Hub : Genes

COL6A2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1320	0.0380	5.1e-07	0.111	0.055	0.112	0.103	0.115	1.9e-13	2.6e-07	1.7e-13	1.7e-12	7.7e-14
2	GTEx	Artery Aorta	0.1040	0.0440	3.9e-03	0.052	NA	0.063	NA	0.056	7.5e-04	NA	2.3e-04	NA	5.0e-04
3	YFS	Blood	0.1457	0.0313	0.0e+00	0.020	0.077	0.080	0.077	0.069	2.3e-07	7.7e-24	5.0e-25	4.2e-24	1.9e-21
4	TCGA	Lung Squamous Cell Carcinoma	0.0476	0.0248	6.6e-03	-0.002	0.011	-0.002	NA	-0.002	9.4e-01	1.9e-02	8.8e-01	NA	7.2e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.4	0.7	2.6	0.2	1.6	0.1	0.0
Bipolar Disorder or Schizophrenia	0.3	0.8	2.4	0.6	-0.6	0.0	-1.5
Depressed Affect (Nagel 2018)	0.4	0.8	2.1	1.4	-0.8	0.5	0.6
Depression (Nagel 2018)	0.3	0.4	0.8	0.9	-0.5	-0.3	0.8
Intelligence (Savage-Jansen 2018)	0.6	1.8	3.6	-0.6	1.8	0.1	1.9
Neuroticism (Nagel 2018)	0.8	1.8	5.7	2.4	-0.3	1.1	0.7
Schizophrenia (2018)	1.0	2.0	6.4	0.7	-2.5	-0.2	-1.1
Schizophrenia vs Biploar Disorder	0.6	0.8	2.8	-0.1	-1.7	-0.6	0.0
Worry (Nagel 2018)	0.5	1.1	2.8	1.7	-1.0	-0.6	0.6
Alzheimer’s Disease (in mother)	1.0	1.2	2.0	-0.8	-0.9	-1.2	-1.4
Alzheimer’s Disease (in father)	1.2	1.3	4.8	-0.5	-2.2	-0.2	-0.1
Alzheimer’s Disease (including proxy)	2.1	3.1	4.7	-1.7	-2.0	-0.7	-2.2
Crohns Disease (2017)	0.5	1.2	3.1	-1.8	-1.0	-0.4	-0.7
Irritable Bowel Disease (IBD)	0.4	0.9	1.5	-0.8	-1.2	-1.2	0.1
Ulcerative Colitis (UC)	0.5	0.9	2.0	0.1	-1.2	-1.4	0.3
Major Depression (MDD)	0.2	0.2	1.0	0.0	0.1	1.0	0.0
Reaction Time	1.7	3.3	8.6	-1.7	-1.4	-0.0	-2.9
Verbal and Numeric Reasoning (VNR)	0.2	0.6	1.2	-0.0	1.1	-0.1	1.1
Breast Cancer	1.4	3.4	8.3	1.2	1.8	-2.9	0.6
Ovarian Cancer	0.5	0.7	2.0	0.3	0.8	0.2	1.4
Prostate Cancer	2.0	2.8	6.7	1.0	1.2	2.6	1.5
Age at First Birth	1.0	1.4	3.8	0.5	1.3	-0.2	2.0
Bipolar Disorder (2011)	0.1	0.1	0.2	-0.0	0.5	0.0	0.0
Body Mass Index (BMI) (2010)	0.5	0.7	1.3	-1.2	0.4	-0.7	-0.9
Coronary Artery Disease (CAD)	1.0	1.2	4.0	-0.5	-0.6	-2.0	0.0
Crohns Disease (2012)	0.6	1.0	3.0	-1.7	-0.8	0.5	0.0
Mean Putamen Volume	2.1	2.4	5.8	-1.5	-1.0	-2.4	-0.8
Fasting Glucose	1.3	1.5	5.2	-0.0	0.5	-2.3	0.8
HbA1C	0.5	0.6	1.0	-1.0	0.6	-0.9	-0.4
HDL Cholesterol	0.7	1.1	2.9	-1.7	-0.9	0.6	-0.6
LDL Cholesterol	1.3	2.0	4.3	-0.7	1.8	-2.1	0.1
Lupus	1.3	2.0	5.8	-0.7	-2.4	-1.3	0.3
Neuroticism (2016)	0.4	0.6	1.1	1.0	-0.2	1.0	0.5
Primary Biliary Cirrhosis	0.7	1.0	1.7	-1.2	-0.7	1.3	0.5
Rheumatoid Arthritis	0.5	0.7	1.5	-0.2	-1.2	0.9	-0.6
Schizophrenia (2014)	0.9	1.9	4.3	0.3	-2.1	0.6	-1.8
Triglycerides	0.4	0.6	1.9	0.4	-0.6	-1.4	-0.4
Type 2 Diabetes (T2D) (2012)	0.3	0.3	1.3	-0.2	-0.2	1.1	0.0
Ulcerative Colitis	1.0	1.5	2.5	1.3	-1.0	0.9	1.6
