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chr2:134,181,178-137,435,625

Best TWAS P=3.02e-16 · Best GWAS P=1.16e-16 conditioned to 0.00188

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Breast Mammary Tissue	MGAT5	0.19	0.00	enet	20	0.02	3.4e-02	0.68	5.8	5.9e-09	-0.03	0.08	0.06	TRUE
2	GTEx	Ovary	DARS	0.28	0.12	lasso	5	0.11	1.1e-03	-7.76	-7.3	2.6e-13	0.67	0.06	0.64	FALSE
3	GTEx	Skin Sun Exposed Lower leg	RAB3GAP1	0.04	0.00	enet	8	0.00	2.3e-01	-7.61	7.6	3.5e-14	-0.74	0.08	0.47	FALSE
4	METSIM	Adipose	CCNT2	0.07	0.02	bslmm	345	0.02	2.6e-04	2.06	5.3	1.3e-07	-0.30	0.89	0.00	FALSE
5	The Cancer Genome Atlas	Breast Invasive Carcinoma	ZRANB3	0.04	0.06	lasso	6	0.06	3.3e-12	-7.85	7.8	4.1e-15	-0.82	0.11	0.89	FALSE
6	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	ZRANB3	0.08	0.01	lasso	11	0.00	1.9e-01	-7.88	7.4	1.4e-13	-0.63	0.06	0.42	FALSE
7	The Cancer Genome Atlas	Colon Adenocarcinoma	ZRANB3	0.06	0.05	blup	118	0.06	3.5e-04	-7.85	7.9	2.1e-15	-0.75	0.10	0.86	FALSE
8	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	RAB3GAP1	0.02	0.01	blup	74	0.02	6.5e-03	-7.92	7.8	8.2e-15	-0.66	0.02	0.66	FALSE
9	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ZRANB3	0.05	0.06	blup	118	0.04	2.5e-05	-7.87	7.4	9.7e-14	-0.67	0.10	0.90	FALSE
10	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ZRANB3	0.12	0.04	blup	118	0.05	6.6e-06	-7.95	8.2	3.0e-16	-0.74	0.08	0.92	TRUE
11	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	ZRANB3	0.04	0.05	blup	118	0.05	5.8e-04	-7.76	8.2	3.3e-16	-0.77	0.07	0.82	FALSE
12	The Cancer Genome Atlas	Lung Adenocarcinoma	RAB3GAP1	0.04	0.01	lasso	5	0.01	1.4e-02	-7.76	7.4	1.9e-13	-0.74	0.02	0.37	FALSE
13	The Cancer Genome Atlas	Lung Adenocarcinoma	ZRANB3	0.02	0.02	lasso	11	0.03	5.4e-04	-7.88	8.2	3.4e-16	-0.81	0.09	0.87	FALSE
14	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ZRANB3	0.05	0.04	blup	118	0.05	1.3e-06	-7.76	7.8	8.8e-15	-0.75	0.10	0.90	FALSE
15	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	ZRANB3	0.27	0.07	enet	39	0.06	7.1e-05	-6.35	5.9	4.8e-09	-0.65	0.17	0.77	FALSE
16	The Cancer Genome Atlas	Prostate Adenocarcinoma	ZRANB3	0.31	0.08	enet	8	0.11	2.8e-11	-8.29	8.1	7.5e-16	-0.92	0.00	1.00	FALSE
17	The Cancer Genome Atlas	Testicular Germ Cell Tumors	ZRANB3	0.19	0.10	lasso	7	0.12	6.5e-05	-7.86	6.8	1.4e-11	-0.57	0.09	0.80	FALSE
18	The Cancer Genome Atlas	Thyroid Carcinoma	R3HDM1	0.04	0.00	enet	6	0.03	4.9e-04	-7.80	-7.0	2.2e-12	0.52	0.02	0.46	FALSE
19	The Cancer Genome Atlas	Thyroid Carcinoma	ZRANB3	0.07	0.04	blup	118	0.06	3.3e-06	-7.76	7.8	9.0e-15	-0.76	0.10	0.90	FALSE