TWAS
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Traits
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Neuroticism
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chr4:89,947,254-91,439,574
Best TWAS P=7.11e-09 · Best GWAS P=1.74e-09 conditioned to 1
90M
90.2M
90.4M
90.6M
90.8M
91M
91.2M
91.4M
0
2
4
6
8
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Heart Left Ventricle
SNCA
0.16
0.15
lasso
8
0.14
5.3e-08
6.0
5.8
7.1e-09
0.99
0.00
1.00
TRUE
2
The Cancer Genome Atlas
Prostate Adenocarcinoma
SNCA
0.16
0.16
enet
9
0.17
3.1e-17
5.1
5.3
9.4e-08
0.90
0.15
0.85
FALSE