Blood Eosinophil Count	0.3	2.0	4.3	0.4	-0.1	2.1	-1.9
Blood Platelet Count	0.5	5.8	9.3	-3.0	-2.3	-2.6	-1.4
Blood Red Count	0.3	3.2	11.1	-0.2	-3.3	-1.2	-0.3
Blood White Count	0.8	5.8	13.4	-1.9	-3.7	-1.3	-2.1
Heel T-Score	1.8	14.0	21.5	-3.4	-3.6	-4.6	-3.1
BMI	0.4	2.1	7.2	-1.0	0.5	2.7	0.1
Height	1.3	25.5	53.7	6.4	-2.4	-1.1	7.3
Waist Hip Ratio (WHR)	3.7	16.4	31.3	5.6	0.3	2.5	5.3
Systolic Blood Pressure	0.3	1.6	4.5	2.1	0.0	0.2	1.3
Smoking Status	0.6	1.5	3.3	1.6	0.3	1.8	-0.1
Allergy or Eczema	0.3	0.9	2.2	-1.5	0.4	1.1	-0.3
Cardiovascular Disease	0.4	1.3	2.5	1.6	-1.0	-0.2	1.3
Hypothyroidism (self reported)	0.2	0.4	1.2	0.1	-0.1	-0.5	-1.1
Respiratory disease	0.2	0.4	1.4	0.3	-0.1	-1.2	-0.1
Type 2 Diabetes (T2D) (2018)	1.4	2.7	4.0	-0.8	-1.4	-2.0	2.0
Lung FEV1/FVC ratio	0.3	1.3	3.5	1.1	-0.5	0.6	1.9
Lung FVC	1.9	9.8	19.8	-3.8	0.3	-2.2	-4.5
Neuroticism	0.4	0.9	1.9	1.4	-1.1	0.0	0.7
Chronotype (morning person)	1.5	3.4	8.8	-1.1	-3.0	-0.7	-1.7
Hair Pigment	0.1	1.7	3.2	-1.1	-1.5	-1.8	0.5
Tanning	0.0	0.3	0.5	0.3	-0.7	-0.4	0.7
Hand grip strength (left)	0.4	1.1	2.4	0.3	1.2	-1.5	0.7
Number of treatments/medications taken	0.6	1.1	2.2	1.4	-0.1	-0.0	1.5
Average weekly spirits intake	0.7	0.9	1.5	0.7	1.0	-1.2	0.6
Sensitivity / hurt feelings	0.1	0.2	0.6	-0.3	-0.3	0.8	0.3
Frequency of depressed mood in last 2 weeks	1.0	1.4	3.1	1.4	-0.1	0.5	1.8
Hearing difficulty/problems: Yes	0.3	0.5	1.5	0.1	0.2	0.6	1.2
Relative age of first facial hair	1.4	2.8	4.0	0.4	-1.9	1.9	2.0
Other serious medical condition/disability diagnosed by doctor	0.3	0.3	0.7	-0.0	-0.8	0.3	-0.7
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.2	-0.1	0.8	-1.1	0.1
Ever had hysterectomy (womb removed)	0.4	0.5	1.1	-1.0	0.7	-0.1	-0.7
Systolic blood pressure, automated reading	0.2	0.6	1.1	1.1	0.0	0.9	0.5
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	1.5	-0.3	-0.9	0.4	-1.2
Angina	0.9	1.2	3.0	-1.0	-1.7	-0.8	-0.3
Medication for hormone replacement therapy	0.4	0.4	1.0	0.2	0.7	-1.0	0.5
Vitamin and mineral supplements	1.2	1.6	3.2	-1.5	-1.8	-0.0	-0.8
Supplements: Zinc	0.3	0.3	0.5	-0.7	0.2	0.4	0.7
Medication: Co-codamol	0.4	0.4	0.7	0.6	-0.8	0.1	-0.7
Medication: Metformin	1.4	1.9	5.2	0.3	-0.1	-2.3	1.5
Diabetes (father)	1.1	1.3	2.6	-0.5	-1.6	-0.2	-1.5
Diabetes (mother)	1.3	1.7	5.9	0.6	0.1	-0.8	2.4
Severe depression (siblings)	1.3	1.4	3.6	1.9	-0.3	1.1	0.9
Pack years adult smoking proportion	0.4	0.6	1.7	0.5	-1.3	-0.5	-0.3
Impedance of leg (right)	0.6	3.0	6.2	-2.5	-1.3	-0.8	-1.9
Leg fat-free mass (left)	0.4	2.4	6.9	1.4	0.4	0.8	2.6
Trunk fat percentage	0.8	3.3	10.7	-3.3	0.5	0.6	-1.3
Hand grip strength (right)	1.2	3.4	8.7	0.0	1.7	-3.0	1.4
