1.8	-1.6
Mother’s age at death	2.0	2.5	3.5	-1.2	-1.9
Family relationship satisfaction	1.9	2.3	4.3	2.1	0.5
Knee pain experienced in last month	1.9	2.9	5.0	0.9	2.2
Leg fat-free mass (right)	1.9	10.2	14.1	3.8	2.5
Leg predicted mass (right)	1.9	10.4	14.6	3.8	2.5
Body Mass Index (BMI) (2010)	1.8	2.5	4.8	-0.3	-2.2
Impedance of leg (left)	1.8	8.7	16.7	-4.1	0.9
Glaucoma (self-reported)	1.8	2.2	3.4	1.0	-1.9
Average weekly beer plus cider intake	1.8	2.6	5.0	2.2	0.5
Fractured/broken bones in last 5 years	1.8	2.3	4.1	2.0	-0.6
Diastolic blood pressure, automated reading	1.8	5.6	10.5	-3.2	0.9
Ovarian Cancer	1.7	2.2	3.8	-1.9	-0.8
Chronotype (morning person)	1.7	3.8	3.9	-2.0	-1.9
Leg fat-free mass (left)	1.7	8.8	13.0	3.6	2.1
Average weekly fortified wine intake	1.7	2.0	3.5	-1.9	0.7
Leg predicted mass (left)	1.7	9.0	13.2	3.6	2.2
Happiness	1.7	2.0	3.8	1.9	0.5
Arm predicted mass (right)	1.7	8.8	10.5	3.2	2.7
Whole body fat-free mass	1.7	9.7	12.0	3.5	2.7
Commuting to job workplace: Walk	1.7	1.9	3.1	1.8	0.8
Whole body water mass	1.7	9.5	12.2	3.5	2.6
Basal metabolic rate	1.7	9.5	10.5	3.2	2.9
Alcohol drinker status: Previous	1.7	2.0	2.0	1.4	1.4
Blood Platelet Count	1.6	18.3	28.8	2.8	5.4
Impedance of leg (right)	1.6	7.6	15.2	-3.9	0.1
Trunk fat-free mass	1.6	9.5	10.4	3.2	2.9
Father’s age at death	1.6	2.1	4.3	-0.1	-2.1
Forced expiratory volume in 1-second (FEV1)	1.6	5.4	8.9	3.0	1.4
Trunk predicted mass	1.6	9.4	10.9	3.3	2.8
Birth weight of first child	1.6	2.9	5.3	0.7	2.3
Pulse wave peak to peak time	1.6	1.9	2.7	1.6	1.0
Eye problems/disorders: Cataract	1.6	1.8	2.5	-1.6	1.0
Arm predicted mass (left)	1.6	7.9	8.1	2.8	2.9
Ulcerative Colitis (UC)	1.5	2.9	4.2	2.1	-1.3
Tinnitus: Yes, but not now, but have in the past	1.5	1.6	2.8	1.7	-0.6
Trunk fat mass	1.5	6.3	12.0	0.7	3.5
Frequency of tenseness / restlessness in last 2 weeks	1.5	2.4	4.4	2.1	-0.6
Weight	1.5	7.2	11.3	1.8	3.4
Arm fat-free mass (right)	1.5	7.7	8.9	3.0	2.5
Arm fat-free mass (left)	1.5	7.6	7.7	2.8	2.7
Bipolar Disorder (2011)	1.4	1.4	2.7	1.6	-0.2
Height	1.4	27.6	48.2	2.6	6.9
Forced expiratory volume in 1-second (FEV1), Best measure	1.4	4.4	5.6	2.4	1.8
Breastfed as a baby	1.4	1.7	2.4	1.0	-1.6
Heart attack/myocardial infarction (self-reported)	1.4	1.7	3.4	-1.8	-0.3
Neuroticism (Nagel 2018)	1.3	3.1	6.1	2.5	-0.0
Irritable Bowel Disease (IBD)	1.3	3.2	3.5	1.7	-1.9
Supplements: Glucosamine	1.3	1.6	2.7	-0.8	1.6
Waist circumference	1.3	4.7	6.3	1.7	2.5
Financial difficulties in last 2 years	1.3	1.8	3.5	1.9	-0.1
Heart attack	1.3	1.6	3.2	-1.8	-0.3
Pulse wave Arterial Stiffness index	1.3	1.6	2.4	-1.6	-0.8
