Hub : Genes

HP1BP3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cerebellum	0.2670	0.1090	0.0057	0.073	NA	0.009	NA	0.033	0.00340	NA	0.170	NA	0.0380
2	GTEx	Whole Blood	0.0380	0.0170	0.0045	0.038	NA	0.015	NA	0.019	0.00019	NA	0.014	NA	0.0063
3	ROSMAP	Brain Pre-frontal Cortex	0.0209	0.0114	0.0170	0.021	0.015	0.000	0.013	0.007	0.00081	0.004	0.310	0.0063	0.0390
4	TCGA	Breast Invasive Carcinoma	0.0098	0.0060	0.0086	0.005	0.004	0.000	NA	-0.001	0.03200	0.042	0.260	NA	0.4900

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.2	0.3	0.4	0.3	-0.5	0.7	0.5
Bipolar Disorder or Schizophrenia	0.4	1.0	2.2	-0.7	0.7	-0.8	-1.5
Depressed Affect (Nagel 2018)	4.5	9.5	12.0	-3.0	3.5	-3.1	-2.6
Depression (Nagel 2018)	5.6	8.4	11.6	-2.8	2.6	-3.4	-2.7
Intelligence (Savage-Jansen 2018)	0.1	0.2	0.6	-0.2	0.2	0.8	0.4
Neuroticism (Nagel 2018)	6.9	16.2	19.4	-3.9	3.8	-4.4	-3.9
Schizophrenia (2018)	1.3	2.8	5.3	-1.2	1.3	-1.6	-2.3
Schizophrenia vs Biploar Disorder	5.4	7.2	11.3	-2.0	2.8	-2.4	-3.4
Worry (Nagel 2018)	6.3	13.2	18.7	-3.4	3.1	-4.3	-3.6
Alzheimer’s Disease (in mother)	2.9	3.4	5.1	-2.2	1.9	-1.6	-1.5
Alzheimer’s Disease (in father)	0.2	0.2	0.3	0.4	0.1	0.5	0.6
Alzheimer’s Disease (including proxy)	2.9	4.2	5.7	-2.2	2.4	-1.8	-1.7
Crohns Disease (2017)	0.4	0.8	1.9	1.4	-0.7	0.6	0.8
Irritable Bowel Disease (IBD)	0.3	0.8	1.6	-0.0	0.3	-1.3	-1.1
Ulcerative Colitis (UC)	2.6	4.8	6.9	-1.7	1.6	-2.6	-2.6
Major Depression (MDD)	2.0	2.4	3.9	-1.6	2.0	-1.4	-1.1
Reaction Time	0.3	0.6	0.9	0.7	0.2	0.9	0.9
Verbal and Numeric Reasoning (VNR)	0.5	1.2	2.7	-1.6	0.9	-0.5	-1.0
Breast Cancer	0.3	0.8	2.3	-0.9	0.3	-1.5	-0.4
Ovarian Cancer	0.3	0.4	0.8	-0.1	-0.5	0.7	0.9
Prostate Cancer	0.4	0.6	1.2	0.0	-1.1	0.9	0.6
Age at First Birth	1.1	1.6	2.1	1.1	-1.4	1.1	1.4
Bipolar Disorder (2011)	0.5	0.4	0.8	0.6	-0.1	0.9	0.8
Body Mass Index (BMI) (2010)	0.1	0.1	0.4	0.6	-0.2	0.3	-0.2
Coronary Artery Disease (CAD)	3.4	4.1	7.5	-1.2	2.7	-1.3	-2.4
Crohns Disease (2012)	0.1	0.1	0.2	0.4	0.5	-0.1	-0.3
Mean Putamen Volume	0.1	0.1	0.4	0.3	0.2	-0.6	-0.3
Fasting Glucose	1.8	2.2	5.3	-2.3	0.5	-1.5	-0.9
HbA1C	0.2	0.2	0.8	0.3	0.9	0.0	-0.1
HDL Cholesterol	2.2	3.7	4.7	1.9	-1.5	2.2	2.1
LDL Cholesterol	1.6	2.5	3.2	-1.4	1.8	-1.7	-1.4
Lupus	0.6	0.9	1.7	0.4	-1.3	0.9	0.9
Neuroticism (2016)	6.3	9.1	12.1	-2.7	3.2	-3.5	-2.7
Primary Biliary Cirrhosis	1.6	2.2	3.5	-1.8	0.7	-1.9	-1.4
Rheumatoid Arthritis	0.7	1.0	1.5	-1.0	1.1	-0.7	-1.2
Schizophrenia (2014)	1.0	2.3	5.1	-1.1	1.1	-1.3	-2.3
Triglycerides	0.6	1.0	1.4	-1.2	1.2	-0.8	-0.7
Type 2 Diabetes (T2D) (2012)	1.4	1.7	2.0	-1.3	1.0	-1.4	-1.4
Ulcerative Colitis	0.9	1.4	3.0	-0.8	0.4	-1.7	-1.3
Blood Eosinophil Count	2.6	19.7	26.1	-3.4	5.1	-4.5	-4.6
