Hub : Genes

NINL

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1950 0.0470 0.0e+00 0.172 0.228 0.225 0.229 0.230 2.2e-20 2.1e-27 6.4e-27 1.9e-27 1.2e-27
2 GTEx Adipose Subcutaneous 0.1120 0.0520 7.2e-04 0.013 NA 0.023 NA 0.017 2.9e-02 NA 5.2e-03 NA 1.5e-02
3 GTEx Artery Aorta 0.1660 0.0510 4.8e-11 0.177 NA 0.170 NA 0.187 5.2e-10 NA 1.2e-09 NA 1.5e-10
4 GTEx Artery Tibial 0.5841 0.0943 8.6e-07 0.050 NA 0.086 NA 0.110 7.9e-05 NA 2.9e-07 NA 6.0e-09
5 GTEx Brain Cerebellar Hemisphere 0.1700 0.0740 5.9e-04 0.068 NA 0.107 NA 0.058 8.2e-03 NA 1.1e-03 NA 1.3e-02
6 GTEx Cells Transformed fibroblasts 0.0670 0.0420 7.5e-03 -0.003 NA 0.013 NA -0.001 6.2e-01 NA 3.4e-02 NA 4.0e-01
7 GTEx Heart Left Ventricle 0.0812 0.0393 1.2e-03 0.028 NA 0.050 NA 0.044 1.2e-02 NA 1.1e-03 NA 2.2e-03
8 GTEx Lung 0.0684 0.0334 8.2e-05 0.052 NA 0.011 NA 0.039 7.4e-05 NA 4.3e-02 NA 5.3e-04
9 GTEx Nerve Tibial 0.1573 0.0495 2.4e-08 0.167 NA 0.129 NA 0.142 6.5e-12 NA 2.1e-09 NA 3.2e-10
10 GTEx Pituitary 0.1150 0.0580 2.1e-03 0.063 NA 0.068 NA 0.110 1.2e-02 NA 8.7e-03 NA 1.0e-03
11 GTEx Thyroid 0.1330 0.0450 1.7e-10 0.183 NA 0.196 NA 0.190 5.9e-14 NA 6.2e-15 NA 1.8e-14
12 ROSMAP Brain Pre-frontal Cortex 0.1911 0.0479 0.0e+00 0.194 0.228 0.254 0.229 0.248 2.3e-24 7.3e-29 2.1e-32 6.1e-29 1.5e-31
13 YFS Blood 0.0437 0.0144 2.5e-07 0.032 0.024 0.028 0.027 0.030 9.3e-11 1.5e-08 1.7e-09 2.1e-09 2.8e-10
14 TCGA Colon Adenocarcinoma 0.2000 0.0770 1.9e-05 0.065 0.064 0.060 NA 0.078 1.3e-04 1.4e-04 2.2e-04 NA 2.7e-05
15 TCGA Head and Neck Squamous Cell Carcinoma 0.1068 0.0507 7.6e-04 0.014 0.044 0.038 NA 0.021 9.4e-03 1.1e-05 4.0e-05 NA 1.6e-03
16 TCGA Testicular Germ Cell Tumors 0.1130 0.0700 2.8e-03 0.029 0.068 0.039 NA 0.026 3.3e-02 2.1e-03 1.7e-02 NA 4.2e-02
17 TCGA Thyroid Carcinoma 0.0810 0.0350 1.7e-11 0.138 0.108 0.116 NA 0.126 2.4e-13 1.2e-10 2.1e-11 NA 2.9e-12

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17
Bipolar Disorder (2018) 0.6 0.9 3.2 0.8 -0.7 1.3 1.0 1.8 -1.0 0.7 -0.8 -0.4 -0.6 -0.9 1.3 0.1 -0.1 0.2 -1.5 -1.3
Bipolar Disorder or Schizophrenia 0.5 1.3 2.5 1.3 -0.7 1.4 1.1 1.0 -0.5 1.6 -1.0 -1.2 -1.4 -1.2 1.3 0.7 0.3 0.7 -1.6 -1.0
Depressed Affect (Nagel 2018) 1.0 2.1 5.0 1.6 -0.9 1.7 -0.1 2.1 -2.1 0.9 -1.5 -1.0 -0.7 -1.9 1.6 -0.3 0.1 -0.6 -2.0 -2.2
Depression (Nagel 2018) 0.6 0.8 2.2 1.1 -0.4 1.3 -1.0 0.4 -1.4 0.7 -1.1 -0.7 -0.8 -1.1 0.1 -0.2 0.0 -0.0 -1.5 -1.3
Intelligence (Savage-Jansen 2018) 0.2 0.6 1.9 -0.1 0.5 -0.3 0.6 -0.4 0.6 -0.2 0.9 1.1 1.3 0.8 -1.2 0.2 -0.3 1.4 0.4 0.5
Neuroticism (Nagel 2018) 0.6 1.3 4.7 0.6 -1.2 1.1 -0.6 1.3 -2.2 0.7 -0.8 -1.3 -0.9 -0.8 0.7 -1.0 -1.0 -1.2 -1.6 -1.3
Schizophrenia (2018) 0.3 0.7 2.2 1.0 -0.3 0.8 0.5 -0.2 0.1 1.5 -0.6 -1.2 -1.3 -0.7 0.7 0.9 0.4 0.8 -0.8 -0.3
Schizophrenia vs Biploar Disorder 0.2 0.3 2.7 -0.2 1.6 0.4 -0.1 -0.5 0.2 0.1 0.5 0.3 0.1 0.5 -0.8 0.5 -0.1 0.9 -0.1 -0.1
Worry (Nagel 2018) 0.2 0.5 2.0 -0.5 -0.7 0.0 -0.6 -0.4 -0.7 0.3 -0.0 -0.8 -0.9 0.8 0.1 -0.9 -1.0 -1.4 -0.3 0.0
Alzheimer’s Disease (in mother) 0.4 0.5 3.1 -0.9 -0.8 -0.3 -1.7 0.4 -0.8 -0.3 1.1 0.4 0.6 0.5 -0.4 -0.8 -0.6 -0.5 0.0 0.1
Alzheimer’s Disease (in father) 1.6 1.8 4.2 -1.1 2.0 -1.3 -0.0 -0.4 1.4 -1.9 1.4 2.0 1.8 1.6 -1.1 -0.0 0.0 0.6 1.7 1.2
Alzheimer’s Disease (including proxy) 0.7 1.0 2.6 -1.5 0.1 -1.0 -1.6 0.0 0.0 -1.1 1.4 1.1 1.1 1.0 -0.7 -1.0 -0.7 -0.7 0.8 0.9
Crohns Disease (2017) 0.7 1.6 3.5 1.5 -0.4 1.8 0.7 1.6 -1.2 1.3 -0.9 -0.5 -0.5 -1.9 1.1 1.1 1.1 1.4 -1.7 -1.7
Irritable Bowel Disease (IBD) 0.1 0.4 0.9 -0.8 0.7 -0.3 0.5 0.2 -0.0 -0.7 0.9 1.0 0.9 0.0 -0.7 -0.5 -0.6 0.5 0.3 0.2
Ulcerative Colitis (UC) 1.1 2.1 4.4 -2.1 1.4 -1.7 -0.0 -1.1 1.0 -1.7 1.8 1.5 1.3 1.6 -1.7 -1.3 -1.4 -0.4 1.5 1.5
Major Depression (MDD) 0.2 0.3 1.0 0.5 -0.4 0.2 0.4 0.5 -0.4 0.3 -0.4 -0.3 0.1 -0.5 0.5 1.0 0.6 0.9 -0.4 -0.5
Reaction Time 2.3 4.4 9.8 1.8 -3.1 1.9 0.8 0.6 -1.2 2.8 -2.8 -3.1 -3.0 -1.9 2.2 1.3 1.8 -0.4 -2.1 -1.8
Verbal and Numeric Reasoning (VNR) 2.0 4.8 9.9 3.1 -0.7 2.9 2.8 2.3 -0.5 2.5 -1.9 -1.1 -0.9 -1.7 1.9 2.7 2.5 2.5 -2.5 -2.3
Breast Cancer 2.3 5.6 10.7 3.1 -1.8 2.9 1.6 2.9 -1.8 2.3 -2.9 -1.5 -1.1 -2.1 3.3 1.9 2.2 1.5 -2.9 -2.8
Ovarian Cancer 0.9 1.2 2.6 0.9 -1.3 0.9 -0.7 0.9 -1.2 1.1 -1.4 -1.4 -1.6 -1.2 1.2 0.1 0.4 -0.8 -1.3 -1.1
Prostate Cancer 5.1 7.2 15.0 -3.8 0.2 -3.9 -1.6 -2.2 0.8 -3.2 2.9 2.1 2.3 2.4 -2.8 -3.1 -3.0 -2.0 3.1 3.2
Age at First Birth 5.8 8.4 17.2 -3.1 1.7 -4.0 -1.0 -3.3 2.7 -3.0 3.3 2.6 2.7 3.5 -3.0 -1.6 -1.9 -0.7 4.0 4.2
Bipolar Disorder (2011) 0.6 0.6 3.4 0.4 -1.9 0.3 0.6 0.3 -0.9 0.9 -0.6 -0.8 -0.7 -1.0 0.4 -0.6 -0.4 0.2 -0.9 -0.1
Body Mass Index (BMI) (2010) 3.1 4.3 10.2 2.9 0.0 2.5 3.2 1.8 -0.0 1.8 -1.8 -0.8 -0.7 -2.0 2.0 3.1 2.9 2.4 -1.5 -2.0
Coronary Artery Disease (CAD) 0.7 0.8 1.7 1.2 -0.6 1.1 0.1 1.2 -1.1 1.1 -1.3 -0.7 -0.6 -0.8 0.9 0.3 0.3 0.6 -1.3 -0.7
Crohns Disease (2012) 0.5 0.9 2.0 1.2 -0.2 1.0 1.4 1.4 -0.6 0.6 -0.6 0.0 0.1 -1.2 1.0 0.9 0.7 1.1 -1.0 -1.0
Mean Putamen Volume 1.8 2.1 3.6 -1.8 1.3 -1.8 -0.4 -1.1 1.0 -1.9 1.2 1.6 1.4 1.9 -1.7 -1.3 -1.5 -0.3 1.6 1.5
Fasting Glucose 3.5 4.2 7.5 -1.6 2.4 -2.5 -0.5 -1.4 2.3 -2.4 2.0 2.5 2.4 2.7 -2.2 -0.7 -0.9 0.5 2.6 2.7
HbA1C 0.7 0.7 2.6 0.3 1.0 0.3 1.3 1.0 0.5 -0.7 0.9 1.6 1.6 0.4 -0.5 0.3 -0.0 1.4 0.2 -0.2
HDL Cholesterol 1.7 2.9 10.8 -1.9 -0.9 -1.3 -3.0 -0.2 -1.7 -1.1 0.5 0.0 0.0 0.1 -0.8 -3.3 -2.9 -3.1 0.0 0.3