Age at first live birth	1.3	2.4	4.7	-2.2	-0.3
Miserableness	1.3	2.3	3.6	1.9	-1.0
Medication: Bendroflumethiazide	1.3	2.0	3.0	-1.7	-1.0
Medication: Lisinopril	1.3	1.6	3.0	-1.7	0.5
Pain experienced in last month	1.3	2.2	4.1	-0.6	-2.0
Depression (Nagel 2018)	1.2	1.8	2.3	1.1	1.5
Ulcerative Colitis	1.2	1.8	3.0	1.7	-0.7
Hearing difficulty/problems: Yes	1.2	1.8	3.6	1.9	-0.1
Hayfever, allergic rhinitis or eczema	1.2	2.6	4.0	1.1	-2.0
Medication: Blood pressure	1.2	2.1	2.5	-1.3	-1.6
Whole body fat mass	1.2	4.9	9.3	0.7	3.1
Comparative height size at age 10	1.2	6.6	8.7	2.1	3.0
Forced expiratory volume in 1-second (FEV1), predicted	1.2	2.4	4.6	0.5	2.2
Osteoarthritis (self-reported)	1.2	1.5	1.9	1.4	-1.1
Medication: Omeprazole (e.g. Zanprol)	1.2	1.4	2.3	-1.5	0.8
Bipolar Disorder (2018)	1.1	1.7	3.5	0.0	-1.9
Trunk fat percentage	1.1	4.6	9.1	-0.2	3.0
Hand grip strength (right)	1.1	3.1	5.8	2.4	0.6
Maternal smoking around birth	1.1	1.6	3.3	0.1	1.8
Pain all over the body in last month	1.1	1.1	1.4	-1.2	0.9
Worrier / anxious feelings	1.1	2.0	2.0	1.4	-1.4
Standing height	1.1	10.7	17.2	2.1	4.1
Exposure to tobacco smoke at home	1.1	1.3	1.9	1.4	-0.8
Medication: Ventolin 100micrograms inhaler	1.1	1.5	1.7	-1.1	1.3
Health satisfaction	1.1	1.5	1.7	1.1	1.3
Commuting to job workplace: Public transport	1.1	1.3	2.1	1.4	-0.7
Ever depressed for a whole week	1.1	1.3	1.6	1.0	1.3
Heart disease (siblings)	1.1	1.4	1.7	1.3	1.0
Impedance of whole body	1.1	5.4	10.2	-3.2	0.8
Prostate Cancer	1.0	1.3	2.7	0.0	-1.6
Mean Putamen Volume	1.0	1.1	1.7	-0.7	-1.3
Average weekly spirits intake	1.0	1.2	1.6	-0.9	-1.2
Fed-up feelings	1.0	1.9	3.8	1.9	0.2
Mouth/teeth dental problems: Dentures	1.0	1.6	3.2	-0.3	-1.8
Arm fat mass (right)	1.0	4.0	6.3	1.3	2.5
Medication: Amlodipine	1.0	1.4	2.5	1.6	-0.5
Body fat percentage	1.0	3.8	7.4	-0.4	2.7
Arm fat mass (left)	1.0	4.2	6.9	1.2	2.6
Illnesses of father: High blood pressure	1.0	1.2	1.8	1.3	0.8
Alcohol drinker status: Never	1.0	1.2	2.3	-0.4	-1.5
Major Depression (MDD)	0.9	1.1	2.1	-1.4	0.4
Waist Hip Ratio (WHR)	0.9	4.0	5.2	1.6	2.3
Hand grip strength (left)	0.9	2.3	4.5	2.1	-0.3
Relative age of first facial hair	0.9	1.8	3.5	0.2	1.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.1	1.2	1.1	1.1
Qualifications: CSEs or equivalent	0.9	1.2	1.8	1.3	0.7
Multivitamins +/- minerals	0.9	1.1	2.1	1.4	0.4
Sitting height	0.9	6.3	9.2	1.8	3.0
Hearing difficulty/problems with background noise	0.9	1.4	2.7	1.6	0.1
Forced vital capacity (FVC)	0.9	3.5	4.6	2.1	1.6
Pulse rate	0.9	1.5	3.0	0.3	1.7
Exposure to tobacco smoke outside home	0.9	1.2	1.7	0.9	-1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	2.0	-0.4	-1.4
