Hub : Genes

COL6A1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.2610	0.0470	1.9e-15	0.061	0.172	0.168	0.182	0.158	6.8e-08	1.9e-20	6.6e-20	1.1e-21	9.7e-19
2	GTEx	Artery Aorta	0.3530	0.0630	2.5e-13	0.255	NA	0.320	NA	0.333	2.8e-14	NA	3.4e-18	NA	4.9e-19
3	GTEx	Artery Tibial	0.2703	0.0613	8.0e-10	0.206	NA	0.148	NA	0.198	5.0e-16	NA	1.1e-11	NA	1.9e-15
4	GTEx	Brain Cerebellar Hemisphere	0.2940	0.1160	1.8e-03	0.152	NA	0.064	NA	0.089	1.0e-04	NA	1.0e-02	NA	2.8e-03
5	GTEx	Brain Cerebellum	0.5400	0.1280	1.1e-04	0.348	NA	0.330	NA	0.328	4.0e-11	NA	1.7e-10	NA	1.9e-10
6	GTEx	Brain Frontal Cortex BA9	0.2789	0.0988	2.3e-03	0.011	NA	0.008	NA	0.004	1.6e-01	NA	1.9e-01	NA	2.4e-01
7	GTEx	Esophagus Gastroesophageal Junction	0.1840	0.0730	6.4e-03	0.089	NA	0.053	NA	0.094	4.2e-04	NA	5.6e-03	NA	2.8e-04
8	GTEx	Nerve Tibial	0.2019	0.0763	4.3e-03	0.064	NA	0.054	NA	0.047	2.6e-05	NA	1.1e-04	NA	2.9e-04
9	GTEx	Spleen	0.2650	0.1150	5.7e-03	0.067	NA	0.025	NA	0.087	8.5e-03	NA	7.5e-02	NA	3.1e-03
10	YFS	Blood	0.0491	0.0149	1.0e-07	0.006	0.023	0.018	0.024	0.020	2.5e-03	4.3e-08	1.3e-06	2.3e-08	3.0e-07
11	TCGA	Thyroid Carcinoma	0.0560	0.0280	5.7e-03	0.018	0.023	0.036	NA	0.029	6.6e-03	2.4e-03	1.9e-04	NA	6.6e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	0.8	1.3	3.3	-0.9	-1.4	-1.6	-0.2	0.6	-1.8	-1.5	-0.2	-1.5	-0.1	-0.5
Bipolar Disorder or Schizophrenia	1.6	3.8	13.6	-1.4	-2.3	-2.1	-1.2	-0.9	-3.7	-2.5	-1.5	-2.4	-0.1	0.2
Depressed Affect (Nagel 2018)	0.3	0.7	3.1	1.1	0.2	0.4	-0.4	-0.3	-0.0	0.7	-0.0	-0.2	1.8	1.7
Depression (Nagel 2018)	1.4	2.1	7.3	0.1	-1.1	-0.5	-2.6	-2.7	-1.4	-0.5	-1.2	-1.1	-0.5	1.6
Intelligence (Savage-Jansen 2018)	0.4	1.2	4.6	1.6	1.2	1.2	0.1	0.1	2.1	0.1	0.2	0.9	1.3	1.0
Neuroticism (Nagel 2018)	0.3	0.7	1.7	1.0	1.0	1.2	-0.4	-0.4	-0.5	0.8	-0.3	0.9	0.8	1.3
Schizophrenia (2018)	1.5	3.1	12.1	-1.1	-1.8	-1.4	-1.4	-1.6	-3.5	-2.0	-1.7	-1.9	-0.2	0.6
Schizophrenia vs Biploar Disorder	0.1	0.2	0.5	0.1	-0.1	-0.2	-0.5	-0.7	-0.5	-0.5	-0.4	0.4	-0.3	0.1
Worry (Nagel 2018)	0.2	0.5	2.4	-0.2	0.4	0.4	-0.3	-0.3	-1.5	-0.1	-1.0	1.0	-0.7	0.1
Alzheimer’s Disease (in mother)	0.3	0.4	2.4	0.2	0.1	-0.1	0.1	0.0	-0.8	-0.4	-0.5	0.6	-1.5	-0.2
Alzheimer’s Disease (in father)	0.6	0.7	2.5	-0.7	-1.2	-1.6	0.8	0.4	-0.3	-0.8	-0.2	-0.7	0.1	-1.1
Alzheimer’s Disease (including proxy)	0.3	0.5	1.4	-0.4	-0.3	-0.8	0.5	0.4	-1.2	-0.5	-0.0	0.4	-1.1	-0.9
Crohns Disease (2017)	1.7	3.6	6.9	-0.2	-2.6	-2.4	-2.1	-2.0	-2.1	-2.2	-1.2	-2.6	0.4	1.0
Irritable Bowel Disease (IBD)	0.7	1.7	3.1	-0.3	-1.8	-1.7	-1.4	-1.7	-1.0	-1.4	-1.4	-1.4	-0.2	0.7
Ulcerative Colitis (UC)	0.1	0.2	0.9	-0.4	-0.1	-0.1	-0.2	-0.6	0.4	-0.3	-1.0	0.4	-0.8	0.0
Major Depression (MDD)	0.2	0.2	0.7	-0.2	-0.1	-0.4	0.2	0.6	-0.7	0.2	0.4	-0.0	0.9	0.0
Reaction Time	0.5	0.9	3.2	-1.8	-0.3	-0.2	0.9	0.8	-1.2	-0.2	-0.5	-0.2	-1.0	-1.4
Verbal and Numeric Reasoning (VNR)	0.1	0.3	1.6	0.7	0.5	0.3	-0.1	0.1	1.3	0.2	0.1	0.8	0.5	0.0
Breast Cancer	0.5	1.1	4.5	0.8	1.0	1.4	0.6	0.3	1.3	0.8	0.3	1.0	-2.1	0.3
Ovarian Cancer	0.6	0.8	2.4	1.0	-0.1	0.4	0.9	1.0	1.1	-0.2	1.1	-0.8	1.6	0.2
Prostate Cancer	1.4	1.9	10.3	1.3	-0.9	-0.7	-0.9	-0.9	0.3	-0.1	0.9	-1.7	3.2	1.7
Age at First Birth	0.8	1.1	1.9	0.8	-1.1	-1.1	-1.3	-1.2	-1.4	-0.4	0.6	-1.2	0.4	1.4
Bipolar Disorder (2011)	2.1	2.0	4.7	-1.3	-2.1	-2.2	-1.0	-0.7	0.0	-2.0	-1.6	-1.7	-0.8	-0.1
Body Mass Index (BMI) (2010)	1.1	1.5	2.7	-1.1	1.1	0.4	1.1	1.5	1.0	1.4	1.5	1.7	0.1	-1.4
Coronary Artery Disease (CAD)	1.0	1.2	2.8	-1.7	0.1	-0.4	1.3	1.0	-1.5	-0.3	-0.9	0.9	-1.2	-1.6
Crohns Disease (2012)	1.4	2.3	6.2	-0.8	-2.3	-2.5	-1.7	-1.6	-1.4	-1.4	-0.8	-1.8	-0.0	0.0
Mean Putamen Volume	2.2	2.5	6.2	-0.7	-1.0	-0.7	-2.2	-2.5	-1.2	-2.0	-2.1	-1.1	-0.4	1.9
Fasting Glucose	1.6	2.0	8.8	-1.7	1.3	0.4	0.7	0.9	0.8	3.0	1.3	1.1	-1.3	-1.1
HbA1C	1.0	1.1	3.8	-0.2	1.1	0.6	0.7	0.9	0.8	1.9	1.8	1.4	-0.1	-0.3
HDL Cholesterol	0.3	0.5	2.6	-0.5	-0.0	-0.1	-0.2	-0.1	-1.2	-1.6	-0.8	-0.2	0.2	-0.1
LDL Cholesterol	0.2	0.3	0.6	0.7	0.5	0.7	0.2	0.1	0.3	0.4	0.2	0.5	-0.5	0.8
Lupus	4.2	6.4	15.8	-0.8	-3.6	-3.1	-1.7	-2.0	-2.4	-4.0	-2.8	-3.4	0.1	0.0
Neuroticism (2016)	1.0	1.4	4.8	1.1	0.9	1.2	-0.6	-0.5	1.6	2.2	1.6	0.8	0.6	0.8