Townsend deprivation index at recruitment	0.3	0.5	0.7	-0.6	-0.6	0.7	-0.9
Current tobacco smoking	0.1	0.2	0.8	0.2	-0.3	0.9	-0.0
Average weekly fortified wine intake	0.8	1.0	2.3	-0.1	-0.7	-1.5	1.1
Maternal smoking around birth	0.4	0.6	1.1	0.8	0.6	1.1	0.8
Fed-up feelings	0.6	1.0	3.6	0.2	-1.9	-0.1	0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.6	0.5	-0.8	-0.2	0.1
Relative age voice broke	2.1	3.2	8.2	1.2	-1.6	0.8	2.9
Taking other prescription medications	0.1	0.2	0.3	-0.5	-0.6	0.1	-0.5
Age when periods started (menarche)	0.1	0.2	0.5	0.6	-0.7	-0.0	-0.0
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.5	0.7	-0.7	0.3	-1.2
Heel bone mineral density (BMD) T-score, automated (left)	1.4	3.2	8.7	-1.9	-0.7	-3.0	-0.6
Tinnitus: Yes, but not now, but have in the past	1.8	1.9	6.0	1.0	0.6	0.5	2.5
Qualifications: CSEs or equivalent	0.8	1.1	2.1	0.3	-1.4	1.4	-0.7
Serious illness, injury or assault to yourself	0.3	0.4	1.0	-0.6	-0.4	-1.0	-0.1
High blood pressure	0.2	0.5	0.9	0.9	-1.0	0.5	0.3
Hayfever, allergic rhinitis or eczema	0.2	0.4	0.8	-0.7	-0.9	0.2	0.2
Multivitamins +/- minerals	0.3	0.3	0.8	-0.4	0.9	0.0	-0.6
Stomach or abdominal pain in last month	1.1	1.4	5.1	-0.7	-2.3	0.1	-0.1
Supplements: Glucosamine	1.5	2.0	3.7	0.3	1.6	1.9	1.2
Diverticular disease/diverticulitis (self-reported)	1.6	1.9	3.7	-1.4	-1.9	-0.9	-1.0
Medication: Atenolol	0.6	0.8	2.2	0.7	-0.1	0.7	1.5
Medication: Levothyroxine sodium	0.5	0.9	1.6	0.5	0.5	1.2	-1.3
Sitting height	0.4	2.7	8.8	0.8	-0.2	-1.2	3.0
Chronic bronchitis/emphysema (father)	0.3	0.3	0.6	0.8	0.6	0.0	-0.5
High blood pressure (mother)	0.4	0.5	1.4	0.1	-0.8	-1.2	-0.1
Body mass index (BMI)	0.3	1.4	2.5	-1.5	0.9	1.6	-0.4
Impedance of leg (left)	0.6	2.8	4.9	-2.2	-1.5	-1.0	-1.8
Leg predicted mass (left)	0.5	2.6	7.6	1.4	0.4	0.8	2.8
Trunk fat mass	0.3	1.2	4.3	-2.1	0.3	0.8	-0.1
Waist circumference	1.0	3.5	8.7	1.0	0.5	2.9	2.0
Number of incorrect matches in round	1.1	1.9	4.1	2.0	-1.7	0.0	-0.7
Past tobacco smoking	0.5	1.0	1.8	-1.3	0.4	-1.3	0.5
Alcohol usually taken with meals	0.4	0.7	1.4	-0.8	-0.7	-0.4	1.2
Nervous feelings	0.2	0.4	0.9	0.6	0.9	0.4	0.3
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	0.7	0.8	-0.4	-0.7	0.6
Hearing difficulty/problems with background noise	0.2	0.3	1.1	-0.2	-0.2	1.0	0.0
Hair/balding pattern: Pattern 2	0.9	1.1	3.8	0.1	0.5	2.0	0.5
Had menopause	1.5	1.9	3.9	-2.0	1.2	-0.5	-1.4
Had other major operations	1.6	2.0	4.9	2.2	1.7	0.2	0.5
Forced vital capacity (FVC)	0.4	1.5	3.3	-1.0	-1.3	-1.8	-0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.9	7.0	-0.4	-0.3	-2.6	0.6
Ever unenthusiastic/disinterested for a whole week	1.3	1.6	3.3	1.0	0.3	1.8	1.5