Qualifications: nursing, teaching	0.9	1.5	1.7	-1.1	-1.3
Irritability	0.9	1.5	2.2	0.8	-1.5
Leg fat mass (left)	0.9	3.7	7.1	0.6	2.7
Alzheimer’s Disease (in mother)	0.8	0.9	1.4	-1.2	-0.6
Age at First Birth	0.8	1.2	2.4	-1.5	-0.3
Triglycerides	0.8	1.3	1.4	-1.2	-1.1
Neuroticism	0.8	1.9	3.4	1.8	-0.6
Frequency of depressed mood in last 2 weeks	0.8	1.1	1.6	1.3	0.8
Townsend deprivation index at recruitment	0.8	1.1	1.7	1.3	0.7
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	1.1	-0.8	-1.1
Medication: Ramipril	0.8	1.0	2.0	0.1	1.4
Neuroticism score	0.8	1.7	2.5	1.6	-0.9
Hair/balding pattern: Pattern 4	0.8	1.8	3.7	-1.9	0.2
Chronic bronchitis/emphysema (mother)	0.8	1.0	1.1	0.9	1.0
Forced vital capacity (FVC), Best measure	0.8	3.0	3.5	1.6	1.9
Medication: Omeprazole	0.8	0.9	1.8	-1.3	-0.1
Age at last live birth	0.8	1.2	2.1	-1.4	-0.6
Medication: Aspirin	0.8	1.1	1.5	1.2	-0.8
Medication: Aspirin	0.8	1.0	1.4	0.7	-1.2
Medication: Paracetamol	0.8	1.2	2.2	1.5	-0.5
Alzheimer’s Disease (in father)	0.7	0.8	1.4	-1.2	0.3
Diabetes (mother)	0.7	0.9	1.8	-1.3	0.0
High blood pressure (mother)	0.7	0.9	1.1	-1.1	-0.9
Leg fat mass (right)	0.7	2.6	5.0	0.5	2.2
Chest pain or discomfort	0.7	1.0	1.5	0.7	-1.2
Smoking status: Previous	0.7	1.1	2.2	0.1	-1.5
Medication: Gliclazide	0.7	0.8	1.6	-0.1	1.3
Average weekly champagne plus white wine intake	0.7	1.0	2.0	1.4	0.2
Leg fat percentage (left)	0.7	2.5	3.8	-1.1	1.9
Crohns Disease (2017)	0.6	1.3	2.6	0.1	-1.6
HbA1C	0.6	0.6	1.1	-0.3	-1.1
Blood White Count	0.6	4.8	9.4	-0.3	3.1
Lung FEV1/FVC ratio	0.6	2.9	5.8	2.4	-0.1
Medication for hormone replacement therapy	0.6	0.6	1.0	-1.0	-0.4
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	1.2	0.5	1.1
Number of incorrect matches in round	0.6	0.9	1.6	0.5	1.3
Alcohol usually taken with meals	0.6	1.0	2.0	-1.4	-0.1
Medication: Simvastatin	0.6	0.9	1.8	0.3	1.3
Arm fat percentage (right)	0.6	2.5	5.0	0.1	2.2
Hip circumference	0.6	2.6	4.8	0.7	2.2
Prospective memory result	0.6	0.7	1.3	-0.4	1.1
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	1.2	1.1	0.6
Wheeze or whistling in the chest in last year	0.6	1.1	2.1	0.5	1.4
Arm fat percentage (left)	0.6	2.4	4.8	0.2	2.2
Mineral and other dietary supplements	0.6	0.8	0.9	0.8	-0.9
Asthma (self-reported)	0.6	1.1	2.2	-1.5	-0.2
Number of operations (self-reported)	0.6	0.9	1.5	-0.6	1.2
Unable to work because of sickness or disability	0.6	0.8	0.9	-0.8	1.0
Basal cell carcinoma (self-reported)	0.6	0.7	1.4	-0.1	-1.2
Pack years of smoking	0.6	0.8	1.1	1.0	0.7
Schizophrenia (2018)	0.5	1.0	1.3	-0.8	1.1
HDL Cholesterol	0.5	0.9	1.4	-0.6	1.2