Primary Biliary Cirrhosis	0.7	1.0	2.5	0.5	-1.1	-0.7	-0.5	-0.7	-1.1	-1.6	-1.0	-1.4	1.3	0.7
Rheumatoid Arthritis	1.0	1.4	3.9	0.5	-1.2	-0.7	-1.4	-2.0	-0.1	-0.4	-1.5	-1.6	-0.3	1.6
Schizophrenia (2014)	1.5	3.3	9.8	-1.0	-2.1	-1.6	-2.2	-2.1	-3.1	-1.5	-0.4	-2.2	0.0	1.3
Triglycerides	0.1	0.2	0.5	0.6	0.0	-0.1	0.3	0.0	0.5	0.4	-0.1	0.4	-0.4	0.7
Type 2 Diabetes (T2D) (2012)	2.9	3.3	11.3	0.0	-2.3	-1.4	-1.7	-1.9	-1.0	-1.8	-1.6	-3.4	1.9	0.7
Ulcerative Colitis	0.9	1.4	3.1	-1.1	-1.6	-1.8	-0.5	-0.5	-1.4	-1.5	-1.5	-0.9	-0.1	-0.5
Blood Eosinophil Count	0.4	2.9	6.4	2.4	1.5	1.8	-0.7	-0.5	2.5	0.8	0.7	1.1	2.2	2.5
Blood Platelet Count	0.1	1.6	7.7	1.0	0.3	-0.5	2.8	2.1	0.4	0.8	0.5	1.4	0.6	-0.9
Blood Red Count	0.1	1.2	6.7	-0.3	-0.5	0.1	-0.4	-1.1	-2.6	-0.0	-0.6	-0.7	-1.5	1.2
Blood White Count	0.2	1.3	6.4	0.9	0.8	0.6	2.5	1.5	0.5	0.9	-0.4	0.8	1.3	-0.5
Heel T-Score	0.4	3.4	7.5	-2.4	-0.6	-1.3	2.7	2.1	-0.9	-0.9	-2.2	-0.4	-2.2	-2.5
BMI	0.1	0.8	5.0	0.8	0.1	0.6	-0.2	-0.0	-0.3	0.2	1.4	-0.3	2.2	0.9
Height	0.5	9.4	27.5	1.8	-0.7	2.0	-3.3	-4.1	5.2	3.4	2.2	-3.4	0.0	3.5
Waist Hip Ratio (WHR)	0.6	2.9	7.2	2.7	0.3	1.8	-1.9	-2.3	1.3	1.6	0.4	-1.1	0.9	2.5
Systolic Blood Pressure	0.7	3.7	8.1	-0.2	2.0	2.0	2.6	2.7	0.9	2.9	2.1	1.3	0.0	-1.9
Smoking Status	0.3	0.8	4.5	1.1	-0.7	-0.5	-0.2	0.1	0.0	-0.3	-0.4	-1.1	2.1	0.9
Allergy or Eczema	0.2	0.5	1.1	-0.6	-0.8	-0.8	-1.0	-0.9	-0.3	-0.9	-0.0	-0.6	0.3	0.2
Cardiovascular Disease	0.2	0.6	1.5	0.1	0.6	0.8	1.1	1.1	0.5	0.7	0.9	0.0	1.2	0.0
Hypothyroidism (self reported)	0.4	0.8	4.8	-1.3	0.6	0.8	-0.1	-0.2	-0.8	0.7	0.4	0.5	-2.2	-0.2
Respiratory disease	0.2	0.4	1.9	-0.4	0.0	-0.3	1.3	1.4	-0.2	-0.7	-0.3	0.2	-0.3	-0.6
Type 2 Diabetes (T2D) (2018)	0.6	1.1	3.2	-0.0	-0.5	0.4	-1.6	-1.8	0.4	-0.7	-1.1	-1.1	-0.7	1.6
Lung FEV1/FVC ratio	0.3	1.5	4.4	-1.4	-0.8	-1.7	1.4	1.3	-1.2	-0.4	-0.4	0.3	0.9	-2.1
Lung FVC	0.4	2.3	8.6	-1.1	-1.2	-2.2	0.9	1.1	0.2	-2.9	-0.8	-0.1	-0.3	-2.5
Neuroticism	0.2	0.5	1.5	0.1	-0.2	-0.2	-0.9	-0.7	-1.2	0.3	-1.2	0.4	0.4	1.0
Chronotype (morning person)	0.8	1.9	4.3	-1.3	-0.6	-1.9	2.0	1.8	-1.4	-0.1	0.7	0.4	0.5	-2.1
Hair Pigment	0.0	0.2	0.7	-0.8	-0.1	-0.2	0.2	0.3	0.3	0.2	-0.6	-0.3	-0.6	0.1
Tanning	0.1	1.4	4.1	-2.0	-1.1	-1.4	-1.8	-1.6	-0.7	0.0	0.3	-0.4	-1.4	0.2
Hand grip strength (left)	0.8	2.0	5.3	1.3	1.6	1.7	1.6	1.3	2.3	1.3	1.5	1.1	-0.4	-0.3
Number of treatments/medications taken	1.0	1.8	3.8	-1.6	0.8	0.6	1.6	1.9	-1.2	0.7	0.8	0.9	-1.6	-1.9
Average weekly spirits intake	1.4	1.8	3.6	-0.4	1.3	0.6	1.8	1.9	0.2	1.5	1.1	1.4	-1.3	-1.8
Sensitivity / hurt feelings	0.2	0.4	1.3	0.3	1.1	1.1	-0.0	-0.0	-0.5	-0.0	-0.6	1.1	0.5	0.1
Frequency of depressed mood in last 2 weeks	0.4	0.5	2.4	0.1	-0.4	0.0	-1.6	-1.4	-0.9	0.3	0.2	-0.2	0.1	0.6
Hearing difficulty/problems: Yes	1.1	1.7	5.2	-1.1	-1.0	-0.5	-2.3	-2.1	-1.1	-1.1	-0.6	-1.1	-1.3	1.1
Relative age of first facial hair	0.8	1.7	6.1	2.2	-0.6	-0.1	-0.4	-0.7	0.1	-0.3	-1.1	-1.3	2.5	1.8
Other serious medical condition/disability diagnosed by doctor	1.6	2.1	6.4	0.9	1.5	1.9	0.0	0.2	1.9	2.5	2.0	1.2	-0.4	0.7
Ever used hormone-replacement therapy (HRT)	0.7	0.9	2.8	0.5	1.5	1.7	0.2	0.2	-0.1	-0.1	-1.2	1.1	-1.4	0.8
Ever had hysterectomy (womb removed)	1.0	1.1	2.3	0.9	1.5	1.5	1.3	1.1	0.1	0.8	1.0	1.1	-0.4	-0.7
Systolic blood pressure, automated reading	0.1	0.4	0.9	-0.9	0.4	0.7	0.6	0.6	-0.5	0.7	0.6	-0.1	-0.2	-1.0
Eye problems/disorders: Diabetes related eye disease	0.0	0.0	0.2	0.5	-0.3	-0.1	0.0	-0.1	0.1	0.3	0.1	-0.3	-0.1	-0.1
Angina	0.5	0.7	2.3	-0.8	-0.9	-0.6	-0.7	-0.7	-1.5	-1.0	0.1	-1.0	-0.4	-0.0
Medication for hormone replacement therapy	1.2	1.3	3.5	1.8	1.7	1.9	0.3	0.5	0.8	0.8	0.3	1.0	0.3	1.3
Vitamin and mineral supplements	2.0	2.7	6.9	1.0	-1.4	-0.6	-2.3	-2.6	1.1	-0.7	-1.2	-2.1	1.0	2.4
Supplements: Zinc	0.9	1.0	2.8	0.3	1.0	0.2	1.4	1.6	-1.1	-0.1	0.0	1.3	0.1	-1.7
Medication: Co-codamol	0.4	0.4	1.7	0.5	-0.4	-0.5	-0.1	-0.2	1.0	0.4	0.7	-0.4	1.3	0.7
Medication: Metformin	0.8	1.2	5.8	-1.5	0.1	0.5	-1.3	-1.4	0.5	-0.0	-0.6	0.4	-2.4	0.4
Diabetes (father)	0.7	0.9	3.7	-1.1	0.1	0.0	1.7	1.3	-0.5	0.1	-0.5	0.3	-0.3	-1.9
Diabetes (mother)	0.6	0.8	2.2	1.0	1.2	1.4	1.0	0.5	1.5	0.5	0.4	0.5	0.4	0.0
