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chr2:127,246,019-129,652,948

Best TWAS P=5.31e-21 · Best GWAS P=9.91e-20 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	CYP27C1	0.05	0.02	enet	10	0.05	5.0e-07	5.5	-5.5	3.7e-08	0.00	0.31	0.49	FALSE
2	GTEx	Adipose Subcutaneous	UGGT1	0.07	0.05	lasso	3	0.06	1.7e-05	9.1	-9.1	9.0e-20	-0.99	0.01	0.99	FALSE
3	GTEx	Adipose Subcutaneous	ERCC3	0.27	0.26	enet	30	0.27	3.2e-22	6.1	-5.5	3.0e-08	0.05	0.15	0.85	TRUE
4	GTEx	Adipose Subcutaneous	MAP3K2	0.12	0.14	enet	10	0.16	1.1e-12	-4.5	6.0	2.0e-09	-0.04	0.09	0.91	FALSE
5	GTEx	Adipose Visceral Omentum	ERCC3	0.25	0.21	lasso	8	0.22	1.5e-11	6.1	-6.0	2.5e-09	0.05	0.14	0.86	FALSE
6	GTEx	Artery Aorta	UGGT1	0.16	0.16	lasso	3	0.17	1.1e-09	9.1	-8.7	5.3e-18	-0.97	0.01	0.99	FALSE
7	GTEx	Artery Aorta	ERCC3	0.21	0.23	lasso	6	0.23	4.5e-13	6.1	-6.1	1.0e-09	0.06	0.13	0.87	FALSE
8	GTEx	Artery Aorta	MAP3K2	0.15	0.08	lasso	2	0.08	3.5e-05	5.2	5.7	1.6e-08	-0.03	0.04	0.95	FALSE
9	GTEx	Artery Coronary	GPR17	0.58	0.15	lasso	7	0.32	1.4e-11	4.1	5.5	3.8e-08	0.20	0.88	0.02	FALSE
10	GTEx	Artery Coronary	MAP3K2	0.25	0.12	lasso	9	0.14	1.7e-05	-4.6	5.8	7.3e-09	-0.01	0.02	0.97	FALSE
11	GTEx	Artery Tibial	UGGT1	0.08	0.04	enet	15	0.04	4.2e-04	9.1	-6.6	3.3e-11	-0.81	0.01	0.98	FALSE
12	GTEx	Artery Tibial	ERCC3	0.15	0.17	enet	21	0.15	1.6e-11	6.2	-6.2	7.5e-10	0.08	0.13	0.87	FALSE
13	GTEx	Brain Cerebellar Hemisphere	ERCC3	0.23	0.02	enet	27	0.05	2.4e-02	6.8	-5.8	7.7e-09	-0.01	0.03	0.75	FALSE
14	GTEx	Breast Mammary Tissue	ERCC3	0.25	0.30	lasso	3	0.35	1.6e-18	6.1	-5.9	3.3e-09	0.06	0.15	0.85	FALSE
15	GTEx	Breast Mammary Tissue	MAP3K2	0.23	0.07	lasso	5	0.07	1.8e-04	6.6	7.3	1.9e-13	0.00	0.01	0.98	TRUE
16	GTEx	Breast Mammary Tissue (Male)	GPR17	0.45	0.02	enet	40	0.14	4.6e-04	6.5	6.5	1.1e-10	0.18	0.11	0.05	TRUE
17	GTEx	Breast Mammary Tissue (Male)	ERCC3	0.24	0.15	lasso	7	0.16	1.3e-04	6.1	-6.3	2.2e-10	0.04	0.11	0.81	FALSE
18	GTEx	Breast Mammary Tissue (Male)	MAP3K2	0.23	0.07	lasso	3	0.10	2.8e-03	6.6	6.3	3.5e-10	-0.01	0.02	0.75	FALSE
19	GTEx	Breast Mammary Tissue (Female)	GPR17	0.13	0.06	enet	12	0.04	2.5e-02	4.1	5.7	1.5e-08	0.30	0.06	0.13	TRUE
20	GTEx	Breast Mammary Tissue (Female)	ERCC3	0.30	0.24	lasso	9	0.28	4.0e-09	6.1	-6.1	1.1e-09	0.05	0.11	0.89	FALSE
21	GTEx	Cells EBV-transformed lymphocytes	MAP3K2	0.29	0.14	lasso	4	0.11	1.6e-04	-4.5	5.6	1.8e-08	-0.04	0.03	0.92	FALSE
22	GTEx	Cells Transformed fibroblasts	UGGT1	0.13	0.13	lasso	3	0.12	2.3e-09	9.0	-9.1	6.1e-20	-0.99	0.01	0.99	FALSE
23	GTEx	Cells Transformed fibroblasts	ERCC3	0.25	0.13	enet	22	0.20	1.4e-14	6.1	-6.0	2.0e-09	0.09	0.16	0.84	FALSE
