Best TWAS P=1.01e-08 · Best GWAS P=1.04e-09 conditioned to 2.25e-07
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | CYP2D6 | 0.26 | 0.10 | enet | 34 | 0.20 | 1.2e-16 | -4.5 | -5.3 | 1.3e-07 | -0.10 | 0.74 | 0.26 | FALSE |
| 2 | GTEx | Adrenal Gland | CYP2D6 | 0.37 | 0.14 | lasso | 12 | 0.16 | 2.3e-06 | -4.6 | -5.3 | 1.4e-07 | -0.07 | 0.55 | 0.43 | FALSE |
| 3 | GTEx | Artery Coronary | CYP2D6 | 0.24 | 0.18 | lasso | 7 | 0.17 | 1.8e-06 | -5.0 | -5.2 | 1.6e-07 | -0.10 | 0.67 | 0.27 | FALSE |
| 4 | GTEx | Brain Cerebellum | SLC25A5P1 | 0.24 | 0.11 | enet | 16 | 0.14 | 7.3e-05 | -5.0 | 5.7 | 1.0e-08 | 0.18 | 0.32 | 0.12 | TRUE |
| 5 | GTEx | Breast Mammary Tissue | CYP2D6 | 0.14 | 0.00 | enet | 28 | 0.02 | 3.4e-02 | -4.6 | -5.2 | 1.6e-07 | -0.35 | 0.09 | 0.32 | FALSE |
| 6 | GTEx | Muscle Skeletal | CYP2D6 | 0.10 | 0.06 | enet | 17 | 0.08 | 3.4e-08 | -4.5 | -5.5 | 3.6e-08 | -0.15 | 0.87 | 0.13 | FALSE |
| 7 | GTEx | Spleen | CCDC134 | 0.23 | 0.00 | enet | 14 | 0.09 | 2.7e-03 | -3.9 | 5.1 | 2.7e-07 | 0.12 | 0.06 | 0.14 | FALSE |