Severe depression (siblings)	2.9	3.2	6.8	0.5	-2.1	-1.7	-2.6	-2.5	-0.1	-1.2	-1.0	-2.3	1.1	2.5
Pack years adult smoking proportion	0.1	0.2	0.7	0.1	-0.4	-0.1	-0.2	-0.1	0.7	-0.2	0.1	-0.8	0.6	0.2
Impedance of leg (right)	0.3	1.4	5.7	0.1	0.6	0.2	2.4	2.3	0.6	1.2	0.3	0.7	-0.0	-1.4
Leg fat-free mass (left)	0.4	2.3	7.5	0.5	-0.9	0.7	-2.5	-2.7	0.6	0.1	1.1	-2.1	0.1	2.0
Trunk fat percentage	0.2	0.7	2.2	-1.0	-1.0	-0.7	0.2	0.5	-0.8	-0.2	1.5	-1.0	0.4	-1.1
Hand grip strength (right)	0.4	1.2	3.7	0.3	1.0	0.9	1.0	0.6	1.9	1.2	0.9	1.0	-1.4	-0.5
Townsend deprivation index at recruitment	0.4	0.6	2.6	-0.4	-0.8	-0.9	-0.5	-0.4	0.4	-0.4	0.8	-1.0	1.6	0.2
Current tobacco smoking	0.4	0.6	1.2	-1.1	-1.0	-1.1	-0.5	-0.3	-1.0	-0.5	0.1	-0.7	-0.6	-0.8
Average weekly fortified wine intake	0.9	1.1	3.2	-0.2	-1.1	-1.2	-1.5	-1.8	0.1	-0.6	-1.1	-0.8	-0.9	0.9
Maternal smoking around birth	1.4	2.0	4.2	0.6	2.0	1.6	1.6	1.8	0.4	1.5	1.4	2.0	0.2	-1.1
Fed-up feelings	0.4	0.7	2.7	-0.1	-1.0	-0.6	-0.8	-0.7	-0.4	-0.2	-0.5	-1.6	1.2	0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	1.0	2.8	-0.2	-0.8	-0.7	-1.6	-1.7	-1.4	-0.4	-0.8	-0.7	-0.5	0.9
Relative age voice broke	0.5	0.8	1.9	1.4	-0.4	-0.0	-0.5	-0.9	0.0	-1.0	-1.4	-0.8	0.9	1.1
Taking other prescription medications	0.1	0.2	0.4	-0.3	-0.1	0.3	0.4	0.6	-0.5	-0.6	0.4	-0.5	0.3	-0.2
Age when periods started (menarche)	0.3	0.7	2.2	0.7	-0.6	-0.5	-0.1	-0.0	-1.1	-1.1	-1.5	-0.5	0.8	0.9
Bilateral oophorectomy (both ovaries removed)	1.3	1.5	3.9	0.4	1.8	2.0	-0.2	-0.1	0.6	2.0	1.3	1.6	-0.7	0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.9	5.2	-1.9	0.1	-0.5	2.3	1.9	0.3	0.6	-0.4	0.3	-1.7	-2.2
Tinnitus: Yes, but not now, but have in the past	0.5	0.6	2.0	0.6	0.8	1.0	0.9	1.0	-0.0	0.2	0.1	0.4	1.4	0.3
Qualifications: CSEs or equivalent	0.7	1.0	3.2	0.6	-0.4	-0.2	-0.7	-0.9	1.8	1.4	1.0	-0.9	1.1	0.9
Serious illness, injury or assault to yourself	0.2	0.2	0.7	0.4	-0.6	-0.8	-0.0	-0.2	-0.1	0.3	-0.1	-0.2	0.8	0.7
High blood pressure	0.1	0.3	0.9	-0.6	-0.1	0.3	0.5	0.5	-0.9	0.1	-0.7	-0.4	-0.3	-0.8
Hayfever, allergic rhinitis or eczema	0.6	1.3	2.5	-1.4	-1.4	-1.5	-0.7	-0.7	-1.2	-1.6	-1.1	-1.1	-0.4	-0.1
Multivitamins +/- minerals	1.7	2.2	6.1	-0.7	1.4	0.8	2.4	2.5	-0.1	0.7	1.0	1.7	-0.4	-2.1
Stomach or abdominal pain in last month	0.5	0.6	1.5	0.5	-0.8	-0.6	-0.8	-1.0	1.1	-0.4	-1.2	-0.5	-0.0	1.0
Supplements: Glucosamine	0.5	0.7	1.7	0.7	0.8	0.8	1.3	1.1	-0.4	0.8	0.7	0.8	0.6	-0.7
Diverticular disease/diverticulitis (self-reported)	1.0	1.2	2.3	-1.4	0.6	-0.3	1.3	1.4	-0.5	-1.2	-0.9	1.5	-0.2	-1.2
Medication: Atenolol	0.7	0.8	2.6	-0.6	-1.0	-0.8	-0.9	-0.8	-1.3	-0.4	-0.6	-1.6	0.9	0.4
Medication: Levothyroxine sodium	0.7	1.1	3.7	-0.6	1.3	1.9	-0.2	0.1	-0.2	1.5	1.8	0.4	-0.7	0.5
Sitting height	0.4	2.9	8.6	0.5	-1.9	-0.6	-2.6	-2.9	1.1	-0.6	-0.3	-2.5	-0.1	2.0
Chronic bronchitis/emphysema (father)	1.1	1.3	4.4	-1.0	-0.4	-0.7	1.7	2.1	-0.3	-0.1	0.1	-0.7	-0.0	-2.1
High blood pressure (mother)	0.2	0.3	0.8	-0.8	-0.3	-0.5	0.9	0.7	0.1	0.1	-0.6	-0.2	-0.3	-0.7
Body mass index (BMI)	0.1	0.4	2.2	-0.0	-0.2	0.3	-0.6	-0.4	-0.7	-0.2	1.5	-0.6	0.6	0.3
Impedance of leg (left)	0.3	1.2	5.1	-0.3	-0.0	-0.5	2.3	2.3	0.5	0.7	-0.0	0.2	0.3	-1.5
Leg predicted mass (left)	0.4	2.4	7.8	0.5	-1.0	0.6	-2.6	-2.8	0.5	0.0	1.1	-2.1	0.1	2.0
Trunk fat mass	0.2	0.7	3.0	-0.4	-1.0	-0.2	-0.6	-0.5	-0.3	0.1	1.7	-1.5	0.5	-0.1
Waist circumference	0.7	2.5	5.7	1.8	-0.5	1.2	-2.0	-2.0	0.6	0.6	1.7	-1.9	1.3	2.4
Number of incorrect matches in round	0.2	0.3	1.9	-0.1	-0.0	-0.1	0.5	0.5	-0.1	1.4	0.5	-0.4	-0.3	-0.7
Past tobacco smoking	0.4	0.8	3.2	-1.1	-0.2	-0.7	0.9	0.7	-0.6	-0.5	0.1	0.4	-1.3	-1.8
Alcohol usually taken with meals	0.4	0.6	1.6	0.4	-0.5	-0.3	-0.6	-0.8	0.1	-1.3	-0.9	-0.6	1.0	1.0
Nervous feelings	0.3	0.5	1.0	0.7	0.8	1.0	0.8	1.0	-0.5	0.4	-0.7	0.5	0.6	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.7	2.0	0.1	0.2	0.3	-1.4	-1.4	0.3	0.2	-0.8	0.6	-0.9	1.3
Hearing difficulty/problems with background noise	1.7	2.7	10.3	-1.5	-0.9	-0.3	-3.2	-2.8	-0.6	-0.4	-0.5	-1.0	-2.2	1.1
Hair/balding pattern: Pattern 2	0.9	1.1	5.4	1.6	-0.4	-0.6	-0.6	-0.5	0.9	-0.6	-0.7	-0.3	2.3	1.2
