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chr2:53,321,216-56,843,605

Best TWAS P=4.25e-209 · Best GWAS P=4.69e-293 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	ACYP2	0.06	0.02	blup	561	0.03	4.8e-05	-4.71	6.4	1.6e-10	-0.08	0.63	0.14	FALSE
2	CommonMind	Brain Pre-frontal Cortex	C2orf73	0.06	0.01	lasso	5	0.03	2.0e-04	-7.22	8.0	1.4e-15	-0.09	0.43	0.11	FALSE
3	CommonMind	Brain Pre-frontal Cortex	EFEMP1	0.31	0.08	bslmm	493	0.24	1.4e-28	5.56	-5.9	4.5e-09	0.43	1.00	0.00	FALSE
4	GTEx	Artery Tibial	EML6	0.24	0.16	lasso	7	0.22	2.9e-17	-6.09	-6.9	4.8e-12	-0.01	0.98	0.02	FALSE
5	GTEx	Artery Tibial	AC008280.3	0.09	0.05	lasso	4	0.06	2.6e-05	-4.82	6.1	1.1e-09	-0.04	0.62	0.13	FALSE
6	GTEx	Brain Caudate basal ganglia	HMGB1P31	0.31	0.23	lasso	5	0.19	3.8e-06	-7.87	-8.3	8.3e-17	0.05	0.24	0.32	FALSE
7	GTEx	Brain Cortex	HMGB1P31	0.14	0.00	enet	19	0.02	1.1e-01	-4.25	-7.3	3.1e-13	0.11	0.13	0.28	FALSE
8	GTEx	Brain Frontal Cortex BA9	SPTBN1	0.25	0.00	enet	23	0.07	6.5e-03	0.23	-6.0	2.0e-09	0.05	0.08	0.20	TRUE
9	GTEx	Brain Frontal Cortex BA9	EFEMP1	0.19	0.10	lasso	8	0.08	3.7e-03	-30.99	-30.9	4.2e-209	0.78	0.04	0.70	TRUE
10	GTEx	Brain Frontal Cortex BA9	HMGB1P31	0.17	0.03	enet	9	0.07	7.3e-03	-7.87	-8.1	8.2e-16	0.06	0.13	0.43	FALSE
11	GTEx	Brain Hippocampus	HMGB1P31	0.23	0.18	lasso	4	0.23	4.3e-06	-7.73	-6.6	5.3e-11	0.12	0.21	0.42	FALSE
12	GTEx	Brain Putamen basal ganglia	HMGB1P31	0.24	0.07	enet	16	0.08	5.8e-03	-3.87	-6.2	4.5e-10	0.11	0.13	0.35	FALSE
13	GTEx	Breast Mammary Tissue	HMGB1P31	0.15	0.08	lasso	2	0.10	1.1e-05	-5.15	-7.0	2.4e-12	0.14	0.30	0.68	FALSE
14	GTEx	Breast Mammary Tissue (Male)	HMGB1P31	0.17	0.09	lasso	1	0.07	1.3e-02	-6.91	-6.9	4.9e-12	0.10	0.10	0.59	FALSE
15	GTEx	Breast Mammary Tissue (Female)	SPTBN1	0.15	-0.01	lasso	3	0.00	4.7e-01	-5.15	-5.8	7.2e-09	0.14	0.07	0.12	FALSE
16	GTEx	Cells EBV-transformed lymphocytes	PNPT1	0.36	0.16	enet	24	0.04	1.7e-02	1.34	-6.1	9.9e-10	0.15	0.46	0.03	TRUE
17	GTEx	Cells Transformed fibroblasts	EFEMP1	0.11	0.00	enet	22	0.05	1.1e-04	1.10	-18.2	4.8e-74	0.39	0.16	0.57	TRUE
18	GTEx	Cells Transformed fibroblasts	ACYP2	0.20	0.09	enet	11	0.19	2.5e-14	-4.02	5.6	2.4e-08	-0.10	1.00	0.00	FALSE