Blood Platelet Count	0.4	5.0	9.7	-3.1	2.6	-1.1	-1.6
Blood Red Count	4.0	39.1	50.4	-7.1	5.3	-5.5	-6.9
Blood White Count	0.4	3.0	5.1	-1.5	2.3	-1.4	-1.7
Heel T-Score	0.7	5.9	9.7	3.1	-2.1	2.5	1.8
BMI	0.0	0.1	0.2	0.0	-0.4	0.4	-0.2
Height	4.9	94.8	132.2	9.9	-11.5	7.3	9.7
Waist Hip Ratio (WHR)	2.9	13.2	17.3	-3.3	3.6	-3.4	-4.2
Systolic Blood Pressure	2.8	14.2	15.4	-3.6	3.9	-3.6	-3.9
Smoking Status	2.3	5.5	8.7	1.6	-1.9	2.6	3.0
Allergy or Eczema	0.1	0.3	0.7	0.2	-0.8	-0.7	0.0
Cardiovascular Disease	3.7	12.1	16.1	-3.6	3.3	-3.0	-4.0
Hypothyroidism (self reported)	0.4	1.0	1.8	-0.9	1.4	-1.1	-0.2
Respiratory disease	0.2	0.5	1.2	0.8	-0.5	0.2	1.1
Type 2 Diabetes (T2D) (2018)	0.4	0.7	1.8	-1.4	-0.2	-0.9	-0.3
Lung FEV1/FVC ratio	1.6	7.9	10.9	-3.3	2.7	-2.1	-2.9
Lung FVC	1.8	9.3	11.8	-3.4	3.2	-2.5	-3.0
Neuroticism	7.4	17.8	21.2	-4.2	3.8	-4.6	-4.3
Chronotype (morning person)	15.0	34.7	47.5	5.6	-5.1	6.9	5.9
Hair Pigment	0.0	0.4	0.7	-0.1	0.8	-0.9	-0.1
Tanning	0.5	6.4	8.2	2.0	-2.9	2.6	2.6
Hand grip strength (left)	2.5	6.6	9.1	3.0	-2.3	2.5	2.5
Number of treatments/medications taken	2.0	3.7	4.6	-1.9	2.1	-1.7	-1.9
Average weekly spirits intake	3.7	4.6	6.6	-2.6	1.5	-2.2	-2.2
Sensitivity / hurt feelings	2.1	3.6	4.5	-1.3	2.0	-2.1	-2.1
Frequency of depressed mood in last 2 weeks	4.7	6.6	9.1	-3.0	2.3	-2.7	-2.2
Hearing difficulty/problems: Yes	1.2	1.8	2.2	-1.4	1.2	-1.5	-1.3
Relative age of first facial hair	0.3	0.6	1.2	-0.6	-0.7	0.8	1.1
Other serious medical condition/disability diagnosed by doctor	1.6	2.1	2.6	-1.6	1.5	-1.4	-1.2
Ever used hormone-replacement therapy (HRT)	0.2	0.3	0.5	-0.7	0.5	-0.5	-0.2
Ever had hysterectomy (womb removed)	1.0	1.1	2.6	-0.4	0.5	-1.6	-1.2
Systolic blood pressure, automated reading	3.3	9.5	12.0	-3.5	2.5	-3.1	-3.2
Eye problems/disorders: Diabetes related eye disease	4.1	4.5	5.9	-1.6	2.4	-2.3	-2.1
Angina	0.3	0.5	1.1	-0.3	1.0	-0.4	-0.7
Medication for hormone replacement therapy	0.0	0.1	0.2	-0.1	-0.0	0.0	-0.4
Vitamin and mineral supplements	0.9	1.2	2.1	1.5	-0.9	1.1	0.9
Supplements: Zinc	0.5	0.5	1.5	-1.2	0.0	-0.7	-0.3
Medication: Co-codamol	0.3	0.4	0.6	-0.8	0.7	-0.2	-0.5
Medication: Metformin	0.1	0.2	0.6	-0.2	-0.7	0.2	0.2
Diabetes (father)	0.4	0.5	0.8	-0.7	0.4	-0.9	-0.7
Diabetes (mother)	0.9	1.1	1.6	0.7	-0.9	1.3	1.1
Severe depression (siblings)	4.8	5.3	5.8	-2.3	2.4	-2.2	-2.4
Pack years adult smoking proportion	0.4	0.5	1.1	0.4	-0.7	1.1	0.7
Impedance of leg (right)	0.3	1.5	3.3	1.2	0.1	1.0	1.8
Leg fat-free mass (left)	0.9	4.9	10.7	2.3	-3.3	1.3	1.5
Trunk fat percentage	0.3	1.3	1.5	-1.1	1.2	-1.0	-1.2
Hand grip strength (right)	3.1	8.5	11.4	3.4	-2.7	2.8	2.8
