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chr2:8,850,817-12,008,798

Best TWAS P=1.22e-25 · Best GWAS P=1.72e-43 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	ADAM17	0.14	0.08	enet	17	0.13	2.2e-15	-9.24	7.7	1.1e-14	0.10	1.00	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	C2orf50	0.20	0.02	lasso	11	0.10	9.2e-13	-1.38	5.5	3.4e-08	-0.10	0.11	0.88	FALSE
3	CommonMind	Brain Pre-frontal Cortex	IAH1	0.08	0.03	bslmm	463	0.03	3.9e-04	-8.61	-8.4	4.5e-17	-0.07	0.13	0.86	TRUE
4	GTEx	Adipose Subcutaneous	CPSF3	0.16	0.11	lasso	5	0.15	1.5e-12	1.37	-5.5	4.4e-08	-0.04	0.13	0.87	FALSE
5	GTEx	Adipose Subcutaneous	PQLC3	0.22	0.16	enet	18	0.18	1.2e-14	6.31	7.1	1.3e-12	-0.05	0.02	0.98	FALSE
6	GTEx	Adipose Visceral Omentum	PQLC3	0.12	0.07	enet	12	0.04	5.7e-03	6.31	7.1	1.4e-12	-0.06	0.03	0.97	FALSE
7	GTEx	Adrenal Gland	PQLC3	0.26	0.23	enet	6	0.26	1.1e-09	-5.18	6.5	6.3e-11	-0.06	0.06	0.94	FALSE
8	GTEx	Adrenal Gland	RP11-95D17.1	0.39	0.16	enet	40	0.09	5.6e-04	2.64	-7.3	2.9e-13	-0.05	0.14	0.04	TRUE
9	GTEx	Artery Tibial	PQLC3	0.13	0.08	enet	9	0.14	8.0e-11	5.64	6.5	7.9e-11	-0.07	0.04	0.96	FALSE
10	GTEx	Brain Cerebellum	KLF11	0.30	0.00	lasso	10	0.02	8.7e-02	0.91	9.2	4.3e-20	0.56	0.04	0.42	FALSE
11	GTEx	Brain Cortex	KLF11	0.42	0.02	enet	38	0.01	1.6e-01	8.12	8.6	8.3e-18	0.52	0.05	0.26	TRUE
12	GTEx	Brain Frontal Cortex BA9	ADAM17	0.20	0.14	lasso	5	0.15	7.8e-05	-9.15	9.3	1.9e-20	0.05	0.51	0.04	TRUE
13	GTEx	Breast Mammary Tissue	PQLC3	0.22	0.12	enet	7	0.09	1.7e-05	6.31	6.5	8.3e-11	-0.05	0.04	0.96	FALSE
14	GTEx	Breast Mammary Tissue (Male)	PQLC3	0.39	0.16	lasso	6	0.13	6.4e-04	6.28	6.5	8.4e-11	-0.05	0.03	0.95	FALSE
15	GTEx	Breast Mammary Tissue (Female)	RP11-254F7.2	0.20	-0.01	lasso	4	-0.01	7.8e-01	4.50	5.5	3.9e-08	0.47	0.05	0.11	TRUE
16	GTEx	Cells Transformed fibroblasts	IAH1	0.09	0.10	lasso	4	0.07	3.7e-06	-8.73	-8.9	6.9e-19	-0.10	0.02	0.98	FALSE
17	GTEx	Cells Transformed fibroblasts	PQLC3	0.20	0.13	enet	28	0.17	1.3e-12	-5.18	5.6	2.3e-08	-0.03	0.13	0.87	FALSE
18	GTEx	Colon Sigmoid	PQLC3	0.29	0.17	lasso	9	0.10	1.7e-04	5.24	5.2	2.2e-07	-0.05	0.10	0.68	FALSE
19	GTEx	Colon Transverse	PQLC3	0.15	0.12	lasso	6	0.10	1.7e-05	-7.26	7.5	4.3e-14	-0.07	0.02	0.98	TRUE
20	GTEx	Esophagus Gastroesophageal Junction	PQLC3	0.21	0.08	lasso	5	0.01	1.8e-01	7.17	7.4	1.1e-13	-0.08	0.03	0.86	FALSE
21	GTEx	Esophagus Mucosa	PQLC3	0.25	0.10	lasso	4	0.18	2.1e-12	-7.27	6.0	2.1e-09	-0.04	0.02	0.98	FALSE