Qualifications: None of the above	0.3	0.6	1.3	0.9	1.2	-0.2	0.2
Financial difficulties in last 2 years	1.2	1.6	4.5	0.3	-2.1	1.2	0.6
Mouth/teeth dental problems	0.3	0.4	0.7	-0.2	0.6	0.8	-0.8
Heart attack	0.0	0.0	0.1	0.2	-0.1	-0.3	0.2
Allergy	0.4	1.0	3.1	1.8	0.3	0.7	0.5
Pain all over the body in last month	0.8	0.8	3.0	0.3	-1.7	-0.0	-0.5
Diabetes (self-reported)	0.2	0.3	0.9	0.3	-0.4	-0.1	1.0
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.5	-0.7	0.7	-0.1	-0.4
Medication: Ramipril	0.2	0.3	0.8	-0.9	-0.0	-0.5	-0.3
Medication: Simvastatin	0.3	0.5	0.9	0.2	0.5	0.9	0.9
Fluid intelligence score	0.6	1.2	2.4	-0.4	1.3	-0.7	1.5
Illnesses of siblings	0.8	1.2	3.9	-0.3	-2.0	0.7	0.4
Neuroticism score	0.4	0.8	1.3	1.1	-1.1	-0.4	0.6
Weight	0.3	1.4	3.7	0.1	0.1	1.3	1.9
Impedance of arm (right)	0.5	2.2	5.6	-2.4	-1.3	-1.0	-0.8
Arm fat percentage (right)	0.6	2.5	7.5	-2.7	0.4	1.4	-0.7
Trunk fat-free mass	1.4	7.8	16.9	3.6	-0.7	1.0	4.1
Hip circumference	0.2	0.9	2.1	-1.0	0.2	1.4	0.7
Time employed in main current job	0.5	0.6	1.8	0.2	-0.4	-1.3	0.7
Alcohol intake versus 10 years previously	0.3	0.5	1.0	1.0	0.4	0.9	-0.1
Father’s age at death	0.8	1.0	1.8	-1.1	1.4	1.1	0.1
Worrier / anxious feelings	0.1	0.2	0.3	0.6	-0.2	-0.2	0.6
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.8	2.8	1.7	-1.3	-0.3	1.7
Falls in the last year	1.5	2.1	6.0	1.2	0.1	2.5	0.9
Hair/balding pattern: Pattern 3	1.1	1.6	3.0	1.7	-0.6	-1.4	1.1
Number of live births	1.0	1.4	3.5	-1.9	-0.3	-0.4	-1.3
Forced expiratory volume in 1-second (FEV1)	0.3	1.0	2.1	-0.7	-1.1	-1.5	0.6
Pulse rate	0.2	0.3	0.6	-0.6	-0.1	0.7	0.4
Happiness	0.9	1.1	2.4	0.8	0.6	1.1	1.5
Noisy workplace	0.8	0.9	2.5	1.0	0.2	0.5	-1.6
Qualifications: A levels/AS levels or equivalent	0.6	1.3	2.7	-1.6	-0.6	-1.4	0.3
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.9	0.2	-1.0	0.0	0.1
Mouth/teeth dental problems: Dentures	0.1	0.2	0.5	-0.5	-0.7	-0.2	0.2
Asthma	0.1	0.2	0.7	-0.2	-0.8	-0.3	0.0
Medication: Ibuprofen (e.g. Nurofen)	1.6	2.0	5.0	1.7	0.2	0.3	2.2
Medication: Cholesterol lowering	0.3	0.4	1.0	0.5	0.2	0.5	1.0
Depression (self-reported)	1.5	1.8	2.9	1.3	0.1	1.5	1.7
Medication: Lansoprazole	0.5	0.5	1.1	0.7	-0.4	0.6	-1.0
Prospective memory result	0.4	0.5	1.1	0.7	-0.1	0.6	1.1
Lung cancer (father)	0.1	0.2	0.5	-0.1	-0.1	-0.7	-0.3
Illnesses of mother	0.9	1.1	2.9	-0.4	1.7	1.1	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	1.1	-1.0	-0.7	-1.1	0.1
Pulse wave Arterial Stiffness index	0.4	0.4	0.8	0.6	0.2	0.9	0.6
Impedance of arm (left)	0.6	3.0	8.1	-2.9	-0.5	-1.5	-1.1
Arm fat mass (right)	0.3	1.2	2.1	-1.5	0.4	1.4	0.5