Townsend deprivation index at recruitment	0.8	1.1	2.2	-1.5	1.2	-0.4	-0.8
Current tobacco smoking	0.0	0.1	0.2	0.2	-0.4	0.1	0.1
Average weekly fortified wine intake	0.4	0.5	0.9	-0.4	0.2	-0.9	-0.8
Maternal smoking around birth	0.2	0.3	0.7	0.9	-0.6	0.1	0.3
Fed-up feelings	4.9	8.9	10.3	-3.0	3.2	-2.9	-2.9
Frequency of unenthusiasm / disinterest in last 2 weeks	7.4	9.9	12.5	-3.4	2.6	-3.5	-3.0
Relative age voice broke	1.2	1.9	3.0	-1.7	1.7	-0.9	-0.9
Taking other prescription medications	1.4	2.2	3.6	-0.9	1.9	-1.4	-1.6
Age when periods started (menarche)	1.4	3.4	5.3	1.7	-1.4	1.9	2.3
Bilateral oophorectomy (both ovaries removed)	6.0	7.0	11.1	-2.9	1.5	-3.3	-2.4
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	2.2	1.5	-0.7	0.9	0.5
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.3	0.3	0.6	-0.4	-0.3
Qualifications: CSEs or equivalent	0.9	1.2	1.9	-1.2	1.4	-0.7	-0.9
Serious illness, injury or assault to yourself	0.2	0.2	0.5	-0.7	0.3	0.5	0.3
High blood pressure	5.3	14.9	18.6	-4.3	3.4	-3.7	-4.0
Hayfever, allergic rhinitis or eczema	0.1	0.3	0.8	-0.4	-0.3	-0.9	-0.2
Multivitamins +/- minerals	1.6	2.1	3.2	-1.8	1.3	-1.4	-1.1
Stomach or abdominal pain in last month	3.0	3.7	5.2	-2.0	2.3	-1.4	-1.8
Supplements: Glucosamine	0.1	0.1	0.2	-0.1	-0.4	0.2	-0.3
Diverticular disease/diverticulitis (self-reported)	5.0	6.0	7.6	-2.8	2.3	-2.2	-2.4
Medication: Atenolol	1.2	1.5	2.0	-1.4	1.2	-1.2	-1.1
Medication: Levothyroxine sodium	1.5	2.6	4.3	-1.8	2.1	-1.5	-0.8
Sitting height	2.5	17.4	27.4	4.3	-5.2	2.4	4.2
Chronic bronchitis/emphysema (father)	0.4	0.5	1.1	0.7	0.6	1.0	-0.2
High blood pressure (mother)	1.7	2.4	2.9	-1.6	1.7	-1.4	-1.4
Body mass index (BMI)	0.5	2.1	3.2	-1.6	0.9	-1.3	-1.8
Impedance of leg (left)	0.4	2.2	5.2	1.3	-0.1	1.3	2.3
Leg predicted mass (left)	1.0	5.2	11.0	2.3	-3.3	1.4	1.6
Trunk fat mass	0.0	0.1	0.1	0.0	-0.3	-0.3	-0.3
Waist circumference	0.9	3.2	4.6	-1.9	1.0	-1.9	-2.1
Number of incorrect matches in round	7.9	13.2	16.0	-3.0	4.0	-3.9	-3.5
Past tobacco smoking	0.2	0.3	1.1	-0.1	-0.2	-0.4	-1.0
Alcohol usually taken with meals	0.8	1.3	3.1	1.8	-0.1	0.9	1.1
Nervous feelings	4.3	7.9	10.9	-2.5	2.0	-3.3	-3.2
Frequency of tenseness / restlessness in last 2 weeks	2.2	3.5	6.2	-2.3	0.3	-2.5	-1.6
Hearing difficulty/problems with background noise	0.2	0.4	1.2	-0.4	-0.2	-1.1	-0.3
Hair/balding pattern: Pattern 2	0.1	0.1	0.4	-0.1	-0.2	-0.3	0.6
Had menopause	0.4	0.5	1.7	-0.1	-1.3	0.3	0.5
Had other major operations	0.5	0.6	1.4	-0.4	-1.2	-0.1	0.9
Forced vital capacity (FVC)	0.8	3.1	3.9	1.9	-2.0	1.1	2.0
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.7	3.7	1.9	-1.1	1.0	0.8
Ever unenthusiastic/disinterested for a whole week	4.5	5.5	7.7	-2.8	2.1	-2.2	-2.3