LDL Cholesterol 4.0 6.3 11.2 3.1 -0.8 3.3 1.1 1.9 -0.6 3.2 -2.5 -2.5 -2.0 -2.5 3.3 2.9 3.3 1.1 -2.7 -3.0
Lupus 0.4 0.5 2.4 0.2 1.6 -0.1 -0.3 -0.3 1.4 -0.4 0.6 0.7 0.5 0.7 -0.7 0.8 0.8 0.8 0.6 0.3
Neuroticism (2016) 1.2 1.8 5.2 -1.2 0.4 -1.2 -0.0 -0.8 0.6 -1.4 2.1 1.6 1.8 1.4 -2.3 -0.8 -1.4 0.6 1.3 1.5
Primary Biliary Cirrhosis 0.3 0.4 1.6 0.3 -0.8 -0.3 1.2 -1.3 0.6 0.6 0.4 -0.4 -0.4 -0.5 0.3 0.3 0.4 0.1 0.4 0.4
Rheumatoid Arthritis 0.9 1.3 2.6 0.9 -0.6 1.6 -0.1 0.3 -1.2 1.4 -1.0 -1.6 -1.4 -1.4 1.4 0.4 0.5 -0.7 -1.6 -1.2
Schizophrenia (2014) 0.2 0.3 1.9 0.8 0.2 0.7 0.7 0.3 0.4 0.9 0.3 -0.2 -0.3 -0.1 0.3 0.7 -0.0 1.4 -0.7 -0.1
Triglycerides 0.7 1.2 2.8 0.2 1.7 -0.1 1.1 -1.0 1.6 -0.4 1.0 1.1 1.4 0.8 -1.0 1.2 0.9 1.5 1.1 0.7
Type 2 Diabetes (T2D) (2012) 1.0 1.2 3.6 -0.6 1.0 -0.8 -0.7 -1.0 1.1 -0.5 1.9 1.1 1.5 1.5 -1.2 0.3 -0.3 1.1 1.0 1.1
Ulcerative Colitis 2.4 3.6 6.8 -2.6 0.7 -2.3 -1.6 -1.0 0.2 -2.3 1.9 1.9 1.9 1.9 -2.1 -2.5 -2.6 -1.0 1.7 1.8
Blood Eosinophil Count 0.8 6.1 11.5 2.6 -3.0 2.1 3.1 1.5 -0.7 3.3 -2.8 -3.0 -2.9 -2.9 3.4 1.8 1.5 0.6 -2.4 -1.9
Blood Platelet Count 1.2 13.8 35.5 2.7 -4.1 3.5 -1.8 3.2 -6.0 2.7 -4.7 -3.6 -3.7 -4.7 3.1 -1.4 -0.8 -2.5 -5.7 -4.4
Blood Red Count 0.4 3.4 10.7 0.8 3.0 0.5 1.3 -2.3 3.2 1.0 -0.2 -0.0 -1.1 1.5 -1.1 3.2 1.8 3.3 0.5 0.7
Blood White Count 0.8 5.8 14.6 2.0 -2.4 2.2 -0.5 3.1 -3.8 2.2 -2.5 -2.1 -1.6 -3.7 2.0 -0.7 -0.6 -0.7 -3.5 -3.0
Heel T-Score 0.5 4.2 9.5 -2.8 1.5 -2.7 -1.1 -2.3 1.7 -2.8 1.4 1.6 1.5 1.9 -2.1 -1.4 -0.9 -2.4 3.1 1.9
BMI 3.4 20.0 42.4 6.5 -1.5 6.0 4.2 4.4 -1.0 4.8 -3.4 -2.6 -2.1 -4.9 4.5 5.6 5.6 4.4 -4.6 -5.3
Height 0.8 14.9 31.1 5.6 -0.3 5.4 3.3 3.6 -1.9 3.9 -3.7 -2.2 -2.1 -3.7 3.9 4.4 4.6 3.7 -4.5 -4.8
Waist Hip Ratio (WHR) 1.2 5.4 12.3 3.2 -0.7 3.3 1.9 3.5 -1.8 2.1 -2.6 -1.3 -1.4 -2.5 2.2 1.8 1.5 1.7 -3.0 -3.0
Systolic Blood Pressure 0.7 3.5 10.3 -1.1 2.9 -1.4 1.4 -3.1 3.2 -0.9 1.7 1.2 0.6 1.4 -1.4 1.4 0.7 1.1 2.7 2.1
Smoking Status 2.9 6.9 21.1 2.8 -3.3 2.8 0.1 1.9 -3.0 2.7 -2.9 -2.7 -2.1 -4.6 2.6 0.5 1.3 -0.3 -3.3 -3.1
Allergy or Eczema 3.5 9.3 19.8 -3.6 2.4 -3.5 -2.3 -1.0 1.2 -4.4 3.2 3.8 3.7 3.6 -2.5 -3.1 -3.5 -1.3 3.2 2.8
Cardiovascular Disease 0.1 0.3 1.0 -0.8 0.3 -0.5 -0.3 -0.8 -0.0 -0.6 1.0 0.5 0.3 -0.2 -1.0 -0.5 -0.7 -0.3 0.6 0.3
Hypothyroidism (self reported) 0.5 1.2 6.6 1.2 0.4 0.7 2.1 0.5 1.0 1.0 0.4 0.4 0.6 -0.0 0.1 1.7 1.2 2.6 -0.3 -0.1
Respiratory disease 1.0 2.2 5.7 1.8 -1.6 1.8 1.1 2.2 -1.6 1.2 -1.2 -1.0 -0.5 -2.4 1.5 0.4 0.8 0.1 -1.7 -2.0
Type 2 Diabetes (T2D) (2018) 1.0 1.8 4.6 -1.2 1.2 -1.1 -1.2 0.8 -0.2 -1.7 1.5 2.1 2.2 1.1 -1.3 -1.3 -1.9 0.6 0.6 0.9
Lung FEV1/FVC ratio 1.0 5.3 17.2 -0.7 3.9 -1.2 1.4 -3.3 4.1 -0.7 1.5 1.3 0.9 3.0 -1.5 2.4 1.4 2.4 2.7 2.3
Lung FVC 3.5 17.6 34.2 -4.8 2.1 -5.5 -2.0 -4.9 3.9 -4.4 4.6 4.0 3.6 5.5 -4.6 -2.2 -3.3 -0.3 5.4 5.8
Neuroticism 0.6 1.5 3.3 0.9 -1.7 1.2 -0.3 1.0 -1.8 1.3 -0.8 -1.6 -1.2 -1.2 1.1 -0.9 -0.9 -1.2 -1.6 -1.4
Chronotype (morning person) 0.1 0.3 1.9 -0.4 0.5 -0.5 -0.2 -0.3 1.1 -0.4 0.4 0.2 0.1 1.4 -0.1 0.2 -0.1 -0.2 0.7 0.7
Hair Pigment 0.2 6.3 25.7 -0.8 -3.0 -0.4 -2.3 -2.7 -1.9 1.1 -2.7 -3.9 -4.9 -0.8 0.8 -2.0 -1.3 -5.1 -0.7 0.5
Tanning 0.2 2.2 11.0 0.8 -1.5 0.6 -1.0 3.3 -2.3 -0.3 0.8 1.4 2.5 -1.5 0.1 -0.7 -0.7 1.6 -1.4 -0.8
Hand grip strength (left) 1.1 2.9 8.6 0.5 1.8 -0.2 1.9 -0.9 2.7 -0.2 2.0 1.7 1.8 1.4 -1.4 2.1 1.8 2.9 1.4 1.0
Number of treatments/medications taken 0.1 0.1 0.4 -0.1 0.6 -0.1 0.4 -0.2 0.4 -0.3 0.3 0.3 0.2 -0.2 -0.4 0.0 -0.4 0.5 0.5 0.6
Average weekly spirits intake 0.6 0.7 2.4 1.0 -0.3 1.0 0.3 1.0 -0.5 0.8 -1.1 -0.6 -0.5 -1.1 1.5 0.8 0.9 0.5 -0.8 -0.9
Sensitivity / hurt feelings 0.2 0.3 1.6 0.4 -0.3 0.5 -0.2 1.2 -0.8 0.0 0.2 0.3 0.4 0.1 -0.1 -0.5 -0.8 0.4 -0.6 -0.5
Frequency of depressed mood in last 2 weeks 0.1 0.2 1.3 0.2 -0.4 0.1 -1.1 -0.7 -0.4 0.3 0.1 -0.3 -0.2 -0.1 -0.8 -0.4 -0.4 0.0 -0.3 0.0
Hearing difficulty/problems: Yes 1.2 1.8 3.9 -1.8 -0.8 -1.6 -2.0 0.0 -0.2 -1.7 1.3 1.2 1.4 0.9 -1.4 -1.9 -1.6 -0.9 1.1 1.3
Relative age of first facial hair 0.5 1.0 3.2 0.9 -0.9 1.1 0.4 -0.4 -0.4 1.2 -1.2 -1.5 -1.8 -1.0 0.8 0.8 1.0 -0.7 -0.8 -0.8
Other serious medical condition/disability diagnosed by doctor 1.5 1.9 4.1 -1.0 1.8 -1.3 1.5 -0.7 2.0 -1.5 1.6 1.8 1.4 1.4 -0.7 0.1 -0.5 0.9 1.8 1.7
Ever used hormone-replacement therapy (HRT) 5.4 6.8 11.6 3.1 -1.6 3.2 1.6 2.4 -2.0 3.0 -3.3 -2.8 -2.8 -3.4 3.4 1.7 1.8 0.4 -3.1 -2.7
Ever had hysterectomy (womb removed) 0.5 0.6 1.5 0.7 -1.2 0.3 -0.1 -0.1 -0.1 0.7 -1.0 -1.2 -1.2 -1.1 1.2 0.5 0.8 -0.4 -0.3 -0.1
Systolic blood pressure, automated reading 1.7 4.9 16.9 2.5 1.9 2.3 3.7 0.5 1.7 1.8 -1.4 -0.7 -1.2 -1.4 2.0 4.1 3.5 2.7 -0.5 -1.2
Eye problems/disorders: Diabetes related eye disease 1.3 1.4 2.8 0.8 -1.1 1.3 1.1 1.6 -1.1 1.2 -1.4 -1.2 -1.2 -1.3 1.5 0.5 0.5 0.0 -1.6 -1.7
Angina 0.8 1.1 2.2 1.2 -0.1 1.5 0.0 1.4 -0.9 0.9 -1.1 -0.5 -0.5 -1.0 1.2 0.9 1.3 0.7 -1.3 -1.5
Medication for hormone replacement therapy 0.5 0.5 2.0 -0.6 -0.7 -0.9 -0.3 -1.4 0.6 -0.1 0.6 -0.2 -0.0 0.2 -0.8 -0.8 -0.9 -0.5 0.7 1.2
Vitamin and mineral supplements 1.6 2.2 4.5 1.5 -1.6 1.5 1.1 1.4 -1.6 2.0 -1.3 -1.7 -1.5 -1.8 1.6 0.4 0.6 0.3 -2.1 -1.7
Supplements: Zinc 0.4 0.4 2.1 -0.0 0.1 -0.8 -0.2 -0.7 1.5 -0.5 0.3 0.7 0.8 0.7 -0.3 0.5 0.6 0.7 1.0 0.7
Medication: Co-codamol 1.2 1.4 3.5 -1.3 1.9 -0.8 0.1 -0.2 -0.2 -1.7 1.4 1.5 1.4 0.9 -1.6 -1.3 -1.4 -0.7 0.9 0.7
