Hub : Genes

COL6A1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.2610 0.0470 1.9e-15 0.061 0.172 0.168 0.182 0.158 6.8e-08 1.9e-20 6.6e-20 1.1e-21 9.7e-19
2 GTEx Artery Aorta 0.3530 0.0630 2.5e-13 0.255 NA 0.320 NA 0.333 2.8e-14 NA 3.4e-18 NA 4.9e-19
3 GTEx Artery Tibial 0.2703 0.0613 8.0e-10 0.206 NA 0.148 NA 0.198 5.0e-16 NA 1.1e-11 NA 1.9e-15
4 GTEx Brain Cerebellar Hemisphere 0.2940 0.1160 1.8e-03 0.152 NA 0.064 NA 0.089 1.0e-04 NA 1.0e-02 NA 2.8e-03
5 GTEx Brain Cerebellum 0.5400 0.1280 1.1e-04 0.348 NA 0.330 NA 0.328 4.0e-11 NA 1.7e-10 NA 1.9e-10
6 GTEx Brain Frontal Cortex BA9 0.2789 0.0988 2.3e-03 0.011 NA 0.008 NA 0.004 1.6e-01 NA 1.9e-01 NA 2.4e-01
7 GTEx Esophagus Gastroesophageal Junction 0.1840 0.0730 6.4e-03 0.089 NA 0.053 NA 0.094 4.2e-04 NA 5.6e-03 NA 2.8e-04
8 GTEx Nerve Tibial 0.2019 0.0763 4.3e-03 0.064 NA 0.054 NA 0.047 2.6e-05 NA 1.1e-04 NA 2.9e-04
9 GTEx Spleen 0.2650 0.1150 5.7e-03 0.067 NA 0.025 NA 0.087 8.5e-03 NA 7.5e-02 NA 3.1e-03
10 YFS Blood 0.0491 0.0149 1.0e-07 0.006 0.023 0.018 0.024 0.020 2.5e-03 4.3e-08 1.3e-06 2.3e-08 3.0e-07
11 TCGA Thyroid Carcinoma 0.0560 0.0280 5.7e-03 0.018 0.023 0.036 NA 0.029 6.6e-03 2.4e-03 1.9e-04 NA 6.6e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bipolar Disorder (2018) 0.8 1.3 3.3 -0.9 -1.4 -1.6 -0.2 0.6 -1.8 -1.5 -0.2 -1.5 -0.1 -0.5
Bipolar Disorder or Schizophrenia 1.6 3.8 13.6 -1.4 -2.3 -2.1 -1.2 -0.9 -3.7 -2.5 -1.5 -2.4 -0.1 0.2
Depressed Affect (Nagel 2018) 0.3 0.7 3.1 1.1 0.2 0.4 -0.4 -0.3 -0.0 0.7 -0.0 -0.2 1.8 1.7
Depression (Nagel 2018) 1.4 2.1 7.3 0.1 -1.1 -0.5 -2.6 -2.7 -1.4 -0.5 -1.2 -1.1 -0.5 1.6
Intelligence (Savage-Jansen 2018) 0.4 1.2 4.6 1.6 1.2 1.2 0.1 0.1 2.1 0.1 0.2 0.9 1.3 1.0
Neuroticism (Nagel 2018) 0.3 0.7 1.7 1.0 1.0 1.2 -0.4 -0.4 -0.5 0.8 -0.3 0.9 0.8 1.3
Schizophrenia (2018) 1.5 3.1 12.1 -1.1 -1.8 -1.4 -1.4 -1.6 -3.5 -2.0 -1.7 -1.9 -0.2 0.6
Schizophrenia vs Biploar Disorder 0.1 0.2 0.5 0.1 -0.1 -0.2 -0.5 -0.7 -0.5 -0.5 -0.4 0.4 -0.3 0.1
Worry (Nagel 2018) 0.2 0.5 2.4 -0.2 0.4 0.4 -0.3 -0.3 -1.5 -0.1 -1.0 1.0 -0.7 0.1
Alzheimer’s Disease (in mother) 0.3 0.4 2.4 0.2 0.1 -0.1 0.1 0.0 -0.8 -0.4 -0.5 0.6 -1.5 -0.2
Alzheimer’s Disease (in father) 0.6 0.7 2.5 -0.7 -1.2 -1.6 0.8 0.4 -0.3 -0.8 -0.2 -0.7 0.1 -1.1
Alzheimer’s Disease (including proxy) 0.3 0.5 1.4 -0.4 -0.3 -0.8 0.5 0.4 -1.2 -0.5 -0.0 0.4 -1.1 -0.9
Crohns Disease (2017) 1.7 3.6 6.9 -0.2 -2.6 -2.4 -2.1 -2.0 -2.1 -2.2 -1.2 -2.6 0.4 1.0
Irritable Bowel Disease (IBD) 0.7 1.7 3.1 -0.3 -1.8 -1.7 -1.4 -1.7 -1.0 -1.4 -1.4 -1.4 -0.2 0.7
Ulcerative Colitis (UC) 0.1 0.2 0.9 -0.4 -0.1 -0.1 -0.2 -0.6 0.4 -0.3 -1.0 0.4 -0.8 0.0
Major Depression (MDD) 0.2 0.2 0.7 -0.2 -0.1 -0.4 0.2 0.6 -0.7 0.2 0.4 -0.0 0.9 0.0
Reaction Time 0.5 0.9 3.2 -1.8 -0.3 -0.2 0.9 0.8 -1.2 -0.2 -0.5 -0.2 -1.0 -1.4
Verbal and Numeric Reasoning (VNR) 0.1 0.3 1.6 0.7 0.5 0.3 -0.1 0.1 1.3 0.2 0.1 0.8 0.5 0.0
Breast Cancer 0.5 1.1 4.5 0.8 1.0 1.4 0.6 0.3 1.3 0.8 0.3 1.0 -2.1 0.3
Ovarian Cancer 0.6 0.8 2.4 1.0 -0.1 0.4 0.9 1.0 1.1 -0.2 1.1 -0.8 1.6 0.2
Prostate Cancer 1.4 1.9 10.3 1.3 -0.9 -0.7 -0.9 -0.9 0.3 -0.1 0.9 -1.7 3.2 1.7
Age at First Birth 0.8 1.1 1.9 0.8 -1.1 -1.1 -1.3 -1.2 -1.4 -0.4 0.6 -1.2 0.4 1.4
Bipolar Disorder (2011) 2.1 2.0 4.7 -1.3 -2.1 -2.2 -1.0 -0.7 0.0 -2.0 -1.6 -1.7 -0.8 -0.1
Body Mass Index (BMI) (2010) 1.1 1.5 2.7 -1.1 1.1 0.4 1.1 1.5 1.0 1.4 1.5 1.7 0.1 -1.4
Coronary Artery Disease (CAD) 1.0 1.2 2.8 -1.7 0.1 -0.4 1.3 1.0 -1.5 -0.3 -0.9 0.9 -1.2 -1.6
Crohns Disease (2012) 1.4 2.3 6.2 -0.8 -2.3 -2.5 -1.7 -1.6 -1.4 -1.4 -0.8 -1.8 -0.0 0.0
Mean Putamen Volume 2.2 2.5 6.2 -0.7 -1.0 -0.7 -2.2 -2.5 -1.2 -2.0 -2.1 -1.1 -0.4 1.9
Fasting Glucose 1.6 2.0 8.8 -1.7 1.3 0.4 0.7 0.9 0.8 3.0 1.3 1.1 -1.3 -1.1
HbA1C 1.0 1.1 3.8 -0.2 1.1 0.6 0.7 0.9 0.8 1.9 1.8 1.4 -0.1 -0.3
HDL Cholesterol 0.3 0.5 2.6 -0.5 -0.0 -0.1 -0.2 -0.1 -1.2 -1.6 -0.8 -0.2 0.2 -0.1
LDL Cholesterol 0.2 0.3 0.6 0.7 0.5 0.7 0.2 0.1 0.3 0.4 0.2 0.5 -0.5 0.8
Lupus 4.2 6.4 15.8 -0.8 -3.6 -3.1 -1.7 -2.0 -2.4 -4.0 -2.8 -3.4 0.1 0.0
Neuroticism (2016) 1.0 1.4 4.8 1.1 0.9 1.2 -0.6 -0.5 1.6 2.2 1.6 0.8 0.6 0.8