Qualifications: None of the above	0.4	0.9	2.0	-0.6	1.4	-0.2	-1.1
Financial difficulties in last 2 years	0.1	0.1	0.2	-0.2	-0.4	0.2	-0.3
Mouth/teeth dental problems	0.1	0.1	0.4	-0.2	0.6	0.1	0.1
Heart attack	1.3	1.7	2.3	-1.0	1.5	-1.1	-1.5
Allergy	0.1	0.3	0.9	0.2	-0.2	1.0	0.3
Pain all over the body in last month	0.3	0.3	0.7	-0.7	0.8	-0.1	-0.1
Diabetes (self-reported)	1.1	1.7	4.0	-2.0	0.8	-1.0	-1.1
Hayfever/allergic rhinitis (self-reported)	1.1	1.5	2.1	1.1	-1.1	1.1	1.4
Medication: Ramipril	1.7	2.1	3.4	-1.3	1.8	-1.4	-1.2
Medication: Simvastatin	1.7	2.5	3.6	-1.2	1.9	-1.4	-1.7
Fluid intelligence score	0.3	0.7	1.8	0.2	-0.5	1.3	0.8
Illnesses of siblings	2.7	3.8	4.2	1.9	-2.0	2.0	1.9
Neuroticism score	11.6	24.3	29.0	-4.8	4.5	-5.4	-4.9
Weight	0.5	2.6	5.4	1.6	-2.3	1.0	1.2
Impedance of arm (right)	0.1	0.5	1.6	0.5	1.2	0.0	0.5
Arm fat percentage (right)	0.9	3.4	4.2	-2.0	1.5	-1.7	-2.1
Trunk fat-free mass	2.5	14.3	26.8	3.7	-5.2	2.6	3.2
Hip circumference	0.1	0.5	1.8	-0.0	-1.3	-0.2	0.3
Time employed in main current job	1.3	1.6	3.2	-1.4	0.7	-0.8	-1.8
Alcohol intake versus 10 years previously	0.0	0.0	0.1	-0.2	-0.2	0.3	-0.1
Father’s age at death	0.6	0.9	2.2	0.4	-1.5	0.8	0.7
Worrier / anxious feelings	6.3	11.8	16.7	-3.7	3.1	-4.1	-2.7
Frequency of tiredness / lethargy in last 2 weeks	4.1	6.6	8.2	-2.9	2.3	-2.6	-2.4
Falls in the last year	0.7	0.9	1.8	0.2	-0.8	1.3	1.1
Hair/balding pattern: Pattern 3	4.2	6.3	10.2	-2.0	3.2	-1.8	-2.7
Number of live births	0.1	0.2	0.7	0.3	0.8	0.1	-0.3
Forced expiratory volume in 1-second (FEV1)	0.0	0.1	0.2	-0.0	-0.4	-0.4	0.3
Pulse rate	0.2	0.3	0.5	-0.7	-0.6	-0.6	0.3
Happiness	6.6	8.0	11.5	-3.4	1.9	-3.1	-2.8
Noisy workplace	0.1	0.2	0.4	-0.0	0.4	0.7	0.2
Qualifications: A levels/AS levels or equivalent	0.2	0.5	0.9	1.0	-0.0	0.6	0.9
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.3	0.6	-0.5	-0.4	-0.8	-0.1
Mouth/teeth dental problems: Dentures	1.2	2.0	2.6	1.5	-1.6	1.5	1.1
Asthma	0.2	0.4	0.7	0.8	-0.3	-0.1	0.8
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.6	0.4	0.6	0.7	0.0
Medication: Cholesterol lowering	0.8	1.3	2.1	-0.6	1.5	-0.8	-1.4
Depression (self-reported)	0.2	0.2	0.8	-0.0	-0.9	-0.0	-0.0
Medication: Lansoprazole	0.5	0.5	1.6	0.7	0.1	1.3	0.0
Prospective memory result	0.3	0.3	0.6	0.3	-0.6	0.8	0.6
Lung cancer (father)	4.8	5.6	7.7	2.1	-2.8	2.7	1.8
Illnesses of mother	2.0	2.5	4.1	1.5	-2.0	1.1	1.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.0	0.0	0.1	-0.2	-0.2	-0.2	0.2
Pulse wave Arterial Stiffness index	0.2	0.2	0.5	-0.3	-0.7	-0.5	0.4
Impedance of arm (left)	0.2	0.7	2.8	0.2	1.7	-0.3	0.2
Arm fat mass (right)	0.1	0.4	0.6	-0.6	-0.2	-0.7	-0.8