Medication: Metformin 0.2 0.3 1.5 0.4 -0.3 0.3 0.6 1.2 -0.8 0.1 -0.5 0.4 0.4 -0.6 0.1 -0.1 -0.5 0.9 -0.8 -0.4
Diabetes (father) 2.3 2.8 6.8 -2.2 0.9 -2.2 -0.1 -2.6 1.7 -1.7 1.9 1.2 0.8 1.2 -2.0 -0.9 -1.1 -0.4 2.5 2.4
Diabetes (mother) 1.9 2.4 9.2 0.5 1.4 0.0 1.4 -0.8 2.7 0.2 0.8 0.6 0.6 0.4 -0.3 3.0 2.9 2.8 1.5 0.5
Severe depression (siblings) 1.2 1.3 2.5 1.5 -1.2 1.5 0.2 0.2 0.0 1.5 -0.7 -1.3 -1.2 -1.6 0.9 1.3 1.4 0.6 -1.1 -1.2
Pack years adult smoking proportion 2.8 4.2 9.5 1.6 -2.1 2.2 -1.0 2.7 -2.7 1.4 -2.3 -1.8 -1.7 -3.1 1.8 -0.1 0.5 -1.0 -2.9 -2.9
Impedance of leg (right) 0.4 1.7 5.5 -1.1 -2.0 -1.0 -2.0 -1.5 -0.8 0.6 -0.6 -1.8 -1.6 -0.5 0.0 -1.6 -0.9 -2.3 0.0 0.6
Leg fat-free mass (left) 2.2 11.4 25.0 5.0 0.3 4.5 3.9 3.6 -0.4 2.9 -2.5 -1.0 -0.8 -3.1 3.2 4.6 4.5 4.2 -3.3 -3.9
Trunk fat percentage 8.8 35.2 63.1 7.9 -2.9 7.6 4.8 6.1 -2.8 6.5 -6.5 -4.7 -4.4 -7.1 6.6 6.0 6.3 3.7 -6.8 -6.9
Hand grip strength (right) 0.9 2.4 8.3 1.0 2.2 0.4 1.8 -0.0 2.2 -0.2 1.3 1.6 1.6 1.0 -0.8 2.4 1.9 2.9 0.8 0.3
Townsend deprivation index at recruitment 0.4 0.6 1.4 1.2 0.1 0.8 0.6 1.1 -0.1 0.6 -0.9 -0.1 0.0 -0.4 0.9 1.0 1.1 0.9 -0.7 -0.9
Current tobacco smoking 1.5 2.4 6.0 1.4 -1.5 1.8 -0.3 1.4 -2.4 1.4 -1.4 -1.3 -1.2 -2.4 1.0 -0.4 -0.5 -0.3 -2.4 -2.1
Average weekly fortified wine intake 0.5 0.5 2.6 -0.9 0.3 -0.4 -0.8 -0.6 -0.9 -0.8 -0.0 -0.0 -0.1 -0.2 -0.5 -1.4 -1.0 -1.6 0.0 -0.0
Maternal smoking around birth 2.9 4.2 7.7 2.5 -1.3 2.5 0.6 1.7 -1.2 2.5 -2.2 -2.2 -2.1 -2.8 2.4 1.9 2.2 0.6 -2.4 -2.3
Fed-up feelings 0.1 0.3 0.8 0.7 -0.3 0.3 0.1 0.8 -0.7 -0.2 -0.3 0.4 0.6 -0.6 0.2 -0.5 -0.9 0.4 -0.5 -0.2
Frequency of unenthusiasm / disinterest in last 2 weeks 1.2 1.6 4.5 1.0 -1.5 1.4 -1.1 0.6 -2.1 1.4 -0.9 -1.4 -1.2 -1.7 0.6 -0.5 -0.3 -0.6 -1.9 -1.4
Relative age voice broke 0.4 0.5 2.6 -0.2 -1.1 -0.2 -0.3 -1.6 0.0 0.1 -0.5 -1.0 -1.1 -0.2 -0.2 -0.2 0.5 -1.6 0.4 -0.1
Taking other prescription medications 0.3 0.5 4.0 0.5 -0.2 0.3 2.0 0.2 0.3 0.8 0.3 -0.2 0.1 -0.5 0.8 0.8 0.3 1.3 -0.1 0.3
Age when periods started (menarche) 0.4 0.9 3.1 -0.7 -0.8 -0.1 -1.8 -1.2 -0.9 -0.1 -1.3 -1.2 -1.6 -0.5 -0.3 -0.8 -0.1 -1.7 -0.3 -0.2
Bilateral oophorectomy (both ovaries removed) 0.7 0.8 2.6 -0.2 -0.6 0.2 -1.3 0.9 -1.6 -0.4 -0.7 -0.3 -0.4 -0.5 0.1 -1.6 -1.3 -1.3 -0.9 -0.5
Heel bone mineral density (BMD) T-score, automated (left) 0.7 1.6 5.6 -0.9 1.2 -0.9 -0.3 0.5 1.0 -2.3 1.3 2.3 2.4 1.2 -1.0 -0.0 0.1 0.5 1.5 0.6
Tinnitus: Yes, but not now, but have in the past 1.1 1.2 3.3 1.0 -1.1 1.2 -0.2 0.5 -1.2 1.8 -1.0 -1.5 -1.3 -1.1 0.9 0.4 0.4 0.4 -1.6 -1.0
Qualifications: CSEs or equivalent 0.1 0.2 1.7 0.0 1.3 0.3 0.3 -0.3 0.5 -0.0 0.3 0.2 -0.0 0.4 -0.5 0.3 0.1 0.2 -0.2 -0.2
Serious illness, injury or assault to yourself 0.4 0.4 2.6 0.6 -0.5 0.6 0.0 1.6 -0.9 -0.2 -0.5 0.3 0.3 -0.6 0.6 -0.3 -0.4 0.4 -0.9 -0.8
High blood pressure 0.4 1.1 4.3 -0.8 2.1 -0.5 0.4 -0.5 0.8 -1.0 1.6 1.5 1.2 0.8 -1.3 0.2 -0.3 0.9 1.0 0.6
Hayfever, allergic rhinitis or eczema 3.0 6.6 10.4 -2.9 2.0 -3.1 -1.0 -1.3 1.8 -3.2 3.1 3.1 3.2 3.2 -2.1 -2.1 -2.6 -0.4 3.0 2.9
Multivitamins +/- minerals 2.1 2.7 4.9 -1.8 0.7 -1.8 -2.2 -1.8 0.9 -1.9 1.5 1.3 1.3 1.7 -2.1 -1.5 -1.6 -1.0 2.0 1.8
Stomach or abdominal pain in last month 0.2 0.2 1.1 -0.4 0.2 -0.4 0.2 -0.6 0.5 -0.2 0.6 0.2 0.2 0.2 -0.5 -0.6 -1.0 0.2 0.3 0.8
Supplements: Glucosamine 0.1 0.1 0.4 0.4 0.2 0.4 0.2 0.3 0.3 -0.2 -0.5 0.1 -0.1 -0.4 0.6 0.4 0.4 -0.0 0.1 -0.1
Diverticular disease/diverticulitis (self-reported) 0.7 0.8 3.0 1.1 -0.9 0.9 0.3 1.7 -1.3 0.5 -0.6 -0.1 0.2 -0.7 1.2 0.0 0.2 0.1 -1.2 -1.3
Medication: Atenolol 0.4 0.6 1.8 -0.0 1.0 -0.3 0.6 -0.0 0.9 -0.1 1.2 0.9 1.1 0.8 -0.5 0.6 0.3 1.4 0.7 0.5
Medication: Levothyroxine sodium 1.0 1.8 7.0 0.3 0.8 -0.4 2.1 -0.7 2.2 0.3 1.2 0.9 1.2 1.1 -0.7 1.7 1.1 2.7 1.2 1.2
Sitting height 2.1 14.8 30.6 5.0 -0.0 5.5 3.3 3.9 -2.4 3.5 -4.1 -2.4 -2.4 -4.2 3.8 4.0 4.5 2.3 -4.6 -5.4
Chronic bronchitis/emphysema (father) 3.0 3.5 8.9 0.3 -1.3 1.6 -1.6 2.6 -3.0 0.3 -1.7 -1.3 -1.6 -2.5 1.2 -1.6 -1.2 -3.0 -2.2 -2.1
High blood pressure (mother) 1.1 1.6 7.3 -0.8 2.7 -0.4 0.2 0.6 0.7 -1.9 1.2 2.2 1.9 1.2 -1.0 -0.1 -0.6 0.9 0.8 0.3
Body mass index (BMI) 4.3 18.3 39.3 6.3 -1.2 5.6 4.4 4.4 -0.9 4.5 -3.8 -2.5 -2.2 -4.7 4.5 5.2 5.0 4.1 -4.4 -4.7
Impedance of leg (left) 0.5 2.6 9.0 -1.7 -2.3 -1.3 -2.5 -1.4 -1.4 0.3 -0.5 -1.7 -1.6 -0.4 -0.5 -2.4 -1.7 -3.0 0.0 0.7
Leg predicted mass (left) 2.2 11.4 25.0 5.0 0.2 4.5 3.9 3.6 -0.4 2.9 -2.5 -1.0 -0.8 -3.2 3.2 4.6 4.5 4.1 -3.3 -3.9
Trunk fat mass 8.1 34.9 66.0 8.1 -2.2 7.6 5.4 5.9 -2.1 6.4 -6.0 -4.2 -3.9 -6.8 6.4 6.6 6.8 4.6 -6.5 -6.8
Waist circumference 5.7 20.8 41.3 6.4 -1.4 6.1 4.5 5.3 -1.6 4.6 -4.3 -2.5 -2.3 -5.0 4.7 5.2 4.9 4.1 -5.0 -5.3
Number of incorrect matches in round 0.3 0.4 1.7 0.3 0.3 0.8 -0.9 1.3 -0.9 0.0 -0.4 -0.0 -0.3 -0.7 0.6 -0.4 -0.8 -0.2 -0.9 -0.8
Past tobacco smoking 0.4 0.7 3.7 -0.4 1.4 -0.3 0.6 -0.5 0.8 -0.6 1.0 1.0 0.6 1.9 -0.7 0.3 -0.3 0.7 0.7 0.7
Alcohol usually taken with meals 0.7 1.2 5.3 0.0 1.6 -0.6 1.7 -0.5 2.3 -0.7 0.2 0.9 0.6 1.3 -0.5 1.0 0.8 1.0 1.4 0.9
Nervous feelings 0.3 0.6 2.9 -1.0 -0.3 -0.7 0.2 -1.0 0.6 -0.1 1.0 0.1 -0.1 1.7 -0.6 -0.5 -1.0 -0.4 0.7 1.1
Frequency of tenseness / restlessness in last 2 weeks 0.6 0.9 3.8 -0.0 -0.7 0.6 -1.9 0.7 -2.0 0.1 -0.5 -0.6 -0.4 -0.7 -0.0 -1.1 -0.9 -1.1 -1.2 -1.0