Primary Biliary Cirrhosis 0.7 1.0 2.5 0.5 -1.1 -0.7 -0.5 -0.7 -1.1 -1.6 -1.0 -1.4 1.3 0.7
Rheumatoid Arthritis 1.0 1.4 3.9 0.5 -1.2 -0.7 -1.4 -2.0 -0.1 -0.4 -1.5 -1.6 -0.3 1.6
Schizophrenia (2014) 1.5 3.3 9.8 -1.0 -2.1 -1.6 -2.2 -2.1 -3.1 -1.5 -0.4 -2.2 0.0 1.3
Triglycerides 0.1 0.2 0.5 0.6 0.0 -0.1 0.3 0.0 0.5 0.4 -0.1 0.4 -0.4 0.7
Type 2 Diabetes (T2D) (2012) 2.9 3.3 11.3 0.0 -2.3 -1.4 -1.7 -1.9 -1.0 -1.8 -1.6 -3.4 1.9 0.7
Ulcerative Colitis 0.9 1.4 3.1 -1.1 -1.6 -1.8 -0.5 -0.5 -1.4 -1.5 -1.5 -0.9 -0.1 -0.5
Blood Eosinophil Count 0.4 2.9 6.4 2.4 1.5 1.8 -0.7 -0.5 2.5 0.8 0.7 1.1 2.2 2.5
Blood Platelet Count 0.1 1.6 7.7 1.0 0.3 -0.5 2.8 2.1 0.4 0.8 0.5 1.4 0.6 -0.9
Blood Red Count 0.1 1.2 6.7 -0.3 -0.5 0.1 -0.4 -1.1 -2.6 -0.0 -0.6 -0.7 -1.5 1.2
Blood White Count 0.2 1.3 6.4 0.9 0.8 0.6 2.5 1.5 0.5 0.9 -0.4 0.8 1.3 -0.5
Heel T-Score 0.4 3.4 7.5 -2.4 -0.6 -1.3 2.7 2.1 -0.9 -0.9 -2.2 -0.4 -2.2 -2.5
BMI 0.1 0.8 5.0 0.8 0.1 0.6 -0.2 -0.0 -0.3 0.2 1.4 -0.3 2.2 0.9
Height 0.5 9.4 27.5 1.8 -0.7 2.0 -3.3 -4.1 5.2 3.4 2.2 -3.4 0.0 3.5
Waist Hip Ratio (WHR) 0.6 2.9 7.2 2.7 0.3 1.8 -1.9 -2.3 1.3 1.6 0.4 -1.1 0.9 2.5
Systolic Blood Pressure 0.7 3.7 8.1 -0.2 2.0 2.0 2.6 2.7 0.9 2.9 2.1 1.3 0.0 -1.9
Smoking Status 0.3 0.8 4.5 1.1 -0.7 -0.5 -0.2 0.1 0.0 -0.3 -0.4 -1.1 2.1 0.9
Allergy or Eczema 0.2 0.5 1.1 -0.6 -0.8 -0.8 -1.0 -0.9 -0.3 -0.9 -0.0 -0.6 0.3 0.2
Cardiovascular Disease 0.2 0.6 1.5 0.1 0.6 0.8 1.1 1.1 0.5 0.7 0.9 0.0 1.2 0.0
Hypothyroidism (self reported) 0.4 0.8 4.8 -1.3 0.6 0.8 -0.1 -0.2 -0.8 0.7 0.4 0.5 -2.2 -0.2
Respiratory disease 0.2 0.4 1.9 -0.4 0.0 -0.3 1.3 1.4 -0.2 -0.7 -0.3 0.2 -0.3 -0.6
Type 2 Diabetes (T2D) (2018) 0.6 1.1 3.2 -0.0 -0.5 0.4 -1.6 -1.8 0.4 -0.7 -1.1 -1.1 -0.7 1.6
Lung FEV1/FVC ratio 0.3 1.5 4.4 -1.4 -0.8 -1.7 1.4 1.3 -1.2 -0.4 -0.4 0.3 0.9 -2.1
Lung FVC 0.4 2.3 8.6 -1.1 -1.2 -2.2 0.9 1.1 0.2 -2.9 -0.8 -0.1 -0.3 -2.5
Neuroticism 0.2 0.5 1.5 0.1 -0.2 -0.2 -0.9 -0.7 -1.2 0.3 -1.2 0.4 0.4 1.0
Chronotype (morning person) 0.8 1.9 4.3 -1.3 -0.6 -1.9 2.0 1.8 -1.4 -0.1 0.7 0.4 0.5 -2.1
Hair Pigment 0.0 0.2 0.7 -0.8 -0.1 -0.2 0.2 0.3 0.3 0.2 -0.6 -0.3 -0.6 0.1
Tanning 0.1 1.4 4.1 -2.0 -1.1 -1.4 -1.8 -1.6 -0.7 0.0 0.3 -0.4 -1.4 0.2
Hand grip strength (left) 0.8 2.0 5.3 1.3 1.6 1.7 1.6 1.3 2.3 1.3 1.5 1.1 -0.4 -0.3
Number of treatments/medications taken 1.0 1.8 3.8 -1.6 0.8 0.6 1.6 1.9 -1.2 0.7 0.8 0.9 -1.6 -1.9
Average weekly spirits intake 1.4 1.8 3.6 -0.4 1.3 0.6 1.8 1.9 0.2 1.5 1.1 1.4 -1.3 -1.8
Sensitivity / hurt feelings 0.2 0.4 1.3 0.3 1.1 1.1 -0.0 -0.0 -0.5 -0.0 -0.6 1.1 0.5 0.1
Frequency of depressed mood in last 2 weeks 0.4 0.5 2.4 0.1 -0.4 0.0 -1.6 -1.4 -0.9 0.3 0.2 -0.2 0.1 0.6
Hearing difficulty/problems: Yes 1.1 1.7 5.2 -1.1 -1.0 -0.5 -2.3 -2.1 -1.1 -1.1 -0.6 -1.1 -1.3 1.1
Relative age of first facial hair 0.8 1.7 6.1 2.2 -0.6 -0.1 -0.4 -0.7 0.1 -0.3 -1.1 -1.3 2.5 1.8
Other serious medical condition/disability diagnosed by doctor 1.6 2.1 6.4 0.9 1.5 1.9 0.0 0.2 1.9 2.5 2.0 1.2 -0.4 0.7
Ever used hormone-replacement therapy (HRT) 0.7 0.9 2.8 0.5 1.5 1.7 0.2 0.2 -0.1 -0.1 -1.2 1.1 -1.4 0.8
Ever had hysterectomy (womb removed) 1.0 1.1 2.3 0.9 1.5 1.5 1.3 1.1 0.1 0.8 1.0 1.1 -0.4 -0.7
Systolic blood pressure, automated reading 0.1 0.4 0.9 -0.9 0.4 0.7 0.6 0.6 -0.5 0.7 0.6 -0.1 -0.2 -1.0
Eye problems/disorders: Diabetes related eye disease 0.0 0.0 0.2 0.5 -0.3 -0.1 0.0 -0.1 0.1 0.3 0.1 -0.3 -0.1 -0.1
Angina 0.5 0.7 2.3 -0.8 -0.9 -0.6 -0.7 -0.7 -1.5 -1.0 0.1 -1.0 -0.4 -0.0
Medication for hormone replacement therapy 1.2 1.3 3.5 1.8 1.7 1.9 0.3 0.5 0.8 0.8 0.3 1.0 0.3 1.3
Vitamin and mineral supplements 2.0 2.7 6.9 1.0 -1.4 -0.6 -2.3 -2.6 1.1 -0.7 -1.2 -2.1 1.0 2.4
Supplements: Zinc 0.9 1.0 2.8 0.3 1.0 0.2 1.4 1.6 -1.1 -0.1 0.0 1.3 0.1 -1.7
Medication: Co-codamol 0.4 0.4 1.7 0.5 -0.4 -0.5 -0.1 -0.2 1.0 0.4 0.7 -0.4 1.3 0.7
Medication: Metformin 0.8 1.2 5.8 -1.5 0.1 0.5 -1.3 -1.4 0.5 -0.0 -0.6 0.4 -2.4 0.4
Diabetes (father) 0.7 0.9 3.7 -1.1 0.1 0.0 1.7 1.3 -0.5 0.1 -0.5 0.3 -0.3 -1.9
Diabetes (mother) 0.6 0.8 2.2 1.0 1.2 1.4 1.0 0.5 1.5 0.5 0.4 0.5 0.4 0.0