Trunk predicted mass	1.4	7.9	16.9	3.6	-0.7	1.0	4.1
Standing height	1.2	12.0	31.3	3.6	-1.9	-0.5	5.6
Length of working week for main job	2.3	2.5	5.3	2.3	0.7	0.8	1.9
Exposure to tobacco smoke at home	0.2	0.2	0.6	0.4	-0.4	-0.8	0.1
Breastfed as a baby	0.5	0.6	1.4	0.6	-1.2	-0.7	0.6
Tense / ‘highly strung’	0.9	1.4	3.3	1.8	-0.8	1.3	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.2	0.5	-0.3	-0.2	-0.0
Hair/balding pattern: Pattern 4	0.2	0.5	1.0	0.8	0.3	-1.0	-0.5
Birth weight of first child	0.2	0.3	0.7	-0.6	0.4	0.8	-0.0
Peak expiratory flow (PEF)	0.3	0.6	1.7	0.5	0.4	-0.7	1.3
Pulse wave reflection index	0.5	0.6	1.8	-0.5	-0.3	-0.4	-1.3
Ever highly irritable/argumentative for 2 days	0.7	0.8	1.4	-0.4	-1.1	-0.8	1.2
Loud music exposure frequency	1.5	1.7	6.1	0.2	-0.7	2.5	0.0
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	3.1	-1.8	-0.9	-0.3	0.4
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	1.1	0.9	-0.6	-0.8	1.0
Blood clot in the leg (DVT)	0.6	0.7	1.0	1.0	0.9	0.5	0.9
Medication: Paracetamol	0.8	1.3	3.6	0.3	-1.9	1.1	-0.5
Headache pain in last month	0.5	0.9	2.8	-0.2	-1.7	-0.8	0.2
Medication for cholesterol, blood pressure or diabetes	0.1	0.1	0.2	-0.3	-0.2	-0.4	-0.4
Glaucoma (self-reported)	0.7	0.8	2.3	-0.7	1.5	0.5	0.2
Gout (self-reported)	0.1	0.2	0.4	0.6	0.4	0.4	0.0
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	1.6	0.5	-0.3	0.5	-1.3
Medication: Amlodipine	0.1	0.2	0.4	0.6	0.6	0.1	-0.2
Medication: Ventolin 100micrograms inhaler	1.1	1.4	3.7	1.4	-1.9	-0.3	0.3
Birth weight	1.0	2.1	5.1	-1.3	2.3	-0.1	-1.3
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.5	-1.2	-0.2	0.4	-0.7
High blood pressure (siblings)	1.0	1.4	4.6	0.7	2.2	0.6	-0.1
Forced vital capacity (FVC), Best measure	0.3	1.0	2.0	-1.4	-0.6	-1.2	-0.7
Body fat percentage	0.9	3.6	11.2	-3.3	0.7	0.9	-1.4
Leg fat percentage (right)	1.4	5.1	14.6	-3.8	1.0	1.1	-1.8
Arm fat-free mass (right)	0.9	4.5	9.8	2.7	-0.0	0.9	3.1
Exposure to tobacco smoke outside home	0.8	1.1	2.9	-0.4	-1.7	0.8	-0.8
Comparative body size at age 10	0.3	0.7	1.6	0.8	0.6	-1.3	-0.5
Number of full brothers	0.7	0.9	2.2	-0.8	-1.5	0.0	0.9
Worry too long after embarrassment	0.7	1.2	2.5	1.6	1.3	0.3	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	2.4	-0.5	-1.1	0.3	-1.6
Wheeze or whistling in the chest in last year	0.6	1.0	3.4	0.7	-1.8	0.4	0.1
Number of children fathered	0.3	0.3	0.8	0.9	-0.3	0.6	0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.6	-1.3	0.0	-0.7	-1.0
Age at first live birth	0.1	0.3	0.8	0.2	0.1	0.3	0.9
Pulse wave peak to peak time	0.2	0.2	0.6	-0.2	-0.2	-0.8	-0.2
Health satisfaction	0.7	0.9	2.0	0.9	-0.8	-0.2	1.4
