Best TWAS P=2.37e-13 · Best GWAS P=2.65e-30 conditioned to 2.83e-19
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | COL6A2 | 0.13 | 0.11 | lasso | 7 | 0.11 | 7.7e-14 | 7.2 | 6.4 | 1.3e-10 | 0.34 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Artery Coronary | LSS | 0.18 | 0.10 | enet | 9 | 0.07 | 1.9e-03 | -2.9 | -5.4 | 8.8e-08 | -0.05 | 0.16 | 0.05 | FALSE |
| 3 | GTEx | Brain Frontal Cortex BA9 | COL6A1 | 0.28 | 0.01 | enet | 43 | 0.01 | 1.9e-01 | 3.3 | 5.2 | 1.6e-07 | 0.09 | 0.09 | 0.05 | TRUE |
| 4 | GTEx | Esophagus Mucosa | MCM3AP-AS1 | 0.18 | 0.07 | enet | 24 | 0.10 | 2.3e-07 | 2.2 | 6.0 | 2.3e-09 | 0.13 | 0.99 | 0.00 | TRUE |
| 5 | GTEx | Nerve Tibial | MCM3AP | 0.20 | 0.12 | lasso | 9 | 0.18 | 5.9e-13 | -3.5 | 5.2 | 1.7e-07 | 0.07 | 1.00 | 0.00 | FALSE |
| 6 | GTEx | Pancreas | DIP2A | 0.13 | 0.12 | enet | 12 | 0.15 | 5.3e-07 | -3.4 | 5.9 | 4.3e-09 | 0.11 | 0.62 | 0.02 | FALSE |
| 7 | METSIM | Adipose | LSS | 0.11 | 0.01 | bslmm | 485 | 0.06 | 6.4e-10 | 2.3 | -6.1 | 1.1e-09 | -0.11 | 0.98 | 0.00 | TRUE |
| 8 | The Cancer Genome Atlas | Lung Adenocarcinoma | FTCD | 0.04 | 0.03 | blup | 66 | 0.03 | 2.6e-04 | -3.8 | 5.1 | 2.6e-07 | 0.16 | 0.16 | 0.03 | FALSE |
| 9 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | COL6A2 | 0.05 | 0.00 | blup | 75 | 0.01 | 1.9e-02 | 8.7 | 7.3 | 2.4e-13 | 0.17 | 0.02 | 0.04 | TRUE |