Severe depression (siblings) 2.9 3.2 6.8 0.5 -2.1 -1.7 -2.6 -2.5 -0.1 -1.2 -1.0 -2.3 1.1 2.5
Pack years adult smoking proportion 0.1 0.2 0.7 0.1 -0.4 -0.1 -0.2 -0.1 0.7 -0.2 0.1 -0.8 0.6 0.2
Impedance of leg (right) 0.3 1.4 5.7 0.1 0.6 0.2 2.4 2.3 0.6 1.2 0.3 0.7 -0.0 -1.4
Leg fat-free mass (left) 0.4 2.3 7.5 0.5 -0.9 0.7 -2.5 -2.7 0.6 0.1 1.1 -2.1 0.1 2.0
Trunk fat percentage 0.2 0.7 2.2 -1.0 -1.0 -0.7 0.2 0.5 -0.8 -0.2 1.5 -1.0 0.4 -1.1
Hand grip strength (right) 0.4 1.2 3.7 0.3 1.0 0.9 1.0 0.6 1.9 1.2 0.9 1.0 -1.4 -0.5
Townsend deprivation index at recruitment 0.4 0.6 2.6 -0.4 -0.8 -0.9 -0.5 -0.4 0.4 -0.4 0.8 -1.0 1.6 0.2
Current tobacco smoking 0.4 0.6 1.2 -1.1 -1.0 -1.1 -0.5 -0.3 -1.0 -0.5 0.1 -0.7 -0.6 -0.8
Average weekly fortified wine intake 0.9 1.1 3.2 -0.2 -1.1 -1.2 -1.5 -1.8 0.1 -0.6 -1.1 -0.8 -0.9 0.9
Maternal smoking around birth 1.4 2.0 4.2 0.6 2.0 1.6 1.6 1.8 0.4 1.5 1.4 2.0 0.2 -1.1
Fed-up feelings 0.4 0.7 2.7 -0.1 -1.0 -0.6 -0.8 -0.7 -0.4 -0.2 -0.5 -1.6 1.2 0.7
Frequency of unenthusiasm / disinterest in last 2 weeks 0.7 1.0 2.8 -0.2 -0.8 -0.7 -1.6 -1.7 -1.4 -0.4 -0.8 -0.7 -0.5 0.9
Relative age voice broke 0.5 0.8 1.9 1.4 -0.4 -0.0 -0.5 -0.9 0.0 -1.0 -1.4 -0.8 0.9 1.1
Taking other prescription medications 0.1 0.2 0.4 -0.3 -0.1 0.3 0.4 0.6 -0.5 -0.6 0.4 -0.5 0.3 -0.2
Age when periods started (menarche) 0.3 0.7 2.2 0.7 -0.6 -0.5 -0.1 -0.0 -1.1 -1.1 -1.5 -0.5 0.8 0.9
Bilateral oophorectomy (both ovaries removed) 1.3 1.5 3.9 0.4 1.8 2.0 -0.2 -0.1 0.6 2.0 1.3 1.6 -0.7 0.5
Heel bone mineral density (BMD) T-score, automated (left) 0.8 1.9 5.2 -1.9 0.1 -0.5 2.3 1.9 0.3 0.6 -0.4 0.3 -1.7 -2.2
Tinnitus: Yes, but not now, but have in the past 0.5 0.6 2.0 0.6 0.8 1.0 0.9 1.0 -0.0 0.2 0.1 0.4 1.4 0.3
Qualifications: CSEs or equivalent 0.7 1.0 3.2 0.6 -0.4 -0.2 -0.7 -0.9 1.8 1.4 1.0 -0.9 1.1 0.9
Serious illness, injury or assault to yourself 0.2 0.2 0.7 0.4 -0.6 -0.8 -0.0 -0.2 -0.1 0.3 -0.1 -0.2 0.8 0.7
High blood pressure 0.1 0.3 0.9 -0.6 -0.1 0.3 0.5 0.5 -0.9 0.1 -0.7 -0.4 -0.3 -0.8
Hayfever, allergic rhinitis or eczema 0.6 1.3 2.5 -1.4 -1.4 -1.5 -0.7 -0.7 -1.2 -1.6 -1.1 -1.1 -0.4 -0.1
Multivitamins +/- minerals 1.7 2.2 6.1 -0.7 1.4 0.8 2.4 2.5 -0.1 0.7 1.0 1.7 -0.4 -2.1
Stomach or abdominal pain in last month 0.5 0.6 1.5 0.5 -0.8 -0.6 -0.8 -1.0 1.1 -0.4 -1.2 -0.5 -0.0 1.0
Supplements: Glucosamine 0.5 0.7 1.7 0.7 0.8 0.8 1.3 1.1 -0.4 0.8 0.7 0.8 0.6 -0.7
Diverticular disease/diverticulitis (self-reported) 1.0 1.2 2.3 -1.4 0.6 -0.3 1.3 1.4 -0.5 -1.2 -0.9 1.5 -0.2 -1.2
Medication: Atenolol 0.7 0.8 2.6 -0.6 -1.0 -0.8 -0.9 -0.8 -1.3 -0.4 -0.6 -1.6 0.9 0.4
Medication: Levothyroxine sodium 0.7 1.1 3.7 -0.6 1.3 1.9 -0.2 0.1 -0.2 1.5 1.8 0.4 -0.7 0.5
Sitting height 0.4 2.9 8.6 0.5 -1.9 -0.6 -2.6 -2.9 1.1 -0.6 -0.3 -2.5 -0.1 2.0
Chronic bronchitis/emphysema (father) 1.1 1.3 4.4 -1.0 -0.4 -0.7 1.7 2.1 -0.3 -0.1 0.1 -0.7 -0.0 -2.1
High blood pressure (mother) 0.2 0.3 0.8 -0.8 -0.3 -0.5 0.9 0.7 0.1 0.1 -0.6 -0.2 -0.3 -0.7
Body mass index (BMI) 0.1 0.4 2.2 -0.0 -0.2 0.3 -0.6 -0.4 -0.7 -0.2 1.5 -0.6 0.6 0.3
Impedance of leg (left) 0.3 1.2 5.1 -0.3 -0.0 -0.5 2.3 2.3 0.5 0.7 -0.0 0.2 0.3 -1.5
Leg predicted mass (left) 0.4 2.4 7.8 0.5 -1.0 0.6 -2.6 -2.8 0.5 0.0 1.1 -2.1 0.1 2.0
Trunk fat mass 0.2 0.7 3.0 -0.4 -1.0 -0.2 -0.6 -0.5 -0.3 0.1 1.7 -1.5 0.5 -0.1
Waist circumference 0.7 2.5 5.7 1.8 -0.5 1.2 -2.0 -2.0 0.6 0.6 1.7 -1.9 1.3 2.4
Number of incorrect matches in round 0.2 0.3 1.9 -0.1 -0.0 -0.1 0.5 0.5 -0.1 1.4 0.5 -0.4 -0.3 -0.7
Past tobacco smoking 0.4 0.8 3.2 -1.1 -0.2 -0.7 0.9 0.7 -0.6 -0.5 0.1 0.4 -1.3 -1.8
Alcohol usually taken with meals 0.4 0.6 1.6 0.4 -0.5 -0.3 -0.6 -0.8 0.1 -1.3 -0.9 -0.6 1.0 1.0
Nervous feelings 0.3 0.5 1.0 0.7 0.8 1.0 0.8 1.0 -0.5 0.4 -0.7 0.5 0.6 -0.2
Frequency of tenseness / restlessness in last 2 weeks 0.5 0.7 2.0 0.1 0.2 0.3 -1.4 -1.4 0.3 0.2 -0.8 0.6 -0.9 1.3
Hearing difficulty/problems with background noise 1.7 2.7 10.3 -1.5 -0.9 -0.3 -3.2 -2.8 -0.6 -0.4 -0.5 -1.0 -2.2 1.1
Hair/balding pattern: Pattern 2 0.9 1.1 5.4 1.6 -0.4 -0.6 -0.6 -0.5 0.9 -0.6 -0.7 -0.3 2.3 1.2