Trunk predicted mass	2.5	14.1	26.2	3.6	-5.1	2.5	3.2
Standing height	4.4	43.5	53.3	7.3	-7.3	4.9	6.6
Length of working week for main job	3.8	4.2	6.8	1.6	-2.0	2.6	1.9
Exposure to tobacco smoke at home	0.8	0.9	1.6	-1.3	0.6	-0.6	-1.1
Breastfed as a baby	1.0	1.3	1.6	-1.3	1.2	-1.0	-0.9
Tense / ‘highly strung’	1.7	2.8	3.5	-1.6	1.5	-1.9	-1.8
Seen doctor (GP) for nerves, anxiety, tension or depression	1.9	3.0	5.8	-2.4	0.7	-1.8	-1.5
Hair/balding pattern: Pattern 4	0.5	1.1	1.7	-1.1	0.8	-1.3	-1.0
Birth weight of first child	0.4	0.6	1.5	0.8	-1.2	0.4	0.5
Peak expiratory flow (PEF)	0.7	1.5	2.7	-1.2	1.0	-1.6	-1.1
Pulse wave reflection index	1.1	1.4	3.6	1.9	-0.4	1.0	0.9
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.4	-0.3	-0.2	0.6	0.7
Loud music exposure frequency	1.1	1.2	2.6	-1.6	-0.9	-1.2	-0.3
Qualifications: O levels/GCSEs or equivalent	0.1	0.1	0.2	0.3	-0.3	-0.1	0.4
Mouth/teeth dental problems: Bleeding gums	2.7	3.5	5.5	-2.3	0.7	-2.2	-1.7
Blood clot in the leg (DVT)	1.1	1.5	2.2	-1.2	1.3	-0.8	-1.5
Medication: Paracetamol	0.6	1.0	1.3	-1.1	1.2	-0.6	-1.1
Headache pain in last month	1.8	3.0	4.4	-2.0	2.1	-1.2	-1.5
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	1.6	1.0	-0.9	0.9	1.3
Glaucoma (self-reported)	0.1	0.1	0.1	-0.1	0.3	-0.3	-0.2
Gout (self-reported)	0.1	0.1	0.1	-0.2	0.2	-0.3	-0.3
Hypothyroidism/myxoedema (self-reported)	1.7	3.3	5.3	-1.8	2.3	-1.8	-1.1
Medication: Amlodipine	1.0	1.4	2.4	-1.2	1.0	-0.9	-1.5
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.6	0.8	0.0	0.3	0.1
Birth weight	0.3	0.7	1.5	1.2	-0.9	0.7	0.3
Chronic bronchitis/emphysema (mother)	0.8	0.9	2.0	1.4	-0.1	1.2	0.4
High blood pressure (siblings)	1.3	1.9	2.9	-1.7	0.9	-1.6	-1.1
Forced vital capacity (FVC), Best measure	0.8	2.8	4.0	1.6	-2.0	1.2	1.8
Body fat percentage	0.4	1.5	1.8	-1.3	1.4	-1.1	-1.2
Leg fat percentage (right)	0.7	2.6	3.2	-1.8	1.6	-1.4	-1.6
Arm fat-free mass (right)	2.0	10.2	18.0	3.1	-4.2	2.3	2.8
Exposure to tobacco smoke outside home	1.2	1.6	2.8	-1.0	0.9	-1.4	-1.7
Comparative body size at age 10	0.1	0.4	1.1	-0.2	1.1	0.4	-0.6
Number of full brothers	1.5	1.9	2.8	-1.2	1.7	-1.4	-1.1
Worry too long after embarrassment	7.8	13.1	20.5	-3.4	2.5	-4.5	-3.7
Seen a psychiatrist for nerves, anxiety, tension or depression	3.4	4.4	6.5	-2.5	1.7	-2.3	-1.7
Wheeze or whistling in the chest in last year	0.2	0.3	0.8	0.9	0.5	0.3	0.2
Number of children fathered	1.2	1.3	2.0	-1.0	1.4	-0.8	-1.3
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	0.9	1.0	-0.1	0.5	0.3
Age at first live birth	1.3	2.3	2.8	1.3	-1.6	1.7	1.5
Pulse wave peak to peak time	0.3	0.3	0.7	0.8	0.2	0.8	0.0
Health satisfaction	2.9	3.8	5.6	-2.4	0.9	-2.4	-1.8