19	GTEx	Cells Transformed fibroblasts	HMGB1P31	0.12	0.03	lasso	3	0.06	2.6e-05	-3.87	-6.9	5.8e-12	0.07	0.57	0.29	FALSE
20	GTEx	Colon Sigmoid	ACYP2	0.35	0.09	enet	21	0.18	4.6e-07	-1.09	5.9	4.0e-09	-0.07	0.93	0.03	FALSE
21	GTEx	Colon Sigmoid	RP11-477N3.1	0.22	0.00	lasso	5	0.00	3.1e-01	-4.46	6.3	2.2e-10	-0.07	0.06	0.34	FALSE
22	GTEx	Colon Transverse	RP11-477N3.1	0.20	0.03	lasso	7	0.08	1.8e-04	-5.90	8.3	1.2e-16	-0.12	0.07	0.77	FALSE
23	GTEx	Esophagus Muscularis	ACYP2	0.24	0.25	enet	21	0.25	2.5e-15	2.90	5.2	2.5e-07	-0.10	1.00	0.00	FALSE
24	GTEx	Esophagus Muscularis	EML6	0.35	0.35	lasso	7	0.36	6.9e-23	-6.09	-5.7	1.2e-08	-0.05	1.00	0.00	FALSE
25	GTEx	Esophagus Muscularis	RP11-477N3.1	0.21	0.10	lasso	5	0.15	1.5e-09	-7.87	7.9	2.4e-15	-0.07	0.23	0.77	FALSE
26	GTEx	Heart Atrial Appendage	RTN4	0.14	0.08	enet	23	0.05	2.9e-03	-4.92	-5.3	9.5e-08	-0.04	0.22	0.04	TRUE
27	GTEx	Heart Atrial Appendage	AC008280.3	0.13	0.00	enet	21	0.08	2.4e-04	-7.87	6.8	7.9e-12	-0.08	0.07	0.13	FALSE
28	GTEx	Heart Left Ventricle	RP11-477N3.1	0.32	0.10	enet	26	0.24	8.1e-13	-6.83	5.3	1.1e-07	-0.06	0.65	0.26	FALSE
29	GTEx	Liver	HMGB1P31	0.18	0.03	enet	9	0.05	1.9e-02	4.89	-8.1	6.1e-16	0.05	0.08	0.14	FALSE
30	GTEx	Muscle Skeletal	RTN4	0.09	0.04	enet	7	0.04	6.6e-05	2.25	-5.2	2.2e-07	0.01	0.72	0.01	FALSE
31	GTEx	Muscle Skeletal	HMGB1P31	0.26	0.17	enet	31	0.22	4.7e-21	-7.87	-5.7	1.3e-08	0.09	0.58	0.42	FALSE
32	GTEx	Nerve Tibial	ACYP2	0.12	0.04	enet	22	0.07	1.4e-05	-5.15	5.2	2.5e-07	-0.07	0.76	0.16	FALSE
33	GTEx	Pancreas	HMGB1P31	0.30	0.15	lasso	10	0.14	1.7e-06	-6.83	-6.1	1.2e-09	0.14	0.28	0.70	FALSE
34	GTEx	Skin Not Sun Exposed Suprapubic	ACYP2	0.09	0.10	lasso	2	0.09	1.5e-05	-5.15	5.5	3.4e-08	-0.14	0.43	0.54	FALSE
35	GTEx	Skin Sun Exposed Lower leg	SMEK2	0.08	0.09	lasso	4	0.08	4.6e-07	8.22	6.3	2.6e-10	-0.06	0.92	0.01	FALSE
36	GTEx	Skin Sun Exposed Lower leg	RP11-477N3.1	0.11	0.04	lasso	4	0.06	6.7e-06	3.18	6.3	3.6e-10	0.03	0.14	0.66	FALSE
37	GTEx	Small Intestine Terminal Ileum	RP11-554J4.1	0.39	0.06	lasso	10	0.16	1.8e-04	1.98	5.3	1.4e-07	-0.01	0.08	0.05	FALSE
