Best TWAS P=6.76e-10 · Best GWAS P=1.7e-08 conditioned to 0.444
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | SSSCA1-AS1 | 0.07 | 0.05 | lasso | 3 | 0.04 | 8.0e-04 | 5.6 | 5.7 | 1.6e-08 | 0.90 | 0.00 | 0.99 | FALSE |
| 2 | GTEx | Breast Mammary Tissue | LTBP3 | 0.08 | 0.01 | lasso | 5 | 0.02 | 5.3e-02 | 5.2 | 5.1 | 2.8e-07 | 0.93 | 0.02 | 0.89 | FALSE |
| 3 | GTEx | Breast Mammary Tissue (Female) | CTSW | 0.11 | 0.05 | enet | 14 | 0.04 | 2.6e-02 | 4.4 | -5.3 | 1.2e-07 | -0.58 | 0.04 | 0.37 | FALSE |
| 4 | GTEx | Cells EBV-transformed lymphocytes | SSSCA1-AS1 | 0.20 | 0.18 | lasso | 3 | 0.09 | 7.3e-04 | 5.6 | 5.7 | 1.2e-08 | 0.84 | 0.01 | 0.97 | TRUE |
| 5 | GTEx | Muscle Skeletal | LTBP3 | 0.09 | 0.02 | lasso | 4 | 0.02 | 1.9e-03 | 4.6 | 5.1 | 2.8e-07 | 0.79 | 0.08 | 0.76 | FALSE |
| 6 | GTEx | Nerve Tibial | LTBP3 | 0.12 | 0.05 | lasso | 3 | 0.09 | 1.2e-06 | 3.9 | 5.5 | 3.8e-08 | 0.75 | 0.02 | 0.98 | FALSE |
| 7 | ROSMAP | Brain Pre-frontal Cortex | CTSW | 0.06 | 0.03 | bslmm | 328 | 0.03 | 3.6e-05 | 4.6 | -6.2 | 6.8e-10 | -0.32 | 0.49 | 0.18 | TRUE |
| 8 | The Cancer Genome Atlas | Prostate Adenocarcinoma | KCNK7 | 0.04 | 0.02 | blup | 42 | 0.03 | 3.1e-04 | 3.8 | -5.4 | 7.7e-08 | -0.68 | 0.06 | 0.54 | FALSE |