Hearing difficulty/problems with background noise 2.0 3.2 8.3 -2.1 -1.4 -2.1 -2.9 -0.4 -0.1 -1.9 2.1 1.5 1.9 1.7 -1.6 -2.2 -1.8 -0.9 1.6 1.9
Hair/balding pattern: Pattern 2 0.7 1.0 3.1 -0.9 -0.4 -0.9 -1.8 -1.0 -0.7 -0.7 0.2 0.1 0.3 0.8 -1.0 -1.7 -1.4 -1.6 0.1 0.4
Had menopause 2.7 3.4 7.5 2.4 -0.0 2.7 1.4 2.4 -0.5 1.7 -2.3 -1.1 -1.5 -1.9 1.9 2.0 1.7 1.6 -2.2 -1.9
Had other major operations 0.4 0.5 2.7 -0.9 1.6 -0.5 0.4 -0.0 0.2 -1.4 0.6 1.0 0.8 0.5 -0.5 -0.2 -0.2 -0.5 0.7 0.2
Forced vital capacity (FVC) 2.7 10.5 21.8 -3.4 2.8 -4.1 -0.5 -3.5 3.8 -3.7 3.5 3.4 3.2 4.0 -3.3 -0.5 -1.0 0.3 4.7 4.2
Heel bone mineral density (BMD) T-score, automated (right) 1.0 2.3 6.7 -1.2 1.7 -1.2 -0.5 0.2 1.5 -2.6 1.4 2.6 2.5 1.7 -1.3 -0.1 0.1 0.5 1.8 0.9
Ever unenthusiastic/disinterested for a whole week 0.9 1.1 3.2 -1.1 -1.6 -1.0 -1.7 -0.7 -0.7 -0.4 0.5 -0.3 -0.1 -0.2 -1.0 -1.8 -1.6 -1.5 0.4 0.7
Qualifications: None of the above 0.7 1.6 3.6 1.2 -1.2 1.5 -0.0 1.0 -1.9 1.3 -1.4 -1.4 -1.3 -1.9 1.2 -0.0 0.0 -0.2 -1.8 -1.4
Financial difficulties in last 2 years 0.2 0.3 2.2 0.2 -1.5 -0.4 -0.1 -0.8 0.0 0.5 -0.0 -0.7 -0.4 -0.8 -0.4 -0.5 -0.3 -0.6 0.1 0.2
Mouth/teeth dental problems 0.3 0.5 2.3 -0.5 1.5 -0.4 0.2 -0.9 0.9 -0.8 0.0 0.5 -0.1 1.2 -0.8 0.3 -0.0 0.1 0.8 0.6
Heart attack 0.6 0.7 2.9 0.9 1.3 0.7 1.2 0.0 0.8 0.8 0.1 0.0 -0.2 -0.1 0.5 1.6 1.0 1.7 -0.1 -0.2
Allergy 0.7 1.5 3.8 1.2 -0.5 1.2 1.0 -0.3 0.1 1.7 -1.5 -1.6 -1.8 -1.0 0.9 1.9 2.0 0.6 -0.9 -0.9
Pain all over the body in last month 1.0 1.1 4.0 -0.6 -1.9 -0.2 -0.8 -0.2 -1.0 0.2 -0.4 -1.1 -1.2 -0.6 -0.3 -1.6 -1.8 -2.0 -0.4 0.2
Diabetes (self-reported) 0.6 0.9 3.1 -1.1 0.5 -0.8 -0.8 0.8 -0.7 -1.1 0.8 1.4 1.4 0.5 -1.0 -1.2 -1.8 0.6 0.0 0.6
Hayfever/allergic rhinitis (self-reported) 1.2 1.6 4.1 -0.7 1.8 -1.0 0.8 0.6 1.5 -1.4 1.5 2.0 2.0 1.6 -0.3 0.4 -0.0 1.3 1.4 1.0
Medication: Ramipril 0.7 0.9 3.9 0.4 2.0 0.5 1.1 0.9 0.5 -0.5 0.5 1.4 1.2 0.6 -0.1 1.1 0.5 2.0 0.1 -0.2
Medication: Simvastatin 0.7 1.0 2.3 1.5 -0.3 1.3 0.1 0.5 -0.9 1.0 -1.2 -0.8 -0.6 -1.3 0.8 1.2 1.4 0.9 -1.1 -1.1
Fluid intelligence score 1.3 2.7 6.0 2.5 -0.9 2.1 1.8 2.1 -0.7 2.0 -1.3 -0.9 -0.6 -1.2 1.6 1.8 1.4 1.9 -2.0 -1.6
Illnesses of siblings 0.4 0.5 1.6 -1.2 -0.4 -1.1 0.4 0.3 -0.3 -0.7 0.4 0.2 0.5 0.9 -0.3 -1.2 -1.1 -0.9 0.5 0.5
Neuroticism score 0.5 1.0 3.6 -0.4 -1.3 -0.1 -1.3 0.4 -1.6 0.2 0.2 -0.6 -0.2 -0.1 -0.1 -1.9 -1.9 -1.5 -0.6 -0.3
Weight 4.9 24.1 49.0 7.0 -1.1 6.4 5.0 4.9 -1.3 5.1 -4.6 -2.9 -2.6 -5.4 5.1 6.0 6.0 4.5 -5.2 -5.6
Impedance of arm (right) 0.5 2.2 9.1 -0.8 -2.1 -0.5 -2.2 -1.1 -1.3 0.7 -1.4 -2.3 -2.3 -0.9 0.4 -1.3 -0.2 -3.0 -0.3 -0.2
Arm fat percentage (right) 5.7 22.5 42.6 6.5 -2.2 6.0 4.0 4.5 -1.7 5.3 -4.9 -3.9 -3.5 -5.8 5.3 5.2 5.5 3.0 -5.0 -5.5
Trunk fat-free mass 0.9 5.1 14.1 3.2 1.3 2.7 3.3 1.6 0.7 1.7 -0.9 -0.0 0.2 -1.5 1.6 3.6 3.3 3.8 -1.6 -2.0
Hip circumference 2.8 11.9 24.6 5.0 -0.6 4.4 3.9 3.4 -0.5 3.3 -2.9 -1.6 -1.3 -3.7 3.5 4.6 4.6 3.7 -3.3 -3.9
Time employed in main current job 1.3 1.5 4.7 1.4 -0.5 1.1 0.6 -0.5 0.6 1.6 -1.3 -1.6 -1.6 -0.8 1.5 1.6 2.2 0.5 -0.6 -0.7
Alcohol intake versus 10 years previously 0.1 0.1 0.9 -0.3 1.0 0.2 -0.2 0.4 -0.0 -0.5 0.2 0.7 0.2 0.5 -0.1 0.3 -0.0 0.4 0.1 0.1
Father’s age at death 0.5 0.6 2.0 -0.8 1.1 -0.7 0.2 -0.2 1.0 -0.9 0.3 1.0 0.7 1.4 -0.1 0.5 0.5 0.5 1.0 0.7
Worrier / anxious feelings 0.1 0.2 0.7 -0.3 -0.9 -0.3 -0.3 -0.2 -0.0 0.3 0.0 -0.5 -0.5 0.8 0.1 -0.5 -0.4 -0.6 -0.0 0.3
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.6 1.9 -0.5 0.3 -0.4 -0.9 -0.7 -0.3 -0.7 1.0 0.9 0.8 0.6 -1.3 -1.0 -1.4 0.3 0.1 0.4
Falls in the last year 5.1 6.8 14.1 -3.4 0.9 -3.6 -2.1 -2.9 2.1 -3.2 2.6 2.0 2.0 2.0 -3.0 -2.1 -1.9 -1.8 3.8 3.2
Hair/balding pattern: Pattern 3 0.9 1.3 4.3 1.2 1.4 1.1 1.8 1.1 0.7 0.0 -0.6 0.6 0.2 -0.0 1.1 2.1 1.8 1.7 -0.1 -0.8
Number of live births 3.4 4.8 8.7 2.2 -1.8 2.5 0.2 2.7 -2.5 1.7 -2.7 -2.0 -1.8 -2.8 2.9 0.6 1.3 -0.9 -2.9 -2.9
Forced expiratory volume in 1-second (FEV1) 4.2 14.1 27.3 -3.9 3.8 -4.6 -0.8 -4.2 4.5 -4.0 3.9 3.9 3.6 4.8 -4.0 -0.6 -1.3 0.5 5.2 4.7
Pulse rate 0.3 0.4 3.5 0.3 1.9 0.2 1.0 -0.0 0.2 0.0 0.2 0.6 0.5 0.3 -0.6 0.2 -0.3 1.1 -0.3 -0.1
Happiness 0.3 0.4 2.8 -0.2 -0.6 -0.2 0.2 -1.7 0.6 0.6 0.5 -0.6 -0.7 0.0 -0.9 0.1 -0.2 0.1 0.5 0.9
Noisy workplace 1.7 2.1 4.8 -1.3 2.2 -1.0 -0.2 -0.9 1.5 -1.9 1.6 2.1 1.9 1.5 -1.8 -0.0 -0.2 0.9 1.6 1.1
Qualifications: A levels/AS levels or equivalent 0.5 1.2 3.9 -0.1 0.7 -0.7 1.9 -1.0 2.0 -0.6 0.8 0.9 0.7 1.3 -0.1 1.2 1.4 0.9 1.5 0.7
Serious illness, injury or assault of a close relative in last 2 years 0.8 0.9 4.2 -0.7 2.0 -0.7 -0.3 -0.1 0.4 -1.9 0.2 1.5 1.4 0.4 -1.0 -0.4 -0.1 -0.1 0.7 0.2
Mouth/teeth dental problems: Dentures 2.6 4.3 9.0 2.3 -0.8 2.7 1.3 2.3 -1.7 2.3 -2.0 -1.7 -1.6 -3.0 2.4 1.6 1.6 0.9 -2.7 -2.7
Asthma 1.4 2.7 7.8 1.9 -1.5 2.0 1.6 2.8 -1.6 1.2 -1.5 -0.7 -0.4 -2.1 1.9 0.8 1.0 0.6 -1.9 -2.2
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.5 1.9 -0.5 -0.6 -0.9 -0.3 -1.4 0.6 -0.5 0.9 0.3 0.5 0.3 -0.8 -0.3 -0.1 -0.1 1.1 0.9
Medication: Cholesterol lowering 0.3 0.5 2.9 0.9 1.2 0.8 -0.1 0.2 -0.2 0.1 0.2 0.7 0.6 -0.1 -0.3 0.8 0.6 1.7 -0.4 -0.5
Depression (self-reported) 1.2 1.4 5.7 -0.8 -1.2 -0.2 -1.3 0.5 -2.1 -0.2 -0.6 -0.7 -0.6 -0.8 0.3 -2.1 -1.7 -2.4 -0.7 -0.2
Medication: Lansoprazole 1.7 1.9 4.1 -1.5 0.8 -1.3 -1.6 0.0 -0.3 -1.9 1.3 1.5 1.8 1.1 -1.9 -2.0 -1.6 -1.2 0.9 0.7
