Best TWAS P=4.73e-12 · Best GWAS P=6.14e-18 conditioned to 4.21e-05
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adrenal Gland | KIAA1841 | 0.13 | 0.01 | enet | 15 | 0.02 | 4.6e-02 | -5.2 | 6.0 | 2.2e-09 | -0.15 | 0.06 | 0.27 | FALSE |
| 2 | GTEx | Brain Hippocampus | USP34 | 0.42 | -0.01 | lasso | 14 | 0.01 | 1.7e-01 | -4.9 | -6.0 | 1.6e-09 | 0.02 | 0.05 | 0.10 | TRUE |
| 3 | GTEx | Cells Transformed fibroblasts | PUS10 | 0.08 | 0.05 | lasso | 6 | 0.05 | 1.8e-04 | -4.6 | -5.4 | 6.2e-08 | 0.59 | 0.68 | 0.01 | FALSE |
| 4 | GTEx | Nerve Tibial | PUS10 | 0.11 | 0.06 | enet | 11 | 0.05 | 1.0e-04 | -3.7 | -5.3 | 1.4e-07 | 0.56 | 0.36 | 0.02 | FALSE |
| 5 | GTEx | Testis | RP11-373L24.1 | 0.12 | 0.08 | enet | 5 | 0.04 | 4.5e-03 | -5.1 | 5.2 | 1.9e-07 | -0.39 | 0.19 | 0.04 | FALSE |
| 6 | GTEx | Whole Blood | PUS10 | 0.10 | 0.02 | lasso | 4 | 0.04 | 2.5e-04 | -4.6 | -5.3 | 1.1e-07 | 0.48 | 0.41 | 0.06 | FALSE |
| 7 | METSIM | Adipose | AC016747.3 | 0.04 | 0.01 | lasso | 4 | 0.02 | 1.2e-04 | 3.3 | 5.9 | 3.0e-09 | -0.44 | 0.27 | 0.08 | FALSE |
| 8 | NTR | Blood | USP34 | 0.02 | 0.01 | lasso | 5 | 0.01 | 7.3e-04 | 4.9 | -6.9 | 4.7e-12 | 0.57 | 0.04 | 0.88 | TRUE |
| 9 | ROSMAP | Brain Pre-frontal Cortex | PUS10 | 0.04 | 0.01 | lasso | 3 | 0.03 | 4.9e-05 | -3.6 | -6.8 | 1.2e-11 | 0.73 | 0.01 | 0.96 | FALSE |
| 10 | The Cancer Genome Atlas | Brain Lower Grade Glioma | PEX13 | 0.04 | 0.02 | enet | 5 | 0.03 | 9.8e-05 | 4.4 | 5.2 | 2.1e-07 | -0.26 | 0.52 | 0.12 | TRUE |