Had menopause	1.2	1.5	5.7	-0.7	-0.7	0.0	-2.4	-2.2	0.0	-0.4	0.7	-0.9	-1.5	1.1
Had other major operations	0.5	0.6	2.3	1.5	0.8	0.9	0.6	0.6	1.1	0.2	-0.5	0.2	0.2	0.4
Forced vital capacity (FVC)	0.2	0.7	2.2	0.0	-1.0	-0.7	-0.5	-0.9	1.5	-1.3	-0.4	-1.1	0.4	0.4
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.3	5.6	-1.3	1.3	0.6	2.4	1.9	0.7	1.2	0.0	1.6	-2.0	-1.9
Ever unenthusiastic/disinterested for a whole week	1.3	1.6	4.4	-0.1	-1.6	-1.3	-1.4	-1.1	-0.8	-2.1	-1.1	-1.6	0.8	0.3
Qualifications: None of the above	0.8	1.7	4.1	-0.2	1.3	0.8	1.7	2.0	1.3	1.7	1.3	1.3	0.3	-0.9
Financial difficulties in last 2 years	0.5	0.6	2.6	0.6	-0.7	-0.2	-0.5	-0.7	0.1	-0.0	-0.2	-1.6	1.4	0.8
Mouth/teeth dental problems	0.4	0.7	1.4	-0.4	-1.2	-1.0	-0.8	-0.6	-1.1	-1.0	-0.9	-0.9	0.3	-0.0
Heart attack	0.1	0.2	0.5	0.5	0.4	0.7	0.2	0.2	0.4	-0.1	-0.1	-0.2	0.6	0.3
Allergy	0.2	0.4	2.0	1.4	-0.0	0.4	-0.4	-0.4	0.7	0.7	-0.5	-0.5	0.9	0.4
Pain all over the body in last month	0.6	0.6	1.8	-1.4	-0.7	-1.3	0.4	0.3	-0.7	-0.2	-0.3	-0.1	-0.9	-1.1
Diabetes (self-reported)	0.9	1.4	3.8	-1.2	-1.1	-0.7	-1.9	-2.0	0.1	-0.6	-1.0	-1.2	-0.9	0.7
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	2.7	-0.8	0.5	0.1	-0.4	-0.1	0.6	0.4	0.5	1.3	-1.7	-0.7
Medication: Ramipril	0.6	0.8	2.2	1.3	1.0	1.5	0.4	0.2	0.7	1.4	0.6	0.3	0.7	0.8
Medication: Simvastatin	0.6	0.9	1.9	0.8	0.5	1.2	-0.6	-0.6	1.3	1.0	1.2	-0.3	0.9	1.4
Fluid intelligence score	0.8	1.7	6.0	1.6	1.5	1.3	0.4	0.3	2.4	1.1	0.5	2.0	0.2	0.3
Illnesses of siblings	1.4	2.0	7.0	0.8	-1.3	-0.6	-2.3	-2.6	0.6	-0.5	-1.2	-1.4	0.2	1.8
Neuroticism score	0.2	0.4	1.5	-0.0	0.5	0.3	-0.4	-0.3	-1.0	0.2	-1.2	1.0	-0.5	0.4
Weight	0.4	2.1	5.9	0.7	-1.1	0.5	-1.9	-2.0	0.6	0.1	1.5	-2.4	1.1	1.8
Impedance of arm (right)	0.2	0.9	2.7	-1.0	-1.3	-1.6	0.8	0.8	-0.3	-0.2	-0.7	-0.6	0.0	-1.5
Arm fat percentage (right)	0.1	0.5	2.1	-0.5	-0.8	-0.4	-0.1	0.2	-0.6	-0.0	1.4	-0.9	0.7	-0.5
Trunk fat-free mass	0.6	3.5	10.0	1.3	-0.7	1.3	-2.6	-3.2	1.3	0.7	0.8	-2.7	0.3	2.9
Hip circumference	0.3	1.2	4.0	0.4	-1.0	0.2	-1.2	-1.1	0.0	0.0	1.5	-2.0	1.1	1.3
Time employed in main current job	1.0	1.1	3.7	-1.4	0.1	-0.4	1.0	0.9	-1.2	-0.7	-1.0	0.3	-1.2	-1.9
Alcohol intake versus 10 years previously	0.6	0.9	2.0	0.8	0.9	0.8	1.3	1.3	-0.5	1.2	1.4	0.4	1.1	-0.1
Father’s age at death	0.4	0.5	1.9	0.9	-0.5	0.2	-0.7	-0.7	-0.5	-0.7	0.2	-1.4	-0.0	0.9
Worrier / anxious feelings	0.2	0.4	1.3	-0.5	0.4	0.3	0.4	0.5	-0.6	0.5	-0.0	0.8	-1.1	-0.7
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	2.9	-0.3	0.6	0.2	1.0	0.9	0.1	1.7	1.0	1.0	-0.1	-0.7
Falls in the last year	1.0	1.4	3.4	1.8	1.0	1.3	1.0	1.1	-0.9	-1.0	-0.8	0.5	1.8	0.8
Hair/balding pattern: Pattern 3	0.9	1.4	5.9	-0.1	1.4	1.7	0.0	-0.2	0.3	1.3	0.7	1.4	-2.4	-0.6
Number of live births	0.9	1.3	4.9	0.8	-0.5	0.1	-1.6	-1.8	0.8	-0.4	-1.0	-0.8	-0.0	2.2
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	2.3	-0.1	-0.8	-0.9	0.2	-0.2	1.4	-1.5	-0.7	-0.7	0.7	-0.4
Pulse rate	0.2	0.3	1.4	-1.0	-0.5	-0.5	0.4	0.3	-0.2	0.2	0.4	-0.3	-0.4	-1.2
Happiness	0.1	0.1	0.5	0.2	-0.4	-0.2	-0.5	-0.5	-0.0	-0.7	-0.3	-0.6	0.2	-0.1
Noisy workplace	0.6	0.8	2.4	-1.5	0.6	0.5	-0.2	-0.1	0.1	1.4	1.0	0.6	-1.3	-0.7
Qualifications: A levels/AS levels or equivalent	1.2	2.6	7.0	0.8	-1.9	-1.3	-2.5	-2.6	0.4	-1.4	-1.4	-1.8	-0.5	1.6
Serious illness, injury or assault of a close relative in last 2 years	2.0	2.3	7.4	-0.6	-1.6	-0.9	-0.8	-1.1	-1.1	-2.5	-2.7	-1.8	-1.0	0.3
Mouth/teeth dental problems: Dentures	0.1	0.1	0.8	0.4	0.2	0.3	-0.2	-0.4	0.0	0.0	-0.2	-0.2	0.1	0.9
Asthma	0.2	0.5	2.0	-0.5	0.2	0.0	1.4	1.4	0.2	-0.1	0.7	-0.2	0.4	-0.4
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	1.7	-0.5	0.3	0.1	-0.2	-0.1	1.0	1.3	0.3	0.4	-0.4	0.0
Medication: Cholesterol lowering	0.7	1.1	4.9	1.0	0.7	1.2	0.1	0.1	1.1	1.4	2.2	0.2	0.5	0.8
Depression (self-reported)	0.3	0.4	2.0	0.8	-0.6	-0.3	-0.2	0.2	-0.4	0.1	0.5	-0.9	1.4	0.4
Medication: Lansoprazole	0.7	0.9	2.9	0.1	1.0	1.2	0.6	0.7	1.3	1.7	0.9	0.6	-0.3	-0.5
Prospective memory result	1.2	1.4	5.2	-0.7	-0.2	-0.7	1.2	1.2	-2.2	0.1	0.9	0.3	-0.8	-2.3
Lung cancer (father)	0.4	0.5	1.9	-0.9	-0.8	-0.5	-0.4	-0.6	-0.2	-0.2	-0.1	-0.8	-1.4	-0.4
