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Traits
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Neuroticism
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chr18:52,209,411-54,028,036
Best TWAS P=5.42e-12 · Best GWAS P=1.07e-14 conditioned to 5.83e-07
52.5M
53M
53.5M
54M
0
5
10
15
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
1
GTEx
Cells Transformed fibroblasts
TCF4
0.06
0.00
enet
4
0.00
5.1e-01
5.5
-6.9
5.4e-12
-0.49
0.19
0.23
TRUE
2
The Cancer Genome Atlas
Lung Adenocarcinoma
TCF4
0.04
0.06
lasso
2
0.06
1.9e-07
5.5
-5.3
1.2e-07
-0.26
0.96
0.03
FALSE