Best TWAS P=1.46e-11 · Best GWAS P=1.31e-12 conditioned to 0.00467
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | KCNJ11 | 0.04 | 0.03 | lasso | 3 | 0.03 | 2.6e-04 | 7.1 | 6.7 | 2.0e-11 | 0.95 | 0.01 | 0.99 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | RP1-239B22.5 | 0.11 | 0.06 | enet | 21 | 0.07 | 1.5e-06 | 6.5 | -6.1 | 1.0e-09 | -0.79 | 0.02 | 0.98 | FALSE |
| 3 | GTEx | Esophagus Mucosa | KCNJ11 | 0.27 | 0.16 | lasso | 8 | 0.22 | 1.6e-14 | -3.8 | -5.9 | 3.9e-09 | -0.72 | 0.73 | 0.27 | FALSE |
| 4 | GTEx | Esophagus Mucosa | NCR3LG1 | 0.38 | 0.38 | enet | 39 | 0.42 | 3.7e-30 | -3.8 | -5.2 | 1.8e-07 | -0.64 | 1.00 | 0.00 | FALSE |
| 5 | GTEx | Esophagus Mucosa | RP1-239B22.5 | 0.28 | 0.28 | enet | 47 | 0.32 | 2.9e-22 | -3.9 | -5.2 | 2.2e-07 | -0.67 | 0.99 | 0.01 | FALSE |
| 6 | GTEx | Nerve Tibial | RP1-239B22.5 | 0.11 | 0.08 | lasso | 2 | 0.08 | 2.9e-06 | -3.4 | -5.6 | 2.1e-08 | -0.66 | 0.07 | 0.80 | FALSE |
| 7 | GTEx | Skin Not Sun Exposed Suprapubic | KCNJ11 | 0.18 | 0.07 | lasso | 6 | 0.12 | 7.0e-07 | 7.1 | -6.5 | 1.1e-10 | -0.85 | 0.01 | 0.99 | FALSE |
| 8 | GTEx | Skin Sun Exposed Lower leg | KCNJ11 | 0.23 | 0.09 | lasso | 10 | 0.12 | 1.7e-10 | 6.8 | -6.4 | 1.9e-10 | -0.81 | 0.02 | 0.98 | FALSE |
| 9 | GTEx | Skin Sun Exposed Lower leg | RP1-239B22.5 | 0.06 | 0.06 | lasso | 2 | 0.07 | 8.6e-07 | -4.3 | -5.9 | 3.3e-09 | -0.72 | 0.06 | 0.93 | FALSE |
| 10 | GTEx | Thyroid | RP1-239B22.5 | 0.08 | 0.07 | enet | 16 | 0.08 | 1.8e-06 | 6.6 | -6.8 | 1.5e-11 | -0.80 | 0.02 | 0.97 | TRUE |
| 11 | ROSMAP | Brain Pre-frontal Cortex | KCNJ11 | 0.05 | 0.06 | enet | 6 | 0.05 | 3.0e-07 | 6.0 | 5.5 | 4.0e-08 | 0.82 | 0.05 | 0.94 | FALSE |
| 12 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | DKFZp686O24166 | 0.04 | 0.00 | blup | 71 | 0.02 | 7.1e-03 | -4.5 | -6.1 | 1.3e-09 | -0.77 | 0.02 | 0.76 | FALSE |
| 13 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | DKFZp686O24166 | 0.05 | 0.03 | blup | 71 | 0.04 | 1.2e-05 | -4.0 | -6.1 | 1.4e-09 | -0.79 | 0.05 | 0.92 | FALSE |
| 14 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | DKFZp686O24166 | 0.03 | 0.01 | blup | 72 | 0.03 | 2.4e-04 | 6.7 | -6.2 | 6.7e-10 | -0.79 | 0.02 | 0.94 | FALSE |
| 15 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | DKFZp686O24166 | 0.08 | 0.07 | lasso | 4 | 0.05 | 1.2e-03 | -4.0 | -5.3 | 1.0e-07 | -0.62 | 0.09 | 0.80 | FALSE |
| 16 | The Cancer Genome Atlas | Lung Adenocarcinoma | DKFZp686O24166 | 0.04 | 0.01 | blup | 71 | 0.02 | 1.5e-03 | 6.6 | -5.9 | 4.3e-09 | -0.84 | 0.01 | 0.90 | FALSE |