Best TWAS P=1.91e-08 · Best GWAS P=1.18e-07 conditioned to 0.0585
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | ABHD12 | 0.10 | 0.17 | blup | 405 | 0.17 | 1.7e-20 | 4.6 | 5.1 | 2.9e-07 | 0.55 | 0.11 | 0.88 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | NINL | 0.19 | 0.17 | lasso | 20 | 0.23 | 1.2e-27 | 5.0 | 5.6 | 2.4e-08 | 0.64 | 0.07 | 0.92 | FALSE |
| 3 | GTEx | Artery Aorta | NINL | 0.17 | 0.18 | lasso | 6 | 0.19 | 1.5e-10 | 5.0 | 5.4 | 5.9e-08 | 0.53 | 0.05 | 0.94 | FALSE |
| 4 | GTEx | Brain Cerebellar Hemisphere | PYGB | 0.20 | 0.16 | lasso | 5 | 0.12 | 5.8e-04 | 4.7 | -5.2 | 1.9e-07 | -0.45 | 0.08 | 0.73 | FALSE |
| 5 | GTEx | Breast Mammary Tissue | ABHD12 | 0.08 | 0.09 | lasso | 5 | 0.09 | 3.3e-05 | 5.0 | 5.2 | 1.8e-07 | 0.53 | 0.07 | 0.90 | FALSE |
| 6 | GTEx | Skin Not Sun Exposed Suprapubic | PYGB | 0.12 | 0.13 | enet | 13 | 0.14 | 4.2e-08 | 4.6 | -5.6 | 1.9e-08 | -0.70 | 0.13 | 0.82 | TRUE |
| 7 | ROSMAP | Brain Pre-frontal Cortex | PYGB | 0.20 | 0.10 | bslmm | 414 | 0.11 | 3.2e-14 | 5.0 | -5.4 | 5.6e-08 | -0.67 | 0.04 | 0.95 | FALSE |