Prospective memory result 1.4 1.7 5.1 0.1 2.3 -0.2 0.8 -0.6 1.7 -0.6 1.5 1.6 1.5 1.6 -0.5 1.3 1.1 2.0 1.1 0.7
Lung cancer (father) 1.2 1.4 5.7 -1.0 1.0 -0.9 0.3 0.7 0.1 -1.8 1.4 2.3 2.4 1.2 -0.9 -0.7 -0.7 1.0 0.8 0.5
Illnesses of mother 0.4 0.5 2.6 -0.0 -1.6 -0.5 0.2 -0.3 -0.3 0.6 -0.5 -1.1 -0.8 -0.6 0.7 -0.6 -0.4 -0.9 0.1 0.6
Forced expiratory volume in 1-second (FEV1), Best measure 4.9 15.7 29.8 -4.2 4.1 -4.8 -0.6 -4.4 4.4 -4.5 4.3 4.2 3.8 5.2 -4.3 -0.9 -1.6 0.3 5.5 4.8
Pulse wave Arterial Stiffness index 0.2 0.2 0.6 0.6 0.6 0.5 0.1 -0.0 -0.4 0.1 0.1 0.3 0.6 -0.6 -0.2 -0.1 -0.1 0.8 -0.5 -0.3
Impedance of arm (left) 0.3 1.5 6.4 -1.0 -1.5 -0.7 -2.1 -1.1 -0.9 0.3 -1.1 -1.6 -1.8 -0.5 0.1 -1.2 -0.3 -2.5 -0.0 0.1
Arm fat mass (right) 6.2 25.3 51.2 7.2 -1.7 6.5 5.0 5.0 -1.3 5.4 -4.8 -3.4 -3.0 -5.7 5.4 5.9 6.0 4.2 -5.2 -5.7
Trunk predicted mass 0.9 5.4 14.3 3.3 1.2 2.8 3.4 1.7 0.7 1.8 -1.0 -0.1 0.1 -1.6 1.7 3.7 3.4 3.8 -1.6 -2.1
Standing height 0.5 4.8 10.8 2.8 0.1 2.8 2.1 1.6 -0.8 2.1 -2.3 -1.4 -1.4 -2.0 2.1 2.8 3.3 2.0 -2.3 -2.7
Length of working week for main job 0.5 0.6 2.5 0.7 -0.9 0.8 -0.3 0.3 -0.7 0.7 -0.6 -0.9 -0.8 -1.6 0.5 0.3 0.8 -0.4 -0.6 -1.1
Exposure to tobacco smoke at home 1.1 1.2 4.5 0.6 -1.2 0.9 -0.6 1.2 -2.1 0.6 -0.9 -0.8 -0.5 -1.4 0.6 -1.1 -0.6 -1.0 -1.7 -1.5
Breastfed as a baby 2.5 3.1 6.8 -2.6 -0.9 -2.6 -1.5 -1.6 1.0 -1.9 1.3 0.9 0.9 2.0 -1.6 -2.0 -1.8 -2.0 2.2 2.1
Tense / ‘highly strung’ 0.6 1.0 3.6 -1.2 -0.8 -0.7 -1.3 -0.2 -0.8 -0.5 0.5 -0.1 0.0 0.8 -0.7 -1.7 -1.9 -1.7 0.2 0.6
Seen doctor (GP) for nerves, anxiety, tension or depression 1.3 2.0 6.4 -1.7 -0.6 -1.5 -2.1 -0.8 -1.1 -1.0 0.9 0.2 0.2 0.5 -1.1 -2.5 -2.5 -2.1 0.5 1.1
Hair/balding pattern: Pattern 4 0.2 0.4 1.3 -0.5 0.4 0.0 -0.7 1.0 -0.7 -0.8 0.2 0.5 0.4 -0.7 -0.4 -1.1 -1.1 -0.8 -0.2 -0.2
Birth weight of first child 1.2 2.1 5.1 1.0 -1.6 1.3 0.9 0.7 -1.1 1.5 -1.9 -2.1 -2.1 -1.4 2.3 0.7 1.4 -0.8 -1.4 -1.4
Peak expiratory flow (PEF) 3.5 8.1 17.5 -1.4 3.7 -2.5 0.0 -1.1 3.7 -2.8 3.1 4.0 4.2 3.8 -2.3 1.1 0.2 3.2 3.3 2.8
Pulse wave reflection index 0.5 0.6 1.7 -0.6 -0.4 -1.1 -0.2 -1.3 0.5 -0.4 0.9 0.2 0.7 0.6 -0.5 -1.0 -0.9 -0.5 0.9 1.1
Ever highly irritable/argumentative for 2 days 0.8 0.9 2.3 1.0 -0.8 1.2 0.9 0.3 -0.9 1.0 -0.9 -1.2 -1.1 -1.5 1.0 0.4 0.5 -0.6 -1.0 -1.2
Loud music exposure frequency 0.6 0.6 2.9 -1.1 -0.1 -0.6 -1.7 -1.1 -0.3 -0.4 0.3 -0.0 -0.2 0.1 -1.3 -1.0 -1.0 -0.4 0.2 0.7
Qualifications: O levels/GCSEs or equivalent 1.3 2.1 7.0 -1.3 1.3 -1.7 0.7 -1.7 2.6 -1.4 1.1 1.0 0.6 2.0 -0.8 0.7 0.6 0.1 2.4 1.9
Mouth/teeth dental problems: Bleeding gums 1.3 1.7 9.0 0.4 -3.0 0.3 -2.1 1.0 -1.6 0.9 -0.9 -1.5 -0.9 -1.5 1.0 -0.9 -0.3 -1.2 -1.0 -0.5
Blood clot in the leg (DVT) 0.1 0.2 0.6 0.7 0.5 0.5 -0.6 0.1 -0.2 0.1 0.0 0.2 0.2 0.1 -0.3 -0.3 -0.3 0.8 -0.7 -0.2
Medication: Paracetamol 0.9 1.5 3.1 -1.5 1.3 -1.2 -0.6 -1.6 0.9 -0.9 1.7 1.0 0.8 1.1 -1.8 -0.5 -1.0 0.8 1.3 1.7
Headache pain in last month 1.8 3.0 5.9 -1.7 1.5 -2.1 -0.4 -1.6 1.5 -1.9 2.4 2.0 2.1 2.1 -1.7 -0.8 -1.2 0.6 2.3 1.9
Medication for cholesterol, blood pressure or diabetes 0.7 1.1 2.9 0.4 -1.6 0.3 0.6 1.2 -0.9 0.4 -1.6 -1.1 -1.1 -0.7 1.7 -0.4 0.0 -1.7 -0.9 -0.9
Glaucoma (self-reported) 2.0 2.4 4.1 -1.7 -0.0 -2.0 -1.8 -0.8 0.8 -1.7 1.9 1.4 1.6 1.8 -1.7 -1.6 -1.8 -0.5 1.7 1.8
Gout (self-reported) 0.3 0.4 1.5 0.4 -1.2 0.2 -0.1 0.1 -0.9 1.1 -0.4 -0.7 -0.3 -0.3 0.8 -0.1 -0.0 0.4 -0.9 -0.2
Hypothyroidism/myxoedema (self-reported) 0.4 0.8 5.1 0.9 -0.1 0.3 1.8 0.1 0.8 0.9 0.5 0.2 0.6 0.1 -0.0 1.4 0.9 2.3 0.0 0.3
Medication: Amlodipine 0.4 0.6 4.2 0.3 -0.9 0.6 -2.0 0.5 -1.5 0.1 0.1 0.0 0.1 -0.3 -0.5 -0.5 -0.7 0.0 -0.8 -0.6
Medication: Ventolin 100micrograms inhaler 1.5 1.9 6.7 1.3 -1.9 1.5 -0.3 2.1 -2.6 0.8 -1.2 -0.6 -0.2 -1.5 0.9 -0.7 -0.6 -0.0 -2.2 -1.9
Birth weight 0.8 1.8 3.9 1.6 0.4 1.4 1.5 -0.6 0.6 2.0 -1.1 -1.4 -1.6 -0.9 1.0 2.0 1.9 1.2 -1.0 -0.9
Chronic bronchitis/emphysema (mother) 0.8 1.0 2.9 0.7 -1.2 1.0 -0.6 1.4 -1.7 0.3 -0.8 -0.4 -0.3 -1.0 0.9 -0.6 -0.1 -0.7 -1.6 -1.5
High blood pressure (siblings) 0.0 0.1 0.3 0.0 0.2 0.2 -0.6 0.1 -0.2 -0.2 -0.0 0.2 0.3 -0.1 0.1 0.3 0.4 0.4 -0.1 -0.1
Forced vital capacity (FVC), Best measure 3.0 11.1 20.5 -3.7 3.2 -4.0 -0.5 -3.5 3.5 -3.9 3.7 3.7 3.3 4.3 -3.6 -0.9 -1.5 0.2 4.5 4.1
Body fat percentage 8.5 33.4 60.5 7.8 -2.8 7.4 4.6 5.8 -2.6 6.3 -6.2 -4.6 -4.2 -7.0 6.5 5.9 6.2 3.5 -6.5 -6.8
Leg fat percentage (right) 8.0 29.0 54.6 7.4 -2.9 6.8 4.3 5.0 -2.1 6.1 -5.5 -4.4 -3.8 -6.6 6.2 5.6 6.0 3.6 -5.9 -6.1
Arm fat-free mass (right) 1.5 7.8 18.4 4.0 1.1 3.7 3.9 3.0 -0.1 2.2 -1.6 -0.2 -0.1 -2.1 2.3 4.0 3.4 4.3 -2.6 -2.9
Exposure to tobacco smoke outside home 1.0 1.3 3.1 0.8 -1.4 0.7 -0.6 -0.0 -1.1 1.1 -1.7 -1.7 -1.6 -1.8 1.2 -0.1 0.3 -0.9 -1.1 -0.8
Comparative body size at age 10 1.6 4.3 10.3 2.2 -1.8 2.2 0.1 1.3 -2.0 2.2 -2.4 -2.4 -2.1 -3.2 2.7 0.6 1.6 -1.0 -2.5 -2.5
Number of full brothers 0.6 0.7 1.9 0.8 -1.0 0.8 -0.3 0.6 -0.7 0.5 -1.4 -0.8 -0.8 -1.3 0.7 0.5 1.1 -0.1 -0.7 -1.1
Worry too long after embarrassment 0.2 0.4 2.9 0.3 -1.7 0.1 0.2 0.3 -0.8 0.7 -0.3 -0.9 -0.4 -0.3 0.6 -0.5 -0.5 -0.8 -0.4 -0.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.8 1.0 4.8 -0.9 0.3 -0.6 -1.8 0.4 -0.8 -0.6 0.2 0.3 0.0 0.7 -0.9 -1.8 -2.2 -1.2 -0.2 0.4
