Best TWAS P=2.14e-09 · Best GWAS P=3.64e-09 conditioned to 0.32
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | RMI1 | 0.07 | 0.06 | lasso | 3 | 0.06 | 1.4e-07 | 5.6 | -5.7 | 1.5e-08 | -0.98 | 0.01 | 0.98 | FALSE |
| 2 | GTEx | Testis | RMI1 | 0.12 | 0.11 | enet | 15 | 0.14 | 1.3e-06 | -4.5 | -5.5 | 4.6e-08 | -0.82 | 0.03 | 0.95 | FALSE |
| 3 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RMI1 | 0.02 | 0.02 | blup | 31 | 0.01 | 8.8e-04 | 5.6 | -5.5 | 3.1e-08 | -0.93 | 0.01 | 0.92 | FALSE |
| 4 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | RMI1 | 0.03 | 0.03 | lasso | 4 | 0.04 | 4.1e-05 | 5.6 | -6.0 | 2.1e-09 | -0.92 | 0.01 | 0.96 | TRUE |
| 5 | The Cancer Genome Atlas | Brain Lower Grade Glioma | RMI1 | 0.03 | 0.03 | blup | 31 | 0.01 | 1.2e-02 | 5.7 | -5.6 | 1.8e-08 | -0.97 | 0.01 | 0.97 | FALSE |
| 6 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | C9orf64 | 0.17 | 0.05 | enet | 8 | 0.09 | 4.5e-04 | -4.9 | 5.2 | 2.2e-07 | 0.75 | 0.02 | 0.72 | FALSE |