Had menopause 1.2 1.5 5.7 -0.7 -0.7 0.0 -2.4 -2.2 0.0 -0.4 0.7 -0.9 -1.5 1.1
Had other major operations 0.5 0.6 2.3 1.5 0.8 0.9 0.6 0.6 1.1 0.2 -0.5 0.2 0.2 0.4
Forced vital capacity (FVC) 0.2 0.7 2.2 0.0 -1.0 -0.7 -0.5 -0.9 1.5 -1.3 -0.4 -1.1 0.4 0.4
Heel bone mineral density (BMD) T-score, automated (right) 1.0 2.3 5.6 -1.3 1.3 0.6 2.4 1.9 0.7 1.2 0.0 1.6 -2.0 -1.9
Ever unenthusiastic/disinterested for a whole week 1.3 1.6 4.4 -0.1 -1.6 -1.3 -1.4 -1.1 -0.8 -2.1 -1.1 -1.6 0.8 0.3
Qualifications: None of the above 0.8 1.7 4.1 -0.2 1.3 0.8 1.7 2.0 1.3 1.7 1.3 1.3 0.3 -0.9
Financial difficulties in last 2 years 0.5 0.6 2.6 0.6 -0.7 -0.2 -0.5 -0.7 0.1 -0.0 -0.2 -1.6 1.4 0.8
Mouth/teeth dental problems 0.4 0.7 1.4 -0.4 -1.2 -1.0 -0.8 -0.6 -1.1 -1.0 -0.9 -0.9 0.3 -0.0
Heart attack 0.1 0.2 0.5 0.5 0.4 0.7 0.2 0.2 0.4 -0.1 -0.1 -0.2 0.6 0.3
Allergy 0.2 0.4 2.0 1.4 -0.0 0.4 -0.4 -0.4 0.7 0.7 -0.5 -0.5 0.9 0.4
Pain all over the body in last month 0.6 0.6 1.8 -1.4 -0.7 -1.3 0.4 0.3 -0.7 -0.2 -0.3 -0.1 -0.9 -1.1
Diabetes (self-reported) 0.9 1.4 3.8 -1.2 -1.1 -0.7 -1.9 -2.0 0.1 -0.6 -1.0 -1.2 -0.9 0.7
Hayfever/allergic rhinitis (self-reported) 0.5 0.6 2.7 -0.8 0.5 0.1 -0.4 -0.1 0.6 0.4 0.5 1.3 -1.7 -0.7
Medication: Ramipril 0.6 0.8 2.2 1.3 1.0 1.5 0.4 0.2 0.7 1.4 0.6 0.3 0.7 0.8
Medication: Simvastatin 0.6 0.9 1.9 0.8 0.5 1.2 -0.6 -0.6 1.3 1.0 1.2 -0.3 0.9 1.4
Fluid intelligence score 0.8 1.7 6.0 1.6 1.5 1.3 0.4 0.3 2.4 1.1 0.5 2.0 0.2 0.3
Illnesses of siblings 1.4 2.0 7.0 0.8 -1.3 -0.6 -2.3 -2.6 0.6 -0.5 -1.2 -1.4 0.2 1.8
Neuroticism score 0.2 0.4 1.5 -0.0 0.5 0.3 -0.4 -0.3 -1.0 0.2 -1.2 1.0 -0.5 0.4
Weight 0.4 2.1 5.9 0.7 -1.1 0.5 -1.9 -2.0 0.6 0.1 1.5 -2.4 1.1 1.8
Impedance of arm (right) 0.2 0.9 2.7 -1.0 -1.3 -1.6 0.8 0.8 -0.3 -0.2 -0.7 -0.6 0.0 -1.5
Arm fat percentage (right) 0.1 0.5 2.1 -0.5 -0.8 -0.4 -0.1 0.2 -0.6 -0.0 1.4 -0.9 0.7 -0.5
Trunk fat-free mass 0.6 3.5 10.0 1.3 -0.7 1.3 -2.6 -3.2 1.3 0.7 0.8 -2.7 0.3 2.9
Hip circumference 0.3 1.2 4.0 0.4 -1.0 0.2 -1.2 -1.1 0.0 0.0 1.5 -2.0 1.1 1.3
Time employed in main current job 1.0 1.1 3.7 -1.4 0.1 -0.4 1.0 0.9 -1.2 -0.7 -1.0 0.3 -1.2 -1.9
Alcohol intake versus 10 years previously 0.6 0.9 2.0 0.8 0.9 0.8 1.3 1.3 -0.5 1.2 1.4 0.4 1.1 -0.1
Father’s age at death 0.4 0.5 1.9 0.9 -0.5 0.2 -0.7 -0.7 -0.5 -0.7 0.2 -1.4 -0.0 0.9
Worrier / anxious feelings 0.2 0.4 1.3 -0.5 0.4 0.3 0.4 0.5 -0.6 0.5 -0.0 0.8 -1.1 -0.7
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.7 2.9 -0.3 0.6 0.2 1.0 0.9 0.1 1.7 1.0 1.0 -0.1 -0.7
Falls in the last year 1.0 1.4 3.4 1.8 1.0 1.3 1.0 1.1 -0.9 -1.0 -0.8 0.5 1.8 0.8
Hair/balding pattern: Pattern 3 0.9 1.4 5.9 -0.1 1.4 1.7 0.0 -0.2 0.3 1.3 0.7 1.4 -2.4 -0.6
Number of live births 0.9 1.3 4.9 0.8 -0.5 0.1 -1.6 -1.8 0.8 -0.4 -1.0 -0.8 -0.0 2.2
Forced expiratory volume in 1-second (FEV1) 0.2 0.7 2.3 -0.1 -0.8 -0.9 0.2 -0.2 1.4 -1.5 -0.7 -0.7 0.7 -0.4
Pulse rate 0.2 0.3 1.4 -1.0 -0.5 -0.5 0.4 0.3 -0.2 0.2 0.4 -0.3 -0.4 -1.2
Happiness 0.1 0.1 0.5 0.2 -0.4 -0.2 -0.5 -0.5 -0.0 -0.7 -0.3 -0.6 0.2 -0.1
Noisy workplace 0.6 0.8 2.4 -1.5 0.6 0.5 -0.2 -0.1 0.1 1.4 1.0 0.6 -1.3 -0.7
Qualifications: A levels/AS levels or equivalent 1.2 2.6 7.0 0.8 -1.9 -1.3 -2.5 -2.6 0.4 -1.4 -1.4 -1.8 -0.5 1.6
Serious illness, injury or assault of a close relative in last 2 years 2.0 2.3 7.4 -0.6 -1.6 -0.9 -0.8 -1.1 -1.1 -2.5 -2.7 -1.8 -1.0 0.3
Mouth/teeth dental problems: Dentures 0.1 0.1 0.8 0.4 0.2 0.3 -0.2 -0.4 0.0 0.0 -0.2 -0.2 0.1 0.9
Asthma 0.2 0.5 2.0 -0.5 0.2 0.0 1.4 1.4 0.2 -0.1 0.7 -0.2 0.4 -0.4
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.3 1.7 -0.5 0.3 0.1 -0.2 -0.1 1.0 1.3 0.3 0.4 -0.4 0.0
Medication: Cholesterol lowering 0.7 1.1 4.9 1.0 0.7 1.2 0.1 0.1 1.1 1.4 2.2 0.2 0.5 0.8
Depression (self-reported) 0.3 0.4 2.0 0.8 -0.6 -0.3 -0.2 0.2 -0.4 0.1 0.5 -0.9 1.4 0.4
Medication: Lansoprazole 0.7 0.9 2.9 0.1 1.0 1.2 0.6 0.7 1.3 1.7 0.9 0.6 -0.3 -0.5
Prospective memory result 1.2 1.4 5.2 -0.7 -0.2 -0.7 1.2 1.2 -2.2 0.1 0.9 0.3 -0.8 -2.3
Lung cancer (father) 0.4 0.5 1.9 -0.9 -0.8 -0.5 -0.4 -0.6 -0.2 -0.2 -0.1 -0.8 -1.4 -0.4