Illnesses of mother	0.5	0.6	1.9	1.2	-0.1	0.0	-0.9	-0.6	0.5	-0.4	-0.2	-0.4	1.4	1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.1	2.8	-0.1	-1.4	-1.4	-0.2	-0.5	1.4	-1.7	-0.5	-1.1	1.2	-0.3
Pulse wave Arterial Stiffness index	0.9	1.0	2.5	1.1	-0.1	0.6	-1.2	-1.5	1.2	1.2	0.3	-0.5	0.7	1.6
Impedance of arm (left)	0.3	1.3	4.7	-1.3	-0.7	-1.4	1.5	1.6	-0.3	-0.1	-0.6	0.3	-0.2	-2.2
Arm fat mass (right)	0.1	0.5	2.4	-0.1	-0.6	0.2	-0.7	-0.6	-0.3	0.2	1.6	-1.3	0.4	0.2
Trunk predicted mass	0.6	3.5	9.9	1.3	-0.7	1.3	-2.6	-3.1	1.4	0.7	0.9	-2.6	0.3	2.9
Standing height	0.6	6.4	18.8	1.3	-2.4	0.0	-3.2	-4.0	2.7	0.4	-0.1	-4.3	0.6	3.2
Length of working week for main job	1.3	1.4	3.8	0.8	1.5	1.2	1.9	1.9	0.0	0.9	0.4	1.5	0.5	-0.7
Exposure to tobacco smoke at home	0.4	0.4	1.3	-1.1	-0.7	-0.8	0.3	0.3	-0.6	0.1	-0.3	-0.8	-0.6	-0.7
Breastfed as a baby	1.1	1.4	3.4	-0.4	-1.4	-1.0	-0.9	-1.3	-0.3	-1.8	-1.8	-1.5	0.0	1.0
Tense / ‘highly strung’	0.5	0.8	3.1	0.6	0.1	-0.1	-1.8	-1.5	-0.4	-0.1	-0.7	0.8	-0.1	1.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.4	0.9	-0.8	-0.0	-0.3	-0.6	-0.4	-1.0	-0.2	-0.9	0.7	-0.5	0.0
Hair/balding pattern: Pattern 4	0.1	0.3	1.3	-0.1	-0.2	-0.1	-0.7	-0.6	-0.2	0.2	-0.6	-0.3	-0.5	1.1
Birth weight of first child	0.2	0.3	0.7	0.8	0.4	0.4	-0.5	-0.4	0.3	0.2	0.6	0.5	0.8	0.6
Peak expiratory flow (PEF)	0.4	0.9	3.3	0.7	1.1	0.7	1.2	1.0	1.8	0.3	0.6	1.0	0.1	-0.9
Pulse wave reflection index	0.4	0.5	1.7	0.4	0.2	-0.2	-0.3	-0.4	1.3	0.1	-0.8	0.6	1.2	1.0
Ever highly irritable/argumentative for 2 days	0.9	1.1	3.6	-0.7	0.0	-0.3	1.9	1.4	-1.4	-0.9	-0.7	0.4	-0.1	-1.6
Loud music exposure frequency	1.1	1.2	3.5	0.2	0.8	0.6	-0.8	-0.7	1.8	1.9	1.8	0.8	0.2	0.7
Qualifications: O levels/GCSEs or equivalent	1.5	2.4	6.6	0.2	-2.0	-1.2	-2.2	-2.6	-0.1	-1.3	-0.8	-2.3	-0.2	1.2
Mouth/teeth dental problems: Bleeding gums	0.1	0.2	1.0	0.1	0.4	0.5	-0.1	0.1	-0.1	-0.2	-0.2	0.4	-1.0	-0.2
Blood clot in the leg (DVT)	0.4	0.5	1.2	-0.8	0.4	-0.1	0.3	0.3	-0.1	0.9	0.7	1.0	-0.6	-1.1
Medication: Paracetamol	0.3	0.4	1.1	-0.2	0.2	0.0	0.9	0.9	1.0	1.0	0.5	0.1	0.4	-0.8
Headache pain in last month	0.8	1.4	3.9	1.7	1.0	1.3	1.2	1.2	0.7	0.8	0.4	0.6	2.0	1.1
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.9	-0.3	-0.3	-0.8	-0.3	-0.3	-0.3	-0.5	-1.0	0.5	-0.3	-0.1
Glaucoma (self-reported)	0.6	0.7	1.6	0.3	0.8	0.8	-0.9	-0.7	-1.0	-0.1	-0.5	1.3	-1.3	0.8
Gout (self-reported)	0.8	1.1	4.7	-0.0	-0.6	-0.0	-1.9	-2.2	1.0	0.1	0.3	-0.4	-1.1	1.0
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	1.0	-0.8	0.7	1.0	0.0	0.2	-0.1	1.0	1.0	0.2	-0.6	0.2
Medication: Amlodipine	0.9	1.2	5.3	-0.0	0.6	1.3	-1.6	-1.6	-0.4	0.3	-0.0	0.2	-2.3	0.6
Medication: Ventolin 100micrograms inhaler	0.7	0.8	3.6	-0.2	-1.5	-1.0	0.3	0.1	-1.2	-0.7	0.0	-1.9	0.7	0.1
Birth weight	0.1	0.2	0.9	0.3	-0.1	0.0	-0.6	-0.2	0.7	-0.0	1.0	-0.1	0.2	0.0
Chronic bronchitis/emphysema (mother)	0.3	0.4	1.5	0.7	0.4	0.7	-0.0	-0.0	-0.6	-0.1	0.2	0.1	1.2	1.0
High blood pressure (siblings)	1.1	1.6	4.1	0.1	1.4	1.0	1.5	1.8	0.2	1.6	2.0	1.2	0.7	-0.8
Forced vital capacity (FVC), Best measure	0.3	1.2	4.8	0.5	-1.2	-0.8	-0.5	-0.8	2.2	-1.2	0.1	-1.3	1.3	0.5
Body fat percentage	0.2	0.6	3.4	-0.7	-0.6	-0.2	0.4	0.7	-0.7	0.1	1.8	-0.8	0.4	-0.9
Leg fat percentage (right)	0.2	0.8	4.8	0.3	0.5	1.0	0.9	1.1	-0.5	0.5	2.2	-0.0	0.6	-0.3
Arm fat-free mass (right)	0.4	2.0	4.8	1.3	-0.4	1.3	-1.7	-2.2	0.8	0.2	0.9	-2.1	0.2	2.1
Exposure to tobacco smoke outside home	0.7	0.9	3.2	-1.2	-1.3	-1.2	-0.2	-0.3	-1.8	-0.2	-0.6	-1.1	-0.0	-0.5
Comparative body size at age 10	0.3	0.8	2.2	0.1	0.9	1.5	-1.0	-1.1	1.0	-0.1	0.3	0.2	-1.3	1.0
Number of full brothers	1.0	1.2	3.3	-0.4	-1.4	-1.6	0.5	0.2	-0.8	-1.2	0.9	-1.4	1.8	-0.7
Worry too long after embarrassment	0.5	0.9	4.2	0.2	1.3	0.9	0.4	0.6	-1.0	-0.3	-1.0	2.0	-0.6	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	2.1	2.7	4.2	-1.4	-2.0	-2.0	-1.9	-1.7	-1.7	-2.0	-2.0	-1.4	-0.4	0.6
Wheeze or whistling in the chest in last year	0.4	0.8	2.5	-1.1	0.2	-0.0	1.5	1.6	-1.3	0.2	-0.2	0.4	0.1	-0.7
Number of children fathered	0.2	0.3	1.8	-0.3	0.3	0.1	-0.0	0.0	1.3	0.0	0.1	0.5	0.8	0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	0.9	-0.8	-0.3	-0.3	-0.3	-0.2	-0.4	-0.9	-0.8	-0.1	-0.8	0.2