Shortness of breath walking on level ground	1.8	2.1	3.0	1.5	-1.5	0.9	1.7
Qualifications: College or University degree	0.2	0.7	1.9	-0.5	-0.7	-0.6	1.4
Eye problems/disorders: None of the above	0.8	0.9	3.1	-0.1	0.2	-1.8	-0.8
Mouth/teeth dental problems: Loose teeth	1.0	1.2	2.3	0.8	-1.5	1.3	0.0
Emphysema/chronic bronchitis	0.8	0.9	3.4	0.2	-0.6	-1.8	0.0
Medication for pain relief, constipation, heartburn	0.7	1.3	3.7	-0.4	1.9	1.0	-0.3
Neck or shoulder pain in last month	1.2	1.7	4.0	1.1	-2.0	-0.7	1.0
Medication: Blood pressure	0.5	0.8	1.5	-1.2	0.6	0.3	-1.2
Angina (self-reported)	1.1	1.4	3.7	-1.0	-1.9	-0.9	-0.2
Migraine (self-reported)	0.7	0.8	1.5	-1.1	-0.5	-1.2	0.7
Medication: Ibuprofen	0.7	0.9	2.3	0.9	0.6	0.2	1.5
Medication: Allopurinol	0.3	0.5	0.9	-0.4	0.5	0.7	-1.0
Medication: Omeprazole	1.1	1.4	1.7	-1.3	-1.3	-1.1	-0.9
Medication: Seretide 50 evohaler	1.1	1.2	2.8	0.5	-0.5	1.7	1.3
Mean time to correctly identify matches	0.8	1.6	5.0	-1.0	-0.5	-0.5	-2.2
Heart disease (mother)	1.3	1.6	3.7	1.4	-0.8	-0.0	1.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	1.0	3.0	1.7	0.3	0.6	0.7
Whole body fat mass	0.3	1.4	4.0	-2.0	0.6	1.1	0.0
Leg fat mass (right)	0.5	1.9	4.8	-2.2	0.9	1.3	-0.5
Arm predicted mass (right)	0.9	4.9	10.4	2.9	-0.2	0.7	3.2
Pulse rate, automated reading	0.2	0.6	1.0	-0.3	-1.0	0.9	-0.8
Alcohol intake frequency.	0.3	0.7	1.7	-0.3	0.9	0.3	-1.3
Comparative height size at age 10	0.9	5.1	10.8	2.5	-1.8	-0.3	3.3
Number of full sisters	2.9	3.6	10.1	1.5	-1.4	3.2	-0.2
Suffer from ‘nerves’	0.0	0.0	0.1	-0.3	-0.1	0.0	0.3
Overall health rating	0.9	1.9	4.9	0.9	-2.2	1.4	0.2
Chest pain or discomfort	1.3	1.9	3.1	1.6	-0.9	1.1	1.8
Had major operations	2.1	2.5	4.9	-1.7	-0.8	1.2	-2.2
Age at last live birth	0.2	0.3	0.5	-0.7	-0.0	0.7	-0.1
Family relationship satisfaction	0.2	0.2	0.4	0.2	-0.6	0.4	-0.6
Leg pain on walking	1.7	2.1	5.2	2.3	-1.5	0.1	1.0
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	1.2	-0.6	0.6	1.1	-0.9
Commuting to job workplace: Car/motor vehicle	0.7	0.8	1.4	-0.5	-0.6	-1.2	1.0
Illness, injury, bereavement, stress in last 2 years	1.6	2.0	4.3	-0.5	2.1	1.1	-1.5
Medication: Aspirin	1.3	1.7	3.8	0.9	0.2	-1.5	1.9
Supplements: Vitamin C	2.2	2.5	5.7	1.1	2.4	1.4	1.0
Knee pain experienced in last month	1.5	2.4	8.8	0.7	0.4	3.0	0.3
Hypertension (Self-reported)	0.5	1.4	2.9	1.7	-0.9	1.2	0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.0	1.2	3.1	0.2	-1.8	-1.0	0.7
Illnesses of father: Heart disease	1.6	2.2	6.1	0.7	1.5	-0.2	2.5
Illnesses of siblings: Diabetes	0.9	1.1	2.3	-0.8	1.5	-1.0	-0.5
Smoking status: Previous	0.7	1.1	4.2	2.0	-0.2	0.5	0.1
Forced expiratory volume in 1-second (FEV1), predicted	1.4	3.0	8.0	1.8	-0.6	-0.6	2.8