Wheeze or whistling in the chest in last year 2.4 4.3 7.8 2.6 -1.7 2.7 2.1 2.4 -1.1 2.4 -1.8 -1.9 -1.5 -2.8 2.1 1.6 1.8 0.7 -2.4 -2.5
Number of children fathered 0.8 0.9 3.1 0.7 1.8 1.1 0.9 1.0 0.1 0.1 0.3 0.7 0.7 -0.2 0.5 1.4 1.3 1.4 -0.3 -1.0
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.5 2.7 0.6 1.6 0.5 0.6 1.0 -0.1 -0.5 -0.6 0.8 0.4 0.6 0.4 0.9 0.9 0.5 -0.2 -0.6
Age at first live birth 1.7 3.1 7.7 -1.4 2.4 -1.6 0.6 -1.5 2.4 -1.2 2.2 1.8 1.5 2.8 -1.7 0.7 0.2 1.3 2.1 2.1
Pulse wave peak to peak time 0.1 0.1 0.5 -0.3 -0.6 -0.2 0.1 0.3 0.2 0.0 -0.3 -0.4 -0.7 0.4 0.4 0.3 0.3 -0.7 0.2 0.0
Health satisfaction 0.6 0.7 2.9 -0.6 -0.1 -0.6 -0.1 -0.7 0.2 -0.2 1.7 0.7 1.1 0.3 -1.7 -0.1 -0.4 1.3 0.7 1.1
Shortness of breath walking on level ground 0.5 0.5 1.9 -0.0 -0.7 0.5 0.2 0.1 -1.1 0.2 -0.9 -0.9 -1.0 -1.4 0.3 -0.5 -0.3 -1.3 -0.6 -0.5
Qualifications: College or University degree 1.0 3.3 6.4 -2.3 0.8 -2.5 -0.2 -1.8 1.2 -1.9 1.8 1.5 1.5 2.4 -1.6 -1.6 -2.1 -0.9 2.1 2.5
Eye problems/disorders: None of the above 0.5 0.6 4.1 -0.2 -1.0 -0.8 0.2 -2.0 0.7 0.8 0.3 -0.9 -0.9 -0.0 -0.3 0.3 0.3 -0.1 0.6 1.1
Mouth/teeth dental problems: Loose teeth 0.1 0.1 0.3 0.2 -0.3 0.1 0.2 0.0 -0.3 0.2 0.5 0.1 0.6 -0.2 0.3 -0.1 0.2 0.3 -0.3 -0.1
Emphysema/chronic bronchitis 1.3 1.5 6.6 0.5 -0.7 1.2 -0.6 2.4 -2.6 -0.2 -0.8 0.1 0.2 -1.5 0.7 -1.0 -0.8 -0.5 -1.7 -1.6
Medication for pain relief, constipation, heartburn 0.2 0.4 1.8 0.6 0.9 0.5 0.3 1.3 -0.1 -0.1 -0.7 0.3 0.4 0.3 0.7 0.3 0.4 0.1 -0.6 -0.9
Neck or shoulder pain in last month 1.0 1.4 3.5 -1.1 1.9 -1.3 0.2 -1.1 1.3 -1.4 1.3 1.3 1.2 1.3 -1.2 -0.5 -0.6 0.1 1.6 1.4
Medication: Blood pressure 0.9 1.5 4.5 -0.3 2.1 -0.4 -0.3 -1.0 1.4 -0.5 1.8 1.3 1.3 1.2 -1.7 0.8 0.2 2.1 1.1 1.1
Angina (self-reported) 1.1 1.4 2.8 1.4 -0.3 1.7 0.1 1.5 -1.1 1.1 -1.2 -0.6 -0.6 -1.1 1.3 1.0 1.4 0.7 -1.5 -1.7
Migraine (self-reported) 0.3 0.4 0.9 -0.1 0.2 -0.1 0.9 -0.7 0.9 -0.1 1.0 0.3 0.3 0.2 -0.5 0.8 0.4 0.9 0.8 0.6
Medication: Ibuprofen 0.3 0.4 1.0 -0.6 -0.1 -0.8 -0.5 -1.0 0.3 -0.9 0.6 0.5 0.6 0.1 -0.7 -0.6 -0.3 -0.5 1.0 0.6
Medication: Allopurinol 0.4 0.6 2.9 0.8 -0.7 0.6 0.2 1.1 -0.6 0.9 -0.1 0.0 0.4 -0.1 0.8 0.6 0.4 1.7 -1.0 -0.3
Medication: Omeprazole 1.0 1.2 5.3 0.8 -2.3 0.8 0.1 0.7 -0.7 1.3 -0.8 -1.3 -1.2 -1.7 1.6 0.4 0.6 -0.2 -1.1 -0.7
Medication: Seretide 50 evohaler 1.0 1.2 5.1 0.2 -0.9 0.4 0.5 -0.2 -0.6 1.1 -1.4 -2.0 -2.3 -1.3 0.9 0.2 0.4 -1.7 -0.4 -0.2
Mean time to correctly identify matches 2.2 4.2 8.3 2.0 -2.5 2.2 0.5 1.1 -1.2 2.6 -2.8 -2.8 -2.9 -2.0 2.2 1.4 1.8 -0.2 -2.3 -2.0
Heart disease (mother) 0.5 0.6 2.2 0.5 0.2 1.0 0.3 0.1 -0.1 0.7 -1.1 -1.1 -1.5 -1.0 0.7 0.7 0.6 -0.6 -0.8 -1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.6 0.7 3.3 0.4 0.9 0.2 1.2 -0.1 1.8 0.1 -0.3 0.0 -0.2 0.3 0.8 1.5 1.4 0.6 0.8 0.3
Whole body fat mass 7.7 32.1 61.8 7.9 -2.2 7.3 5.2 5.7 -2.0 6.1 -5.7 -4.0 -3.6 -6.6 6.2 6.3 6.5 4.4 -6.2 -6.5
Leg fat mass (right) 7.0 27.2 54.6 7.4 -1.9 6.7 4.9 5.2 -1.5 5.5 -5.0 -3.5 -3.1 -6.0 5.7 6.1 6.2 4.3 -5.5 -6.0
Arm predicted mass (right) 1.6 8.2 17.1 4.1 0.7 3.8 3.8 3.1 -0.2 2.3 -1.8 -0.4 -0.3 -2.4 2.5 4.0 3.6 4.1 -2.7 -3.1
Pulse rate, automated reading 0.3 1.0 7.5 0.8 2.7 1.3 0.6 -0.1 -0.5 0.3 -0.7 -0.0 -0.7 -1.1 -0.6 0.8 0.1 1.2 -1.0 -1.0
Alcohol intake frequency. 0.3 0.7 3.6 -1.0 -0.3 -0.7 -1.2 0.4 -0.4 -1.0 -0.4 -0.1 -0.5 0.4 0.2 -1.1 -1.1 -1.9 0.3 0.3
Comparative height size at age 10 0.6 3.5 9.9 2.3 0.1 2.1 1.9 0.6 -0.0 2.2 -1.4 -1.2 -1.1 -1.3 1.9 3.0 3.1 2.6 -1.5 -1.5
Number of full sisters 0.9 1.1 6.2 0.0 -1.3 0.4 -0.1 1.3 -2.5 0.2 -0.5 -0.4 -0.1 -0.6 0.1 -1.5 -1.4 -1.2 -1.3 -0.9
Suffer from ‘nerves’ 0.6 0.9 3.0 0.7 -1.1 1.0 1.1 -0.1 -0.6 1.7 -0.5 -1.5 -1.3 -0.4 1.1 0.4 0.0 -0.0 -1.2 -0.5
Overall health rating 0.3 0.7 4.3 0.4 1.1 0.1 0.8 0.5 0.5 0.1 1.0 1.0 1.2 0.2 -0.8 0.5 -0.2 2.1 -0.1 0.3
Chest pain or discomfort 2.5 3.6 10.5 2.3 -0.6 2.4 0.5 3.2 -1.4 1.1 -2.1 -1.0 -0.9 -2.2 2.4 1.6 2.2 0.5 -2.0 -2.5
Had major operations 0.7 0.8 2.2 -0.9 0.6 -1.1 0.3 -1.1 0.9 -0.5 1.2 0.8 0.9 1.0 -1.0 -0.4 -0.7 0.8 0.9 1.5
Age at last live birth 0.9 1.3 3.3 -1.0 1.5 -1.1 0.1 -0.4 1.2 -1.4 1.0 1.7 1.6 1.8 -0.8 0.4 0.3 0.9 1.3 1.1
Family relationship satisfaction 0.9 1.1 2.3 1.1 -1.4 0.7 1.4 -0.2 0.1 1.5 -0.9 -1.4 -1.2 -1.1 0.9 1.3 1.4 0.4 -0.5 -0.3
Leg pain on walking 0.3 0.4 2.0 0.3 0.6 0.3 1.4 0.8 0.1 -0.4 -0.1 0.6 0.7 -0.4 0.4 0.7 0.7 0.5 0.1 -0.6
Qualifications: NVQ or HND or HNC or equivalent 0.4 0.5 2.3 0.3 0.5 0.5 -0.3 1.5 -0.7 -0.7 -0.3 1.0 1.0 -0.1 0.1 0.0 0.1 0.3 -0.5 -1.1
Commuting to job workplace: Car/motor vehicle 1.0 1.2 4.5 1.1 1.5 1.0 2.1 -0.8 1.1 1.1 -0.5 -0.8 -0.9 -0.6 0.8 1.7 1.4 0.9 -0.1 -0.2
Illness, injury, bereavement, stress in last 2 years 0.2 0.2 0.7 -0.5 0.2 -0.6 0.8 0.2 0.6 0.0 0.5 0.4 0.4 0.7 0.2 0.2 -0.2 0.4 0.5 0.8
Medication: Aspirin 1.2 1.6 3.9 1.1 -1.7 1.1 -0.8 0.3 -1.2 1.3 -1.4 -1.8 -1.9 -2.0 0.6 0.2 0.6 -1.0 -1.3 -1.4
Supplements: Vitamin C 0.6 0.7 2.0 0.6 0.5 0.8 0.5 0.3 0.2 0.5 -1.3 -0.8 -1.1 -0.9 1.4 1.1 1.3 -0.4 -0.3 -0.6
Knee pain experienced in last month 0.4 0.6 2.0 0.8 -0.5 0.9 -0.3 0.6 -0.6 0.5 -0.8 -0.4 -0.3 -1.0 0.9 0.9 1.4 0.3 -0.6 -1.0
Hypertension (Self-reported) 0.3 0.7 2.7 -1.0 1.7 -0.5 0.3 -0.4 0.4 -1.0 1.4 1.2 0.9 0.6 -1.2 -0.2 -0.7 0.2 0.8 0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.3 1.2 -0.3 -0.9 -0.6 -0.4 -1.1 0.3 0.2 0.3 -0.4 -0.2 -0.4 -0.4 -0.4 -0.3 -0.3 0.5 1.0