Age at first live birth	1.1	1.9	5.7	1.3	-1.4	-0.7	-2.1	-2.4	0.3	-0.1	-0.6	-1.4	0.8	2.1
Pulse wave peak to peak time	0.7	0.8	2.0	-0.9	0.1	-0.4	1.1	1.4	-0.9	-0.9	-0.0	0.4	-0.6	-1.4
Health satisfaction	0.4	0.5	1.9	-0.4	-0.7	-1.3	-0.7	-0.4	-0.1	-0.7	-1.4	0.3	0.2	-0.0
Shortness of breath walking on level ground	0.2	0.3	1.1	-0.4	-0.1	-0.6	0.3	0.5	-0.4	0.4	0.0	0.5	-0.4	-1.1
Qualifications: College or University degree	0.9	2.8	5.4	1.9	-1.5	-0.9	-2.0	-2.3	0.4	-1.9	-1.8	-1.8	0.6	2.1
Eye problems/disorders: None of the above	1.3	1.4	4.2	-2.1	-1.4	-1.5	-0.5	-0.6	-0.1	-0.3	0.2	-1.2	-1.7	-1.5
Mouth/teeth dental problems: Loose teeth	0.9	1.0	3.7	1.2	0.1	0.4	-1.3	-1.3	1.3	0.6	0.1	-0.4	0.8	1.9
Emphysema/chronic bronchitis	0.4	0.4	1.4	1.2	0.6	0.1	0.3	0.2	-0.3	0.1	-0.0	1.2	-0.9	0.6
Medication for pain relief, constipation, heartburn	0.5	0.9	3.2	1.8	0.0	0.2	-0.9	-0.9	-0.4	-0.9	-0.3	-0.3	1.5	1.4
Neck or shoulder pain in last month	0.4	0.6	3.0	0.3	-0.6	-0.9	0.7	0.4	-0.4	-0.5	-1.7	-0.2	0.9	0.4
Medication: Blood pressure	0.3	0.5	1.0	-0.4	0.7	1.0	0.7	0.9	0.2	0.6	1.0	0.0	-0.3	-0.8
Angina (self-reported)	0.6	0.9	3.2	-1.2	-0.9	-0.7	-0.7	-0.7	-1.8	-1.1	-0.1	-0.9	-0.6	-0.1
Migraine (self-reported)	0.8	1.0	3.4	0.4	0.9	0.3	1.8	1.8	0.2	0.7	0.2	1.2	0.9	-0.4
Medication: Ibuprofen	0.6	0.8	2.9	0.4	0.9	0.7	0.4	0.6	1.5	1.7	0.7	0.7	0.4	0.3
Medication: Allopurinol	0.7	0.9	3.8	-0.7	-0.6	0.1	-1.7	-1.9	0.8	0.3	0.2	-0.9	-0.5	0.9
Medication: Omeprazole	0.8	1.0	2.1	0.3	0.9	0.7	1.1	1.2	0.6	1.4	1.4	1.3	-0.5	-0.4
Medication: Seretide 50 evohaler	0.8	0.9	3.8	0.4	-0.6	-0.5	-0.2	0.1	1.0	0.9	1.7	-0.8	2.0	0.3
Mean time to correctly identify matches	0.7	1.4	4.6	-2.1	-0.3	-0.2	0.5	0.4	-1.6	-0.2	-0.9	-0.1	-2.0	-1.6
Heart disease (mother)	0.8	1.0	3.7	-1.1	-1.1	-1.1	0.8	0.7	-0.6	-0.2	0.2	-1.1	-0.8	-1.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	3.3	1.8	0.9	0.7	-0.2	-0.1	0.1	-0.6	-0.4	0.5	1.4	1.2
Whole body fat mass	0.1	0.6	3.3	-0.3	-0.7	0.2	-0.5	-0.4	-0.4	0.2	1.8	-1.4	0.3	-0.0
Leg fat mass (right)	0.2	0.7	5.3	0.3	-0.1	0.9	-0.2	-0.1	-0.1	0.7	2.3	-0.8	0.3	0.4
Arm predicted mass (right)	0.4	2.1	6.2	1.1	-0.6	1.1	-2.0	-2.5	0.6	0.0	0.6	-2.2	0.2	2.2
Pulse rate, automated reading	0.2	0.6	1.6	-1.3	-0.5	-0.7	0.6	0.7	-1.1	-0.5	0.1	-0.2	0.6	-0.9
Alcohol intake frequency.	0.3	0.6	1.1	-1.0	-0.8	-1.0	-1.0	-0.6	-1.1	-0.6	0.2	-0.8	-0.4	0.6
Comparative height size at age 10	0.5	2.5	7.4	0.2	-1.5	0.0	-2.2	-2.7	1.7	0.6	-0.1	-2.4	-0.5	2.0
Number of full sisters	2.3	2.8	10.1	0.3	-2.2	-1.9	-1.2	-1.2	0.7	-1.1	-0.5	-2.6	3.2	0.8
Suffer from ‘nerves’	0.7	1.1	6.9	-0.9	-0.5	-0.6	0.7	0.7	-2.6	-1.0	-0.6	-0.3	0.3	-0.9
Overall health rating	0.6	1.3	4.2	1.2	0.5	0.6	0.6	0.6	0.8	1.6	2.0	0.3	1.7	0.9
Chest pain or discomfort	0.2	0.3	0.6	0.6	-0.3	0.0	0.8	0.6	-0.8	-0.6	-0.4	-0.4	0.4	-0.1
Had major operations	0.5	0.6	1.8	1.3	0.1	0.5	-0.4	-0.2	1.0	0.4	1.2	-0.0	1.0	1.0
Age at last live birth	1.2	1.7	4.8	0.8	-1.4	-0.8	-2.0	-2.2	0.2	-0.4	-0.7	-1.2	0.9	2.0
Family relationship satisfaction	1.3	1.6	4.5	1.7	-0.9	-0.1	-2.1	-1.9	0.3	-0.6	0.1	-1.2	0.3	2.0
Leg pain on walking	1.6	1.9	4.7	-1.8	-1.7	-1.9	-0.5	-0.5	-2.2	-1.2	-1.5	-1.4	-0.4	-0.6
Qualifications: NVQ or HND or HNC or equivalent	0.8	1.0	3.0	-1.5	-0.2	-0.6	0.4	0.5	-1.6	0.1	0.7	0.3	-1.2	-1.7
Commuting to job workplace: Car/motor vehicle	1.0	1.2	3.5	-0.1	-0.5	0.5	-1.9	-1.9	0.2	-0.2	-0.8	-0.7	-1.7	1.3
Illness, injury, bereavement, stress in last 2 years	1.2	1.5	5.1	0.9	1.4	1.2	-0.7	-0.3	1.3	1.2	2.2	1.2	0.5	1.2
Medication: Aspirin	0.4	0.5	3.7	-1.1	0.2	0.1	0.2	0.3	-0.5	0.2	0.3	0.4	-1.9	-0.7
Supplements: Vitamin C	1.0	1.2	3.1	0.1	1.4	1.0	1.0	1.5	-0.7	0.3	1.6	1.8	0.2	-0.7
Knee pain experienced in last month	0.9	1.4	6.5	1.2	0.1	0.4	-0.7	-0.4	0.1	0.7	0.8	-0.4	2.5	2.2
Hypertension (Self-reported)	0.1	0.2	0.6	0.0	0.1	0.5	0.6	0.6	-0.6	0.2	-0.8	-0.3	0.3	-0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.5	1.8	5.5	-1.1	-0.2	-0.6	2.0	2.1	-1.5	0.3	1.4	-0.1	0.0	-2.3
Illnesses of father: Heart disease	0.9	1.3	2.4	-0.3	1.4	1.3	1.4	1.5	-0.0	0.6	0.4	1.5	-0.8	-1.5