Whole body fat-free mass	0.9	5.4	12.9	2.8	-0.2	1.0	3.6
Leg fat-free mass (right)	0.6	3.4	9.2	1.9	0.2	0.8	3.0
Arm fat percentage (left)	0.7	3.0	9.2	-3.0	0.7	1.1	-1.0
Average weekly red wine intake	0.8	1.2	2.2	1.3	-1.5	0.9	0.5
Handedness (chirality/laterality): Left-handed	1.0	1.2	1.8	-1.1	-0.2	-1.3	-1.4
Mood swings	0.7	1.3	2.9	1.7	-1.1	-0.0	1.1
Loneliness, isolation	1.1	1.5	4.0	-0.2	-2.0	1.3	-0.5
Long-standing illness, disability or infirmity	0.9	1.4	4.1	2.0	-0.8	0.5	0.9
Ever had bowel cancer screening	1.3	1.5	3.3	1.5	-0.6	1.8	0.5
Diabetes diagnosed by doctor	1.1	1.9	4.1	0.5	-2.0	-1.0	1.5
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	0.6	-0.6	-0.8	-0.8	0.1
Friendships satisfaction	0.9	1.1	2.3	0.8	-1.5	-1.0	0.8
Qualifications: nursing, teaching	0.8	1.2	3.4	-0.3	0.6	1.8	0.9
Commuting to job workplace: Walk	1.3	1.4	3.4	1.4	-0.4	1.8	0.6
Eye problems/disorders: Cataract	3.2	3.7	10.5	1.3	0.9	3.2	1.4
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.7	0.8	0.6	-0.0	0.3
Medication for cholesterol	1.0	1.5	5.0	-2.2	-0.3	-0.8	-0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	0.7	0.3	-0.8	-0.1	-0.5
Back pain experienced in last month	0.6	0.8	2.7	0.1	-0.8	1.6	0.1
Mineral and other dietary supplements	0.8	1.1	2.5	-0.7	-1.6	-0.0	-1.2
Breast cancer (self-reported)	0.5	0.6	1.4	0.5	-0.8	1.2	-0.2
Asthma (self-reported)	0.1	0.3	0.7	-0.2	-0.8	-0.6	0.2
Osteoporosis (self-reported)	0.5	0.6	1.4	-0.1	0.8	1.2	-0.6
Osteoarthritis (self-reported)	0.7	0.9	2.5	0.7	0.6	1.6	-0.5
Medication: Aspirin	1.3	1.7	4.1	1.0	0.0	-1.3	2.0
Medication: Gliclazide	1.8	2.0	4.7	2.2	0.7	-0.2	1.7
Illnesses of father: None of the above (group 1)	0.4	0.5	1.6	-0.3	-1.3	0.2	-0.5
Smoking status: Current	0.3	0.5	1.4	-0.3	-0.4	1.2	-0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.3	2.8	4.6	-2.0	0.0	-2.1	-1.7
Whole body water mass	1.0	5.4	12.9	2.8	-0.3	1.0	3.6
Leg predicted mass (right)	0.6	3.3	9.3	1.8	0.2	0.7	3.1
Arm fat mass (left)	0.3	1.3	2.7	-1.7	0.5	1.5	0.4
Number of self-reported non-cancer illnesses	0.2	0.4	0.7	0.9	-0.9	0.1	-0.2
Average weekly champagne plus white wine intake	0.7	1.0	1.6	-1.0	-1.3	-0.2	1.1
Miserableness	0.5	0.9	2.2	1.5	-0.7	0.8	0.5
Guilty feelings	0.7	1.1	2.2	0.9	0.8	1.5	-0.9
Wears glasses or contact lenses	1.4	1.6	3.7	-0.8	1.3	-0.6	-1.9
Ever taken oral contraceptive pill	0.2	0.2	0.5	-0.4	0.0	-0.7	0.6
Hearing aid user	1.0	1.1	2.9	-0.7	-1.0	-0.4	-1.7
Mother’s age at death	0.2	0.3	0.6	-0.1	0.5	-0.8	-0.6
Financial situation satisfaction	0.7	0.9	2.4	-0.0	-1.6	1.0	-0.1
Tinnitus: Yes, now most or all of the time	0.4	0.5	1.3	0.5	1.1	0.3	0.6