Shortness of breath walking on level ground	0.2	0.2	0.9	0.0	-0.3	-1.0	0.0
Qualifications: College or University degree	2.2	6.9	9.1	2.8	-3.0	2.3	2.4
Eye problems/disorders: None of the above	0.7	0.8	1.4	0.9	-0.9	1.2	0.5
Mouth/teeth dental problems: Loose teeth	0.3	0.3	0.9	-0.5	-1.0	-0.0	0.4
Emphysema/chronic bronchitis	0.4	0.4	1.4	-0.3	1.2	0.2	-0.2
Medication for pain relief, constipation, heartburn	0.3	0.6	1.2	-0.9	-0.5	-1.1	-0.1
Neck or shoulder pain in last month	0.3	0.4	0.8	0.9	-0.4	0.7	0.3
Medication: Blood pressure	0.5	0.9	1.3	-0.8	0.8	-1.1	-1.0
Angina (self-reported)	0.3	0.4	0.8	-0.3	0.9	-0.4	-0.7
Migraine (self-reported)	0.3	0.3	0.7	0.8	0.2	0.7	-0.2
Medication: Ibuprofen	0.1	0.2	0.6	0.3	0.2	0.8	0.1
Medication: Allopurinol	0.1	0.1	0.3	0.1	0.5	-0.4	-0.2
Medication: Omeprazole	0.4	0.5	1.4	0.2	1.2	-0.1	-0.8
Medication: Seretide 50 evohaler	0.1	0.1	0.3	0.2	-0.0	0.3	-0.5
Mean time to correctly identify matches	0.7	1.3	4.2	-0.8	2.1	-0.2	-0.6
Heart disease (mother)	0.4	0.5	1.4	-1.2	-0.5	0.1	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.4	0.6	-0.7	0.2	0.1
Whole body fat mass	0.0	0.1	0.1	-0.1	-0.3	-0.2	-0.3
Leg fat mass (right)	0.0	0.2	0.3	-0.4	-0.2	-0.5	-0.5
Arm predicted mass (right)	2.2	11.1	19.6	3.1	-4.4	2.5	3.0
Pulse rate, automated reading	0.1	0.4	1.2	-1.1	0.7	0.2	0.1
Alcohol intake frequency.	0.3	0.6	1.8	0.0	1.3	0.4	-0.8
Comparative height size at age 10	5.1	27.9	40.7	5.5	-6.4	4.0	4.9
Number of full sisters	2.1	2.5	3.5	-1.8	1.3	-1.2	-1.9
Suffer from ‘nerves’	7.4	11.6	13.3	-3.5	2.7	-3.6	-3.6
Overall health rating	2.1	4.4	8.9	-3.0	2.2	-1.4	-1.4
Chest pain or discomfort	2.9	4.2	9.8	-3.1	1.4	-1.6	-1.6
Had major operations	2.4	2.8	4.7	-2.2	1.6	-1.4	-1.4
Age at last live birth	1.8	2.6	4.1	2.0	-1.1	1.8	1.4
Family relationship satisfaction	0.3	0.3	0.7	-0.8	-0.5	-0.4	-0.5
Leg pain on walking	0.8	1.1	1.8	-1.0	0.4	-1.1	-1.3
Qualifications: NVQ or HND or HNC or equivalent	0.0	0.0	0.1	-0.1	0.1	-0.1	-0.2
Commuting to job workplace: Car/motor vehicle	2.1	2.4	3.1	1.8	-1.7	1.5	1.2
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.1	-0.1	0.6	-1.1	-0.6
Medication: Aspirin	0.9	1.2	2.9	-0.6	1.7	-1.0	-0.9
Supplements: Vitamin C	0.2	0.2	0.3	-0.6	0.3	-0.4	-0.6
Knee pain experienced in last month	1.1	1.8	3.3	-1.5	0.8	-0.9	-1.8
Hypertension (Self-reported)	5.5	15.3	17.8	-4.2	3.6	-3.7	-4.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	0.5	0.5	-0.6	0.7	0.3
Illnesses of father: Heart disease	2.9	4.1	6.2	-1.8	1.6	-2.1	-2.5
Illnesses of siblings: Diabetes	0.4	0.5	1.2	-0.5	0.5	-0.4	-1.1
Smoking status: Previous	0.4	0.6	1.5	0.2	0.1	0.9	1.2