Illnesses of siblings: Diabetes	0.8	1.0	2.7	0.0	0.9	0.4	1.5	1.7	0.8	0.9	0.9	1.2	0.0	-1.2
Smoking status: Previous	0.3	0.5	1.9	0.7	-0.0	0.3	-0.6	-0.5	0.5	0.2	-0.6	-0.4	1.4	1.4
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.6	1.7	0.2	-1.3	-0.9	-0.7	-0.9	0.3	-0.7	-0.3	-1.3	0.7	0.3
Whole body fat-free mass	0.5	3.1	9.4	1.1	-0.9	1.0	-2.6	-3.1	0.9	0.3	0.9	-2.6	0.2	2.6
Leg fat-free mass (right)	0.5	2.9	9.1	0.3	-1.5	0.0	-2.8	-3.0	0.5	-0.4	0.7	-2.7	0.4	2.1
Arm fat percentage (left)	0.1	0.5	2.5	-0.7	-0.5	-0.3	0.2	0.5	-0.8	-0.0	1.6	-0.6	0.6	-0.8
Average weekly red wine intake	1.4	2.1	5.1	-0.1	-1.2	-1.2	-1.8	-1.9	-1.0	-2.0	-2.3	-1.3	-0.2	1.3
Handedness (chirality/laterality): Left-handed	0.3	0.3	1.2	-0.2	-0.5	-0.3	-0.8	-0.9	0.4	-0.1	-0.1	-0.5	-1.1	0.5
Mood swings	0.2	0.3	0.8	-0.2	-0.6	-0.5	-0.9	-0.8	-0.6	-0.1	-0.3	-0.5	0.2	0.7
Loneliness, isolation	0.7	1.0	2.7	-0.4	-1.1	-1.2	1.1	0.8	-1.2	-0.7	-0.0	-1.1	1.7	-0.2
Long-standing illness, disability or infirmity	0.2	0.3	1.5	-0.6	0.1	0.5	-0.2	-0.1	-0.2	1.2	1.1	-0.1	-0.7	0.2
Ever had bowel cancer screening	0.4	0.5	1.0	0.2	1.0	1.0	0.7	0.6	0.3	0.6	0.4	0.9	1.0	0.3
Diabetes diagnosed by doctor	1.2	1.9	4.7	-1.1	-1.6	-1.0	-2.1	-2.2	-0.4	-1.0	-1.0	-1.9	-0.7	1.0
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	2.9	-1.2	-0.6	-0.5	-1.1	-1.1	-1.7	-0.5	-0.0	-0.8	-1.3	0.0
Friendships satisfaction	0.8	1.0	2.5	0.9	-0.7	-0.3	-1.3	-1.6	1.3	-0.5	-0.4	-1.1	0.2	1.6
Qualifications: nursing, teaching	1.0	1.6	3.3	1.7	-0.8	-0.2	-1.7	-1.5	-0.2	-1.4	-1.3	-0.7	0.8	1.8
Commuting to job workplace: Walk	0.9	1.0	4.6	1.6	0.0	0.1	-0.4	-0.4	1.6	0.2	0.3	-0.2	2.2	1.0
Eye problems/disorders: Cataract	2.3	2.6	11.1	2.4	1.2	1.2	1.3	1.7	0.3	1.1	1.4	0.8	3.3	0.8
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	2.9	0.0	0.6	-0.2	1.6	1.7	0.5	0.2	1.2	1.1	1.0	-1.1
Medication for cholesterol	0.1	0.2	0.7	0.1	-0.2	-0.5	0.8	0.4	0.0	-0.8	-0.0	0.2	-0.3	-0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	1.0	2.1	-1.3	-1.0	-0.9	-1.4	-1.3	1.4	-0.0	-0.0	-0.7	-1.0	-0.3
Back pain experienced in last month	0.2	0.3	1.1	0.1	0.5	0.7	-0.2	-0.2	0.4	0.4	0.4	0.3	0.7	1.1
Mineral and other dietary supplements	0.4	0.5	2.9	0.2	-0.4	-0.2	-0.4	-0.4	1.7	-0.4	0.2	-0.8	1.0	0.7
Breast cancer (self-reported)	0.7	0.8	2.4	1.2	0.7	0.7	0.6	0.6	1.5	0.8	0.7	0.3	1.3	0.0
Asthma (self-reported)	0.3	0.5	2.4	-0.6	0.0	-0.2	1.6	1.5	0.0	-0.3	0.5	-0.2	0.4	-0.6
Osteoporosis (self-reported)	0.3	0.3	0.9	-0.4	-0.8	-0.6	-0.9	-0.6	0.1	-0.5	-0.4	-0.6	-0.0	0.6
Osteoarthritis (self-reported)	2.9	3.7	9.4	0.7	2.2	2.1	2.3	2.4	0.4	2.6	3.1	1.6	1.0	-0.5
Medication: Aspirin	0.3	0.4	2.4	-0.7	0.3	0.4	0.3	0.4	-0.6	0.3	0.3	0.4	-1.6	-0.5
Medication: Gliclazide	0.1	0.1	0.3	-0.5	-0.2	-0.1	-0.2	0.0	0.0	0.5	0.0	-0.3	-0.2	-0.2
Illnesses of father: None of the above (group 1)	2.9	3.5	10.2	1.2	-2.0	-1.5	-2.9	-3.2	1.0	-0.7	-0.5	-2.1	0.9	2.3
Smoking status: Current	0.3	0.4	1.1	-0.6	-0.9	-1.0	-0.4	-0.2	-1.0	-0.6	0.1	-0.7	-0.1	-0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.1	7.3	-1.1	-0.6	-1.3	1.6	1.7	-0.4	-2.7	-1.4	0.5	-0.1	-2.2
Whole body water mass	0.6	3.3	10.2	1.0	-0.9	1.0	-2.8	-3.2	1.0	0.3	0.8	-2.6	0.1	2.6
Leg predicted mass (right)	0.5	2.7	8.7	0.2	-1.4	0.1	-2.7	-3.0	0.5	-0.3	0.7	-2.6	0.4	2.0
Arm fat mass (left)	0.1	0.5	2.5	-0.1	-0.6	0.1	-0.8	-0.7	-0.4	0.1	1.6	-1.2	0.4	0.2
Number of self-reported non-cancer illnesses	0.9	1.5	4.3	-1.1	1.1	1.3	1.7	2.1	-0.4	1.0	1.5	0.7	-0.5	-1.3
Average weekly champagne plus white wine intake	1.4	1.9	4.4	-1.0	-1.7	-1.6	-2.1	-2.1	-0.0	-0.6	-1.8	-1.3	-0.9	0.5
Miserableness	0.3	0.5	3.1	-0.0	0.7	0.6	0.3	0.5	0.2	1.8	0.6	0.8	-0.1	0.1
Guilty feelings	0.3	0.5	1.2	0.6	1.1	1.0	-0.2	-0.3	0.8	0.7	-0.4	1.0	-0.8	0.5
Wears glasses or contact lenses	0.2	0.2	0.8	0.6	0.4	0.9	-0.1	-0.0	0.1	-0.2	0.2	-0.2	0.4	0.9
Ever taken oral contraceptive pill	1.6	1.8	4.7	1.6	1.7	1.8	1.1	0.7	2.2	1.4	0.7	1.2	0.0	0.8
Hearing aid user	0.3	0.4	1.0	-0.8	-0.2	-1.0	-0.6	-0.3	-0.1	-0.0	-0.7	0.5	-1.0	-0.2
Mother’s age at death	0.6	0.8	1.6	-1.0	-0.9	-0.9	-0.3	-0.5	-0.7	-1.2	-1.3	-0.6	-1.3	-0.2
Financial situation satisfaction	0.3	0.4	1.1	-1.0	-0.9	-0.8	-0.7	-0.7	0.2	-0.1	-0.1	-0.9	0.3	-0.2
