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chr2:15,703-2,448,088

Best TWAS P=2.92e-30 · Best GWAS P=1.92e-23 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	FAM110C	0.09	0.00	bslmm	232	0.01	8.2e-03	-0.34	-6.4	1.5e-10	-0.47	0.22	0.48	TRUE
2	CommonMind	Brain Pre-frontal Cortex	SH3YL1	0.11	0.12	lasso	2	0.13	5.8e-16	-9.64	6.7	2.0e-11	0.11	0.05	0.95	FALSE
3	GTEx	Adipose Subcutaneous	SH3YL1	0.08	0.10	lasso	1	0.08	4.1e-07	9.91	9.9	3.7e-23	1.00	0.01	0.99	FALSE
4	GTEx	Adipose Subcutaneous	PXDN	0.11	0.12	lasso	3	0.11	2.2e-09	6.63	6.5	5.8e-11	0.01	0.24	0.76	TRUE
5	GTEx	Adipose Visceral Omentum	SH3YL1	0.15	0.03	lasso	4	0.01	6.5e-02	7.42	10.0	1.5e-23	0.87	0.02	0.90	TRUE
6	GTEx	Adrenal Gland	SH3YL1	0.21	0.10	lasso	7	0.08	8.1e-04	7.42	-7.2	5.9e-13	-0.83	0.02	0.92	FALSE
7	GTEx	Artery Tibial	SH3YL1	0.10	0.02	lasso	3	0.01	2.9e-02	9.85	9.9	3.0e-23	0.95	0.01	0.98	TRUE
8	GTEx	Brain Cerebellum	AC092159.2	0.37	-0.01	lasso	10	-0.01	7.3e-01	-6.69	-6.0	1.8e-09	-0.09	0.07	0.14	FALSE
9	GTEx	Cells Transformed fibroblasts	SH3YL1	0.16	0.09	lasso	7	0.10	3.3e-08	-9.90	9.9	4.3e-23	0.45	0.03	0.97	FALSE
10	GTEx	Colon Sigmoid	SH3YL1	0.20	0.14	lasso	3	0.14	1.3e-05	9.93	9.7	3.9e-22	0.94	0.01	0.97	FALSE
11	GTEx	Colon Transverse	SH3YL1	0.36	0.25	lasso	7	0.26	1.2e-12	9.88	-9.8	9.5e-23	-0.99	0.01	0.99	FALSE
12	GTEx	Esophagus Gastroesophageal Junction	SH3YL1	0.21	0.09	lasso	7	0.14	1.3e-05	6.24	8.5	2.2e-17	0.80	0.02	0.96	FALSE
13	GTEx	Esophagus Mucosa	SH3YL1	0.60	0.67	lasso	4	0.66	9.2e-58	9.96	-9.8	1.4e-22	-0.99	0.01	0.99	FALSE
14	GTEx	Esophagus Muscularis	SH3YL1	0.30	0.23	enet	50	0.28	4.6e-17	9.93	9.7	3.3e-22	0.83	0.01	0.99	FALSE
15	GTEx	Heart Atrial Appendage	SH3YL1	0.27	0.23	lasso	6	0.22	2.1e-10	9.85	9.8	1.2e-22	0.98	0.01	0.99	FALSE
16	GTEx	Heart Left Ventricle	SH3YL1	0.14	0.11	enet	16	0.10	8.2e-06	9.70	11.4	2.9e-30	0.93	0.01	0.99	TRUE
17	GTEx	Lung	SH3YL1	0.09	0.08	lasso	5	0.05	8.5e-05	9.70	-8.3	1.4e-16	-0.95	0.01	0.99	FALSE
18	GTEx	Muscle Skeletal	SH3YL1	0.12	0.10	lasso	3	0.09	4.1e-09	9.93	9.8	1.4e-22	0.99	0.01	0.99	FALSE
19	GTEx	Nerve Tibial	SH3YL1	0.33	0.23	enet	35	0.25	5.6e-18	9.93	9.7	2.6e-22	0.90	0.01	0.99	FALSE
20	GTEx	Nerve Tibial	PXDN	0.10	0.03	lasso	2	0.02	1.6e-02	6.63	6.3	2.5e-10	0.00	0.03	0.81	FALSE
21	GTEx	Ovary	SH3YL1	0.48	0.29	enet	18	0.34	3.2e-09	9.70	6.7	1.7e-11	0.87	0.01	0.98	TRUE
22	GTEx	Pancreas	SH3YL1	0.48	0.43	lasso	11	0.41	6.9e-19	9.96	-9.8	6.6e-23	-0.99	0.01	0.99	FALSE
23	GTEx	Skin Not Sun Exposed Suprapubic	SH3YL1	0.47	0.53	lasso	2	0.53	2.1e-33	9.91	-9.9	3.8e-23	-1.00	0.01	0.99	FALSE
24	GTEx	Skin Sun Exposed Lower leg	SH3YL1	0.42	0.44	lasso	5	0.45	3.3e-41	9.91	-9.9	4.4e-23	-1.00	0.01	0.99	FALSE
25	GTEx	Stomach	SH3YL1	0.33	0.21	lasso	6	0.20	3.8e-10	9.70	-9.8	1.1e-22	-0.97	0.01	0.99	FALSE
26	GTEx	Thyroid	SH3YL1	0.29	0.32	lasso	4	0.31	2.9e-24	9.96	-9.8	1.1e-22	-0.99	0.01	0.99	FALSE
27	GTEx	Whole Blood	SH3YL1	0.21	0.17	lasso	6	0.18	2.6e-16	9.96	-9.8	7.3e-23	-0.99	0.01	0.99	FALSE
28	METSIM	Adipose	SH3YL1	0.03	0.02	lasso	3	0.02	9.5e-04	6.24	7.3	2.3e-13	0.56	0.05	0.90	FALSE
