Best TWAS P=2.92e-12 · Best GWAS P=9.1e-11 conditioned to 0.734
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Cortex | TMEM161B-AS1 | 0.35 | 0.15 | lasso | 15 | 0.30 | 6.5e-09 | 4.2 | 5.4 | 7.9e-08 | 0.30 | 0.77 | 0.04 | FALSE |
| 2 | GTEx | Brain Hippocampus | TMEM161B-AS1 | 0.17 | 0.10 | enet | 13 | 0.08 | 5.4e-03 | 5.1 | 5.4 | 5.7e-08 | 0.21 | 0.12 | 0.07 | FALSE |
| 3 | ROSMAP | Brain Pre-frontal Cortex | LINC00461 | 0.10 | 0.07 | lasso | 2 | 0.05 | 4.5e-07 | 6.1 | 6.1 | 1.3e-09 | 0.89 | 0.01 | 0.98 | TRUE |
| 4 | ROSMAP | Brain Pre-frontal Cortex | TMEM161B-AS1 | 0.05 | 0.02 | lasso | 6 | 0.04 | 2.1e-05 | 3.8 | 5.5 | 5.0e-08 | 0.24 | 0.89 | 0.03 | FALSE |
| 5 | The Cancer Genome Atlas | Lung Adenocarcinoma | LOC645323 | 0.05 | 0.01 | blup | 72 | 0.01 | 2.8e-02 | -4.5 | 7.0 | 2.9e-12 | 0.47 | 0.02 | 0.17 | TRUE |
| 6 | The Cancer Genome Atlas | Thyroid Carcinoma | TMEM161B | 0.03 | 0.01 | blup | 48 | 0.01 | 4.6e-02 | 4.3 | 5.8 | 6.6e-09 | 0.18 | 0.00 | 0.12 | TRUE |