22	GTEx	Esophagus Muscularis	PQLC3	0.16	0.10	enet	5	0.07	4.3e-05	6.24	6.5	5.6e-11	-0.06	0.08	0.92	FALSE
23	GTEx	Esophagus Muscularis	RP11-400L8.2	0.10	0.04	lasso	6	0.02	1.6e-02	-8.84	9.1	8.9e-20	0.07	0.03	0.87	TRUE
24	GTEx	Lung	PQLC3	0.26	0.20	enet	24	0.21	6.9e-16	5.64	5.3	1.4e-07	-0.03	0.18	0.82	FALSE
25	GTEx	Muscle Skeletal	ADAM17	0.07	0.07	enet	5	0.05	4.5e-06	-8.83	-8.6	7.1e-18	-0.11	0.99	0.00	TRUE
26	GTEx	Muscle Skeletal	RP11-400L8.2	0.11	0.11	lasso	7	0.11	7.9e-11	-8.54	8.6	7.5e-18	0.10	0.33	0.67	FALSE
27	GTEx	Nerve Tibial	ADAM17	0.10	0.02	enet	8	0.01	3.9e-02	-8.73	8.9	7.5e-19	0.11	0.63	0.02	FALSE
28	GTEx	Nerve Tibial	PQLC3	0.29	0.20	lasso	7	0.22	2.6e-15	5.64	5.7	1.1e-08	-0.07	0.63	0.37	FALSE
29	GTEx	Ovary	PQLC3	0.32	0.11	lasso	5	0.12	9.5e-04	5.68	6.5	6.5e-11	-0.05	0.07	0.66	FALSE
30	GTEx	Skin Not Sun Exposed Suprapubic	CPSF3	0.11	0.07	lasso	6	0.04	1.9e-03	-8.55	-7.2	5.2e-13	-0.10	0.02	0.94	FALSE
31	GTEx	Skin Not Sun Exposed Suprapubic	PQLC3	0.16	0.10	lasso	5	0.05	1.4e-03	5.64	6.0	1.9e-09	-0.06	0.04	0.96	FALSE
32	GTEx	Skin Sun Exposed Lower leg	CPSF3	0.09	0.07	lasso	3	0.06	7.2e-06	-8.52	-8.5	1.5e-17	-0.10	0.02	0.98	FALSE
33	GTEx	Skin Sun Exposed Lower leg	PQLC3	0.14	0.07	lasso	7	0.09	9.3e-08	6.31	6.7	2.4e-11	-0.06	0.04	0.96	FALSE
34	GTEx	Skin Sun Exposed Lower leg	RP11-254F7.2	0.21	0.10	enet	11	0.17	6.3e-14	8.25	-5.5	3.2e-08	-0.31	1.00	0.00	TRUE
35	GTEx	Stomach	PQLC3	0.17	0.08	lasso	3	0.04	4.0e-03	6.24	6.2	5.2e-10	-0.05	0.07	0.90	FALSE
36	GTEx	Testis	ITGB1BP1	0.27	0.22	lasso	3	0.21	7.5e-10	-8.52	-8.6	8.4e-18	-0.10	0.23	0.77	FALSE
37	GTEx	Testis	CPSF3	0.17	0.03	enet	11	0.05	4.2e-03	-8.84	-8.8	2.1e-18	-0.05	0.09	0.74	TRUE
38	GTEx	Testis	IAH1	0.30	0.07	lasso	6	0.09	5.8e-05	-8.72	-8.9	5.0e-19	-0.09	0.10	0.85	FALSE
39	GTEx	Testis	PQLC3	0.13	0.16	enet	13	0.15	3.2e-07	6.24	5.7	1.4e-08	-0.03	0.06	0.92	FALSE
40	GTEx	Thyroid	GRHL1	0.15	0.04	enet	30	0.02	1.2e-02	-4.22	10.5	1.2e-25	0.33	0.18	0.21	TRUE
41	GTEx	Thyroid	PQLC3	0.19	0.18	enet	21	0.17	3.6e-13	-7.26	7.0	2.5e-12	-0.06	0.02	0.98	FALSE
42	METSIM	Adipose	PQLC3	0.11	0.04	bslmm	515	0.04	6.0e-07	6.24	-5.5	3.1e-08	0.03	0.74	0.24	FALSE
43	NTR	Blood	ADAM17	0.03	0.03	lasso	8	0.03	2.1e-09	-8.70	8.9	4.5e-19	0.10	1.00	0.00	FALSE
44	NTR	Blood	IAH1	0.03	0.03	lasso	10	0.04	8.8e-12	-8.69	9.2	3.1e-20	0.09	0.10	0.90	FALSE
45	NTR	Blood	PQLC3	0.15	0.14	enet	14	0.15	1.8e-45	6.28	5.5	3.1e-08	-0.06	0.94	0.06	FALSE