38	GTEx	Stomach	SMEK2	0.14	0.02	enet	19	0.04	3.9e-03	1.06	-8.4	5.4e-17	0.08	0.10	0.04	TRUE
39	GTEx	Stomach	ACYP2	0.16	0.04	lasso	7	0.06	1.1e-03	-4.25	5.1	2.8e-07	-0.13	0.61	0.25	FALSE
40	GTEx	Stomach	HMGB1P31	0.11	0.07	lasso	4	0.07	3.1e-04	-5.29	-8.6	7.2e-18	0.09	0.19	0.63	TRUE
41	GTEx	Testis	ACYP2	0.12	0.07	lasso	5	0.07	3.3e-04	4.36	5.2	2.6e-07	-0.11	0.59	0.23	FALSE
42	GTEx	Testis	HMGB1P31	0.17	0.01	enet	21	0.02	4.6e-02	-7.87	-6.3	3.9e-10	0.05	0.21	0.36	FALSE
43	GTEx	Thyroid	RTN4	0.60	0.43	enet	38	0.63	1.5e-61	-6.29	-5.1	2.8e-07	-0.04	1.00	0.00	FALSE
44	GTEx	Thyroid	SMEK2	0.13	0.09	lasso	4	0.07	6.8e-06	8.29	6.2	5.2e-10	-0.07	0.96	0.00	TRUE
45	GTEx	Thyroid	ACYP2	0.13	0.06	lasso	6	0.08	1.8e-06	4.36	5.3	1.3e-07	-0.12	0.98	0.02	FALSE
46	GTEx	Whole Blood	RP11-554J4.1	0.13	0.03	lasso	5	0.03	6.4e-04	-8.21	-12.3	6.1e-35	0.08	0.16	0.13	FALSE
47	METSIM	Adipose	CCDC104	0.06	0.04	blup	440	0.02	3.3e-04	0.87	-8.1	4.2e-16	0.21	0.71	0.05	TRUE
48	METSIM	Adipose	EFEMP1	0.03	0.01	lasso	2	0.01	2.8e-03	11.61	-8.9	8.1e-19	-0.15	0.09	0.03	TRUE
49	NTR	Blood	PNPT1	0.02	0.01	enet	21	0.02	7.7e-06	1.64	-5.5	4.6e-08	0.09	0.94	0.00	FALSE
50	ROSMAP	Brain Pre-frontal Cortex	PSME4	0.07	0.08	enet	21	0.09	3.9e-11	-7.32	7.2	7.1e-13	-0.09	0.06	0.94	FALSE
51	ROSMAP	Brain Pre-frontal Cortex	ERLEC1	0.03	0.00	blup	467	0.01	5.1e-03	-8.53	-5.4	6.9e-08	0.11	0.05	0.90	FALSE
52	ROSMAP	Brain Pre-frontal Cortex	EFEMP1	0.29	0.14	enet	37	0.19	2.2e-24	-16.71	-16.1	5.3e-58	0.64	1.00	0.00	TRUE
53	ROSMAP	Brain Pre-frontal Cortex	PNPT1	0.06	0.01	blup	464	0.01	1.1e-02	5.45	12.1	1.2e-33	-0.12	0.76	0.01	TRUE
54	ROSMAP	Brain Pre-frontal Cortex	SMEK2	0.07	0.05	lasso	2	0.04	6.3e-06	4.84	-5.5	3.0e-08	0.02	0.75	0.01	FALSE
55	ROSMAP	Brain Pre-frontal Cortex	AC092839.1	0.10	0.07	enet	17	0.09	4.3e-12	5.79	7.5	6.9e-14	-0.01	1.00	0.00	FALSE
56	YFS	Blood	PSME4	0.04	0.02	enet	20	0.04	1.1e-11	-7.83	-6.3	3.9e-10	0.12	0.04	0.96	FALSE
57	YFS	Blood	SMEK2	0.07	0.04	enet	34	0.05	7.1e-17	0.33	10.2	2.0e-24	-0.24	1.00	0.00	FALSE
58	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	PSME4	0.05	0.02	blup	65	0.02	8.9e-03	-7.46	-6.2	7.6e-10	0.05	0.02	0.78	FALSE