29	NTR	Blood	SH3YL1	0.12	0.17	lasso	5	0.16	6.2e-51	9.91	-9.5	3.0e-21	-0.99	0.01	0.99	FALSE
30	ROSMAP	Brain Pre-frontal Cortex	SH3YL1	0.15	0.12	bslmm	364	0.13	3.3e-16	-0.61	-5.5	3.2e-08	-0.61	1.00	0.00	FALSE
31	ROSMAP	Brain Pre-frontal Cortex	ACP1	0.03	0.04	lasso	2	0.02	4.7e-04	9.70	-9.6	6.3e-22	-0.96	0.01	0.98	FALSE
32	ROSMAP	Brain Pre-frontal Cortex	FAM150B	0.06	0.01	bslmm	381	0.03	9.9e-05	-9.25	-9.7	4.6e-22	-0.63	0.03	0.93	FALSE
33	YFS	Blood	SH3YL1	0.48	0.40	enet	100	0.46	3.2e-171	9.91	-8.8	1.5e-18	-0.91	0.01	0.99	FALSE
34	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	SH3YL1	0.25	0.15	blup	67	0.18	2.8e-15	9.96	-8.3	7.6e-17	-0.86	0.01	0.99	FALSE
35	The Cancer Genome Atlas	Breast Invasive Carcinoma	SH3YL1	0.19	0.31	lasso	5	0.32	2.5e-66	9.88	-9.3	1.3e-20	-0.99	0.01	0.99	FALSE
36	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	SH3YL1	0.32	0.27	enet	14	0.28	6.6e-14	9.93	-8.4	3.7e-17	-0.97	0.01	0.99	FALSE
37	The Cancer Genome Atlas	Colon Adenocarcinoma	SH3YL1	0.32	0.34	lasso	6	0.35	2.8e-21	9.96	-9.5	3.2e-21	-0.99	0.01	0.99	TRUE
38	The Cancer Genome Atlas	Esophageal Carcinoma	SH3YL1	0.16	0.02	blup	67	0.08	1.9e-03	9.70	-11.1	1.6e-28	-0.87	0.01	0.92	FALSE
39	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	SH3YL1	0.24	0.25	lasso	4	0.25	8.1e-28	9.70	-9.8	7.5e-23	-0.98	0.01	0.99	FALSE
40	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SH3YL1	0.16	0.04	blup	67	0.06	5.6e-07	9.98	-9.7	2.6e-22	-0.77	0.01	0.99	FALSE
41	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SH3YL1	0.20	0.05	blup	67	0.09	9.5e-06	9.98	-8.0	1.4e-15	-0.90	0.01	0.98	FALSE
42	The Cancer Genome Atlas	Brain Lower Grade Glioma	FAM150B	0.07	0.07	lasso	2	0.06	5.8e-07	9.98	-10.0	9.6e-24	-1.00	0.00	1.00	FALSE
43	The Cancer Genome Atlas	Brain Lower Grade Glioma	SH3YL1	0.05	0.02	lasso	4	0.03	2.4e-04	-9.90	5.8	8.8e-09	0.07	0.04	0.96	TRUE
44	The Cancer Genome Atlas	Lung Adenocarcinoma	SH3YL1	0.17	0.24	enet	15	0.24	5.8e-28	9.96	-8.8	9.4e-19	-0.98	0.01	0.99	FALSE
45	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SH3YL1	0.11	0.10	lasso	5	0.10	4.5e-11	9.96	-8.4	6.2e-17	-0.96	0.01	0.99	FALSE
46	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	SH3YL1	0.11	0.13	enet	8	0.13	3.7e-09	9.96	-7.8	7.5e-15	-0.95	0.01	0.99	TRUE
47	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	SH3YL1	0.21	0.18	lasso	1	0.15	9.6e-07	9.70	-9.7	2.9e-22	-0.98	0.01	0.99	FALSE
48	The Cancer Genome Atlas	Rectum Adenocarcinoma	SH3YL1	0.51	0.29	blup	67	0.38	6.8e-10	9.96	-9.4	5.5e-21	-0.90	0.01	0.99	FALSE
49	The Cancer Genome Atlas	Soft Tissue Sarcoma	SH3YL1	0.07	0.04	enet	9	0.05	1.0e-03	-9.28	10.1	4.7e-24	0.37	0.08	0.22	FALSE
50	The Cancer Genome Atlas	Stomach Adenocarcinoma	SH3YL1	0.19	0.21	enet	12	0.23	2.1e-16	9.88	-8.5	2.6e-17	-0.96	0.01	0.99	FALSE
51	The Cancer Genome Atlas	Thyroid Carcinoma	SH3YL1	0.54	0.56	lasso	4	0.57	1.1e-67	9.96	-9.5	2.7e-21	-0.99	0.01	0.99	FALSE
52	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	SH3YL1	0.16	0.14	lasso	2	0.09	1.8e-03	9.88	-8.7	2.6e-18	-0.98	0.01	0.92	FALSE