Illnesses of father: Heart disease 0.5 0.7 2.9 -0.5 1.4 -0.4 0.3 -1.0 1.7 -0.9 0.7 0.6 0.1 0.3 -0.7 0.5 0.3 -0.4 1.4 0.6
Illnesses of siblings: Diabetes 0.3 0.4 2.2 0.7 0.5 0.2 0.5 0.0 1.1 0.1 0.2 0.6 0.6 0.0 -0.2 1.0 0.5 1.5 0.2 0.3
Smoking status: Previous 0.4 0.6 2.6 0.7 -1.1 0.4 0.1 0.4 -0.1 0.7 -1.0 -0.9 -0.6 -1.6 1.2 0.5 1.0 -0.1 -0.4 -0.4
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.3 1.3 -0.1 -0.0 -0.0 0.8 0.6 -1.1 -0.4 -0.2 0.2 0.5 -0.1 0.3 -0.9 -0.6 -0.9 -0.3 -0.5
Whole body fat-free mass 1.3 7.2 16.2 3.9 1.0 3.4 3.6 2.5 0.3 2.1 -1.5 -0.3 -0.1 -2.1 2.2 4.0 3.8 4.0 -2.2 -2.8
Leg fat-free mass (right) 1.4 7.7 16.9 4.1 0.5 3.7 3.3 3.2 -0.5 2.1 -2.0 -0.5 -0.3 -2.5 2.4 3.8 3.6 3.6 -2.7 -3.3
Arm fat percentage (left) 5.9 23.4 45.4 6.7 -1.8 6.2 4.3 4.8 -1.4 5.3 -4.8 -3.5 -3.2 -5.6 5.4 5.6 5.7 3.6 -5.1 -5.5
Average weekly red wine intake 0.5 0.8 3.5 1.1 0.1 0.1 1.9 -0.3 1.4 0.8 -0.6 -0.7 -0.5 -0.4 0.7 1.2 1.5 0.4 0.1 -0.1
Handedness (chirality/laterality): Left-handed 0.2 0.2 0.7 -0.6 0.5 -0.2 -0.1 -0.4 0.4 -0.5 0.4 0.5 0.2 0.8 -0.5 0.1 0.0 0.3 0.5 0.3
Mood swings 1.2 2.2 8.2 0.9 -1.1 1.5 -0.0 2.9 -2.6 0.9 -1.4 -1.1 -0.8 -1.5 1.7 -0.6 -0.5 -0.8 -2.1 -2.0
Loneliness, isolation 0.8 1.1 2.5 1.2 -1.4 0.9 -0.7 0.4 -0.6 0.9 -1.1 -1.2 -0.9 -1.6 1.0 0.1 0.9 -1.2 -0.9 -1.4
Long-standing illness, disability or infirmity 0.7 1.0 2.3 -1.0 1.0 -1.2 0.5 -0.6 0.7 -1.3 1.2 1.2 1.3 0.4 -0.9 -1.1 -1.5 -0.1 1.0 1.4
Ever had bowel cancer screening 0.8 0.9 2.8 -0.3 0.9 -0.6 0.4 -0.3 1.3 -0.7 1.1 1.2 1.5 1.3 -0.6 0.4 0.2 1.7 1.0 1.0
Diabetes diagnosed by doctor 0.5 0.8 2.9 -1.0 0.5 -0.6 -0.7 1.2 -1.0 -1.0 0.7 1.3 1.3 0.2 -0.7 -1.1 -1.7 0.4 -0.1 0.4
Ever had stillbirth, spontaneous miscarriage or termination 0.5 0.5 1.8 0.1 0.3 -0.2 1.3 -1.0 1.4 0.1 0.1 -0.3 -0.3 0.0 0.2 1.1 1.1 0.5 0.8 0.8
Friendships satisfaction 1.1 1.3 3.4 1.6 -0.6 1.2 1.7 0.3 0.3 1.8 -0.5 -1.1 -0.9 -1.1 0.7 1.6 1.4 1.4 -0.9 -0.7
Qualifications: nursing, teaching 0.2 0.2 1.2 0.1 0.2 0.5 -0.3 1.1 -0.3 -0.8 -0.2 0.5 0.5 -0.5 0.3 0.0 0.5 -0.2 -0.1 -0.7
Commuting to job workplace: Walk 2.2 2.4 4.9 -1.7 0.5 -1.9 -1.2 -1.1 1.1 -1.7 1.9 1.8 1.9 2.2 -2.0 -0.7 -0.7 0.6 1.9 1.8
Eye problems/disorders: Cataract 0.8 0.9 3.4 1.0 0.5 1.0 1.8 1.8 0.5 0.2 -0.8 0.3 0.2 -0.3 1.4 1.1 0.8 1.1 -0.5 -0.7
Mouth/teeth dental problems: Mouth ulcers 1.0 1.6 3.3 -1.4 -1.5 -1.7 -0.3 -1.2 1.1 -1.0 1.8 0.8 1.1 1.3 -0.9 -1.1 -1.2 -0.6 1.8 1.7
Medication for cholesterol 0.8 1.2 3.3 1.5 -0.3 1.1 0.7 1.1 0.3 1.1 -0.9 -0.6 -0.5 -0.6 1.5 1.6 1.8 1.3 -0.7 -0.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 3.5 4.1 7.7 -2.8 2.0 -2.3 -0.4 -2.2 1.7 -2.0 2.5 1.6 1.5 2.4 -2.4 -1.1 -1.6 -0.4 2.6 2.8
Back pain experienced in last month 0.4 0.5 2.1 0.3 0.8 0.7 1.5 1.1 0.2 0.1 -0.3 -0.0 -0.3 -1.2 0.9 0.9 0.8 0.5 -0.1 -0.4
Mineral and other dietary supplements 1.1 1.5 4.7 1.4 -0.6 1.2 1.2 0.1 0.4 2.2 -0.7 -1.4 -1.3 -0.5 1.0 1.8 1.6 1.6 -1.1 -0.7
Breast cancer (self-reported) 2.5 3.0 6.2 -2.5 1.2 -2.1 0.6 -0.8 0.8 -2.4 1.7 1.8 1.5 1.9 -2.1 -1.8 -1.9 -1.2 1.9 1.9
Asthma (self-reported) 1.4 2.7 8.6 1.8 -1.7 2.0 1.3 2.9 -1.8 1.2 -1.5 -0.8 -0.4 -2.2 1.9 0.6 0.8 0.3 -1.9 -2.3
Osteoporosis (self-reported) 1.7 2.1 4.9 1.6 -0.1 1.8 1.4 1.2 -0.9 1.6 -1.8 -1.5 -1.7 -1.6 2.2 1.0 0.8 0.3 -1.9 -1.6
Osteoarthritis (self-reported) 2.8 3.6 8.8 -2.1 2.0 -1.6 -0.5 0.5 0.2 -2.8 2.4 3.0 2.7 2.1 -1.6 -1.8 -2.4 -0.1 1.4 1.2
Medication: Aspirin 1.2 1.5 3.6 1.1 -1.8 1.1 -0.8 0.6 -1.2 1.2 -1.5 -1.6 -1.8 -1.9 0.7 0.2 0.6 -0.8 -1.2 -1.4
Medication: Gliclazide 0.6 0.6 2.3 -0.7 0.3 -0.8 -0.6 -0.4 -0.1 -0.5 1.1 0.9 1.1 0.4 -1.5 -0.6 -1.1 0.8 0.4 1.0
Illnesses of father: None of the above (group 1) 0.1 0.1 1.1 -0.0 -0.4 -0.6 0.1 -1.1 -0.0 0.3 -0.3 -0.4 -0.0 0.1 -0.2 -0.3 0.0 -0.0 0.1 0.4
Smoking status: Current 1.5 2.3 6.0 1.4 -1.7 1.7 -0.3 1.3 -2.4 1.4 -1.5 -1.4 -1.3 -2.5 0.9 -0.4 -0.4 -0.5 -2.3 -2.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 8.9 18.8 34.3 -4.9 3.7 -5.1 -1.4 -4.2 4.2 -4.8 5.1 4.7 4.3 5.9 -4.9 -1.7 -2.9 0.3 5.5 5.5
Whole body water mass 1.2 7.1 15.8 3.9 1.0 3.4 3.6 2.5 0.2 2.1 -1.5 -0.3 -0.2 -2.1 2.1 4.0 3.7 4.0 -2.2 -2.8
Leg predicted mass (right) 1.4 7.2 15.8 4.0 0.5 3.6 3.2 3.1 -0.5 2.1 -1.9 -0.5 -0.4 -2.5 2.3 3.7 3.5 3.5 -2.6 -3.1
Arm fat mass (left) 6.1 25.3 50.9 7.1 -1.4 6.5 5.1 5.1 -1.2 5.2 -4.8 -3.2 -2.9 -5.7 5.3 6.1 6.0 4.3 -5.2 -5.7
Number of self-reported non-cancer illnesses 0.5 0.9 5.1 1.1 -0.0 0.9 2.3 0.9 0.4 1.0 0.2 -0.3 -0.2 -0.9 0.9 1.2 0.9 1.4 -0.4 -0.4
Average weekly champagne plus white wine intake 0.3 0.5 2.0 -0.4 1.0 -0.6 -0.2 -1.3 1.4 -0.2 0.2 -0.1 -0.4 0.3 -0.4 0.5 0.2 0.1 1.0 0.9
Miserableness 0.7 1.1 3.6 1.0 -1.3 0.9 -1.2 1.5 -1.9 0.7 -0.5 -0.7 -0.2 -1.1 0.7 -1.0 -0.7 -0.4 -1.5 -1.4
Guilty feelings 1.7 2.6 8.4 -0.8 -2.1 -0.3 -2.5 0.3 -2.5 0.1 -0.3 -1.0 -0.8 -1.0 -0.2 -2.9 -2.5 -2.9 -1.0 -0.4
Wears glasses or contact lenses 1.1 1.2 3.1 -1.1 1.8 -0.8 -0.2 -0.4 0.7 -1.2 1.5 1.6 1.5 1.2 -1.2 -0.1 -0.5 1.0 1.1 0.9
Ever taken oral contraceptive pill 0.2 0.2 1.2 0.5 0.7 0.2 1.1 0.4 -0.2 0.1 -0.1 0.4 0.6 -0.3 0.3 0.3 0.2 0.6 -0.1 -0.3
Hearing aid user 0.6 0.7 1.7 -0.5 0.7 -0.6 0.5 0.8 1.1 -1.1 0.4 1.3 1.2 1.2 -0.2 0.4 0.2 1.0 1.1 0.8
Mother’s age at death 0.6 0.7 1.8 1.0 -1.0 1.0 1.3 0.9 -0.2 1.0 -0.9 -0.6 -0.7 -0.1 1.1 0.7 0.6 0.9 -0.8 -0.5