Neuroticism (2016)	0.5	0.7	1.4	1.2	-0.0
Rheumatoid Arthritis	0.5	0.7	1.2	0.4	1.1
Blood Red Count	0.5	4.6	8.9	-3.0	-0.4
Cardiovascular Disease	0.5	1.8	3.5	-1.9	0.0
Ever had hysterectomy (womb removed)	0.5	0.5	1.0	-0.2	1.0
Taking other prescription medications	0.5	0.7	0.8	-0.8	0.9
Body mass index (BMI)	0.5	2.0	2.9	1.0	1.7
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.0	2.1	-1.4	-0.1
Impedance of arm (right)	0.5	2.4	4.8	-2.2	0.2
Impedance of arm (left)	0.5	2.1	4.2	-2.0	0.2
Length of working week for main job	0.5	0.6	1.0	-0.4	1.0
Peak expiratory flow (PEF)	0.5	1.2	1.6	1.3	0.9
Number of children fathered	0.5	0.6	0.9	-0.5	-1.0
Medication: Ibuprofen	0.5	0.6	1.1	-1.1	-0.2
Pulse rate, automated reading	0.5	1.7	3.3	0.1	1.8
Illnesses of father: None of the above (group 1)	0.5	0.6	0.7	0.6	-0.9
Guilty feelings	0.5	0.7	1.1	0.6	-1.1
Eye problems/disorders: Glaucoma	0.5	0.6	1.1	0.4	-1.0
Risk taking	0.5	0.7	1.3	-1.2	0.1
Worry (Nagel 2018)	0.4	0.8	0.9	0.8	-1.0
LDL Cholesterol	0.4	0.7	0.7	0.9	0.8
Heel T-Score	0.4	3.4	4.4	-2.1	1.5
Supplements: Zinc	0.4	0.4	0.8	-0.9	-0.0
Severe depression (siblings)	0.4	0.5	1.0	-0.2	-1.0
Pack years adult smoking proportion	0.4	0.7	1.2	1.1	0.4
Stomach or abdominal pain in last month	0.4	0.5	0.5	0.6	-0.7
Nervous feelings	0.4	0.7	1.4	-0.1	-1.2
Illnesses of siblings	0.4	0.6	1.1	0.2	-1.0
Asthma	0.4	0.8	1.5	-1.2	-0.1
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.1	-1.0	-0.0
Depression (self-reported)	0.4	0.4	0.6	-0.6	0.7
Medication: Paracetamol	0.4	0.7	1.0	1.0	-0.6
Leg fat percentage (right)	0.4	1.6	1.8	-1.2	1.3
Worry too long after embarrassment	0.4	0.6	1.2	1.1	-0.2
Migraine (self-reported)	0.4	0.5	0.5	0.7	-0.7
Mean time to correctly identify matches	0.4	0.7	1.2	1.1	-0.5
Number of full sisters	0.4	0.5	0.9	0.2	1.0
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.0	0.1	-1.0
Illnesses of father: Heart disease	0.4	0.5	0.8	-0.9	0.5
Illnesses of siblings: Diabetes	0.4	0.5	0.6	-0.6	0.8
High cholesterol (Self-reported)	0.4	0.8	1.4	0.4	1.2
Myopia	0.4	0.6	0.8	-0.6	-0.9
Cholesterol lowering medication	0.4	0.6	0.8	0.9	0.7
Intelligence (Savage-Jansen 2018)	0.3	0.8	0.9	-0.8	1.0
Reaction Time	0.3	0.6	0.8	0.7	-0.9
Breast Cancer	0.3	0.7	1.1	-0.5	-1.1
Fasting Glucose	0.3	0.4	0.6	-0.5	-0.8
Allergy or Eczema	0.3	0.7	1.3	0.4	-1.1
Hypothyroidism (self reported)	0.3	0.6	0.7	-0.9	-0.7
Angina	0.3	0.3	0.7	0.8	0.0
Medication: Co-codamol	0.3	0.3	0.6	0.1	-0.8
Relative age voice broke	0.3	0.4	0.8	-0.9	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	1.4	-1.2	0.2
Medication: Levothyroxine sodium	0.3	0.5	0.8	-0.9	-0.6
Had other major operations	0.3	0.3	0.6	0.2	0.8
