Best TWAS P=7.9e-10 · Best GWAS P=5.24e-10 conditioned to 0.00393
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Brain Cerebellum | CRAT | 0.35 | 0.27 | lasso | 8 | 0.27 | 1.1e-08 | 4.9 | -5.2 | 2.2e-07 | -0.42 | 0.72 | 0.27 | FALSE |
2 | GTEx | Cells Transformed fibroblasts | RP11-247A12.1 | 0.07 | 0.04 | enet | 8 | 0.04 | 5.0e-04 | 5.3 | -5.1 | 2.7e-07 | -0.39 | 0.25 | 0.51 | FALSE |
3 | GTEx | Heart Left Ventricle | RP11-247A12.1 | 0.14 | 0.11 | lasso | 5 | 0.13 | 1.7e-07 | 5.0 | -5.3 | 9.5e-08 | -0.38 | 0.70 | 0.22 | FALSE |
4 | GTEx | Stomach | CRAT | 0.26 | 0.10 | lasso | 7 | 0.08 | 1.6e-04 | 4.9 | -5.2 | 1.5e-07 | -0.41 | 0.49 | 0.29 | FALSE |
5 | The Cancer Genome Atlas | Glioblastoma Multiforme | PPP2R4 | 0.16 | 0.04 | blup | 42 | 0.08 | 2.3e-03 | 4.7 | -6.2 | 7.9e-10 | -0.66 | 0.02 | 0.69 | TRUE |
6 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | IER5L | 0.02 | 0.03 | lasso | 2 | 0.02 | 1.1e-03 | 5.5 | -5.5 | 3.5e-08 | -0.44 | 0.06 | 0.50 | FALSE |
7 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | PPP2R4 | 0.06 | 0.05 | blup | 41 | 0.08 | 3.7e-05 | 5.0 | -5.3 | 1.4e-07 | -0.55 | 0.32 | 0.45 | FALSE |
8 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CRAT | 0.03 | 0.04 | blup | 31 | 0.03 | 1.6e-04 | 5.0 | -5.2 | 2.2e-07 | -0.40 | 0.01 | 0.98 | FALSE |
9 | The Cancer Genome Atlas | Lung Adenocarcinoma | PPP2R4 | 0.03 | 0.01 | blup | 40 | 0.03 | 2.9e-04 | 4.9 | -5.7 | 9.7e-09 | -0.64 | 0.04 | 0.90 | FALSE |
10 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | PPP2R4 | 0.07 | 0.04 | blup | 45 | 0.03 | 1.8e-02 | 5.3 | -5.6 | 1.7e-08 | -0.51 | 0.04 | 0.26 | FALSE |
11 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CRAT | 0.02 | 0.02 | blup | 31 | 0.02 | 4.5e-03 | 4.8 | -5.1 | 2.7e-07 | -0.43 | 0.02 | 0.82 | FALSE |
12 | The Cancer Genome Atlas | Stomach Adenocarcinoma | CRAT | 0.07 | 0.06 | blup | 29 | 0.08 | 3.1e-06 | 4.9 | -5.3 | 1.4e-07 | -0.45 | 0.02 | 0.97 | FALSE |