24	GTEx	Cells Transformed fibroblasts	MAP3K2	0.10	0.07	lasso	4	0.08	2.2e-06	5.3	5.4	7.8e-08	-0.03	0.09	0.91	FALSE
25	GTEx	Colon Transverse	GPR17	0.23	0.05	enet	31	0.10	2.1e-05	1.4	5.5	2.8e-08	0.05	0.46	0.05	TRUE
26	GTEx	Colon Transverse	ERCC3	0.17	0.19	lasso	4	0.14	5.0e-07	6.1	-6.1	8.7e-10	0.06	0.14	0.86	FALSE
27	GTEx	Esophagus Gastroesophageal Junction	ERCC3	0.17	0.08	lasso	3	0.10	1.8e-04	6.2	-6.4	1.8e-10	0.06	0.09	0.86	FALSE
28	GTEx	Esophagus Mucosa	ERCC3	0.18	0.13	lasso	7	0.13	9.7e-09	6.1	-6.2	4.5e-10	0.07	0.15	0.85	FALSE
29	GTEx	Esophagus Mucosa	MAP3K2	0.10	0.06	enet	9	0.06	6.0e-05	6.1	6.7	1.9e-11	-0.07	0.04	0.95	FALSE
30	GTEx	Esophagus Muscularis	UGGT1	0.12	0.13	lasso	7	0.13	2.7e-08	9.1	-9.1	1.0e-19	-0.98	0.01	0.99	FALSE
31	GTEx	Esophagus Muscularis	GPR17	0.59	0.23	enet	46	0.40	7.6e-26	4.1	6.1	8.2e-10	0.30	1.00	0.00	FALSE
32	GTEx	Esophagus Muscularis	ERCC3	0.18	0.11	lasso	7	0.15	3.2e-09	6.1	-6.4	1.6e-10	0.06	0.16	0.84	FALSE
33	GTEx	Esophagus Muscularis	MAP3K2	0.13	0.12	enet	11	0.18	8.1e-11	-4.3	6.1	1.3e-09	-0.05	0.01	0.99	FALSE
34	GTEx	Heart Atrial Appendage	ERCC3	0.21	0.14	lasso	7	0.11	1.2e-05	5.9	-6.2	4.6e-10	0.01	0.07	0.92	FALSE
35	GTEx	Lung	ERCC3	0.20	0.18	lasso	3	0.17	6.7e-13	6.1	-6.0	1.9e-09	0.07	0.14	0.86	FALSE
36	GTEx	Muscle Skeletal	ERCC3	0.12	0.12	enet	8	0.11	1.6e-10	6.1	-6.1	9.8e-10	0.07	0.15	0.85	FALSE
37	GTEx	Nerve Tibial	UGGT1	0.18	0.15	enet	18	0.13	1.6e-09	9.1	-9.4	5.3e-21	-0.91	0.01	0.99	TRUE
38	GTEx	Nerve Tibial	ERCC3	0.45	0.41	enet	12	0.43	1.5e-32	6.1	-6.1	8.3e-10	0.07	0.16	0.84	FALSE
39	GTEx	Nerve Tibial	MAP3K2	0.18	0.06	enet	10	0.06	4.4e-05	-4.5	6.0	1.4e-09	-0.03	0.02	0.98	FALSE
40	GTEx	Pancreas	GPR17	0.43	0.19	enet	25	0.35	2.1e-15	4.1	5.5	4.7e-08	0.09	0.90	0.01	TRUE
41	GTEx	Pancreas	ERCC3	0.21	0.13	lasso	5	0.15	6.9e-07	6.1	-5.9	3.9e-09	0.06	0.12	0.85	FALSE
42	GTEx	Prostate	ERCC3	0.28	0.06	lasso	5	0.03	5.8e-02	5.5	-6.1	8.2e-10	0.02	0.05	0.65	FALSE
43	GTEx	Skin Not Sun Exposed Suprapubic	UGGT1	0.13	0.01	lasso	3	0.01	7.8e-02	9.1	-5.2	2.3e-07	-0.85	0.02	0.81	FALSE
44	GTEx	Skin Not Sun Exposed Suprapubic	ERCC3	0.19	0.15	enet	15	0.21	7.7e-12	6.1	-5.4	8.2e-08	0.07	0.16	0.84	FALSE
45	GTEx	Skin Not Sun Exposed Suprapubic	MAP3K2	0.17	0.10	lasso	3	0.09	1.5e-05	-4.4	5.4	6.2e-08	-0.04	0.26	0.71	FALSE
46	GTEx	Skin Sun Exposed Lower leg	UGGT1	0.07	0.07	lasso	5	0.05	6.3e-05	9.1	-9.2	5.0e-20	-0.99	0.01	0.99	FALSE
47	GTEx	Skin Sun Exposed Lower leg	ERCC3	0.26	0.21	enet	16	0.22	2.5e-18	6.1	-5.5	3.3e-08	0.10	0.16	0.84	FALSE
48	GTEx	Skin Sun Exposed Lower leg	MAP3K2	0.06	0.04	enet	11	0.04	5.0e-04	6.8	6.2	4.7e-10	0.01	0.00	0.99	FALSE