Hayfever/allergic rhinitis (self-reported)	0.3	0.3	0.3	-0.6	-0.6
Time employed in main current job	0.3	0.4	0.7	0.8	0.3
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	0.5	-0.7	0.7
Number of live births	0.3	0.4	0.4	0.7	0.5
Noisy workplace	0.3	0.4	0.7	-0.3	0.9
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	0.6	0.8	-0.2
Tense / ‘highly strung’	0.3	0.5	0.7	0.9	-0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	0.9	0.1	-1.0
Qualifications: College or University degree	0.3	0.8	1.6	-0.3	-1.3
Medication for pain relief, constipation, heartburn	0.3	0.5	1.1	-1.0	-0.0
Angina (self-reported)	0.3	0.4	0.6	0.8	0.4
Heart disease (mother)	0.3	0.4	0.7	-0.9	-0.3
Alcohol intake frequency.	0.3	0.7	1.1	-0.6	-1.0
Average weekly red wine intake	0.3	0.4	0.7	-0.8	-0.3
Long-standing illness, disability or infirmity	0.3	0.4	0.5	0.7	-0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.4	0.6	0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	0.4	0.7	-0.6
Number of self-reported non-cancer illnesses	0.3	0.6	0.6	-0.8	0.7
Pain type(s) experienced in last month: Hip pain	0.3	0.3	0.6	0.1	0.8
Medication: Atorvastatin	0.3	0.4	0.7	0.8	0.3
Coronary Artery Disease (CAD)	0.2	0.2	0.4	0.6	-0.1
Type 2 Diabetes (T2D) (2018)	0.2	0.4	0.6	0.8	-0.5
Lung FVC	0.2	0.8	1.4	0.3	-1.2
Tanning	0.2	2.7	4.2	1.1	2.1
Vitamin and mineral supplements	0.2	0.3	0.4	-0.6	0.4
Diabetes (father)	0.2	0.3	0.4	-0.7	0.4
Serious illness, injury or assault to yourself	0.2	0.3	0.5	-0.7	-0.3
Past tobacco smoking	0.2	0.4	0.7	-0.3	0.9
Hair/balding pattern: Pattern 2	0.2	0.2	0.3	-0.5	-0.3
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.3	0.5	0.5
Diabetes (self-reported)	0.2	0.4	0.6	-0.4	0.8
Fluid intelligence score	0.2	0.4	0.7	-0.3	-0.8
Lung cancer (father)	0.2	0.3	0.6	0.0	0.7
Headache pain in last month	0.2	0.3	0.3	-0.4	0.6
Overall health rating	0.2	0.5	1.0	0.0	1.0
Supplements: Vitamin C	0.2	0.3	0.5	0.2	-0.7
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.3	0.3	0.5
Mood swings	0.2	0.4	0.7	0.9	-0.1
Diabetes diagnosed by doctor	0.2	0.3	0.6	-0.0	0.8
Medication for cholesterol	0.2	0.3	0.5	0.7	-0.4
Osteoporosis (self-reported)	0.2	0.2	0.3	-0.3	0.5
Financial situation satisfaction	0.2	0.3	0.5	0.7	-0.1
Supplements: Fish oil (including cod liver oil)	0.2	0.2	0.5	-0.7	-0.1
Ever had prostate specific antigen (PSA) test	0.2	0.3	0.5	-0.7	-0.3
Vascular/heart problems diagnosed by doctor	0.2	0.4	0.8	0.9	0.1
Supplements: Calcium	0.2	0.2	0.4	-0.7	0.1
Bipolar Disorder or Schizophrenia	0.1	0.2	0.4	-0.7	-0.2
Verbal and Numeric Reasoning (VNR)	0.1	0.1	0.3	-0.5	0.1
Schizophrenia (2014)	0.1	0.2	0.5	-0.7	0.1