Illnesses of mother 0.5 0.6 1.9 1.2 -0.1 0.0 -0.9 -0.6 0.5 -0.4 -0.2 -0.4 1.4 1.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 1.1 2.8 -0.1 -1.4 -1.4 -0.2 -0.5 1.4 -1.7 -0.5 -1.1 1.2 -0.3
Pulse wave Arterial Stiffness index 0.9 1.0 2.5 1.1 -0.1 0.6 -1.2 -1.5 1.2 1.2 0.3 -0.5 0.7 1.6
Impedance of arm (left) 0.3 1.3 4.7 -1.3 -0.7 -1.4 1.5 1.6 -0.3 -0.1 -0.6 0.3 -0.2 -2.2
Arm fat mass (right) 0.1 0.5 2.4 -0.1 -0.6 0.2 -0.7 -0.6 -0.3 0.2 1.6 -1.3 0.4 0.2
Trunk predicted mass 0.6 3.5 9.9 1.3 -0.7 1.3 -2.6 -3.1 1.4 0.7 0.9 -2.6 0.3 2.9
Standing height 0.6 6.4 18.8 1.3 -2.4 0.0 -3.2 -4.0 2.7 0.4 -0.1 -4.3 0.6 3.2
Length of working week for main job 1.3 1.4 3.8 0.8 1.5 1.2 1.9 1.9 0.0 0.9 0.4 1.5 0.5 -0.7
Exposure to tobacco smoke at home 0.4 0.4 1.3 -1.1 -0.7 -0.8 0.3 0.3 -0.6 0.1 -0.3 -0.8 -0.6 -0.7
Breastfed as a baby 1.1 1.4 3.4 -0.4 -1.4 -1.0 -0.9 -1.3 -0.3 -1.8 -1.8 -1.5 0.0 1.0
Tense / ‘highly strung’ 0.5 0.8 3.1 0.6 0.1 -0.1 -1.8 -1.5 -0.4 -0.1 -0.7 0.8 -0.1 1.5
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.4 0.9 -0.8 -0.0 -0.3 -0.6 -0.4 -1.0 -0.2 -0.9 0.7 -0.5 0.0
Hair/balding pattern: Pattern 4 0.1 0.3 1.3 -0.1 -0.2 -0.1 -0.7 -0.6 -0.2 0.2 -0.6 -0.3 -0.5 1.1
Birth weight of first child 0.2 0.3 0.7 0.8 0.4 0.4 -0.5 -0.4 0.3 0.2 0.6 0.5 0.8 0.6
Peak expiratory flow (PEF) 0.4 0.9 3.3 0.7 1.1 0.7 1.2 1.0 1.8 0.3 0.6 1.0 0.1 -0.9
Pulse wave reflection index 0.4 0.5 1.7 0.4 0.2 -0.2 -0.3 -0.4 1.3 0.1 -0.8 0.6 1.2 1.0
Ever highly irritable/argumentative for 2 days 0.9 1.1 3.6 -0.7 0.0 -0.3 1.9 1.4 -1.4 -0.9 -0.7 0.4 -0.1 -1.6
Loud music exposure frequency 1.1 1.2 3.5 0.2 0.8 0.6 -0.8 -0.7 1.8 1.9 1.8 0.8 0.2 0.7
Qualifications: O levels/GCSEs or equivalent 1.5 2.4 6.6 0.2 -2.0 -1.2 -2.2 -2.6 -0.1 -1.3 -0.8 -2.3 -0.2 1.2
Mouth/teeth dental problems: Bleeding gums 0.1 0.2 1.0 0.1 0.4 0.5 -0.1 0.1 -0.1 -0.2 -0.2 0.4 -1.0 -0.2
Blood clot in the leg (DVT) 0.4 0.5 1.2 -0.8 0.4 -0.1 0.3 0.3 -0.1 0.9 0.7 1.0 -0.6 -1.1
Medication: Paracetamol 0.3 0.4 1.1 -0.2 0.2 0.0 0.9 0.9 1.0 1.0 0.5 0.1 0.4 -0.8
Headache pain in last month 0.8 1.4 3.9 1.7 1.0 1.3 1.2 1.2 0.7 0.8 0.4 0.6 2.0 1.1
Medication for cholesterol, blood pressure or diabetes 0.1 0.2 0.9 -0.3 -0.3 -0.8 -0.3 -0.3 -0.3 -0.5 -1.0 0.5 -0.3 -0.1
Glaucoma (self-reported) 0.6 0.7 1.6 0.3 0.8 0.8 -0.9 -0.7 -1.0 -0.1 -0.5 1.3 -1.3 0.8
Gout (self-reported) 0.8 1.1 4.7 -0.0 -0.6 -0.0 -1.9 -2.2 1.0 0.1 0.3 -0.4 -1.1 1.0
Hypothyroidism/myxoedema (self-reported) 0.2 0.4 1.0 -0.8 0.7 1.0 0.0 0.2 -0.1 1.0 1.0 0.2 -0.6 0.2
Medication: Amlodipine 0.9 1.2 5.3 -0.0 0.6 1.3 -1.6 -1.6 -0.4 0.3 -0.0 0.2 -2.3 0.6
Medication: Ventolin 100micrograms inhaler 0.7 0.8 3.6 -0.2 -1.5 -1.0 0.3 0.1 -1.2 -0.7 0.0 -1.9 0.7 0.1
Birth weight 0.1 0.2 0.9 0.3 -0.1 0.0 -0.6 -0.2 0.7 -0.0 1.0 -0.1 0.2 0.0
Chronic bronchitis/emphysema (mother) 0.3 0.4 1.5 0.7 0.4 0.7 -0.0 -0.0 -0.6 -0.1 0.2 0.1 1.2 1.0
High blood pressure (siblings) 1.1 1.6 4.1 0.1 1.4 1.0 1.5 1.8 0.2 1.6 2.0 1.2 0.7 -0.8
Forced vital capacity (FVC), Best measure 0.3 1.2 4.8 0.5 -1.2 -0.8 -0.5 -0.8 2.2 -1.2 0.1 -1.3 1.3 0.5
Body fat percentage 0.2 0.6 3.4 -0.7 -0.6 -0.2 0.4 0.7 -0.7 0.1 1.8 -0.8 0.4 -0.9
Leg fat percentage (right) 0.2 0.8 4.8 0.3 0.5 1.0 0.9 1.1 -0.5 0.5 2.2 -0.0 0.6 -0.3
Arm fat-free mass (right) 0.4 2.0 4.8 1.3 -0.4 1.3 -1.7 -2.2 0.8 0.2 0.9 -2.1 0.2 2.1
Exposure to tobacco smoke outside home 0.7 0.9 3.2 -1.2 -1.3 -1.2 -0.2 -0.3 -1.8 -0.2 -0.6 -1.1 -0.0 -0.5
Comparative body size at age 10 0.3 0.8 2.2 0.1 0.9 1.5 -1.0 -1.1 1.0 -0.1 0.3 0.2 -1.3 1.0
Number of full brothers 1.0 1.2 3.3 -0.4 -1.4 -1.6 0.5 0.2 -0.8 -1.2 0.9 -1.4 1.8 -0.7
Worry too long after embarrassment 0.5 0.9 4.2 0.2 1.3 0.9 0.4 0.6 -1.0 -0.3 -1.0 2.0 -0.6 -0.4
Seen a psychiatrist for nerves, anxiety, tension or depression 2.1 2.7 4.2 -1.4 -2.0 -2.0 -1.9 -1.7 -1.7 -2.0 -2.0 -1.4 -0.4 0.6
Wheeze or whistling in the chest in last year 0.4 0.8 2.5 -1.1 0.2 -0.0 1.5 1.6 -1.3 0.2 -0.2 0.4 0.1 -0.7
Number of children fathered 0.2 0.3 1.8 -0.3 0.3 0.1 -0.0 0.0 1.3 0.0 0.1 0.5 0.8 0.1
