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chr9:138,605,924-141,054,761

Best TWAS P=6.22e-10 · Best GWAS P=5.8e-08 conditioned to 0.0612

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	INPP5E	0.18	0.14	enet	21	0.21	1.6e-24	5.4	-5.5	2.9e-08	-0.88	0.01	0.99	FALSE
2	GTEx	Brain Caudate basal ganglia	INPP5E	0.23	0.20	enet	8	0.22	7.2e-07	5.3	-5.2	1.6e-07	-0.91	0.02	0.96	FALSE
3	GTEx	Brain Cerebellar Hemisphere	INPP5E	0.25	0.23	enet	6	0.17	3.4e-05	5.2	-5.5	4.0e-08	-0.90	0.02	0.96	FALSE
4	GTEx	Brain Cerebellum	INPP5E	0.40	0.30	enet	20	0.29	3.6e-09	5.3	-5.5	3.4e-08	-0.89	0.02	0.98	FALSE
5	GTEx	Cells Transformed fibroblasts	SDCCAG3	0.12	0.03	enet	21	0.06	5.4e-05	5.0	-5.6	2.3e-08	-0.74	0.03	0.96	FALSE
6	GTEx	Colon Transverse	SDCCAG3	0.11	0.01	lasso	8	0.02	5.5e-02	5.0	-6.0	1.8e-09	-0.66	0.04	0.82	TRUE
7	GTEx	Esophagus Muscularis	SDCCAG3	0.10	0.02	enet	5	0.02	3.6e-02	4.1	-5.7	1.5e-08	-0.78	0.02	0.91	FALSE
8	GTEx	Heart Atrial Appendage	INPP5E	0.13	0.12	lasso	2	0.10	3.5e-05	5.4	-5.4	6.7e-08	-0.98	0.01	0.95	FALSE
9	GTEx	Heart Atrial Appendage	MRPL41	0.14	0.03	lasso	4	0.03	2.6e-02	-5.1	-6.2	6.2e-10	-0.01	0.02	0.60	TRUE
10	GTEx	Nerve Tibial	INPP5E	0.13	0.17	enet	10	0.14	3.7e-10	5.2	-5.3	1.4e-07	-0.92	0.02	0.98	FALSE
11	GTEx	Pancreas	SEC16A	0.28	0.10	enet	16	0.16	4.1e-07	5.4	-5.3	9.2e-08	-0.81	0.01	0.98	FALSE
12	GTEx	Pancreas	SDCCAG3	0.21	0.03	lasso	4	0.01	9.5e-02	5.3	-5.2	2.5e-07	-0.53	0.03	0.73	FALSE
13	GTEx	Pituitary	INPP5E	0.21	0.24	lasso	3	0.14	1.8e-04	5.3	5.1	2.8e-07	0.94	0.02	0.92	FALSE
14	GTEx	Skin Sun Exposed Lower leg	INPP5E	0.10	0.10	lasso	2	0.09	5.2e-08	5.2	-5.3	8.7e-08	-0.91	0.02	0.98	FALSE
15	GTEx	Testis	INPP5E	0.24	0.32	enet	10	0.30	5.4e-14	5.2	-5.2	2.5e-07	-0.93	0.02	0.98	FALSE
16	GTEx	Testis	SDCCAG3	0.15	0.09	lasso	4	0.13	3.3e-06	5.0	-5.7	1.5e-08	-0.87	0.02	0.98	FALSE
17	GTEx	Thyroid	INPP5E	0.23	0.35	enet	16	0.37	8.2e-30	5.2	-5.6	2.1e-08	-0.83	0.03	0.97	FALSE
18	GTEx	Thyroid	SDCCAG3	0.16	0.11	lasso	3	0.12	9.4e-10	5.0	-5.4	7.4e-08	-0.58	0.03	0.97	FALSE
19	GTEx	Whole Blood	SEC16A	0.07	0.05	lasso	5	0.04	1.3e-04	5.4	-5.3	1.3e-07	-0.97	0.01	0.99	FALSE
20	GTEx	Whole Blood	SDCCAG3	0.07	0.03	enet	6	0.02	3.4e-03	5.3	-5.2	1.5e-07	-0.64	0.05	0.93	FALSE
21	YFS	Blood	INPP5E	0.33	0.55	lasso	6	0.57	2.9e-235	4.6	-5.2	1.6e-07	-0.95	0.02	0.98	FALSE
22	The Cancer Genome Atlas	Breast Invasive Carcinoma	SEC16A	0.02	0.00	blup	69	0.01	1.0e-03	5.3	-5.1	2.8e-07	-0.83	0.02	0.92	FALSE
23	The Cancer Genome Atlas	Colon Adenocarcinoma	SDCCAG3	0.08	0.01	lasso	4	0.02	3.1e-02	5.3	-6.0	2.5e-09	-0.83	0.01	0.72	FALSE
24	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SDCCAG3	0.04	0.05	enet	6	0.04	5.1e-05	5.3	-5.5	3.9e-08	-0.65	0.01	0.99	FALSE
25	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	INPP5E	0.07	0.04	blup	54	0.07	6.0e-05	4.9	-5.4	8.0e-08	-0.88	0.02	0.93	FALSE
26	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	SDCCAG3	0.05	0.01	blup	61	0.01	5.9e-02	5.4	-5.3	1.4e-07	-0.64	0.02	0.74	FALSE
27	The Cancer Genome Atlas	Prostate Adenocarcinoma	SDCCAG3	0.08	0.05	lasso	2	0.05	3.3e-06	5.3	-5.4	7.8e-08	-0.64	0.01	0.98	FALSE
28	The Cancer Genome Atlas	Prostate Adenocarcinoma	SEC16A	0.08	0.10	lasso	4	0.08	1.9e-08	5.2	-5.2	2.2e-07	-0.70	0.04	0.96	FALSE
29	The Cancer Genome Atlas	Testicular Germ Cell Tumors	INPP5E	0.10	0.06	blup	54	0.08	8.1e-04	5.2	-5.7	1.3e-08	-0.83	0.02	0.78	FALSE
30	The Cancer Genome Atlas	Thyroid Carcinoma	INPP5E	0.11	0.16	lasso	3	0.16	2.4e-15	4.7	-5.3	1.3e-07	-0.74	0.10	0.89	FALSE
31	The Cancer Genome Atlas	Thyroid Carcinoma	SDCCAG3	0.16	0.14	lasso	4	0.12	8.2e-12	5.3	-5.4	7.5e-08	-0.56	0.01	0.99	FALSE