Forced expiratory volume in 1-second (FEV1), predicted	6.4	13.3	16.3	3.7	-4.0	3.4	3.4
Whole body fat-free mass	1.9	11.0	21.4	3.2	-4.6	2.2	2.7
Leg fat-free mass (right)	1.2	6.3	12.8	2.5	-3.6	1.7	1.9
Arm fat percentage (left)	1.1	4.5	5.6	-2.3	1.9	-2.0	-2.4
Average weekly red wine intake	0.1	0.1	0.3	-0.1	-0.0	-0.1	0.6
Handedness (chirality/laterality): Left-handed	2.0	2.5	3.0	-1.6	1.5	-1.5	-1.7
Mood swings	3.6	6.6	8.5	-2.9	2.5	-2.7	-2.2
Loneliness, isolation	2.6	3.6	4.5	-1.9	1.7	-1.8	-2.1
Long-standing illness, disability or infirmity	1.4	2.1	2.8	-1.7	1.4	-1.4	-1.3
Ever had bowel cancer screening	0.9	1.0	1.5	-0.2	1.1	-1.2	-1.2
Diabetes diagnosed by doctor	1.3	2.2	3.8	-1.9	1.2	-1.3	-1.4
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.1	2.3	1.5	-0.7	1.0	0.8
Friendships satisfaction	5.2	6.4	10.1	-2.6	1.5	-3.2	-2.6
Qualifications: nursing, teaching	0.1	0.1	0.1	-0.3	-0.4	-0.1	-0.3
Commuting to job workplace: Walk	0.2	0.3	1.0	-0.2	1.0	-0.2	0.1
Eye problems/disorders: Cataract	1.1	1.2	2.3	-1.3	0.6	-1.5	-0.8
Mouth/teeth dental problems: Mouth ulcers	3.2	5.0	7.8	-1.7	2.8	-1.9	-2.4
Medication for cholesterol	3.3	5.0	6.9	2.6	-2.1	1.9	2.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.2	0.6	0.1	0.3	-0.0	-0.8
Back pain experienced in last month	0.7	1.0	2.4	0.4	-1.0	1.6	0.6
Mineral and other dietary supplements	0.5	0.7	1.8	1.3	-0.6	0.8	0.3
Breast cancer (self-reported)	1.6	1.9	2.8	-0.1	-1.5	1.5	1.7
Asthma (self-reported)	0.2	0.5	0.9	0.9	-0.5	0.0	0.9
Osteoporosis (self-reported)	0.1	0.1	0.2	0.1	0.4	-0.2	0.2
Osteoarthritis (self-reported)	0.9	1.1	1.8	-0.9	0.6	-1.3	-1.2
Medication: Aspirin	1.0	1.3	3.0	-0.6	1.7	-0.9	-1.1
Medication: Gliclazide	2.6	3.0	4.6	-2.1	0.8	-1.8	-1.8
Illnesses of father: None of the above (group 1)	3.7	4.5	8.0	1.6	-2.3	1.6	2.8
Smoking status: Current	0.0	0.0	0.1	0.1	-0.4	-0.0	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	1.7	-0.7	1.3	-0.6	-1.2
Whole body water mass	1.9	10.7	20.9	3.2	-4.6	2.2	2.7
Leg predicted mass (right)	1.2	6.2	12.5	2.4	-3.5	1.6	1.9
Arm fat mass (left)	0.1	0.4	0.7	-0.6	-0.2	-0.7	-0.8
Number of self-reported non-cancer illnesses	8.3	14.3	15.4	-3.8	3.5	-3.9	-3.9
Average weekly champagne plus white wine intake	1.0	1.4	1.6	1.1	-1.1	1.2	1.3
Miserableness	1.7	2.9	4.4	-1.5	2.1	-2.0	-1.0
Guilty feelings	3.4	5.0	7.3	-2.7	2.0	-2.3	-1.9
Wears glasses or contact lenses	2.7	3.1	3.8	-1.8	1.8	-1.9	-1.6
Ever taken oral contraceptive pill	0.2	0.2	0.6	0.1	-0.7	-0.5	0.3
Hearing aid user	1.5	1.7	2.1	-1.2	1.1	-1.4	-1.4
Mother’s age at death	2.8	3.5	4.5	1.6	-1.6	2.0	2.1
Financial situation satisfaction	9.3	11.6	13.4	-3.7	2.9	-3.3	-3.7
Tinnitus: Yes, now most or all of the time	1.1	1.3	1.4	-1.1	1.2	-1.2	-1.0
