Best TWAS P=1.76e-10 · Best GWAS P=3.59e-17 conditioned to 3.24e-08
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Artery Coronary | ZNF514 | 0.32 | 0.20 | lasso | 8 | 0.22 | 4.3e-08 | -5.986 | 6.3 | 2.4e-10 | -0.83 | 0.15 | 0.77 | FALSE |
2 | GTEx | Esophagus Muscularis | ZNF514 | 0.47 | 0.15 | enet | 22 | 0.27 | 1.2e-16 | -5.986 | 5.2 | 1.5e-07 | -0.67 | 0.01 | 0.99 | FALSE |
3 | GTEx | Heart Atrial Appendage | ZNF514 | 0.22 | 0.00 | enet | 19 | 0.08 | 1.2e-04 | -3.889 | 6.0 | 2.1e-09 | -0.62 | 0.05 | 0.72 | FALSE |
4 | GTEx | Heart Left Ventricle | ZNF514 | 0.29 | 0.07 | enet | 21 | 0.20 | 8.9e-11 | -3.372 | 5.9 | 4.3e-09 | -0.53 | 0.35 | 0.58 | FALSE |
5 | GTEx | Pancreas | ZNF514 | 0.25 | 0.09 | lasso | 4 | 0.16 | 2.8e-07 | -1.504 | 5.8 | 7.9e-09 | -0.69 | 0.01 | 0.96 | FALSE |
6 | GTEx | Skin Not Sun Exposed Suprapubic | ZNF514 | 0.46 | 0.02 | enet | 34 | 0.24 | 3.3e-13 | 2.690 | 5.3 | 1.1e-07 | -0.52 | 0.02 | 0.94 | FALSE |
7 | GTEx | Spleen | ZNF514 | 0.29 | 0.06 | enet | 10 | 0.12 | 4.8e-04 | -8.425 | 6.4 | 1.8e-10 | -0.79 | 0.01 | 0.80 | TRUE |
8 | The Cancer Genome Atlas | Glioblastoma Multiforme | ZNF514 | 0.41 | 0.02 | lasso | 4 | 0.17 | 6.1e-06 | -8.425 | 6.0 | 1.4e-09 | -0.71 | 0.00 | 0.81 | FALSE |
9 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | ZNF514 | 0.70 | 0.05 | lasso | 3 | 0.30 | 4.7e-13 | 0.072 | 5.3 | 1.3e-07 | -0.60 | 0.03 | 0.93 | FALSE |