46	ROSMAP	Brain Pre-frontal Cortex	IAH1	0.08	0.07	lasso	5	0.07	8.8e-09	-8.64	-7.7	1.7e-14	-0.10	0.27	0.73	FALSE
47	ROSMAP	Brain Pre-frontal Cortex	PQLC3	0.17	0.07	enet	20	0.12	8.7e-15	-3.84	5.3	1.0e-07	-0.03	0.07	0.93	FALSE
48	ROSMAP	Brain Pre-frontal Cortex	RP11-254F7.2	0.35	0.21	bslmm	562	0.30	1.4e-39	7.94	7.8	7.9e-15	0.58	1.00	0.00	TRUE
49	YFS	Blood	YWHAQ	0.07	0.04	bslmm	485	0.05	1.9e-15	2.76	6.9	5.3e-12	-0.05	1.00	0.00	TRUE
50	The Cancer Genome Atlas	Breast Invasive Carcinoma	ADAM17	0.03	0.02	blup	41	0.03	1.8e-06	-8.93	-8.6	6.4e-18	-0.10	0.08	0.91	TRUE
51	The Cancer Genome Atlas	Breast Invasive Carcinoma	PQLC3	0.02	0.01	blup	52	0.01	5.2e-04	-5.82	5.7	1.2e-08	-0.04	0.01	0.98	FALSE
52	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	PQLC3	0.03	0.03	blup	52	0.01	1.5e-02	7.17	6.2	4.4e-10	-0.09	0.01	0.85	FALSE
53	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	IAH1	0.03	0.01	blup	35	0.02	1.7e-03	-8.73	-9.7	2.1e-22	-0.07	0.02	0.80	TRUE
54	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PQLC3	0.10	0.08	blup	51	0.10	6.9e-11	6.31	6.6	4.9e-11	-0.01	0.08	0.92	FALSE
55	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PQLC3	0.06	0.03	blup	51	0.02	3.6e-02	6.28	6.3	2.4e-10	-0.05	0.02	0.73	FALSE
56	The Cancer Genome Atlas	Lung Adenocarcinoma	ADAM17	0.03	0.01	blup	41	0.02	4.7e-03	-8.70	-7.6	3.0e-14	-0.16	0.05	0.49	FALSE
57	The Cancer Genome Atlas	Lung Adenocarcinoma	PQLC3	0.08	0.07	blup	52	0.08	2.0e-09	-6.84	6.0	2.7e-09	-0.06	0.01	0.99	FALSE
58	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	PQLC3	0.06	0.01	blup	51	0.05	1.5e-04	6.28	6.2	4.7e-10	-0.04	0.01	0.96	FALSE
59	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	ITGB1BP1	0.17	-0.01	blup	32	0.09	1.9e-04	-1.11	-6.5	1.1e-10	0.00	0.01	0.26	TRUE
60	The Cancer Genome Atlas	Prostate Adenocarcinoma	PQLC3	0.10	0.14	enet	13	0.14	6.3e-15	-7.18	6.5	5.7e-11	-0.05	0.01	0.99	FALSE
61	The Cancer Genome Atlas	Stomach Adenocarcinoma	PQLC3	0.07	0.05	lasso	5	0.05	2.5e-04	-6.84	6.7	2.6e-11	-0.06	0.01	0.98	FALSE
62	The Cancer Genome Atlas	Testicular Germ Cell Tumors	ADAM17	0.10	0.14	lasso	2	0.13	3.2e-05	-8.80	-9.3	1.9e-20	-0.12	0.06	0.90	FALSE
63	The Cancer Genome Atlas	Testicular Germ Cell Tumors	PQLC3	0.23	0.10	enet	12	0.21	6.2e-08	7.17	6.3	3.2e-10	-0.05	0.01	0.99	FALSE
64	The Cancer Genome Atlas	Thyroid Carcinoma	PQLC3	0.18	0.17	lasso	9	0.20	2.5e-19	-7.26	5.9	4.4e-09	-0.04	0.01	0.99	FALSE