Best TWAS P=3.02e-17 · Best GWAS P=1.24e-19 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Coronary | LMAN2L | 0.11 | 0.01 | enet | 9 | 0.05 | 8.3e-03 | -6.2 | -6.6 | 3.4e-11 | -0.10 | 0.09 | 0.06 | FALSE |
| 2 | GTEx | Brain Hippocampus | LMAN2L | 0.20 | 0.09 | lasso | 9 | 0.06 | 1.6e-02 | 4.9 | -5.3 | 1.0e-07 | 0.00 | 0.11 | 0.11 | FALSE |
| 3 | GTEx | Brain Hippocampus | ANKRD36 | 0.33 | 0.02 | enet | 22 | 0.12 | 7.6e-04 | -5.7 | -5.5 | 3.0e-08 | -0.01 | 0.07 | 0.08 | FALSE |
| 4 | GTEx | Cells Transformed fibroblasts | LMAN2L | 0.11 | 0.09 | lasso | 3 | 0.11 | 1.7e-08 | -5.9 | -6.6 | 5.5e-11 | -0.18 | 0.99 | 0.00 | TRUE |
| 5 | GTEx | Cells Transformed fibroblasts | ANKRD36 | 0.32 | 0.04 | enet | 21 | 0.15 | 2.3e-11 | 2.6 | -5.3 | 9.4e-08 | 0.10 | 0.97 | 0.00 | FALSE |
| 6 | GTEx | Esophagus Mucosa | LMAN2L | 0.09 | 0.09 | lasso | 3 | 0.08 | 9.7e-06 | -7.4 | -7.5 | 8.3e-14 | -0.14 | 0.62 | 0.13 | FALSE |
| 7 | GTEx | Heart Left Ventricle | LMAN2L | 0.07 | 0.00 | enet | 12 | 0.01 | 1.1e-01 | -6.2 | -5.6 | 2.1e-08 | -0.23 | 0.12 | 0.18 | FALSE |
| 8 | GTEx | Muscle Skeletal | LMAN2L | 0.12 | 0.08 | enet | 7 | 0.07 | 8.8e-08 | -7.5 | -6.9 | 6.5e-12 | -0.16 | 0.99 | 0.00 | FALSE |
| 9 | GTEx | Nerve Tibial | LMAN2L | 0.16 | 0.14 | lasso | 2 | 0.14 | 5.5e-10 | -6.1 | -6.2 | 7.1e-10 | -0.18 | 1.00 | 0.00 | FALSE |
| 10 | GTEx | Nerve Tibial | ACTR1B | 0.42 | 0.19 | enet | 11 | 0.23 | 2.3e-16 | -4.8 | -5.6 | 1.8e-08 | 0.06 | 0.63 | 0.37 | TRUE |
| 11 | GTEx | Pancreas | ACTR1B | 0.09 | 0.09 | enet | 26 | 0.08 | 2.0e-04 | -7.6 | -5.9 | 3.0e-09 | 0.05 | 0.00 | 0.97 | TRUE |
| 12 | GTEx | Skin Sun Exposed Lower leg | LMAN2L | 0.07 | 0.02 | lasso | 3 | 0.01 | 3.1e-02 | -7.4 | -7.6 | 2.6e-14 | -0.15 | 0.10 | 0.15 | FALSE |
| 13 | GTEx | Testis | ANKRD36 | 0.20 | 0.05 | lasso | 4 | 0.02 | 3.1e-02 | 2.6 | -6.2 | 5.4e-10 | 0.49 | 0.02 | 0.57 | FALSE |
| 14 | GTEx | Whole Blood | ACTR1B | 0.09 | 0.04 | lasso | 3 | 0.04 | 1.7e-04 | -4.8 | -5.8 | 6.8e-09 | 0.07 | 0.01 | 0.99 | FALSE |
| 15 | METSIM | Adipose | ACTR1B | 0.18 | 0.14 | lasso | 7 | 0.16 | 2.0e-22 | -7.6 | -7.6 | 2.6e-14 | 0.11 | 0.00 | 1.00 | TRUE |
| 16 | METSIM | Adipose | ANKRD36 | 0.07 | 0.04 | lasso | 5 | 0.04 | 1.2e-06 | -4.8 | -6.1 | 1.1e-09 | 0.03 | 0.96 | 0.00 | FALSE |
| 17 | YFS | Blood | ARID5A | 0.06 | 0.04 | lasso | 8 | 0.05 | 3.9e-17 | -4.7 | -5.4 | 7.9e-08 | 0.04 | 0.26 | 0.74 | FALSE |
| 18 | YFS | Blood | LMAN2L | 0.07 | 0.02 | enet | 18 | 0.02 | 2.7e-08 | -7.5 | -8.4 | 3.0e-17 | 0.02 | 1.00 | 0.00 | TRUE |
| 19 | The Cancer Genome Atlas | Breast Invasive Carcinoma | LMAN2L | 0.03 | 0.01 | enet | 2 | 0.02 | 1.6e-04 | 4.8 | -7.1 | 1.5e-12 | -0.01 | 0.18 | 0.02 | TRUE |
| 20 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | TMEM131 | 0.08 | 0.00 | blup | 72 | 0.01 | 5.4e-02 | -7.6 | -5.8 | 5.0e-09 | 0.12 | 0.01 | 0.83 | FALSE |
| 21 | The Cancer Genome Atlas | Brain Lower Grade Glioma | LMAN2L | 0.03 | 0.01 | blup | 22 | 0.01 | 8.9e-03 | 5.2 | -6.8 | 1.1e-11 | -0.19 | 0.01 | 0.04 | FALSE |
| 22 | The Cancer Genome Atlas | Prostate Adenocarcinoma | LMAN2L | 0.05 | 0.01 | blup | 23 | 0.03 | 3.4e-04 | 4.8 | -7.7 | 1.3e-14 | 0.05 | 0.06 | 0.04 | FALSE |
| 23 | The Cancer Genome Atlas | Thyroid Carcinoma | LMAN2L | 0.09 | 0.09 | blup | 22 | 0.07 | 1.1e-07 | -7.5 | -5.7 | 1.5e-08 | -0.24 | 0.99 | 0.00 | TRUE |