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.3 0.9 -0.8 -0.3 -0.3 -0.3 -0.2 -0.4 -0.9 -0.8 -0.1 -0.8 0.2
Age at first live birth 1.1 1.9 5.7 1.3 -1.4 -0.7 -2.1 -2.4 0.3 -0.1 -0.6 -1.4 0.8 2.1
Pulse wave peak to peak time 0.7 0.8 2.0 -0.9 0.1 -0.4 1.1 1.4 -0.9 -0.9 -0.0 0.4 -0.6 -1.4
Health satisfaction 0.4 0.5 1.9 -0.4 -0.7 -1.3 -0.7 -0.4 -0.1 -0.7 -1.4 0.3 0.2 -0.0
Shortness of breath walking on level ground 0.2 0.3 1.1 -0.4 -0.1 -0.6 0.3 0.5 -0.4 0.4 0.0 0.5 -0.4 -1.1
Qualifications: College or University degree 0.9 2.8 5.4 1.9 -1.5 -0.9 -2.0 -2.3 0.4 -1.9 -1.8 -1.8 0.6 2.1
Eye problems/disorders: None of the above 1.3 1.4 4.2 -2.1 -1.4 -1.5 -0.5 -0.6 -0.1 -0.3 0.2 -1.2 -1.7 -1.5
Mouth/teeth dental problems: Loose teeth 0.9 1.0 3.7 1.2 0.1 0.4 -1.3 -1.3 1.3 0.6 0.1 -0.4 0.8 1.9
Emphysema/chronic bronchitis 0.4 0.4 1.4 1.2 0.6 0.1 0.3 0.2 -0.3 0.1 -0.0 1.2 -0.9 0.6
Medication for pain relief, constipation, heartburn 0.5 0.9 3.2 1.8 0.0 0.2 -0.9 -0.9 -0.4 -0.9 -0.3 -0.3 1.5 1.4
Neck or shoulder pain in last month 0.4 0.6 3.0 0.3 -0.6 -0.9 0.7 0.4 -0.4 -0.5 -1.7 -0.2 0.9 0.4
Medication: Blood pressure 0.3 0.5 1.0 -0.4 0.7 1.0 0.7 0.9 0.2 0.6 1.0 0.0 -0.3 -0.8
Angina (self-reported) 0.6 0.9 3.2 -1.2 -0.9 -0.7 -0.7 -0.7 -1.8 -1.1 -0.1 -0.9 -0.6 -0.1
Migraine (self-reported) 0.8 1.0 3.4 0.4 0.9 0.3 1.8 1.8 0.2 0.7 0.2 1.2 0.9 -0.4
Medication: Ibuprofen 0.6 0.8 2.9 0.4 0.9 0.7 0.4 0.6 1.5 1.7 0.7 0.7 0.4 0.3
Medication: Allopurinol 0.7 0.9 3.8 -0.7 -0.6 0.1 -1.7 -1.9 0.8 0.3 0.2 -0.9 -0.5 0.9
Medication: Omeprazole 0.8 1.0 2.1 0.3 0.9 0.7 1.1 1.2 0.6 1.4 1.4 1.3 -0.5 -0.4
Medication: Seretide 50 evohaler 0.8 0.9 3.8 0.4 -0.6 -0.5 -0.2 0.1 1.0 0.9 1.7 -0.8 2.0 0.3
Mean time to correctly identify matches 0.7 1.4 4.6 -2.1 -0.3 -0.2 0.5 0.4 -1.6 -0.2 -0.9 -0.1 -2.0 -1.6
Heart disease (mother) 0.8 1.0 3.7 -1.1 -1.1 -1.1 0.8 0.7 -0.6 -0.2 0.2 -1.1 -0.8 -1.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.7 0.8 3.3 1.8 0.9 0.7 -0.2 -0.1 0.1 -0.6 -0.4 0.5 1.4 1.2
Whole body fat mass 0.1 0.6 3.3 -0.3 -0.7 0.2 -0.5 -0.4 -0.4 0.2 1.8 -1.4 0.3 -0.0
Leg fat mass (right) 0.2 0.7 5.3 0.3 -0.1 0.9 -0.2 -0.1 -0.1 0.7 2.3 -0.8 0.3 0.4
Arm predicted mass (right) 0.4 2.1 6.2 1.1 -0.6 1.1 -2.0 -2.5 0.6 0.0 0.6 -2.2 0.2 2.2
Pulse rate, automated reading 0.2 0.6 1.6 -1.3 -0.5 -0.7 0.6 0.7 -1.1 -0.5 0.1 -0.2 0.6 -0.9
Alcohol intake frequency. 0.3 0.6 1.1 -1.0 -0.8 -1.0 -1.0 -0.6 -1.1 -0.6 0.2 -0.8 -0.4 0.6
Comparative height size at age 10 0.5 2.5 7.4 0.2 -1.5 0.0 -2.2 -2.7 1.7 0.6 -0.1 -2.4 -0.5 2.0
Number of full sisters 2.3 2.8 10.1 0.3 -2.2 -1.9 -1.2 -1.2 0.7 -1.1 -0.5 -2.6 3.2 0.8
Suffer from ‘nerves’ 0.7 1.1 6.9 -0.9 -0.5 -0.6 0.7 0.7 -2.6 -1.0 -0.6 -0.3 0.3 -0.9
Overall health rating 0.6 1.3 4.2 1.2 0.5 0.6 0.6 0.6 0.8 1.6 2.0 0.3 1.7 0.9
Chest pain or discomfort 0.2 0.3 0.6 0.6 -0.3 0.0 0.8 0.6 -0.8 -0.6 -0.4 -0.4 0.4 -0.1
Had major operations 0.5 0.6 1.8 1.3 0.1 0.5 -0.4 -0.2 1.0 0.4 1.2 -0.0 1.0 1.0
Age at last live birth 1.2 1.7 4.8 0.8 -1.4 -0.8 -2.0 -2.2 0.2 -0.4 -0.7 -1.2 0.9 2.0
Family relationship satisfaction 1.3 1.6 4.5 1.7 -0.9 -0.1 -2.1 -1.9 0.3 -0.6 0.1 -1.2 0.3 2.0
Leg pain on walking 1.6 1.9 4.7 -1.8 -1.7 -1.9 -0.5 -0.5 -2.2 -1.2 -1.5 -1.4 -0.4 -0.6
Qualifications: NVQ or HND or HNC or equivalent 0.8 1.0 3.0 -1.5 -0.2 -0.6 0.4 0.5 -1.6 0.1 0.7 0.3 -1.2 -1.7
Commuting to job workplace: Car/motor vehicle 1.0 1.2 3.5 -0.1 -0.5 0.5 -1.9 -1.9 0.2 -0.2 -0.8 -0.7 -1.7 1.3
Illness, injury, bereavement, stress in last 2 years 1.2 1.5 5.1 0.9 1.4 1.2 -0.7 -0.3 1.3 1.2 2.2 1.2 0.5 1.2
Medication: Aspirin 0.4 0.5 3.7 -1.1 0.2 0.1 0.2 0.3 -0.5 0.2 0.3 0.4 -1.9 -0.7
Supplements: Vitamin C 1.0 1.2 3.1 0.1 1.4 1.0 1.0 1.5 -0.7 0.3 1.6 1.8 0.2 -0.7
Knee pain experienced in last month 0.9 1.4 6.5 1.2 0.1 0.4 -0.7 -0.4 0.1 0.7 0.8 -0.4 2.5 2.2
Hypertension (Self-reported) 0.1 0.2 0.6 0.0 0.1 0.5 0.6 0.6 -0.6 0.2 -0.8 -0.3 0.3 -0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.5 1.8 5.5 -1.1 -0.2 -0.6 2.0 2.1 -1.5 0.3 1.4 -0.1 0.0 -2.3
Illnesses of father: Heart disease 0.9 1.3 2.4 -0.3 1.4 1.3 1.4 1.5 -0.0 0.6 0.4 1.5 -0.8 -1.5