Tinnitus: Yes, now most or all of the time	1.4	1.6	4.3	-1.2	-1.6	-0.9	-1.8	-1.5	-0.7	-1.0	-0.1	-2.1	-1.3	-0.2
Commuting to job workplace: Public transport	0.9	1.1	4.5	-0.6	0.4	-0.0	1.8	1.8	0.3	0.6	0.3	0.4	0.6	-2.1
Eye problems/disorders: Glaucoma	0.7	0.9	3.9	0.5	1.5	1.3	-0.1	0.1	-0.4	0.6	0.1	2.0	-0.3	0.7
Medication: Blood pressure	0.2	0.4	1.0	0.5	-0.1	0.4	-1.0	-0.6	0.3	1.0	-0.5	-0.3	1.0	0.7
Pain type(s) experienced in last month: Hip pain	1.2	1.5	5.1	2.0	-0.2	0.1	-0.4	-0.3	1.3	-0.2	-1.1	-0.7	2.3	2.0
Supplements: Fish oil (including cod liver oil)	0.2	0.2	1.8	0.4	0.1	0.1	0.4	0.5	-1.3	0.5	0.1	0.0	-0.2	-0.2
High cholesterol (Self-reported)	0.5	0.8	4.9	0.3	0.5	1.1	-0.7	-0.6	-0.1	1.1	2.2	0.1	0.2	0.9
Medication: Bendroflumethiazide	0.2	0.3	1.7	0.6	0.5	0.7	0.1	0.4	-1.3	0.2	-0.4	0.4	0.3	0.1
Medication: Paracetamol	0.1	0.2	0.9	0.2	-0.2	-0.1	0.3	0.4	0.9	0.9	0.4	-0.2	0.3	-0.2
Medication: Lisinopril	0.3	0.3	1.6	0.3	0.8	1.3	-0.4	-0.0	-0.3	-0.1	0.3	0.1	-0.1	1.1
Medication: Atorvastatin	1.2	1.5	3.1	1.1	1.3	1.7	-1.1	-0.9	1.3	1.5	1.4	1.1	-0.4	1.3
Illnesses of father: High blood pressure	0.9	1.2	2.6	-0.3	1.5	1.5	1.5	1.6	-0.1	1.1	0.5	0.9	0.1	-0.7
Alcohol drinker status: Never	0.9	1.0	2.9	-1.7	-0.6	-0.8	-0.7	-0.7	-1.2	-1.1	-1.1	-0.1	-1.5	-0.5
Ever smoked	0.6	1.1	4.9	1.4	0.3	0.9	-1.0	-0.8	0.5	0.2	-0.1	-0.6	1.3	2.2
Basal metabolic rate	0.5	2.8	7.9	0.9	-1.0	0.8	-2.5	-2.8	0.8	0.2	1.0	-2.6	0.5	2.3
Leg fat percentage (left)	0.2	0.7	4.1	-0.0	0.1	0.6	0.9	1.1	-0.5	0.3	2.0	-0.2	0.6	-0.5
Arm fat-free mass (left)	0.5	2.7	7.3	1.3	-0.7	1.1	-2.3	-2.7	0.7	0.3	0.9	-2.4	0.4	2.5
Number of operations (self-reported)	2.5	3.7	8.5	2.1	2.7	2.9	1.5	1.7	1.1	2.1	2.0	2.3	0.2	0.9
Average weekly beer plus cider intake	0.3	0.5	2.6	-0.0	-0.2	-0.2	0.7	0.5	0.4	1.6	1.0	-0.3	0.8	-0.0
Irritability	0.7	1.3	4.1	1.1	1.8	2.0	0.5	0.6	0.8	0.9	0.1	1.6	0.4	0.3
Risk taking	0.6	1.0	2.5	-0.5	-1.1	-1.0	-1.5	-1.6	-0.7	-0.6	-0.2	-1.2	-0.8	0.5
Ever had prostate specific antigen (PSA) test	0.3	0.4	1.5	0.1	0.8	0.9	-0.3	0.1	-0.0	0.7	1.2	0.6	0.1	0.2
Fractured/broken bones in last 5 years	2.1	2.8	7.2	2.4	1.7	1.8	0.1	0.5	2.1	0.7	1.4	1.4	2.7	1.5
Age started oral contraceptive pill	1.2	1.5	4.5	1.4	-0.4	0.5	-0.8	-1.0	-1.2	-1.7	-2.1	-1.2	0.3	1.7
Diastolic blood pressure, automated reading	0.4	1.3	3.1	-1.7	-0.8	-1.2	0.9	1.4	-1.2	-1.3	0.6	-0.4	0.9	-1.5
Ever depressed for a whole week	1.1	1.4	3.3	-1.5	-1.4	-1.5	-0.6	-0.2	-1.8	-1.4	-0.8	-1.0	-0.5	-1.2
Unable to work because of sickness or disability	0.5	0.6	2.1	0.7	0.3	0.1	1.5	1.3	-0.5	0.7	0.5	0.4	0.7	-0.7
Commuting to job workplace: Cycle	0.7	0.8	2.9	0.8	0.6	-0.0	1.6	1.7	0.6	-0.1	-0.7	1.0	0.5	-0.7
Myopia	2.3	3.3	13.7	-2.5	-0.9	-1.9	1.9	2.0	-1.9	-1.1	0.1	-0.3	-0.7	-3.7
Vascular/heart problems diagnosed by doctor	0.2	0.4	1.3	0.2	0.4	-0.1	-0.7	-0.7	1.1	0.3	1.0	0.9	-0.2	0.6
Cholesterol lowering medication	0.4	0.6	1.7	0.2	0.7	1.3	-0.9	-0.7	0.5	0.9	1.1	0.2	-0.0	1.0
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	1.9	0.2	1.0	0.8	0.8	0.9	0.7	1.2	1.3	1.4	-0.5	-0.3
Pain experienced in last month	0.3	0.5	1.6	-0.1	-0.5	-0.4	-0.1	-0.3	-0.2	-0.9	1.1	-0.8	-0.3	-1.3
Supplements: Calcium	0.4	0.4	1.4	0.3	-0.1	-0.4	1.2	1.0	-0.6	-0.8	-0.7	-0.1	0.1	-0.9
Basal cell carcinoma (self-reported)	1.0	1.2	5.9	-2.4	-0.7	-0.9	-0.2	-0.2	-0.9	-0.3	-0.1	-0.2	-1.8	-1.3
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.6	0.4	0.1	0.4	0.1	0.1	0.4	-0.3	-0.1	-0.5	0.8	0.3
Deep venous thrombosis (DVT) (self-reported)	0.6	0.7	2.0	-0.7	0.9	0.4	0.4	0.4	0.2	1.3	0.9	1.4	-0.7	-1.1
Heart disease (siblings)	0.6	0.7	1.7	-1.0	0.8	0.4	1.0	1.0	-0.1	-0.6	-0.3	0.9	-0.7	-1.3
Alcohol drinker status: Previous	2.6	3.0	7.4	-0.2	-2.6	-2.4	-1.9	-1.8	-1.0	-1.8	-1.0	-2.7	-0.3	1.1
Pack years of smoking	0.2	0.3	1.0	0.4	-0.1	0.4	-0.3	-0.2	1.0	0.2	0.5	-0.8	0.6	0.7
Impedance of whole body	0.2	1.1	3.4	-0.9	-0.5	-1.2	1.7	1.8	0.0	0.2	-0.3	0.3	-0.1	-1.8
Leg fat mass (left)	0.2	0.7	5.2	0.2	-0.1	0.8	-0.3	-0.2	-0.0	0.7	2.3	-0.8	0.3	0.4
Arm predicted mass (left)	0.6	3.0	7.8	1.4	-0.6	1.3	-2.3	-2.7	1.0	0.5	1.2	-2.4	0.8	2.8