Best TWAS P=4.53e-08 · Best GWAS P=9.63e-53 conditioned to 4.33e-54
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | EPB41L5 | 0.11 | 0.13 | lasso | 11 | 0.12 | 1.8e-14 | 4.6 | -5.2 | 1.7e-07 | 0.01 | 0.93 | 0.07 | FALSE |
| 2 | GTEx | Adrenal Gland | TMEM185B | 0.27 | 0.00 | lasso | 4 | 0.02 | 8.7e-02 | 4.5 | 5.4 | 7.1e-08 | -0.01 | 0.08 | 0.10 | FALSE |
| 3 | GTEx | Brain Cerebellar Hemisphere | EPB41L5 | 0.33 | 0.22 | lasso | 16 | 0.20 | 1.0e-05 | 5.6 | -5.2 | 1.7e-07 | -0.06 | 0.09 | 0.86 | FALSE |
| 4 | GTEx | Brain Cerebellum | EPB41L5 | 0.37 | 0.30 | lasso | 4 | 0.22 | 3.8e-07 | 5.0 | -5.2 | 2.2e-07 | -0.04 | 0.12 | 0.87 | FALSE |
| 5 | GTEx | Brain Cerebellum | AC012363.4 | 0.34 | 0.06 | lasso | 5 | 0.08 | 1.9e-03 | 5.0 | -5.3 | 9.7e-08 | -0.05 | 0.08 | 0.71 | FALSE |
| 6 | GTEx | Cells Transformed fibroblasts | PTPN4 | 0.06 | 0.02 | lasso | 2 | 0.03 | 1.5e-03 | 5.6 | 5.3 | 9.6e-08 | 0.05 | 0.06 | 0.93 | FALSE |
| 7 | GTEx | Small Intestine Terminal Ileum | AC012363.4 | 0.33 | 0.01 | enet | 28 | 0.04 | 5.2e-02 | 3.6 | -5.2 | 1.8e-07 | 0.01 | 0.04 | 0.14 | FALSE |
| 8 | GTEx | Testis | TMEM185B | 0.12 | 0.09 | enet | 10 | 0.12 | 5.7e-06 | 3.5 | 5.1 | 2.9e-07 | 0.02 | 0.23 | 0.74 | FALSE |
| 9 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | TMEM185B | 0.03 | 0.03 | lasso | 3 | 0.02 | 5.2e-03 | 5.6 | 5.5 | 4.5e-08 | 0.03 | 0.00 | 0.96 | TRUE |
| 10 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | TMEM185B | 0.07 | 0.03 | blup | 21 | 0.03 | 1.3e-02 | 5.6 | 5.2 | 2.0e-07 | 0.01 | 0.00 | 0.87 | FALSE |
| 11 | The Cancer Genome Atlas | Thyroid Carcinoma | EPB41L5 | 0.03 | 0.01 | blup | 54 | 0.00 | 3.2e-01 | 4.4 | -5.1 | 2.9e-07 | 0.00 | 0.03 | 0.41 | FALSE |