Illnesses of siblings: Diabetes 0.8 1.0 2.7 0.0 0.9 0.4 1.5 1.7 0.8 0.9 0.9 1.2 0.0 -1.2
Smoking status: Previous 0.3 0.5 1.9 0.7 -0.0 0.3 -0.6 -0.5 0.5 0.2 -0.6 -0.4 1.4 1.4
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.6 1.7 0.2 -1.3 -0.9 -0.7 -0.9 0.3 -0.7 -0.3 -1.3 0.7 0.3
Whole body fat-free mass 0.5 3.1 9.4 1.1 -0.9 1.0 -2.6 -3.1 0.9 0.3 0.9 -2.6 0.2 2.6
Leg fat-free mass (right) 0.5 2.9 9.1 0.3 -1.5 0.0 -2.8 -3.0 0.5 -0.4 0.7 -2.7 0.4 2.1
Arm fat percentage (left) 0.1 0.5 2.5 -0.7 -0.5 -0.3 0.2 0.5 -0.8 -0.0 1.6 -0.6 0.6 -0.8
Average weekly red wine intake 1.4 2.1 5.1 -0.1 -1.2 -1.2 -1.8 -1.9 -1.0 -2.0 -2.3 -1.3 -0.2 1.3
Handedness (chirality/laterality): Left-handed 0.3 0.3 1.2 -0.2 -0.5 -0.3 -0.8 -0.9 0.4 -0.1 -0.1 -0.5 -1.1 0.5
Mood swings 0.2 0.3 0.8 -0.2 -0.6 -0.5 -0.9 -0.8 -0.6 -0.1 -0.3 -0.5 0.2 0.7
Loneliness, isolation 0.7 1.0 2.7 -0.4 -1.1 -1.2 1.1 0.8 -1.2 -0.7 -0.0 -1.1 1.7 -0.2
Long-standing illness, disability or infirmity 0.2 0.3 1.5 -0.6 0.1 0.5 -0.2 -0.1 -0.2 1.2 1.1 -0.1 -0.7 0.2
Ever had bowel cancer screening 0.4 0.5 1.0 0.2 1.0 1.0 0.7 0.6 0.3 0.6 0.4 0.9 1.0 0.3
Diabetes diagnosed by doctor 1.2 1.9 4.7 -1.1 -1.6 -1.0 -2.1 -2.2 -0.4 -1.0 -1.0 -1.9 -0.7 1.0
Ever had stillbirth, spontaneous miscarriage or termination 0.8 0.9 2.9 -1.2 -0.6 -0.5 -1.1 -1.1 -1.7 -0.5 -0.0 -0.8 -1.3 0.0
Friendships satisfaction 0.8 1.0 2.5 0.9 -0.7 -0.3 -1.3 -1.6 1.3 -0.5 -0.4 -1.1 0.2 1.6
Qualifications: nursing, teaching 1.0 1.6 3.3 1.7 -0.8 -0.2 -1.7 -1.5 -0.2 -1.4 -1.3 -0.7 0.8 1.8
Commuting to job workplace: Walk 0.9 1.0 4.6 1.6 0.0 0.1 -0.4 -0.4 1.6 0.2 0.3 -0.2 2.2 1.0
Eye problems/disorders: Cataract 2.3 2.6 11.1 2.4 1.2 1.2 1.3 1.7 0.3 1.1 1.4 0.8 3.3 0.8
Mouth/teeth dental problems: Mouth ulcers 0.6 1.0 2.9 0.0 0.6 -0.2 1.6 1.7 0.5 0.2 1.2 1.1 1.0 -1.1
Medication for cholesterol 0.1 0.2 0.7 0.1 -0.2 -0.5 0.8 0.4 0.0 -0.8 -0.0 0.2 -0.3 -0.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.8 1.0 2.1 -1.3 -1.0 -0.9 -1.4 -1.3 1.4 -0.0 -0.0 -0.7 -1.0 -0.3
Back pain experienced in last month 0.2 0.3 1.1 0.1 0.5 0.7 -0.2 -0.2 0.4 0.4 0.4 0.3 0.7 1.1
Mineral and other dietary supplements 0.4 0.5 2.9 0.2 -0.4 -0.2 -0.4 -0.4 1.7 -0.4 0.2 -0.8 1.0 0.7
Breast cancer (self-reported) 0.7 0.8 2.4 1.2 0.7 0.7 0.6 0.6 1.5 0.8 0.7 0.3 1.3 0.0
Asthma (self-reported) 0.3 0.5 2.4 -0.6 0.0 -0.2 1.6 1.5 0.0 -0.3 0.5 -0.2 0.4 -0.6
Osteoporosis (self-reported) 0.3 0.3 0.9 -0.4 -0.8 -0.6 -0.9 -0.6 0.1 -0.5 -0.4 -0.6 -0.0 0.6
Osteoarthritis (self-reported) 2.9 3.7 9.4 0.7 2.2 2.1 2.3 2.4 0.4 2.6 3.1 1.6 1.0 -0.5
Medication: Aspirin 0.3 0.4 2.4 -0.7 0.3 0.4 0.3 0.4 -0.6 0.3 0.3 0.4 -1.6 -0.5
Medication: Gliclazide 0.1 0.1 0.3 -0.5 -0.2 -0.1 -0.2 0.0 0.0 0.5 0.0 -0.3 -0.2 -0.2
Illnesses of father: None of the above (group 1) 2.9 3.5 10.2 1.2 -2.0 -1.5 -2.9 -3.2 1.0 -0.7 -0.5 -2.1 0.9 2.3
Smoking status: Current 0.3 0.4 1.1 -0.6 -0.9 -1.0 -0.4 -0.2 -1.0 -0.6 0.1 -0.7 -0.1 -0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.0 2.1 7.3 -1.1 -0.6 -1.3 1.6 1.7 -0.4 -2.7 -1.4 0.5 -0.1 -2.2
Whole body water mass 0.6 3.3 10.2 1.0 -0.9 1.0 -2.8 -3.2 1.0 0.3 0.8 -2.6 0.1 2.6
Leg predicted mass (right) 0.5 2.7 8.7 0.2 -1.4 0.1 -2.7 -3.0 0.5 -0.3 0.7 -2.6 0.4 2.0
Arm fat mass (left) 0.1 0.5 2.5 -0.1 -0.6 0.1 -0.8 -0.7 -0.4 0.1 1.6 -1.2 0.4 0.2
Number of self-reported non-cancer illnesses 0.9 1.5 4.3 -1.1 1.1 1.3 1.7 2.1 -0.4 1.0 1.5 0.7 -0.5 -1.3
Average weekly champagne plus white wine intake 1.4 1.9 4.4 -1.0 -1.7 -1.6 -2.1 -2.1 -0.0 -0.6 -1.8 -1.3 -0.9 0.5
Miserableness 0.3 0.5 3.1 -0.0 0.7 0.6 0.3 0.5 0.2 1.8 0.6 0.8 -0.1 0.1
Guilty feelings 0.3 0.5 1.2 0.6 1.1 1.0 -0.2 -0.3 0.8 0.7 -0.4 1.0 -0.8 0.5
Wears glasses or contact lenses 0.2 0.2 0.8 0.6 0.4 0.9 -0.1 -0.0 0.1 -0.2 0.2 -0.2 0.4 0.9
Ever taken oral contraceptive pill 1.6 1.8 4.7 1.6 1.7 1.8 1.1 0.7 2.2 1.4 0.7 1.2 0.0 0.8
Hearing aid user 0.3 0.4 1.0 -0.8 -0.2 -1.0 -0.6 -0.3 -0.1 -0.0 -0.7 0.5 -1.0 -0.2
Mother’s age at death 0.6 0.8 1.6 -1.0 -0.9 -0.9 -0.3 -0.5 -0.7 -1.2 -1.3 -0.6 -1.3 -0.2