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.2	-0.2	-0.4
Smoking Status	0.1	0.2	0.4	0.0	-0.6
Respiratory disease	0.1	0.2	0.3	-0.3	0.6
Sensitivity / hurt feelings	0.1	0.2	0.4	0.2	-0.7
Ever used hormone-replacement therapy (HRT)	0.1	0.2	0.2	0.3	-0.5
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.2	0.2	0.4
Current tobacco smoking	0.1	0.2	0.2	0.5	0.4
High blood pressure	0.1	0.4	0.6	-0.8	-0.4
Had menopause	0.1	0.1	0.2	0.1	-0.5
Qualifications: None of the above	0.1	0.2	0.4	-0.1	0.7
Allergy	0.1	0.3	0.6	-0.2	0.8
Falls in the last year	0.1	0.1	0.3	-0.0	-0.5
Hair/balding pattern: Pattern 3	0.1	0.2	0.4	0.6	0.2
Qualifications: A levels/AS levels or equivalent	0.1	0.3	0.5	0.7	-0.3
Medication: Cholesterol lowering	0.1	0.1	0.2	0.5	0.2
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.1	0.4	0.2
Blood clot in the leg (DVT)	0.1	0.1	0.2	-0.4	0.2
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.4	0.6	-0.1
Hypothyroidism/myxoedema (self-reported)	0.1	0.3	0.5	-0.7	-0.1
High blood pressure (siblings)	0.1	0.1	0.2	0.2	0.4
Comparative body size at age 10	0.1	0.3	0.5	0.7	0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.2	0.2	-0.3	-0.5
Shortness of breath walking on level ground	0.1	0.1	0.1	0.1	0.3
Eye problems/disorders: None of the above	0.1	0.1	0.1	0.3	0.4
Suffer from ‘nerves’	0.1	0.1	0.2	0.4	0.3
Had major operations	0.1	0.2	0.3	-0.2	-0.6
Qualifications: NVQ or HND or HNC or equivalent	0.1	0.1	0.2	0.1	-0.5
Hypertension (Self-reported)	0.1	0.3	0.5	-0.7	-0.1
Ever had bowel cancer screening	0.1	0.1	0.2	-0.0	0.4
Smoking status: Current	0.1	0.2	0.4	0.6	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.3	0.5	0.3	-0.7
Medication: Blood pressure	0.1	0.2	0.3	-0.6	0.3
Ever smoked	0.1	0.2	0.3	-0.6	0.1
Age started oral contraceptive pill	0.1	0.1	0.1	-0.0	-0.4
BMI	0.0	0.0	0.1	-0.3	-0.0
Hair Pigment	0.0	1.2	1.7	1.3	-0.9
Number of treatments/medications taken	0.0	0.0	0.1	-0.3	-0.0
Medication: Metformin	0.0	0.0	0.1	-0.1	0.2
Age when periods started (menarche)	0.0	0.0	0.1	-0.0	0.2
Medication: Atenolol	0.0	0.0	0.0	0.1	-0.1
Alcohol intake versus 10 years previously	0.0	0.0	0.1	-0.2	0.1
Qualifications: O levels/GCSEs or equivalent	0.0	0.1	0.1	0.3	-0.1
Number of full brothers	0.0	0.0	0.0	0.2	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.0	0.0	0.0	0.2	-0.2
Leg pain on walking	0.0	0.0	0.0	0.0	0.1
Tinnitus: Yes, now most or all of the time	0.0	0.0	0.0	-0.1	-0.1
Commuting to job workplace: Cycle	0.0	0.0	0.0	0.1	-0.0
Deep venous thrombosis (DVT) (self-reported)	0.0	0.0	0.0	-0.1	-0.0

Hub : Genes

DSTN

Models

Trait associations