49	GTEx	Spleen	ERCC3	0.44	0.42	enet	21	0.42	4.9e-12	6.1	-6.3	2.4e-10	0.05	0.12	0.88	FALSE
50	GTEx	Stomach	ERCC3	0.14	0.11	lasso	2	0.12	3.6e-06	-4.3	-5.4	7.0e-08	0.06	0.45	0.38	FALSE
51	GTEx	Testis	MAP3K2	0.17	0.12	lasso	2	0.12	3.5e-06	5.2	6.0	1.9e-09	-0.04	0.09	0.91	FALSE
52	GTEx	Thyroid	ERCC3	0.22	0.22	lasso	5	0.24	4.1e-18	6.1	-6.2	5.0e-10	0.06	0.16	0.84	FALSE
53	METSIM	Adipose	ERCC3	0.15	0.15	lasso	13	0.17	3.9e-25	6.1	-5.8	7.7e-09	0.05	0.11	0.89	FALSE
54	METSIM	Adipose	UGGT1	0.10	0.10	enet	17	0.10	2.5e-14	9.0	-8.0	1.5e-15	-0.94	0.01	0.99	FALSE
55	ROSMAP	Brain Pre-frontal Cortex	ERCC3	0.27	0.33	enet	25	0.34	2.5e-45	6.1	-6.0	1.4e-09	0.06	0.15	0.85	FALSE
56	ROSMAP	Brain Pre-frontal Cortex	MAP3K2	0.11	0.08	enet	19	0.08	3.2e-10	6.1	6.5	8.6e-11	-0.06	0.11	0.89	FALSE
57	YFS	Blood	ERCC3	0.07	0.03	bslmm	457	0.05	6.5e-16	6.2	-6.4	1.5e-10	0.07	0.11	0.89	FALSE
58	The Cancer Genome Atlas	Breast Invasive Carcinoma	ERCC3	0.06	0.00	enet	10	0.01	1.7e-02	5.3	-5.7	1.1e-08	0.09	0.01	0.37	FALSE
59	The Cancer Genome Atlas	Breast Invasive Carcinoma	UGGT1	0.02	0.02	blup	65	0.02	2.5e-04	8.8	-9.0	2.4e-19	-0.89	0.02	0.88	FALSE
60	The Cancer Genome Atlas	Glioblastoma Multiforme	PROC	0.14	0.06	blup	39	0.07	2.8e-03	5.0	-6.5	8.7e-11	0.03	0.01	0.67	FALSE
61	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ERCC3	0.05	0.06	lasso	3	0.06	7.1e-07	6.1	-6.1	1.1e-09	0.07	0.01	0.99	FALSE
62	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MAP3K2	0.03	0.00	enet	10	0.02	3.3e-03	6.1	6.0	2.1e-09	-0.06	0.01	0.61	FALSE
63	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PROC	0.05	0.05	lasso	2	0.04	7.2e-05	6.8	-6.7	3.0e-11	0.03	0.00	1.00	FALSE
64	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PROC	0.08	0.03	lasso	5	0.03	7.9e-03	6.6	-6.5	5.8e-11	0.02	0.00	0.96	FALSE
65	The Cancer Genome Atlas	Brain Lower Grade Glioma	UGGT1	0.06	0.02	enet	7	0.04	1.7e-05	4.4	-6.7	2.0e-11	-0.76	0.05	0.89	FALSE
66	The Cancer Genome Atlas	Lung Adenocarcinoma	ERCC3	0.04	0.04	lasso	3	0.03	7.1e-05	5.2	-5.7	9.3e-09	0.04	0.01	0.97	FALSE
67	The Cancer Genome Atlas	Lung Adenocarcinoma	UGGT1	0.04	0.03	blup	65	0.02	9.4e-04	3.6	-6.8	9.6e-12	-0.74	0.03	0.47	FALSE
68	The Cancer Genome Atlas	Prostate Adenocarcinoma	ERCC3	0.04	0.03	blup	45	0.04	9.1e-05	-4.6	-5.9	3.3e-09	0.06	0.02	0.77	FALSE
69	The Cancer Genome Atlas	Soft Tissue Sarcoma	UGGT1	0.08	0.03	enet	15	0.02	1.7e-02	6.1	-6.6	4.7e-11	-0.58	0.02	0.48	TRUE
70	The Cancer Genome Atlas	Thyroid Carcinoma	ERCC3	0.05	0.05	lasso	4	0.06	2.7e-06	6.2	-6.2	4.9e-10	0.05	0.01	0.99	FALSE
71	The Cancer Genome Atlas	Thyroid Carcinoma	UGGT1	0.04	0.00	blup	65	0.02	8.6e-03	9.0	-8.9	6.0e-19	-0.92	0.01	0.81	FALSE