Commuting to job workplace: Public transport	0.4	0.4	0.7	0.7	0.8	0.8	-0.1
Eye problems/disorders: Glaucoma	0.6	0.7	2.1	-0.7	1.4	0.6	-0.2
Medication: Blood pressure	2.9	5.5	14.3	3.8	0.6	1.9	1.9
Pain type(s) experienced in last month: Hip pain	0.7	0.9	1.8	0.5	-1.3	0.6	-1.1
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.4	-0.1	1.2	-0.1	-0.1
High cholesterol (Self-reported)	0.3	0.6	2.0	-0.2	0.0	1.4	0.5
Medication: Bendroflumethiazide	1.1	1.6	2.8	0.8	1.4	1.0	1.7
Medication: Paracetamol	0.7	1.0	3.6	-0.1	-1.9	0.6	-0.3
Medication: Lisinopril	0.7	0.9	1.2	1.0	0.9	0.6	-1.1
Medication: Atorvastatin	0.8	0.9	2.2	0.3	1.1	-0.5	1.5
Illnesses of father: High blood pressure	0.2	0.2	0.7	0.2	0.8	0.1	0.4
Alcohol drinker status: Never	0.2	0.3	0.4	-0.5	-0.5	-0.6	-0.6
Ever smoked	0.4	0.7	2.5	0.4	0.3	1.6	-0.4
Basal metabolic rate	0.8	4.3	11.1	2.2	-0.1	1.2	3.3
Leg fat percentage (left)	1.0	3.7	10.9	-3.3	0.9	0.8	-1.6
Arm fat-free mass (left)	1.0	5.0	11.8	2.7	-0.3	1.0	3.4
Number of operations (self-reported)	2.5	3.8	9.4	-2.0	0.8	0.9	-3.1
Average weekly beer plus cider intake	0.6	0.9	2.1	-0.5	-1.0	0.4	-1.4
Irritability	0.9	1.5	4.2	2.0	0.2	0.4	1.3
Risk taking	0.6	0.8	2.1	-1.4	-1.1	0.4	0.2
Ever had prostate specific antigen (PSA) test	2.4	2.8	3.9	1.1	2.0	2.0	1.5
Fractured/broken bones in last 5 years	1.6	2.0	6.4	-0.9	2.5	0.9	0.1
Age started oral contraceptive pill	0.2	0.2	0.8	-0.1	0.9	0.3	-0.3
Diastolic blood pressure, automated reading	2.0	6.2	11.3	-3.3	1.6	0.1	-3.4
Ever depressed for a whole week	0.4	0.5	1.4	-0.2	0.2	1.2	0.7
Unable to work because of sickness or disability	0.5	0.7	1.1	0.5	-1.0	0.4	-1.1
Commuting to job workplace: Cycle	0.6	0.7	1.5	0.6	1.2	-0.9	-0.2
Myopia	0.9	1.4	2.6	-1.3	-1.0	0.4	-1.6
Vascular/heart problems diagnosed by doctor	0.2	0.7	1.5	-0.9	1.2	-0.1	-0.6
Cholesterol lowering medication	0.3	0.5	1.0	0.5	0.7	1.0	0.3
Medication: Omeprazole (e.g. Zanprol)	1.6	1.9	3.0	-1.5	-1.4	-0.6	-1.7
Pain experienced in last month	0.4	0.7	2.1	-0.8	1.4	0.0	-0.2
Supplements: Calcium	0.5	0.6	2.2	-0.1	0.0	-1.5	0.4
Basal cell carcinoma (self-reported)	0.8	0.9	2.7	-0.6	-0.7	-1.7	-0.0
Heart attack/myocardial infarction (self-reported)	0.0	0.0	0.0	0.1	-0.2	-0.1	0.1
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	2.1	1.0	1.4	0.5	0.8
Heart disease (siblings)	0.2	0.3	0.8	0.0	-0.5	-0.9	0.0
Alcohol drinker status: Previous	1.3	1.4	2.8	-1.7	-0.9	-0.1	-1.4
Pack years of smoking	0.3	0.4	1.1	0.6	-1.1	-0.3	-0.3
Impedance of whole body	0.7	3.3	7.4	-2.7	-1.0	-1.5	-1.7
Leg fat mass (left)	0.4	1.5	3.8	-1.9	0.8	1.2	-0.4
Arm predicted mass (left)	0.9	4.7	10.4	2.5	-0.3	1.4	3.2