Financial situation satisfaction 0.3 0.3 1.4 -0.2 -0.9 0.2 0.0 0.4 -1.2 0.2 -0.1 -0.4 -0.4 -0.7 -0.3 -0.8 -1.0 -0.4 -0.6 -0.2
Tinnitus: Yes, now most or all of the time 2.5 2.9 9.3 -1.5 2.5 -0.9 -0.8 0.7 0.5 -2.7 1.8 3.0 2.8 2.1 -1.8 -0.7 -1.1 0.8 1.1 0.6
Commuting to job workplace: Public transport 1.0 1.2 5.2 -0.9 0.6 -1.1 -0.4 -0.2 0.7 -0.7 1.6 1.5 1.5 2.3 -1.4 -0.4 -0.8 1.1 0.7 0.9
Eye problems/disorders: Glaucoma 0.8 1.0 2.0 -1.1 -0.1 -1.3 -1.4 -0.9 0.7 -0.9 1.1 0.7 0.9 1.2 -1.1 -1.1 -1.0 -0.6 1.0 1.2
Medication: Blood pressure 1.2 2.2 4.0 -1.9 1.4 -1.5 -0.3 -0.6 0.2 -1.9 1.7 1.9 1.7 1.6 -1.9 -1.6 -2.0 -0.6 1.2 1.1
Pain type(s) experienced in last month: Hip pain 1.0 1.2 4.2 -0.4 1.4 -0.3 -0.9 1.4 -0.4 -1.5 1.2 2.0 2.0 0.5 -0.7 -1.0 -1.2 0.9 0.2 0.2
Supplements: Fish oil (including cod liver oil) 2.3 3.0 6.9 -2.1 0.9 -2.1 -1.9 -1.0 0.6 -2.6 1.3 1.9 1.8 1.3 -1.7 -2.0 -1.8 -1.4 2.0 1.7
High cholesterol (Self-reported) 0.3 0.6 1.7 1.0 -0.3 1.1 -0.1 -0.0 -0.9 1.0 -0.7 -0.8 -1.0 -1.3 0.1 0.5 0.4 0.6 -1.0 -0.8
Medication: Bendroflumethiazide 0.1 0.1 0.3 -0.0 0.3 0.1 -0.1 -0.1 -0.2 -0.3 0.2 0.5 0.6 0.0 -0.5 0.0 0.3 0.3 -0.1 -0.2
Medication: Paracetamol 0.3 0.4 1.9 -0.9 0.6 -0.5 -0.6 -1.4 0.6 -0.2 0.7 0.1 -0.3 0.1 -0.8 0.1 -0.1 0.2 0.8 1.0
Medication: Lisinopril 0.3 0.4 2.2 0.4 0.1 -0.1 1.0 -0.5 1.1 0.9 0.7 0.0 0.3 0.1 0.2 0.8 0.4 1.5 0.2 0.6
Medication: Atorvastatin 0.2 0.2 0.6 0.4 0.6 0.8 0.1 0.6 -0.7 0.2 0.0 0.2 -0.1 -0.3 -0.1 0.2 -0.2 0.6 -0.7 -0.7
Illnesses of father: High blood pressure 0.2 0.3 0.8 -0.3 0.3 -0.1 0.7 0.2 0.6 -0.2 0.9 0.5 0.5 0.5 0.3 0.6 0.5 0.8 0.4 0.3
Alcohol drinker status: Never 0.3 0.3 1.2 0.2 0.5 0.6 -1.1 1.0 -0.8 -0.1 -0.3 0.2 0.1 0.5 0.2 0.1 0.3 0.2 -0.5 -0.8
Ever smoked 0.3 0.5 1.7 -0.4 -0.7 -0.1 -1.1 -0.0 -0.9 -0.0 -0.3 -0.6 -0.4 -1.3 -0.2 -1.1 -0.7 -1.2 -0.5 -0.4
Basal metabolic rate 1.9 10.6 22.6 4.8 0.4 4.2 4.0 3.2 -0.2 2.9 -2.4 -1.0 -0.8 -3.1 3.0 4.5 4.3 4.2 -3.1 -3.6
Leg fat percentage (left) 7.1 25.6 47.8 6.9 -2.9 6.4 4.0 5.1 -2.2 5.7 -5.2 -4.1 -3.6 -6.3 5.7 5.1 5.3 3.2 -5.7 -5.8
Arm fat-free mass (left) 2.0 10.0 20.4 4.5 0.4 4.1 4.4 3.1 -0.2 2.8 -2.4 -1.1 -1.0 -3.0 3.0 4.3 4.1 3.8 -2.9 -3.4
Number of operations (self-reported) 0.2 0.3 1.4 0.1 1.2 0.3 0.8 1.0 0.0 -0.5 -0.3 0.5 0.2 0.2 0.8 0.4 0.4 0.2 -0.1 -0.2
Average weekly beer plus cider intake 0.3 0.4 2.0 0.3 0.4 0.5 -0.5 1.4 -0.6 -0.0 -0.1 0.6 0.9 -0.3 0.2 0.5 0.7 0.9 -0.6 -0.8
Irritability 0.2 0.4 2.0 -0.4 -0.9 -0.2 -0.3 -0.3 -0.5 0.4 0.2 -0.8 -0.7 -0.3 -0.1 -1.2 -1.4 -1.0 -0.2 -0.0
Risk taking 0.5 0.7 2.3 1.2 0.8 0.7 0.8 0.3 0.5 0.3 -0.8 -0.1 -0.3 -0.6 1.2 1.5 1.5 0.6 -0.1 -0.6
Ever had prostate specific antigen (PSA) test 0.4 0.5 2.4 -0.0 -0.5 -0.6 0.4 -1.1 1.5 0.0 0.7 0.0 0.1 0.8 0.5 0.3 0.3 0.1 1.0 1.1
Fractured/broken bones in last 5 years 1.8 2.3 4.5 -1.9 1.1 -2.1 0.2 -0.5 1.1 -1.9 1.7 1.7 1.8 1.2 -1.2 -1.3 -1.7 -0.5 2.0 1.9
Age started oral contraceptive pill 0.2 0.2 0.9 -0.6 0.6 -0.3 0.5 0.5 0.2 -1.0 -0.3 0.7 0.3 0.6 0.3 0.2 -0.0 -0.1 0.5 0.5
Diastolic blood pressure, automated reading 0.4 1.1 4.2 0.8 1.9 0.6 1.6 -0.4 1.6 0.4 -0.3 -0.1 -0.5 -0.5 0.5 2.1 1.8 0.8 0.5 -0.4
Ever depressed for a whole week 0.5 0.7 2.7 -0.4 -1.5 -0.5 -1.1 -0.8 -0.6 0.1 -0.3 -0.9 -0.8 -0.4 -0.1 -1.2 -0.6 -1.6 0.0 0.4
Unable to work because of sickness or disability 1.5 1.9 6.6 -1.2 2.6 -0.9 -0.5 0.1 1.3 -2.2 1.2 2.2 1.8 1.3 -1.4 -0.6 -1.3 0.3 1.3 1.1
Commuting to job workplace: Cycle 1.3 1.5 3.3 -1.8 0.4 -1.4 -1.7 -0.1 -0.2 -1.8 1.3 1.5 1.4 1.2 -1.6 -1.2 -1.1 -0.6 1.0 0.8
Myopia 0.5 0.7 1.6 -0.5 0.7 -1.1 0.6 -0.9 1.0 -0.4 1.3 0.9 0.7 0.9 -0.8 -0.2 -1.0 0.5 0.9 1.2
Vascular/heart problems diagnosed by doctor 0.2 0.4 2.6 0.4 -1.6 0.1 -0.6 0.4 -0.4 0.4 -1.1 -0.8 -0.6 -0.3 0.8 -0.4 -0.0 -0.7 -0.5 -0.2
Cholesterol lowering medication 0.7 1.0 2.5 0.9 -0.9 1.1 0.5 0.2 -1.1 0.7 -1.4 -1.1 -1.3 -1.6 0.8 0.6 0.9 -0.8 -1.0 -1.3
Medication: Omeprazole (e.g. Zanprol) 0.4 0.5 3.1 0.4 -1.8 0.3 0.2 0.4 -0.4 0.7 -0.3 -0.8 -0.6 -1.2 1.2 0.1 0.3 -0.3 -0.5 -0.2
Pain experienced in last month 0.1 0.2 0.6 0.5 -0.8 0.3 -0.7 0.1 -0.5 0.6 -0.6 -0.7 -0.5 0.0 0.0 0.1 0.4 -0.2 -0.6 -0.4
Supplements: Calcium 0.3 0.3 1.4 0.1 1.2 0.3 0.9 0.3 1.1 -0.2 -0.2 0.1 -0.4 -0.3 0.5 0.8 0.4 0.3 0.3 0.2
Basal cell carcinoma (self-reported) 0.3 0.4 2.3 -0.3 0.5 -0.2 0.8 -1.5 0.9 -0.1 -0.2 -0.5 -0.8 0.1 -0.1 0.2 0.5 -0.9 0.6 0.3
Heart attack/myocardial infarction (self-reported) 0.6 0.8 3.5 1.0 1.3 0.6 1.2 -0.2 1.0 0.9 0.3 0.0 -0.2 0.1 0.4 1.7 1.1 1.9 -0.1 -0.1
Deep venous thrombosis (DVT) (self-reported) 0.2 0.2 1.0 0.9 0.5 0.7 -0.1 0.1 -0.2 0.3 -0.0 0.2 0.2 0.1 -0.1 -0.0 -0.0 1.0 -0.8 -0.4
Heart disease (siblings) 0.2 0.2 1.4 0.7 1.2 0.6 -0.3 0.0 0.1 -0.1 -0.5 0.2 -0.2 -0.4 -0.2 0.4 0.1 0.1 -0.5 -0.6
Alcohol drinker status: Previous 0.5 0.5 1.9 -0.4 -0.3 -0.4 -0.9 1.0 -0.4 -0.7 0.7 0.9 1.0 0.6 -0.5 -1.1 -1.4 0.0 0.0 0.3
Pack years of smoking 3.2 4.7 9.8 2.1 -1.7 2.6 -0.2 3.0 -2.4 1.7 -2.6 -1.7 -1.7 -3.1 2.2 0.6 1.1 -0.2 -3.1 -3.1
Impedance of whole body 0.5 2.6 9.2 -0.8 -2.5 -0.3 -2.1 -0.7 -1.9 0.9 -1.5 -2.3 -2.3 -1.1 0.5 -1.7 -0.8 -3.0 -0.8 -0.3
Leg fat mass (left) 6.4 24.8 50.0 7.1 -1.8 6.5 4.7 5.2 -1.6 5.2 -4.7 -3.2 -2.8 -5.8 5.3 5.7 5.7 4.2 -5.3 -5.7
Arm predicted mass (left) 1.9 9.8 20.7 4.5 0.3 4.2 4.0 3.1 -0.4 2.9 -2.3 -1.1 -0.9 -3.0 2.9 4.2 3.9 3.9 -3.1 -3.5