Financial situation satisfaction 0.3 0.4 1.1 -1.0 -0.9 -0.8 -0.7 -0.7 0.2 -0.1 -0.1 -0.9 0.3 -0.2
Tinnitus: Yes, now most or all of the time 1.4 1.6 4.3 -1.2 -1.6 -0.9 -1.8 -1.5 -0.7 -1.0 -0.1 -2.1 -1.3 -0.2
Commuting to job workplace: Public transport 0.9 1.1 4.5 -0.6 0.4 -0.0 1.8 1.8 0.3 0.6 0.3 0.4 0.6 -2.1
Eye problems/disorders: Glaucoma 0.7 0.9 3.9 0.5 1.5 1.3 -0.1 0.1 -0.4 0.6 0.1 2.0 -0.3 0.7
Medication: Blood pressure 0.2 0.4 1.0 0.5 -0.1 0.4 -1.0 -0.6 0.3 1.0 -0.5 -0.3 1.0 0.7
Pain type(s) experienced in last month: Hip pain 1.2 1.5 5.1 2.0 -0.2 0.1 -0.4 -0.3 1.3 -0.2 -1.1 -0.7 2.3 2.0
Supplements: Fish oil (including cod liver oil) 0.2 0.2 1.8 0.4 0.1 0.1 0.4 0.5 -1.3 0.5 0.1 0.0 -0.2 -0.2
High cholesterol (Self-reported) 0.5 0.8 4.9 0.3 0.5 1.1 -0.7 -0.6 -0.1 1.1 2.2 0.1 0.2 0.9
Medication: Bendroflumethiazide 0.2 0.3 1.7 0.6 0.5 0.7 0.1 0.4 -1.3 0.2 -0.4 0.4 0.3 0.1
Medication: Paracetamol 0.1 0.2 0.9 0.2 -0.2 -0.1 0.3 0.4 0.9 0.9 0.4 -0.2 0.3 -0.2
Medication: Lisinopril 0.3 0.3 1.6 0.3 0.8 1.3 -0.4 -0.0 -0.3 -0.1 0.3 0.1 -0.1 1.1
Medication: Atorvastatin 1.2 1.5 3.1 1.1 1.3 1.7 -1.1 -0.9 1.3 1.5 1.4 1.1 -0.4 1.3
Illnesses of father: High blood pressure 0.9 1.2 2.6 -0.3 1.5 1.5 1.5 1.6 -0.1 1.1 0.5 0.9 0.1 -0.7
Alcohol drinker status: Never 0.9 1.0 2.9 -1.7 -0.6 -0.8 -0.7 -0.7 -1.2 -1.1 -1.1 -0.1 -1.5 -0.5
Ever smoked 0.6 1.1 4.9 1.4 0.3 0.9 -1.0 -0.8 0.5 0.2 -0.1 -0.6 1.3 2.2
Basal metabolic rate 0.5 2.8 7.9 0.9 -1.0 0.8 -2.5 -2.8 0.8 0.2 1.0 -2.6 0.5 2.3
Leg fat percentage (left) 0.2 0.7 4.1 -0.0 0.1 0.6 0.9 1.1 -0.5 0.3 2.0 -0.2 0.6 -0.5
Arm fat-free mass (left) 0.5 2.7 7.3 1.3 -0.7 1.1 -2.3 -2.7 0.7 0.3 0.9 -2.4 0.4 2.5
Number of operations (self-reported) 2.5 3.7 8.5 2.1 2.7 2.9 1.5 1.7 1.1 2.1 2.0 2.3 0.2 0.9
Average weekly beer plus cider intake 0.3 0.5 2.6 -0.0 -0.2 -0.2 0.7 0.5 0.4 1.6 1.0 -0.3 0.8 -0.0
Irritability 0.7 1.3 4.1 1.1 1.8 2.0 0.5 0.6 0.8 0.9 0.1 1.6 0.4 0.3
Risk taking 0.6 1.0 2.5 -0.5 -1.1 -1.0 -1.5 -1.6 -0.7 -0.6 -0.2 -1.2 -0.8 0.5
Ever had prostate specific antigen (PSA) test 0.3 0.4 1.5 0.1 0.8 0.9 -0.3 0.1 -0.0 0.7 1.2 0.6 0.1 0.2
Fractured/broken bones in last 5 years 2.1 2.8 7.2 2.4 1.7 1.8 0.1 0.5 2.1 0.7 1.4 1.4 2.7 1.5
Age started oral contraceptive pill 1.2 1.5 4.5 1.4 -0.4 0.5 -0.8 -1.0 -1.2 -1.7 -2.1 -1.2 0.3 1.7
Diastolic blood pressure, automated reading 0.4 1.3 3.1 -1.7 -0.8 -1.2 0.9 1.4 -1.2 -1.3 0.6 -0.4 0.9 -1.5
Ever depressed for a whole week 1.1 1.4 3.3 -1.5 -1.4 -1.5 -0.6 -0.2 -1.8 -1.4 -0.8 -1.0 -0.5 -1.2
Unable to work because of sickness or disability 0.5 0.6 2.1 0.7 0.3 0.1 1.5 1.3 -0.5 0.7 0.5 0.4 0.7 -0.7
Commuting to job workplace: Cycle 0.7 0.8 2.9 0.8 0.6 -0.0 1.6 1.7 0.6 -0.1 -0.7 1.0 0.5 -0.7
Myopia 2.3 3.3 13.7 -2.5 -0.9 -1.9 1.9 2.0 -1.9 -1.1 0.1 -0.3 -0.7 -3.7
Vascular/heart problems diagnosed by doctor 0.2 0.4 1.3 0.2 0.4 -0.1 -0.7 -0.7 1.1 0.3 1.0 0.9 -0.2 0.6
Cholesterol lowering medication 0.4 0.6 1.7 0.2 0.7 1.3 -0.9 -0.7 0.5 0.9 1.1 0.2 -0.0 1.0
Medication: Omeprazole (e.g. Zanprol) 0.7 0.8 1.9 0.2 1.0 0.8 0.8 0.9 0.7 1.2 1.3 1.4 -0.5 -0.3
Pain experienced in last month 0.3 0.5 1.6 -0.1 -0.5 -0.4 -0.1 -0.3 -0.2 -0.9 1.1 -0.8 -0.3 -1.3
Supplements: Calcium 0.4 0.4 1.4 0.3 -0.1 -0.4 1.2 1.0 -0.6 -0.8 -0.7 -0.1 0.1 -0.9
Basal cell carcinoma (self-reported) 1.0 1.2 5.9 -2.4 -0.7 -0.9 -0.2 -0.2 -0.9 -0.3 -0.1 -0.2 -1.8 -1.3
Heart attack/myocardial infarction (self-reported) 0.1 0.1 0.6 0.4 0.1 0.4 0.1 0.1 0.4 -0.3 -0.1 -0.5 0.8 0.3
Deep venous thrombosis (DVT) (self-reported) 0.6 0.7 2.0 -0.7 0.9 0.4 0.4 0.4 0.2 1.3 0.9 1.4 -0.7 -1.1
Heart disease (siblings) 0.6 0.7 1.7 -1.0 0.8 0.4 1.0 1.0 -0.1 -0.6 -0.3 0.9 -0.7 -1.3
Alcohol drinker status: Previous 2.6 3.0 7.4 -0.2 -2.6 -2.4 -1.9 -1.8 -1.0 -1.8 -1.0 -2.7 -0.3 1.1
Pack years of smoking 0.2 0.3 1.0 0.4 -0.1 0.4 -0.3 -0.2 1.0 0.2 0.5 -0.8 0.6 0.7
Impedance of whole body 0.2 1.1 3.4 -0.9 -0.5 -1.2 1.7 1.8 0.0 0.2 -0.3 0.3 -0.1 -1.8
Leg fat mass (left) 0.2 0.7 5.2 0.2 -0.1 0.8 -0.3 -0.2 -0.0 0.7 2.3 -0.8 0.3 0.4
Arm predicted mass (left) 0.6 3.0 7.8 1.4 -0.6 1.3 -2.3 -2.7 1.0 0.5 1.2 -2.4 0.8 2.8