59	The Cancer Genome Atlas	Breast Invasive Carcinoma	ACYP2	0.02	0.00	blup	122	0.01	2.0e-02	-5.61	6.4	1.6e-10	-0.12	0.25	0.07	FALSE
60	The Cancer Genome Atlas	Breast Invasive Carcinoma	C2orf73	0.12	0.09	lasso	6	0.12	1.4e-22	-7.22	6.7	2.7e-11	-0.10	0.50	0.50	FALSE
61	The Cancer Genome Atlas	Breast Invasive Carcinoma	EFEMP1	0.02	0.01	blup	79	0.02	3.9e-05	-36.59	17.0	3.8e-65	-0.73	0.00	1.00	TRUE
62	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	EML6	0.14	0.13	lasso	4	0.13	1.0e-14	5.17	5.4	7.4e-08	0.03	1.00	0.00	FALSE
63	The Cancer Genome Atlas	Brain Lower Grade Glioma	ACYP2	0.06	0.04	lasso	3	0.03	1.3e-04	-5.61	5.5	5.0e-08	-0.10	0.87	0.01	FALSE
64	The Cancer Genome Atlas	Brain Lower Grade Glioma	C2orf73	0.19	0.08	lasso	6	0.16	2.8e-18	3.13	5.9	3.9e-09	-0.08	0.92	0.08	FALSE
65	The Cancer Genome Atlas	Brain Lower Grade Glioma	SPTBN1	0.10	0.04	lasso	3	0.05	2.1e-06	3.80	5.8	6.6e-09	-0.03	0.82	0.02	FALSE
66	The Cancer Genome Atlas	Brain Lower Grade Glioma	TSPYL6	0.09	0.05	lasso	5	0.06	2.8e-07	2.48	-5.6	1.7e-08	-0.08	0.42	0.55	FALSE
67	The Cancer Genome Atlas	Lung Adenocarcinoma	C2orf73	0.05	0.02	lasso	7	0.04	3.9e-05	-7.22	6.4	1.2e-10	-0.06	0.21	0.36	FALSE
68	The Cancer Genome Atlas	Lung Adenocarcinoma	RTN4	0.07	0.08	blup	100	0.08	1.9e-09	2.25	-5.7	1.2e-08	0.04	1.00	0.00	FALSE
69	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	EML6	0.17	0.07	enet	5	0.07	2.5e-05	-5.99	-5.7	1.2e-08	-0.05	0.71	0.02	FALSE
70	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	C2orf73	0.30	0.23	blup	70	0.21	9.8e-09	-7.22	6.2	4.7e-10	-0.11	0.49	0.51	FALSE
71	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	SPTBN1	0.15	0.07	lasso	3	0.05	5.2e-03	-6.95	7.2	5.8e-13	0.04	0.06	0.29	TRUE
72	The Cancer Genome Atlas	Prostate Adenocarcinoma	C2orf73	0.29	0.13	lasso	4	0.17	1.4e-17	-7.21	6.0	1.5e-09	-0.08	0.51	0.49	FALSE
73	The Cancer Genome Atlas	Testicular Germ Cell Tumors	C2orf73	0.15	0.00	enet	13	0.06	3.8e-03	-2.74	6.0	1.7e-09	-0.08	0.04	0.24	FALSE
74	The Cancer Genome Atlas	Thyroid Carcinoma	C2orf73	0.45	0.26	lasso	6	0.32	1.1e-31	-7.22	6.4	1.7e-10	-0.11	0.50	0.50	FALSE