Commuting to job workplace: Public transport	1.8	2.1	2.6	-1.6	1.4	-1.4	-1.3
Eye problems/disorders: Glaucoma	0.4	0.4	0.9	0.4	-0.0	0.9	0.9
Medication: Blood pressure	5.3	10.0	11.5	-3.1	3.2	-3.0	-3.4
Pain type(s) experienced in last month: Hip pain	1.1	1.4	2.8	-1.1	0.6	-1.2	-1.7
Supplements: Fish oil (including cod liver oil)	0.2	0.3	0.5	-0.7	0.7	-0.4	0.2
High cholesterol (Self-reported)	1.3	2.4	3.2	-1.4	1.8	-1.2	-1.8
Medication: Bendroflumethiazide	0.6	0.9	1.7	-1.3	0.8	-0.9	-0.6
Medication: Paracetamol	0.4	0.7	1.4	-0.7	0.8	-0.4	-1.2
Medication: Lisinopril	0.1	0.1	0.3	0.1	0.5	-0.3	-0.4
Medication: Atorvastatin	2.0	2.5	4.5	-1.3	2.1	-0.9	-1.7
Illnesses of father: High blood pressure	2.0	2.4	6.2	-0.8	2.5	-0.5	-1.6
Alcohol drinker status: Never	0.9	1.1	2.2	1.0	1.5	-0.1	-1.1
Ever smoked	0.1	0.3	0.5	-0.3	0.7	-0.7	-0.1
Basal metabolic rate	1.6	8.6	17.2	2.9	-4.2	1.9	2.3
Leg fat percentage (left)	0.6	2.0	2.6	-1.6	1.5	-1.2	-1.3
Arm fat-free mass (left)	2.2	11.3	21.1	3.2	-4.6	2.4	2.9
Number of operations (self-reported)	2.4	3.5	4.9	-2.2	1.4	-2.2	-1.5
Average weekly beer plus cider intake	2.7	3.9	4.2	2.1	-2.0	1.8	2.0
Irritability	2.6	4.4	6.0	-1.7	2.4	-2.0	-2.2
Risk taking	4.0	5.9	8.1	1.5	-2.7	2.4	2.8
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.3	0.6	-0.3	-0.6	-0.3
Fractured/broken bones in last 5 years	0.3	0.4	0.8	-0.6	0.1	-0.9	-0.6
Age started oral contraceptive pill	2.0	2.5	4.9	-1.3	2.2	-1.3	-1.4
Diastolic blood pressure, automated reading	2.6	8.1	12.2	-3.5	2.6	-2.5	-2.7
Ever depressed for a whole week	0.3	0.4	0.6	-0.8	0.7	-0.2	-0.7
Unable to work because of sickness or disability	0.6	0.8	1.8	-1.3	-0.9	-0.8	0.1
Commuting to job workplace: Cycle	0.1	0.1	0.2	0.5	0.1	0.2	0.2
Myopia	1.8	2.6	4.8	-0.9	2.0	-1.0	-2.2
Vascular/heart problems diagnosed by doctor	6.5	17.8	21.9	4.7	-4.0	3.8	4.3
Cholesterol lowering medication	2.6	3.9	5.7	-2.0	2.4	-1.7	-1.8
Medication: Omeprazole (e.g. Zanprol)	0.1	0.2	0.4	0.4	0.6	0.1	-0.3
Pain experienced in last month	0.1	0.2	0.6	0.2	-0.5	-0.8	0.2
Supplements: Calcium	0.5	0.6	1.3	1.1	-0.9	-0.0	0.4
Basal cell carcinoma (self-reported)	0.2	0.2	0.5	-0.7	0.1	-0.4	-0.5
Heart attack/myocardial infarction (self-reported)	1.0	1.3	1.7	-0.9	1.3	-0.9	-1.3
Deep venous thrombosis (DVT) (self-reported)	0.6	0.7	1.3	-0.8	0.9	-0.4	-1.1
Heart disease (siblings)	4.4	5.4	6.7	-2.3	2.6	-2.2	-2.2
Alcohol drinker status: Previous	0.3	0.4	0.6	0.7	0.3	0.8	0.5
Pack years of smoking	0.1	0.1	0.5	0.0	-0.1	0.7	0.3
Impedance of whole body	0.2	1.0	2.0	1.0	0.8	0.6	1.4
Leg fat mass (left)	0.0	0.1	0.1	-0.2	-0.4	-0.3	-0.2
Arm predicted mass (left)	2.3	11.7	21.4	3.2	-4.6	2.4	3.0