Best TWAS P=5.49e-12 · Best GWAS P=8.34e-12 conditioned to 0.878
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | HTR6 | 0.09 | 0.05 | lasso | 5 | 0.03 | 4.9e-05 | 5.6 | 5.4 | 5.6e-08 | 0.08 | 0.04 | 0.96 | TRUE |
| 2 | GTEx | Brain Cerebellum | HP1BP3 | 0.27 | 0.07 | lasso | 4 | 0.03 | 3.8e-02 | 5.4 | 5.6 | 2.8e-08 | 0.81 | 0.05 | 0.37 | FALSE |
| 3 | GTEx | Heart Atrial Appendage | EIF4G3 | 0.23 | 0.06 | lasso | 6 | 0.03 | 1.1e-02 | -4.1 | -5.3 | 1.0e-07 | -0.74 | 0.07 | 0.84 | FALSE |
| 4 | GTEx | Lung | EIF4G3 | 0.08 | 0.03 | lasso | 3 | 0.02 | 5.7e-03 | 6.8 | -6.6 | 4.5e-11 | -0.95 | 0.03 | 0.96 | FALSE |
| 5 | GTEx | Muscle Skeletal | EIF4G3 | 0.09 | 0.05 | lasso | 6 | 0.03 | 2.9e-04 | 6.8 | -6.5 | 6.3e-11 | -0.94 | 0.02 | 0.98 | FALSE |
| 6 | GTEx | Whole Blood | RP5-930J4.4 | 0.07 | 0.09 | lasso | 5 | 0.09 | 1.0e-08 | -4.8 | -5.5 | 4.2e-08 | -0.81 | 0.43 | 0.57 | FALSE |
| 7 | ROSMAP | Brain Pre-frontal Cortex | HP1BP3 | 0.02 | 0.02 | blup | 467 | 0.02 | 4.0e-03 | 6.4 | 6.9 | 5.5e-12 | 0.92 | 0.06 | 0.86 | TRUE |
| 8 | The Cancer Genome Atlas | Breast Invasive Carcinoma | HP1BP3 | 0.01 | 0.00 | blup | 52 | 0.00 | 4.2e-02 | 6.2 | 5.9 | 4.3e-09 | 0.91 | 0.01 | 0.72 | FALSE |
| 9 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SH2D5 | 0.04 | 0.04 | blup | 56 | 0.02 | 2.2e-03 | 6.3 | -5.9 | 3.7e-09 | -0.87 | 0.00 | 0.99 | FALSE |